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indapamide (Fludex SR / Natrilix SR / indapamide SR)

✓ Approved

Servier · SLC12A3 · Small Molecule

What is indapamide?

indapamide is a small molecule developed by Servier. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesFludex SR, Natrilix SR, indapamide SR
CompanyServier
Drug ClassSmall Molecule
Molecular TargetSLC12A3
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Servier

Mechanism of Action

Molecular Targets

indapamide acts on 1 molecular target:

SLC12A3solute carrier family 12 member 3 (NCCT, NCC)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

indapamide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersHypertension✓ Approved

Related Research Articles

PubMedFrontiers in cardiovascular medicine2026-11-12

Standardized 4-step surgical approach to address atrial fibrillation during coronary artery bypass grafting in a patient with severely reduced left ventricular function: a case report.

Gökler Johannes J, Szalkiewicz Philipp P, Damian Ilinca I, Illek Jacqueline J et al.

Atrial fibrillation (AF) may result in haemodynamic deterioration and is particularly detrimental in patients with severely impaired left ventricular function. In this high-risk population, the maintenance or restoration of sinus rhythm (SR) in cardiac surgery are of paramount importance, warranting the use of all available surgical strategies to comprehensively address atrial fibrillation. We report the case of a 60-year-old man who underwent successful out-of-hospital cardiopulmonary resuscitation following an acute myocardial infarction. Coronary angiography revealed severe three-vessel coronary artery disease, accompanied by highly reduced left ventricular function. The patient had a history of symptomatic paroxysmal AF and had recently undergone electrical cardioversion to restore SR after the index myocardial infarction. In addition to surgical coronary revascularization via median sternotomy, a standardized four-step concomitant AF procedure was performed. This approach included bipolar radiofrequency ablation, exclusion of the left atrial appendage, transection of the ligament of Marshall, and left-sided posterior pericardiotomy. The patient was successfully weaned from cardiopulmonary bypass in SR and maintained stable SR throughout an 8-month follow-up period without AF recurrence. This case highlights the importance of systematically addressing AF during cardiac surgery, especially in high-risk patients with severely reduced ventricular function, where maintenance of sinus rhythm may have haemodynamic benefits.

PMID 43016452
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PubMedJournal of refractive surgery (Thorofare, N.J. : 1995)2026-11-12

In Vitro Optical Bench Assessment of an Extended Depth-of-Focus Intraocular Lens Based on Segmented Refractive Design.

Tu Biyue B, Tong Yanxia Y, Zhu Zhanpeng Z, Jiang Haifeng H et al.

To assess the in vitro optical performance of a low-addition segmented refractive intraocular lens (IOL) and compare it with extended depth-of-focus (EDOF) standards, monofocal IOLs, and high-addition bifocal IOLs manufactured from the same material. Three identical material IOLs were assessed, namely a monofocal lens (HD), a low-addition multifocal lens (+2.00 diopters [D], SBL-2), and a high-addition multi-focal lens (+3.00 D, SBL-3). An optical bench measured the through-focus modulation transfer function (MTF) curves for 3- and 4.5-mm apertures. MTF values at five focal points (0 to -3.00 D) were evaluated. The area under the MTF curve was used to determine simulated visual acuity and depth of focus, compared to International Organization for Standardization (ISO) EDOF standards. Strehl ratio (SR) and United States Air Force (USAF) target imaging offered further quantitative and qualitative analyses. Through-focus MTF analysis confirmed distinct peaks corresponding to each IOL's design. The monofocal IOL provided the best distance (0 D) performance, whereas the low-addition IOL demonstrated the highest MTF values at intermediate foci (-1.50 to -2.50 D) and the high-addition IOL was superior at near (-3.00 D). The low-add IOL's depth of focus exceeded that of the monofocal IOL by 0.90 D at 0.20 logarithm of the minimum angle of resolution (logMAR), meeting the ISO EDOF standard. The monofocal IOL had the highest SR values. The USAF image indicated that the low-addition IOL provides stable image quality at intermediate focus, whereas the high-addition IOL excels at near focus. The low-addition IOL demonstrated superior intermediate optical performance compared with the monofocal and high-addition IOLs and fulfilled the ISO depth of focus criterion for EDOF IOLs. The high-addition IOL demonstrated superior optical performance at near focus.

PMID 43017895
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PubMedMicrovascular research2026-11-11

Microvascular oxygenation responses are associated with the reactive hyperemic stimulus but not brachial artery flow-mediated dilation.

Pennartz Kase J KJ, Hein Ethan E, Sprick Justin D JD, Keller Joshua L JL

Microvascular responses contribute to the post-occlusive shear rate stimulus (quantified as the area under the curve [SR AUC]) that precedes flow-mediated dilation (FMD). While FMD is measured via ultrasonography, near-infrared spectroscopy (NIRS) characterizes aspects of microvascular function; however, the extent to which NIRS-derived indices relate to FMD remains unclear. Therefore, this investigation examined the associations between NIRS-derived metrics and peak hyperemic velocity (PHV), FMD, and SR AUC in 20 healthy adults. Skeletal muscle tissue oxygenation (StO2) was assessed using NIRS during a vascular occlusion test, while brachial artery diameter and blood velocity were measured using duplex ultrasound. NIRS-derived measures included the rate of resaturation (upslope), maximum resaturation (StO2max), and the area under the curve (AUC) of sustained hypersaturation. Pearson correlations and multiple linear regression were used to assess relationships between NIRS-derived measures, PHV, FMD, and SR AUC. There were no observed significant associations between NIRS-derived metrics and FMD (p > 0.08). In contrast, StO2max was significantly related to PHV (r = 0.530, p = 0.016) and SR AUC (r = 0.629; p = 0.004), and independently predicted SR AUC (β = 0.632, t = 3.893, p = 0.001). Baseline artery diameter (p = 0.346), SR AUC (p = 0.153), and upslope (p = 0.790) did not predict FMD (R = 0.668, adjusted R2 = 0.336, F(3,15) = 4.03, p = 0.027). These findings suggest that NIRS-derived metrics represent distinct yet complementary measures to FMD, while the association between StO2max and SR AUC suggests a relationship between microvascular function and the shear stimulus underlying FMD.

PMID 43014668
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PubMedSurgical endoscopy2026-11-11

Suture reinforcement versus no reinforcement in laparoscopic sleeve gastrectomy: what do randomized trials show? A meta-analysis and trial sequential analysis.

Brucchi Francesco F, Sassun Richard R, Sperotto Beatrice B, Cirocchi Roberto R et al.

Suture reinforcement (SR) of the staple line is widely used in laparoscopic sleeve gastrectomy (LSG), but whether it prevents staple-line leak remains unresolved. We updated the randomized evidence comparing SR with no reinforcement (NR) and assessed its robustness for leak. PubMed, MEDLINE, Embase, and CENTRAL were searched to 31 July 2026, with hand-searching of previous meta-analyses. Risk of bias was assessed for each outcome (RoB 2). Rare events were pooled with Peto odds ratios and Mantel-Haenszel risk ratios (RRs), and operative time as a mean difference (MD). Trial sequential analysis (TSA) and GRADE were applied. Fourteen RCTs (2,646 patients; SR 1,410, NR 1,236) are included; seven are at high risk of bias. SR probably reduces postoperative bleeding (RR 0.36, 95% CI 0.21-0.62; 25 fewer per 1,000; moderate certainty), consistently across risk-of-bias subgroups. Leak occurs in 0.9% with SR and 2.3% with NR (RR 0.38, 95% CI 0.20-0.72), but the reduction is driven by small trials at high risk of bias and is not significant when these are excluded (RR 0.48, 95% CI 0.22-1.08). TSA shows that 21.4% of the required information has accrued, without crossing the monitoring boundary; certainty is very low. SR may increase operative time (MD + 18.5 min, 95% CI 13.3-23.7; low certainty). Suture reinforcement probably reduces postoperative bleeding at the cost of a longer operation. Its effect on staple-line leak is very uncertain and rests on small trials at high risk of bias; adequately powered contemporary trials are needed.

PMID 43009616
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PubMedJournal of psychiatric practice2026-11-11

Factor Structure of the Yale-Brown Obsessive-Compulsive Scale-II Self Report Symptom Checklist Among Trauma Survivors.

Pinciotti Caitlin M CM

The Yale-Brown Obsessive-Compulsive Scale-II Self Report Symptom Checklist (Y-BOCS-II-SR-SC) offers a structured assessment of obsessive-compulsive disorder (OCD) symptoms. A previous evaluation of the Y-BOCS-II-SR-SC suggested the existence of 4 factors: Symmetry/Order, Contamination/Washing, Hoarding, and Sexual/Religious/Aggression symptoms. However, existing factor analytic work has not considered the influence of trauma exposure despite its established impact on the presence, presentation, and function of obsessions and compulsions. Trauma-exposed individuals with OCD (N=258) were recruited to complete the Y-BOCS-II-SR-SC, which was subsequently subjected to descriptive and factor analyses. Contrary to previous research, the present study found strong support for a 3-factor model comprising Saving, Exactness/Prevention, and Cleaning symptoms, evidencing adequate-to-strong internal consistency. Exactness/Prevention symptoms were endorsed by nearly the entire sample (91%), followed by Cleaning (65%) and, lastly, Saving symptoms (36%). Factor analysis in a trauma-exposed sample can provide insight into the clustering, presentation, and underlying function of OCD symptoms that may be related to trauma. Although continued research is needed, findings contribute to a small but growing body of literature supporting the connection between symmetry/exactness and harm prevention symptoms among trauma survivors with OCD.

PMID 43013858
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PubMedFrontiers in psychology2026-11-11

Baseline cognitive insight moderates the efficacy of metacognitive training for psychosis: an individual participant data analysis.

Goncalves Adrien A, Ochoa Susana S, Moritz Steffen S, Gawęda Łukasz Ł et al.

Metacognitive Training (MCT) for psychosis is designed to target metacognitive processes, yet evidence for its effects on cognitive insight remains inconclusive, owing primarily to the limited methodological quality of available trials. A potential explanation lies in baseline heterogeneity, with a substantial proportion of participants presenting high baseline cognitive insight, thereby limiting observable change. This study used harmonized individual participant data from the PERMEPSY database, including 614 participants with schizophrenia spectrum disorders from 13 international studies. Cognitive insight was assessed using the Beck Cognitive Insight Scale (BCIS), including Self-Reflectiveness (SR), Self-Certainty (SC), and a composite index (CI). Baseline moderation effects were examined using ANCOVA models with a continuous Group × Baseline interaction term, complemented by stratified ANOVAs to visualize the interaction pattern and estimate within-stratum effect sizes. ANCOVA models revealed significant Group × Baseline interactions across all BCIS dimensions, indicating that baseline cognitive insight moderated treatment response. Stratified ANOVAs yielded convergent results for SR and SC. Effect sizes followed a consistent gradient, with larger improvements observed among participants with lower baseline insight. Notably, 26.5% of participants already scored in the high-insight category at baseline, suggesting that ceiling effects may have partially obscured treatment effects at the group level in previous trials. MCT appears to improve cognitive insight, particularly among participants with greater baseline impairment. These findings suggest that baseline heterogeneity is a key determinant of MCT efficacy and may account for previously inconsistent results.

PMID 43011308
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