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miconazole + benzoyl peroxide (Acnidazil / Acne Creme Plus)

✓ Approved

Teva Pharmaceutical Industries Ltd. · Small Molecule · Small Molecule

What is miconazole + benzoyl peroxide?

miconazole + benzoyl peroxide is a small molecule developed by Teva Pharmaceutical Industries Ltd.. It is approved for therapeutic indications.

Drug Profile

Brand NamesAcnidazil, Acne Creme Plus
CompanyTeva Pharmaceutical Industries Ltd.
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Teva Pharmaceutical Industries Ltd.

Therapeutic Indications

miconazole + benzoyl peroxide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersAcne✓ Approved

Related Research Articles

PubMedCureus2026-09-20

Vulvovaginal Candidiasis in Pregnancy: Species Distribution and Antifungal Resistance Patterns to Commonly Used Topical Azoles at a Tertiary Care Center in Central India.

Bhadade Arati A AA, Karuna Tadepalli T, Singh Bharti B, Ramani Anirban A et al.

Vulvovaginal candidiasis (VVC) is a common fungal infection during pregnancy. Topical azoles, including clotrimazole and miconazole, are recommended as first-line therapy; however, data on the distribution of Candida species and their in vitro susceptibility to these agents remain limited. This study aimed to determine the species distribution of Candida causing VVC in pregnant women and evaluate the in vitro activity of clotrimazole and miconazole. This six-month observational cross-sectional study was conducted at a tertiary care center in Central India. High vaginal swabs were collected from 108 symptomatic pregnant women and examined by direct microscopy and culture. Candida isolates were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Antifungal susceptibility testing for clotrimazole and miconazole was performed using the Etest method. Minimum inhibitory concentration (MIC) values were analyzed descriptively because clinical breakpoints (CBPs) and epidemiological cutoff values (ECVs) for these topical azoles were unavailable. Descriptive statistics included frequencies, percentages, mean, median, mode, and MIC ranges. Candida species were isolated from 45 of 108 pregnant women (41.67%). Candida albicans was the predominant isolate (36/45, 80.0%), followed by Nakaseomyces glabrata (4/45, 8.89%), Candida tropicalis (2/45, 4.44%), Pichia kudriavzevii (1/45, 2.22%), Candida parapsilosis (1/45, 2.22%), and Candida lusitaniae (1/45, 2.22%). Clotrimazole demonstrated lower MIC values than miconazole. Higher MIC values (>32 µg/mL), indicating reduced in vitro activity, were observed in nine (25.0%) Candida albicans isolates with miconazole, compared with one (2.78%) with clotrimazole. Candida albicans remained the predominant cause of VVC among pregnant women. Clotrimazole demonstrated lower MIC values than miconazole in this study, indicating greater in vitro activity based on the observed MIC distribution. Continued surveillance of antifungal susceptibility patterns and the establishment of validated CBPs for topical azoles against Candida species are essential for improving understanding of emerging antifungal resistance and supporting evidence-based management of VVC.

PMID 42763638
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PubMedJournal of nanobiotechnology2026-09-19

Visualized self-propelled nanorobots overcome tumor barriers for boosted photothermal-nanocatalytic synergistic therapy against triple-negative breast cancer.

Wang Ze Z, Chu Hongyu H, Du Jincheng J, Liang Hao H et al.

Conventional nanozyme-based therapeutics for triple-negative breast cancer (TNBC) are severely hindered by insufficient tumor penetration and lysosomal degradation-induced enzyme inactivation, crippling therapeutic efficacy. Herein, we rationally construct visualized dual-propelled Janus PDAPdAu nanorobots (PPA NBs) with cascade catalytic activity for synergistic photothermal-nanocatalytic therapy of TNBC. Powered by near-infrared light-triggered thermophoresis and nanozyme-fueled oxygen propulsion, PPA NBs realize deep tumor penetration and lysosomal escape. PPA NBs exhibit catalase-mimicking activity to alleviate tumor hypoxia through hydrogen peroxide decomposition, and glucose oxidase-mimicking activity to deplete glucose and downregulate heat shock proteins, thus sensitizing TNBC to photothermal therapy (PTT). Localized hyperthermia further enhances nanozyme catalysis, forming an amplified synergy between nanocatalytic therapy and PTT that affords an outstanding 97% tumor inhibition rate. Furthermore, PPA NBs act as excellent fluorescent biosensing probes for visual lesion localization. Overall, this work provides visual diagnosis and advanced TNBC phototherapy strategies, a reliable paradigm for cancer patients' health monitoring and treatment.

PMID 42760553
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PubMedWater research2026-09-19

Decoding the oxidative digestion mechanism for polystyrene nanoplastic detection in the Great Lakes using a customizable Raman spectral processing algorithm.

Wu Ziyan Z, Janssen Sarah E SE, Tate Michael T MT, Cook Bryce A BA et al.

Despite the concerns surging around nanoplastics (NPs) regarding their prevalence and bioavailability in freshwater systems, robust detection of NPs in complex environmental matrices is hindered by the lack of standardized sample pretreatment and a mechanistic understanding of oxidative digestion. Here, we systematically investigate the interaction between hydrogen peroxide (H2O2) and polystyrene (PS) NPs during digestion in deionized (DI) water and four environmental matrices from in and around the Great Lakes Basin. To facilitate high-throughput analysis, we develop Pre_peak, a customizable Raman spectral processing algorithm that achieves >99% accuracy for both NP identification and interference rejection, allowing reliable NP quantification via pixel counting and systematic decoding of the oxidative digestion mechanisms. In DI water, varying H2O2 doses from 0 to 30% has negligible effects on the recovery and Raman signal intensity of PS NPs over 24 h of digestion. However, morphological changes and aggregation of PS NPs are observed when the H2O2 dose exceeds 20%. Prolonged digestion further leads to progressive NP loss. In natural waters, the optimal dosage and digestion duration depend on matrix characteristics, including dissolved organic matter (DOM) and ion composition. This study provides mechanistic insights into NP-oxidant interactions and underscores the need for matrix-tailored digestion protocols to advance standardized NP detection in freshwater environments.

PMID 42762742
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PubMedFrontiers in cell and developmental biology2026-09-19

Progress on hydrogel delivery systems targeting metabolism disorders in the treatment of diabetic foot ulcers.

Liu Shihua S, Huang Lixian L, Dong Hong H

Diabetic foot ulcer (DFU) is a severe and difficult-to-heal complication of diabetes in which systemic metabolic dysregulation is translated into local neurovascular injury and dysfunction of wound-healing cells. This narrative review examines the relationships among glucose, lipid, and amino acid/protein metabolism disorders, the dysfunction of macrophages, fibroblasts, and endothelial cells, and hydrogel-based therapeutic strategies. Persistent hyperglycemia disrupts the tricarboxylic acid cycle, activates the polyol and advanced glycation pathways, and induces pseudohypoxia, oxidative stress, and inflammatory metabolic reprogramming. Dyslipidemia promotes lipid peroxidation, mitochondrial injury, impaired fatty acid oxidation, and ferroptosis, whereas amino acid and protein metabolic abnormalities disturb insulin signaling, arginine metabolism, collagen-precursor availability, and extracellular matrix turnover. These metabolic alterations sustain pro-inflammatory macrophage programs, impair fibroblast migration and matrix production, and compromise endothelial angiogenesis. We further critically compare hydrogel systems that provide glucose-responsive insulin release, catalytic glucose consumption and oxygen generation, lipid-peroxide scavenging, immunometabolic regulation, and support for extracellular matrix remodeling and vascular regeneration. Metabolism-targeted hydrogels provide a promising bridge between mechanistic metabolic intervention and local wound management; however, most available evidence remains preclinical. Future translation requires direct validation of metabolic regulation, standardized manufacturing, long-term biosafety assessment, and evaluation in clinically relevant DFU models.

PMID 42761806
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PubMedRSC advances2026-09-19

Quasi-spherical gold nanoparticles as peroxidase-like nanozymes for broad-range colorimetric detection of hydrogen peroxide and glucose.

Tuyet Nguyen Vu Anh NVA, Trang Tran Thu TT, Vu Xuan Hoa XH, Pham Thi Thu Ha TTH et al.

Gold-based (Au-based) nanozymes have emerged as promising substitutes for natural peroxidase enzymes, exhibiting distinctive advantages such as high stability, cost-effectiveness, and relatively good catalytic activity. However, to further enhance their catalytic performance, considerable efforts have been devoted to designing and synthesizing Au-based nanozymes with more sophisticated nanostructures. In this work, quasi-spherical gold nanoparticles (Au NPs) with an average size of 15-20 nm were facilely synthesized via a simple chemical reduction method and investigated for their peroxidase-like (POD-like) catalytic activity. Their catalytic activity was confirmed using 3,3',5,5'-tetramethylbenzidine (TMB) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) as chromogenic substrates. Steady-state kinetic analysis yielded apparent K m values of 0.75 ± 0.2 mM for TMB and 0.036 ± 0.005 mM for H2O2, indicating favorable H2O2 affinity and supporting the strong H2O2 responsiveness of the Au NPs nanozyme. Based on TMB oxidation, the Au NPs system enabled colorimetric determination of H2O2 over a broad working range of 0.059 µM-97 mM, and was further extended to glucose detection over 0.5-300 µM through a glucose oxidase-mediated reaction. The practical applicability of Au NPs nanozyme was further supported by H2O2 determination in spiked bottled mineral water, giving recoveries of approximately 94-105%.

PMID 42761934
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PubMedDental materials : official publication of the Academy of Dental Materials2026-09-19

Citric acid promotes effective in vitro decontamination of titanium while supporting surface, electrochemical, and biological properties compared with conventional chemical agents.

Corrêa Mirtes Maria Ferreira MMF, Santos Mariana Alves MA, Celles Cícero Andrade Sigilião CAS, Silva João Pedro Dos Santos JPDS et al.

This in vitro study evaluated the antimicrobial, physicochemical, electrochemical, and biological effects of chemical agents used for titanium (Ti) surface decontamination, with emphasis on identifying an optimal citric acid (CA) concentration for peri-implant disease management. Surface integrity, electrochemical behavior, and protein adsorption were analyzed after 1-min immersion in phosphate-buffered saline (PBS; control), 0.2% chlorhexidine (CHX), 3% hydrogen peroxide (HP), 1% sodium hypochlorite (SH), and CA (10, 20, 30, and 40%). Antimicrobial activity was assessed using a two-phase polymicrobial biofilm model under aerobic and anaerobic conditions. Biological effects of chemicals were evaluated by fibroblast viability. Pre-osteoblast viability and mineralization were performed on biofilm-treated surfaces. SH and CA40 induced morphological damage, whereas CA10-30 preserved surface integrity and showed nobler electrochemical behavior. Regarding antimicrobial activity, SH, CA30, and CA40 significantly reduced biofilm (≈6 log; p < 0.05), demonstrating a concentration-dependent CA effect, whereas CHX and HP performed similarly to PBS. Biologically, protein adsorption was comparable across groups, and CHX reduced early viability (24 h) (p < 0.05). However, after 14 days, CHX- and CA30-treated surfaces promoted greater mineralized nodule formation (p < 0.05). CHX and HP did not reduce biofilm after 1-min immersion, highlighting limitations of these short exposure protocols. In contrast, CA30 demonstrated a favorable balance between antimicrobial efficacy, controlled surface alterations, and biological effects, supporting its potential as an adjuvant chemical strategy for peri-implantitis treatment.

PMID 42763229
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