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aviptadil + phentolamine mesylate (Invicorp / VIP, Senetek / Resurgam)

✓ Approved

Johnson & Johnson Services, Inc. · VIPR1 · Small Molecule

What is aviptadil + phentolamine mesylate?

aviptadil + phentolamine mesylate is a small molecule developed by Johnson & Johnson Services, Inc.. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesInvicorp, VIP, Senetek, Resurgam
CompanyJohnson & Johnson Services, Inc.
Drug ClassSmall Molecule
Molecular TargetVIPR1
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Johnson & Johnson Services, Inc.

Mechanism of Action

Molecular Targets

aviptadil + phentolamine mesylate acts on 1 molecular target:

VIPR1vasoactive intestinal peptide receptor 1 (PACAP-R2, V1RG)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

aviptadil + phentolamine mesylate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Reproductive system and breast disordersErectile dysfunction✓ Approved

Related Research Articles

PubMedThe American journal of case reports2026-11-11

Primary Synovial Sarcoma of the Thyroid Gland Presenting With Early Pulmonary Metastasis: Diagnostic Pathway, SS18 Gene Fusion Confirmation, and Clinical Course.

Edwards Andrew G AG, Petroski Jack J, Patel Raj R, Koyfman Sergey S

BACKGROUND Primary synovial sarcoma of the thyroid gland (PSST) is an exceptionally rare and aggressive neoplasm. Twenty-one cases have been reported in the literature to date, making this the 22nd reported occurrence. This report presents the case of a 47-year-old woman with PSST confirmed by SS18 gene fusion on fluorescence in situ hybridization (FISH), who subsequently developed pulmonary metastasis and doxorubicin-induced congestive heart failure, illustrating the aggressive clinical course of this entity. CASE REPORT We report the case of a 47-year-old woman presenting with dysphagia and a left-sided neck mass. Initial FNA was non-diagnostic; repeat FNA raised concern for a spindle cell neoplasm. Left hemithyroidectomy was performed with negative margins, and SS18 gene fusion was confirmed by FISH, establishing the diagnosis of PSST. Following multidisciplinary review, adjuvant chemotherapy was deferred and neck radiation was administered. Pulmonary metastasis was discovered 6 months postoperatively. The patient received eribulin mesylate and subsequent palliative doxorubicin, and her case was complicated by doxorubicin-induced congestive heart failure. She subsequently developed progressive systemic metastatic disease, including brain and bone involvement, and died of the disease 65 months after initial presentation. CONCLUSIONS This case demonstrates that SS18 FISH confirmation is essential when FNA is non-diagnostic for a thyroid spindle cell mass. Despite negative margins and adjuvant radiation, early pulmonary metastasis and ultimately fatal systemic metastatic disease to the brain and bone occurred, underscoring the aggressive clinical course of PSST. Doxorubicin-induced cardiac toxicity further illustrates the systemic therapy burden. BCL-2-directed strategies remain investigational. Complete surgical resection with negative margins is the cornerstone of management.

PMID 43010634
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PubMedProceedings (Baylor University. Medical Center)2026-11-10

Local complications of peripheral intravenous vasopressor use with phentolamine as an antidote: a retrospective review.

Crossland David D, Kesireddy Nithin N, Acton Tayler T, Fillerup Ian I et al.

Prior studies have indicated that peripheral administration of vasopressors, particularly norepinephrine, can be considered safe, with local complications occurring in 0% to 1.8% of patients. Our study further explored the local skin complications from peripheral vasopressor administration treated with phentolamine in a large health care system. A retrospective chart review was performed on patients who received phentolamine for effects of local infiltration of pressors. Data were collected for demographics, vasopressor dose and duration of use, phentolamine dose and time after extravasation until administration, peripheral intravenous characteristics, as well as outcomes such as length of stay and mortality. Data on patients who did and did not require central venous catheter placement postextravasation were compared. Of 92 patients with infiltrated vasopressor intravenous access who required phentolamine, the mean age was 69, with 65% being female and a mean body mass index of 28 kg/m2. The most common sites of intravenous access were the antecubital fossa (33%) and forearm (27%). Mean number of hours prior to extravasation of peripheral vasopressors requiring phentolamine administration was 21 hours. Mean number of minutes prior to phentolamine administration after extravasation was 131 minutes. Seventy-six percent of patients did not any have significant ischemic tissue injury with extravasation, and 24% of patients had only minor bruising and erythema. Two significant reactions occurred, including deep vein thrombosis and local skin necrosis. Fifty-two percent of patients required a subsequent central venous line placement. The mean length of stay was 5.4 days in the intensive care unit and 11.8 days in the hospital, and in-patient mortality was 17%. In our large cohort of patients with extravasation from peripheral vasopressors managed with local phentolamine administration, severe tissue skin or soft tissue injury was rare.

PMID 43006831
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PubMedFrontiers in neuroscience2026-11-10

Effect of ultrasound-guided stellate ganglion block on intraoperative hemodynamics in laparoscopic partial adrenalectomy: a randomized clinical trial.

Nie Jingyi J, Wang Huang H, Zhang Wenjing W, Wang Hui H et al.

This study aimed to evaluate the effect of ultrasound-guided stellate ganglion block (SGB) on intraoperative hemodynamic parameters in patients undergoing laparoscopic partial adrenalectomy. A total of 72 patients with adrenal tumors scheduled for laparoscopic partial adrenalectomy were enrolled and randomly assigned in a 1:1 ratio to either the stellate ganglion block (SGB) group or the control group. The primary outcome was the incidence of intraoperative hypertension, defined as a systolic blood pressure (SBP) ≥180 mmHg or an increase of ≥30% in mean arterial pressure (MAP) from baseline. Secondary outcomes included MAP and heart rate (HR) measured at nine predefined perioperative time points, intraoperative vasoactive drug consumption, and the incidence of perioperative adverse events. The incidence of intraoperative hypertension was significantly lower in the SGB group than in the control group (14.3% vs. 37.1%, p = 0.029). Compared with the control group, patients in the SGB group exhibited significantly lower MAP and HR at eight time points ranging from immediately after tracheal intubation until the end of surgery (p < 0.05). The intraoperative consumption of phentolamine was significantly lower in the SGB group than in the control group [0 (0-4) mg vs. 0 (0-0) mg; p = 0.008]. In contrast, the consumption of norepinephrine was significantly higher in the SGB group [0 (0-0) mg vs. 0 (0-8) mg; p = 0.004]. No statistically significant differences were observed between the two groups in the consumption of esmolol and atropine, or in the incidence of perioperative adverse events. Ultrasound-guided SGB lowers intraoperative hypertension incidence and phentolamine demand in laparoscopic partial adrenalectomy. Although the SGB group observed a slight increase in the intraoperative dose of norepinephrine, no perioperative adverse events occurred. There was also no significant difference in the incidence of adverse reactions between the two groups.

PMID 43005334
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PubMedPLoS pathogens2026-11-10

Modulation of Fe3+ homeostasis by African Swine Fever virus facilitates its efficient replication in Ornithodoros lahorensis and pigs.

Sun Hua-Lin HL, Liu Ying Y, Hao Rong-Zeng RZ, Zhao Zi-Min ZM et al.

African swine fever virus (ASFV) can be transmitted through direct contact and, in specific ecological settings, by Ornithodoros spp. soft ticks. However, the cellular mechanisms that support ASFV replication in both porcine host and tick vector remain poorly understood. Iron is essential for cellular metabolism and viral replication, but excessive labile iron can induce oxidative stress and ferroptosis-like morphological changes in mitochondria. Whether and how ASFV exploits intracellular Fe3+ homeostasis to sustain its replication has not been fully defined. In this study, proteomic analysis of ASFV-infected PAM (pig) and OME/CTVM24 (derived from Ornithodoros moubata) cells revealed a marked reduction in ferritin/FTH1 abundance, suggesting that ASFV infection alters intracellular iron storage and availability. Further analyses showed that ASFV dynamically regulated labile Fe3+ levels during infection. At the early stage, ASFV promoted NCOA4-associated ferritin turnover, increased labile Fe3+ release, enhanced mitochondria-endoplasmic reticulum contact, and induced ferroptosis-like changes in mitochondrial morphology. At later stages, ASFV restrained excessive iron-associated damage, thereby maintaining an intracellular environment compatible with continued viral replication. Pharmacological depletion of labile iron with deferoxamine mesylate markedly suppressed ASFV replication in both porcine and tick-derived cells, indicating that controlled Fe3+ availability is required for efficient viral propagation. Mechanistically, the ASFV-encoded protein pA151R interacted with NCOA4 and promoted autophagic degradation of FTH1 in a manner dependent on its intact LC3-interacting region motif. pA151R also impaired mitochondrial outer membrane integrity and disrupted MDA5-MAVS/VISA signaling. Deletion of A151R impaired the ability of ASFV to modulate Fe3+ homeostasis and significantly reduced viral replication. ASFV infection increased serum iron levels in pigs and caused abnormal iron redistribution and depletion in splenic tissues in vivo. Similar iron depletion and transient ferroptosis-like morphological changes in mitochondria were observed in the salivary glands of ASFV-infected O. lahorensis. Collectively, these findings demonstrate that ASFV exploits Fe3+ homeostasis through a pA151R-NCOA4-FTH1-dependent mechanism to support replication in host and vector cells. This study provides new insights into ASFV metabolic regulation and identifies iron homeostasis and pA151R-mediated ferritinophagy as potential targets for strategies aimed at limiting ASFV replication and tick-associated transmission.

PMID 43008086
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PubMedSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy2026-11-08

Seed-mediated synthesis of Au@Ag core-shell nanoparticles as SERS substrates for rapid identification and quantification of four quinolone antibiotic residues in aquatic samples.

Zhang Ziwen Z, Wu Dongan D, Liang Ping P, Li Jinru J et al.

Antibiotic residues in aquaculture threaten food safety and ecological balance, calling for rapid and sensitive analytical methods. Herein, uniform Au@Ag core-shell nanoparticles (Au@Ag NPs) were fabricated via a seed-mediated strategy and used as SERS substrates for the sensitive detection and spectral discrimination of four quinolone antibiotics: enrofloxacin, enoxacin, levofloxacin, and danofloxacin mesylate. Using malachite green (MG) as a probe, the substrate showed an ultra-low LOD of 8.17 × 10-14 M and an enhancement factor of 1.64 × 108. Good batch-to-batch reproducibility (RSD = 5.75%), signal uniformity (RSD < 7.5%), and 60-day stability (69.60% residual signal) were achieved. Individual quantitative detection of the four antibiotics gave LODs ranging from 0.00031 to 0.0049 ppm. On grass carp scales as a complex aquatic matrix, concentration-dependent SERS signals and good linear calibration curves were obtained. Recovery experiments gave recoveries of 83.14%-116.61%, with RSD values below 9.5%, indicating satisfactory analytical accuracy and repeatability. PCA was employed for spectral dimensionality reduction to distinguish the four structurally similar quinolones. The first three principal components accounted for 86.5% of the total variance and achieved complete separation in 2D and 3D score plots. Overall, this study of four representative quinolones under controlled exposure conditions provides a foundation for further evaluation of matrix variability, competitive adsorption in mixed-residue systems, and performance in naturally contaminated samples, while demonstrating the potential of the Au@Ag NP-based SERS platform combined with chemometric classification for rapid screening of quinolone residues in aquaculture applications.

PMID 42998499
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PubMedFrontiers in immunology2026-11-05

Eribulin mesylate in combination with ivonescimab as first-line treatment for unresectable locally advanced or metastatic triple-negative breast cancer(EMIT): study protocol for a single-arm, multicenter clinical trial.

Lu Haiqi H, Wang Xufei X, Wang Zhuo Z, Chen Miaoqin M et al.

Advanced triple-negative breast cancer (TNBC) has an extremely poor prognosis, and current therapies offer limited benefits for patients with low programmed cell death ligand 1(PD-L1) expression. This study innovatively proposes a "novel chemotherapy + bispecific antibody" model. Eribulin Mesylate (hereinafter referred to as Eribulin), a novel microtubule inhibitor, kills tumor cells while remodeling the tumor microenvironment. When combined with the PD-1/VEGF bispecific antibody Ivonescimab, it concurrently dismantles immunosuppression and angiogenesis to synergistically overcome immunotherapy resistance. This is a multicenter, open-label, single-arm clinical trial designed to enroll 29 patients with locally advanced or metastatic TNBC who have not received prior systemic anticancer therapy, and who are either ineligible for radical surgical resection or local therapy, or have experienced disease progression following postoperative adjuvant therapy. The primary endpoint is the objective response rate (ORR) assessed by Investigator Assessment (INV) at each participating center based on strict adherence to Response Evaluation Criteria in Solid Tumors version 1.1(RECIST v1.1) criteria. Secondary endpoints include progression-free survival (PFS), overall survival (OS), duration of response (DoR), and safety. Exploratory endpoints involve potential biomarkers, the correlation between PD-L1 expression and efficacy, and patient-reported outcomes (PROs). This combination regimen is expected to leverage the synergistic advantages of "chemotherapy-promoted immunity and potent bispecific antibody efficacy," providing novel evidence-based medical evidence for the first-line treatment of metastatic TNBC and thereby effectively addressing significant unmet clinical needs. http://www.chictr.org.cn/, identifier ChiCTR2600117652.

PMID 42984708
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