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Hoe-285 (Hoe 285 / Brainorm / Albex 285)

✓ Approved

Sanofi S.A · Small Molecule · Small Molecule

What is Hoe-285?

Hoe-285 is a small molecule developed by Sanofi S.A. It is approved for therapeutic indications via injectable (others) or intravenous (iv) or oral (po).

Drug Profile

Brand NamesHoe 285, Brainorm, Albex 285
CompanySanofi S.A
Drug ClassSmall Molecule
RouteInjectable (Others), Intravenous (IV), Oral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Sanofi S.A

Therapeutic Indications

Hoe-285 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersDelayed ischaemic neurological deficit✓ Approved

Related Research Articles

PubMedOccupational medicine (Oxford, England)2026-09-20

Trauma- and treatment-associated peripheral nerve injuries following occupational accidents: a retrospective study.

Holzapfel K K, Schulz S S, Braadt L L, Naumann M M et al.

Peripheral nerve injuries after occupational accidents can result in significant functional and socioeconomic consequences. This study aims to describe the characteristics and patterns of trauma- and treatment-related peripheral nerve injuries resulting from occupational accidents. We retrospectively analysed 276 cases of traumatic peripheral nerve injury following occupational accidents, treated between 2018 and 2024 at a German university hospital. Injuries were classified by severity and anatomical location. Associations between injury characteristics, occupational sectors, treatment modalities and work incapacity were examined. Most cases occurred in construction, trade/transport, metal industry and agriculture/forestry (63%). The leading causes were falls, crush, penetrating/cutting and impact injuries. In 24%, the nerve injury was treatment-related rather than caused by the initial trauma. The median, ulnar and peroneal nerves were most commonly affected. Severe deficits were present in 44% of patients at baseline; 26% remained severely affected at follow-up. Nerve surgery was performed in 38% of severe cases. Longer work incapacity was associated with fracture-related injuries (median = 210 days, Q1 = 133-Q3 = 375; Q1 = 25th, Q3 = 75th percentile), lower extremity involvement (240, 148-403 versus 180, 89-285; P < 0.001) and age >50 years (210, 140-409 versus 81, 29-143; P < 0.001). Peripheral nerve injuries from occupational accidents are linked to substantial work incapacity. Key predictors of prolonged recovery include fractures, lower extremity involvement and older age. Treatment-related nerve damage accounts for a considerable share. Many patients show persistent deficits despite comprehensive care.

PMID 42763424
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PubMedF1000Research2026-09-20

Closing the Gap in Early Mathematics: Domain and Cognitive Insights from TIMSS 2023 in South Africa and Singapore.

Mokgwathi Mathelela Steyn MS

South Africa continues to underperform in primary mathematics, yet overall mean comparisons obscure where achievement gaps are most concentrated. This study examines domain-specific patterns of mathematics achievement using data from the Trends in International Mathematics and Science Study (TIMSS) 2023, benchmarking South African Grade 5 learners against Singaporean Grade 4 learners assessed on the same TIMSS Grade 4 mathematics framework. A quantitative secondary analysis was conducted using nationally representative TIMSS 2023 datasets comprising 10,424 South African learners from 285 schools and 6,530 Singaporean learners from 181 schools. South Africa assessed learners in Grade 5 using the TIMSS Grade 4 mathematics instruments, consistent with TIMSS procedures where curriculum exposure aligns with the benchmark framework. Mathematics achievement was analysed across content domains (Number, Measurement and Geometry, Data) and cognitive domains (Knowing, Applying, Reasoning). Weighted estimates, replicate-based variance estimation, and effect sizes (Cohen's d) were computed in accordance with IEA technical guidelines. The analysis is descriptive and comparative rather than causal. South African learners performed substantially below the international centre point across all domains. The largest content-domain gap relative to Singapore was observed in Measurement and Geometry, indicating pronounced weaknesses in spatial reasoning. The largest cognitive-domain gap occurred in Knowing, reflecting fragile foundational fluency. Although Applying was relatively stronger within the South African profile, it remained substantially below benchmark levels. Achievement gaps were therefore concentrated in foundational and spatial domains rather than uniformly distributed. Concentrated achievement gaps in foundational knowledge and geometry characterise the underperformance of primary mathematics in South Africa. The findings provide a structured diagnostic profile of domain-specific achievement disparities, highlighting the concentration of gaps in foundational knowledge and spatial reasoning.

PMID 42763458
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PubMedEye (London, England)2026-09-19

Distinct postoperative anatomical outcomes between lamellar macular holes and epiretinal membrane foveoschisis.

Lam Marion M, Philippakis Elise E, Erginay Ali A, Gaudric Alain A et al.

To compare the postoperative anatomical outcomes between eyes with lamellar macular hole (LMH), epiretinal membrane foveoschisis (ERM-FS) and macular pseudohole (MPH). A retrospective single-centre study, including patients operated for LMH, ERM-FS or MPH, was conducted in a tertiary care centre in Paris, France. LMH eyes underwent vitrectomy with epiretinal proliferation peeling and tamponade, while ERM-FS and MPH eyes underwent ERM peeling without tamponade. Eighty-three eyes were included with a mean follow-up of 10.4 months: 16 with LMH, 50 with ERM-FS, and 17 with MPH. The mean preoperative central macular thickness (CMT) in LMH eyes (300 ± 43 µm) was thinner than normal and significantly differed from that in ERM-FS and MPH eyes (425 ± 80 µm vs. 380 ± 81 µm, p < 0.0001 and p = 0.02, respectively), which were thicker than normal. In LMH eyes, the mean postoperative CMT remained stable (285 ± 35 µm, p = 0.2) and thinner than in ERM-FS eyes, which was significantly decreased to 371 ± 46 µm (p < 0.0001). The mean postoperative central foveal thickness was significantly increased in ERM-FS eyes (from 191 to 271 µm, p < 0.0001) and in MPH eyes (from 189 to 288 µm, p < 0.0006), while stable compared to before surgery in LMH eyes (141 and 165 µm, p = 0.11) and thinner than normal. Lamellar macular hole is a distinct vitreoretinal interface disorder from ERM-FS, with different anatomical postoperative outcomes. Eyes with LMH can improve vision after vitrectomy but its surgical management may differ from that of ERM-FS.

PMID 42760329
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PubMedFrontiers in plant science2026-09-18

Mapping antimicrobials in plant lineages.

Bitchagno Gabin Thierry M GTM, Coates Paula P, Garcia Erin E, Bhatia Sohini S et al.

Plant species with antimicrobial activity occur across many angiosperm families, yet the factors driving the diversity of bioactive compounds remain unclear. This study investigates the antimicrobial activity of 285 flowering plants representing 65 families and 131 genera across lineages reputed to exhibit antimicrobial potential. Over 462 plant extracts were screened against Staphylococcus aureus, Escherichia coli and Aspergillus brasiliensis. Active extracts were fractionated and metabolomically profiled using LC-MS and NMR to identify chemical drivers and their phylogenetic distribution. About 37% of extracts, including preliminary and serial extracts, inhibited S. aureus and 4% inhibited E. coli (MIC ≤ 1000 µg/mL). Hexane and EtOAc extracts showed the highest activity against S. aureus while 60%MeOH extracts showed limited activity against E. coli. The lowest MIC values were <1.95 and 125 µg/mL, respectively, and no antifungal activity was detected. Active extracts mainly contained phenols or diterpenes with characteristic pharmacophores. Phylogenetic comparison revealed antimicrobial hotspots, highlighting plants as promising sources of anti-S. aureus compounds but limited leads against E. coli or A. brasiliensis.

PMID 42756018
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PubMedAffective science2026-09-18

Off the Cuff: Self-Reported Positive Urgency Predicts Rapid Choices During Risky Decision-Making.

Fu Ziqi Z, Dong Y Doug YD, Devine Sean S, Weinberg Anna A et al.

Impulsivity is a multifaceted personality trait reflecting a tendency to act on immediate urges, often linked to maladaptive real-world behaviors. One facet of impulsivity, Positive Urgency-the tendency to act rashly in response to positive affect-has been increasingly recognized as an important predictor of detrimental risk-taking behaviors. While a body of past work has uncovered modest predictive relationships between Positive Urgency and laboratory-assseed risk preferences, little work has examined whether Positive Urgency relates to speed at which risky choices are made. Here we directly examined the relationship between Positive Urgency (measured using the SUPPS-P Impulsive Behavior Scale) and risky choice behavior in a simple, gain-only risky decision-making task wherein outcomes and probabilities were fully described to participants. Across two samples (a laboratory and a direct online replication; total N = 285), we observed that participants higher in Positive Urgency made significantly faster risky choices, but not faster choices to the certain option. This predictive effect was specific to Positive Urgency as other impulsivity dimensions, such as Sensation Seeking and Negative Urgency, did not appear to relate to risky choice speed. Together, these results highlight how Positive Urgency captures the "rash" aspect of impulsive decision-making for rewards under risk. The online version contains supplementary material available at https://doi.org/10.1007/s42761-026-00377-6.

PMID 42756272
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PubMedJournal of the American Heart Association2026-09-18

Stillbirth as a Risk Marker for Postpartum Readmission for Cardiovascular Disease: A Population-Based Retrospective Cohort Study.

Pande Anushka A, Lin Ruby R, Lee Rachel R, Rosenfeld Emily B EB et al.

Cardiovascular disease (CVD) remains a leading cause of pregnancy-related morbidity and death in the early postpartum period. Stillbirth is associated with elevated long-term CVD risk. However, whether stillbirth unmasks short-term CVD is less well characterized. We conducted a population-based retrospective cohort study of singleton delivery hospitalizations using the Nationwide Readmissions Database (2010-2020). The primary outcome was CVD-related readmission or in-hospital death within the calendar year of delivery, including heart disease and stroke. Associations were estimated using adjusted Cox proportional hazards models and corrected for unmeasured confounding. Analyses were stratified by chronic hypertension, ischemic placental disease, and diabetes. Among 18 253 997 singleton delivery hospitalizations, 117 230 (6.5 per 1000) resulted in stillbirth. Median follow-up was 6.4 months (interquartile range, 3.7-9.1). The rate of CVD-related readmission was higher following stillbirth than live birth (404.0 versus 166.0 per 100 000 delivery hospitalizations; incidence proportion difference, 238 per 100 000 [95% CI, 192-285]). Stillbirth was associated with higher hazards of CVD hospitalization (adjusted hazard ratio [HR], 2.03 [95% CI, 1.78-2.32]), including heart disease (adjusted HR, 2.00 [95% CI, 1.72-2.32]), stroke (adjusted HR, 2.29 [95% CI, 1.80-2.92]), and CVD-related death (adjusted HR, 2.08 [95% CI, 1.12-3.84]). CVD hospitalization risk was elevated within 30 days postpartum and peaked from 60 to 89 days. Risks of CVD hospitalization were higher with co-occurring chronic hypertension, ischemic placental disease, or diabetes. Stillbirth was associated with increased short-term CVD-related readmission and death, extending prior evidence linking stillbirth to long-term CVD risk.

PMID 42757888
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