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Uralyt-K

✓ Approved

Rottapharm Madaus · Small Molecule · Small Molecule

What is Uralyt-K?

Uralyt-K is a small molecule developed by Rottapharm Madaus. It is approved for therapeutic indications via oral (po).

Drug Profile

CompanyRottapharm Madaus
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved

Therapeutic Indications

Uralyt-K is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersCalculus urinary✓ Approved

Related Research Articles

PubMedJournal of applied clinical medical physics2026-11-12

Accuracy of reference air kerma in estimating incident air kerma at skin in interventional neuroradiology: Effect of X-ray field size and alternative PERP corrections.

Fukuda Atsushi A, Ichikawa Nao N, Hayashi Takuma T, Lin Pei-Jan Paul PP et al.

Kerma-area product (KAP) meters monitor reference air kerma ( K a , r ) and KAP ( P K A ) . While K a , r K A P , H y b r i d is calculated using P K A and collimator positions, K a , r K A P , M e a s . is directly measured via a small central ionization chamber. Although K a , r is a common surrogate for incident air kerma at the skin ( K a , s k i n ), its clinical application to interventional neuroradiological procedures carries higher uncertainty than regular interventional radiology, with source-to-skin distance being the greatest factor due to the smaller head size. Additionally, K a , r may not perfectly represent actual K a , s k i n due to variations in beam quality, filtration, and X-ray field size. This study investigated (1) the accuracy of K a , r K A P , H y b r i d and K a , r K A P , M e a s . , and (2) the feasibility of employing them as surrogates for K a , s k i n during cerebral angiography and interventional neuroradiological procedures. A solid-state dosimeter (AGMS-DM+) was placed at the patient entrance reference point (PERP) on a polymethyl methacrylate phantom to measure K a , r A G M S - D M + . Accuracies of K a , r K A P , H y b r i d and K a , r K A P , M e a s . were evaluated against K a , r A G M S - D M + in two investigations. First, effects of tube voltage and spectral shaping filters (1.2 mmAl, 0.03 mmTa, and 0.2 mmCu) were evaluated with/without equalization filters inserted symmetrically by 2.5 cm from both sides at a fixed X-ray field size of 10 × 10 cm2. Second, the effect of varying the X-ray field size was investigated for each filter. Additionally, a fluoroscopic system and a head phantom were modeled using computer-aided design software. Three fields of view (FOVs) were evaluated to simulate different clinical stages: 30 × 30 cm2 (for whole angiography), 15 × 15 cm2, and 3.8 × 3.8 cm2 (for targeted interventional neuroradiology). Target centers were aligned with the brain center and precallosal segment of the anterior cerebral artery. Six typical clinical projections were used per FOV to determine source-to-skin distance and X-ray field size at the PERP, allowing calculation of the skin-level errors for both K a , r K A P , H y b r i d and K a , r K A P , M e a s . . The effects of the corrections were also investigated using the X-ray field size measured by P K A / K a , r K A P , M e a s . and an alternative PERP (aPERP) positioned 11 cm from the isocenter toward the X-ray focus. Relative errors for both methods as functions of tube voltage across the three filters were within ± 4.0%. With equalization filters, K a , r K A P , H y b r i d errors ranged from -49.0%--33.9%, exceeding the acceptable accuracy tolerance (± 35%), whereas K a , r K A P , M e a s . errors (-15.8%--10.8%) remained within the tolerance. The relative errors of K a , r K A P , H y b r i d and K a , r K A P , M e a s . as a function of the X-ray field size ranged from -9.7%-12.7% and -58.3%-26.1%, respectively. Although most skin-level errors for both K a , r K A P , H y b r i d and K a , r K A P , M e a s . remained within the ± 35% tolerance in clinical simulation, those for K a , r K A P , M e a s . at the 3.8 × 3.8 cm2 FOV exceeded it. However, with the X-ray field size and aPERP corrections, the errors for K a , r K A P , M e a s . were reduced to within ± 2.7%. K a , r K A P , H y b r i d and K a , r K A P , M e a s . should be strategically selected based on the specific clinical application, such as standard cerebral angiography versus targeted interventional neuroradiology. Particularly, K a , r K A P , M e a s . provides superior accuracy when equalization filters are used or when appropriate corrections for X-ray field size and aPERP are applied in small-field dosimetry.

PubMedThe journal of physical chemistry. B2026-11-12

Anomalous Reversal of CO2-Induced Viscosity/Diffusivity Trends in Water: A Molecular Dynamics Study.

Shiga Masashige M, Morishita Tetsuya T, Mannai Mahrez M, Nishiyama Naoki N et al.

Experimental viscosity data for dilute, water-rich aqueous CO2 are available only up to moderate temperatures, with reported measurements up to 449 K, leaving the temperature regime relevant to geothermal and carbon capture, utilization, and storage (CCUS) applications largely unexplored. Here, equilibrium molecular dynamics (MD) simulations were used to compute viscosity, self-diffusion coefficients, and density of CO2-H2O mixtures over 278-900 K and 10-30 MPa using multiple combinations of force fields for water and CO2. At 278-443 K, increasing the CO2 fraction increased viscosity and decreased molecular mobility, consistent with available low-temperature measurements. At 573 K, however, the trend reversed: at xCO2 = 5 mol %, the viscosity decreased by about 10% relative to pure water at 25 MPa, whereas the diffusivity increased by about 8% at 20 MPa. Above 700 K, composition effects became weaker and often comparable to the associated uncertainties. Analyses of number density, CO2 hydration, hydrogen bonding, tetrahedral order, and rotational relaxation show that the reversal behavior originates from the temperature-dependent volumetric and structural response of the water network to CO2 dissolution. The results identify a transport anomaly near 573 K that should be considered in modeling water-rich CO2-bearing fluids.

PubMedBMC microbiology2026-11-12

Bacillus licheniformis as a therapeutic alternative for Klebsiella pneumoniae infection.

Wang Ye Y, Liu Yuchen Y, Abbas Salbia S, Yang Haidi H et al.

Klebsiella pneumoniae is a significant zoonotic pathogen. In recent years, the frequent emergence of hypervirulent (hvKP) and multidrug-resistant (MDR) strains has posed serious threats to both human and animal health, becoming a major concern for global public health security. This study characterized the phenotype of a K. pneumoniae strain (KP-01) isolated from a red panda and investigated the protective effects of Bacillus licheniformis against this pathogen through animal experiments, aiming to explore alternative therapeutic approaches for K. pneumoniae infections. KP-01 was identified as a hypervirulent K. pneumoniae (hvKP) strain, which was susceptible to most clinically relevant antibiotics except for intermediate susceptibility to imipenem and kanamycin. Despite lacking hypermucoviscosity, carried hallmark hvKP virulence genes (iroB, rmpA2, peg-344, and iucA). Pre-treatment with B. licheniformis significantly reduced bacterial burden in infected tissues, suppressed inflammatory cytokine expression, and ameliorated histopathological damage. B. licheniformis exhibits significant protective effects against K. pneumoniae infection and may serve as a potential antibiotic-alternative therapy.

PubMedJournal of medicinal chemistry2026-11-12

A Novel Chemotype of Orally Active SARS-CoV-2 NSP14 Methyltransferase Inhibitors.

Meyer Cindy C, Garzia Aitor A, Merritt James R JR, Freundlich Joel S JS et al.

The periodic emergence of human coronaviruses (hCoVs) necessitates direct-acting antivirals targeting underexploited viral proteins with broad-spectrum potential. Building on our discovery of TDI-015051, a first-in-class SARS-CoV-2 mRNA cap guanine-N7 methyltransferase (MTase) NSP14 inhibitor whose translational development was limited by metabolic liabilities, we conducted medicinal chemistry optimization of a structurally distinct high-throughput screening hit. We arrived at MAVDA-K-256, a small-molecule inhibitor with improved pharmacological properties compared to TDI-015051. MAVDA-K-256 engaged NSP14 through the formation of a ternary complex with S-adenosyl-l-homocysteine, potently inhibiting its MTase activity and SARS-CoV-2 replication (EC50 = 24.6 nM). MAVDA-K-256 demonstrated broad-spectrum antiviral activity against diverse hCoVs without targeting the host mRNA cap MTase. Its favorable metabolic stability and pharmacokinetic properties enabled twice-daily oral dosing in a murine SARS-CoV-2 infection model, resulting in a five-log reduction in viral lung burden. These findings validate NSP14 inhibition as a promising antiviral strategy and support further preclinical development of MAVDA-K-256.

PubMedJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada2026-11-12

Widely disseminated necrotizing infection and refractory septic shock with hypervirulent Klebsiella pneumoniae: A case report.

Mocanu Victor V, Salehmohamed Qadeem Q, Wagner Kelsey K, Koleva Petya P et al.

Emerging strains of hypervirulent Klebsiella pneumoniae are increasingly recognized to cause life-threatening, community-acquired infections in persons without significant immunocompromise. Beyond the association with pyogenic liver abscesses and bacteremia, additional sites of involvement include skin and soft tissue, bone, eyes, and the central nervous system. Individuals with diabetes mellitus and originating from the Asian Pacific Rim appear to be at higher risk for colonization and infection. Genetic testing for defining virulence factors was recently proposed as a standard for differentiating hypervirulent from classical K. pneumoniae strains. Retrospective review of a K. pneumoniae infection in a middle-aged male. The patient had untreated type 2 diabetes, hypertension, and obesity, and immigrated from a Southeast Asian country to Canada over one decade prior. He presented with profound refractory septic shock leading to progressive multiorgan system failure. In totality, the infection involved necrotizing fasciitis of bilateral legs, bilateral emphysematous pyelonephritis, emphysematous cholecystitis, multifocal necrotizing pneumonia, and bacteremia notably without liver abscess. K. pneumoniae was later isolated from blood and sputum. Whole-genome sequencing identified K. pneumoniae sensu stricto with K1 capsule belonging to sequence type 23 and harbouring the characteristic virulence genes iucA, iroB, peg-344, rmpA, and rmpA2. This case demonstrates a remarkable extent of dissemination and expands the known clinical spectrum for hypervirulent K. pneumoniae infection. Genetic testing has the potential to proactively identify hypervirulent strains and inform clinical management. Heightened clinical vigilance, development of accessible rapid diagnostic tools, and further research into treatment strategies are needed for this emerging pathogen.

PubMedChemphyschem : a European journal of chemical physics and physical chemistry2026-11-12

Temperature and Pressure Effects on Adsorption Enthalpies and Selectivities of CO2, CH4, and N2 in ZIF-412.

Vinoba Mari M, Alomair Abdulaziz A AA, Alqaheem Yousef Y, Pathak Ashish A et al.

Zeolitic imidazolate frameworks (ZIFs) are promising adsorbents due to their tunable pore structures and surface-active sites for selective gas adsorption. This study presents the synthesis and characterization of a large-cage polyhedral zeolitic imidazolate framework (ZIF-412) and evaluates its adsorption capacities for CO2, N2, and CH4 at different temperatures and pressures. ZIF-412 exhibits a surface area of 917.76 m2/g, with 88% microporosity. The adsorption-desorption and cyclic adsorption tests for CO2, N2, and CH4 were conducted at 303 K up to 3000 kPa, demonstrating excellent reversibility and stability. At 273 K and 3000 kPa, the maximum uptakes were 8.1, 2.8, and 4.7 mmol/g, respectively, whereas at 323 K, the corresponding values were 6.0, 1.7, and 3.3 mmol/g for CO2, N2, and CH4, respectively. The gas adsorption enthalpies derived using the Freundlich-Langmuir, virial, and Clausius-Clapeyron models were about -24, -14, and -17 kJ/mol for CO2, N2, and CH4, respectively, indicating an exothermic physisorption process influenced by pore confinement and framework-gas interactions. Additionally, ZIF-412 exhibited high CO2/N2 selectivity above 20, compared with 3 for CO2/CH4 below 20 kPa at 273-313 K. The trade-off between adsorption capacity and selectivity highlights its potential for low-energy CO2 capture applications.

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