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Uralyt-K

✓ Approved

Rottapharm Madaus · Small Molecule · Small Molecule

What is Uralyt-K?

Uralyt-K is a small molecule developed by Rottapharm Madaus. It is approved for therapeutic indications via oral (po).

Drug Profile

CompanyRottapharm Madaus
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Rottapharm Madaus

Therapeutic Indications

Uralyt-K is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersCalculus urinary✓ Approved

Related Research Articles

PubMedPhoton science2026-07-25

Robust Automatic EXAFS First-Shell Fits.

Chen Yanna Y, Huang Juanjuan J, Kelly Shelly S

Extended X-ray absorption fine structure (EXAFS) is a widely used technique for atomic structure determination. Fourier transformation connects EXAFS in k space and R space. However, determining the appropriate k-range for the transformation can be challenging, but critical for the first-shell fit. In this study, we present an automatic method to determine the k-range using the Larch package and a Python program. The first step is to estimate spectral noise across a series of k-ranges with a fixed minimum value and identify the optimal maximum value in the k-range (k max ). The k max is determined by an empirical noise threshold that marks the point where the noise level in the Fourier transformed spectrum changes dramatically. Using the obtained k max value, the first shell is modeled to determine the minimum k value (k min ) by optimizing the background function through alignment of the spectrum with theory. The optimal k min corresponds to the point of the minimum R-factor, which quantifies the difference between the experimental and fitted spectrum. Our method was tested on various typical datasets and yielded suitable k-ranges for Fourier transformation and accurate first-shell fits. This approach helps avoid unreliable, irreproducible data analysis, especially for noisy data from diluted samples, and enables robust automatic first-shell EXAFS fitting.

PMID 42499322
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PubMedEcology and evolution2026-07-25

Biosystematics and Taxonomic Treatment of Three New Kengyilia Species in the Triticeae (Poaceae).

Pan Xiao-Yang XY, Li Shuang-Dan SD, Zhang Chang-Bing CB, He Jia-Yue JY et al.

In the present study, we discovered and investigated three new species of Kengyilia (Triticeae, Poaceae): Kengyilia changduensis C. B. Zhang, H. Q. Zhang et Y. H. Zhou, Kengyilia dingqinensis Y. H. Zhou, D. D. Wu et X. Y. Pan, and Kengyilia tibetica Y. H. Zhou, C. B. Zhang et D. D. Wu, in Changdu, Tibet, China based on morphological, cytological, and molecular data. Each species is morphologically characterized and distinguished from existing Kengyilia species by smooth internodes, glumes oblong- lanceolate and awns 2 mm, lemmas pubescent and awns 5-10 mm of K. changduensis, the lower part of the spikes is sparse, internodes hairy, glumes covered with soft hairs, awns 2 mm, lemmas oblong and awns 5 mm of K. dingqinensis, and internodes hairy, glumes oblong-lanceolate and awns 2-6 mm of K. tibetica. The genomic in situ hybridization results confirm that K. changduensis, K. dingqinensis, and K. tibetica are allohexaploid with StStYYPP genomic constitutions. Phylogenetic analyses, based on GBSSI nuclear gene and chloroplast genome sequences, suggest that K. changduensis, K. dingqinensis, and K. tibetica were closely related to genera Pseudoroegneria, Roegneria and Agropyron, and the Roegneria served as the maternal donors during its polyploid speciation of K. changduensis and K. tibetica, and Agropyron served as the maternal donors of K. dingqinensis.

PMID 42500201
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PubMedBioresource technology2026-07-25

Lignin-derived fulvic acid-like substances from spent pulping liquor enhanced rice salt tolerance via K+/Na+ homeostasis modulated by plasma membrane H+-ATPase.

Liu Yan Y, Wang Xiaoqi X, Liu Lu L, Li Shan S et al.

Lignin, the primary component of spent pulping liquor from the pulping industry, poses a unique challenge for bioresource utilization due to its complex aromatic structure, which requires harsh conditions for degradation. This study presents a novel approach to address these limitations by transforming the spent pulping liquor into a value-added, fulvic acid-like substance (PFA) product. Advanced chemical characterization revealed that PFA exhibited functional groups similar to natural fulvic acid (FA). Laboratory experimentation showed that the enriched surface functional groups (-OH and -COOH) confer salt tolerance by modulating the plasma membrane H+-ATPase activity to maintain K+/Na+ homeostasis in rice seedlings. This mechanism was confirmed using a specific inhibitor of H+-ATPase proton-conducting activity and an osa1 mutant. Furthermore, targeted functional group inactivation and model compound testing revealed that -COOH exerted a greater effect than C-OH in promoting Na+ efflux and K+ influx. Finally, field trials demonstrated the application of PFA improves K+/Na+ ratio, achieving a synergistic balance between high yield and high quality even with reduced potassium fertilizer. Ultimately, this study establishes a sustainable strategy for valorizing industrial lignin into effective agricultural biostimulants, providing a foundation for the targeted catalytic design of lignin-derived materials with high bioactivity.

PMID 42498014
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PubMedMicrobial biotechnology2026-07-25

In Vivo Enzyme Catalytic Rates in Formate-Growing Methanococcus maripaludis.

Mekki Celma C, Faquir Hamza H, de Dios Mateos Enrique E, Scheller Silvan S et al.

Turnover numbers ( k cat ) describe intrinsic catalytic capacities of enzymes. Although they have been characterized in vitro for many model organisms, such data is scarce for anaerobic Archaea like the methanogen Methanococcus maripaludis. Moreover, the apparent in vivo catalytic rates of enzymes operating in C1 utilization have neither been quantified experimentally nor predicted computationally. Here, we determined the in vivo catalytic rates of 99 M. maripaludis enzymes during growth on formate as the sole carbon source and electron donor. The determination was performed using previously published proteomics data and genome-scale metabolic model simulations constrained with experimental data across multiple growth rates. The obtained in vivo catalytic rates ( k app ) were compared to sequence-derived maximum turnover numbers ( k cat ) previously predicted by a machine-learning model trained on in vitro data. Sequence-derived turnover numbers and maximum in vivo catalytic rates did not correlate. The quantitative insight into methanogenic C1 metabolism and the in vivo catalytic rates can be used to guide metabolic engineering strategies. Engineered methanogens can serve as hosts in disruptive solutions of future biotechnological chemical production from one-carbon compounds.

PMID 42499146
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PubMedJournal of environmental sciences (China)2026-07-25

Transformation and fate of trace elements during germanium-containing lignite combustion.

You Jinxiang J, Li Ao A, Lu Hang H, Zhang Baoxu B et al.

Studying the migration and transformation behaviors of trace elements during lignite combustion holds significant applied value and strategic importance for guiding the recovery of valuable metals from coal, controlling the emission of toxic pollutants, and supporting the development of clean and efficient utilization for lignite. This study investigates the occurrence characteristics and migration of trace elements (Ge, As, Sb, Pb, Zn and W) during lignite combustion under varying roasting temperatures and oxygen concentrations. Thermodynamic analysis shows that high-valent oxides of trace elements can be readily reduced to low-valent oxides or elemental species by CO or H2. Experiment results indicate that the volatilization efficiencies of trace elements increase with the increasing combustion temperature, while it decreases with the increasing O2 concentrations. Under 21 % O2 concentration, the volatilization efficiencies of Sb and Zn consistently remained above 90 % across combustion temperatures. While the volatilization efficiencies of Ge, As, Pb and W markedly increased from 5.14 %, 3.50 %, 12.36 % and 7.57 % at 773 K to 97.83 %, 97.56 %, 91.93 % and 24.48 % at 1473 K, respectively. Fixed the combustion temperature at 1373 K, the volatilization efficiencies of Ge and Pb moderately decreased from 97.37 % and 93.70 % to 88.52 % and 83.94 %, respectively, with the O2 concentration increasing from 0 to 21 vol.%. Conversely, the volatilization efficiency of As significantly decreased from 95.31 % to 68.76 %. This finding provides theoretical basis and technical support for the clean and efficient utilization of germanium-containing lignite.

PMID 42498371
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PubMedArthroscopy techniques2026-07-25

Repositioned Kirschner Wires as a Temporary Metaphyseal Block to Prevent Articular Extension During Opening-Wedge High Tibial Osteotomy.

García Bordes Luis L, Cuscó Segarra Xavier X, Álvarez Díaz Pedro P, Seijas Vázquez Roberto R et al.

Lateral hinge fracture is a frequent complication of medial opening-wedge high tibial osteotomy. Previous strategies-such as inserting an additional third Kirschner wire (K-wire) from the lateral tibial cortex-reinforce the lateral cortex but do not address the potential fracture line that propagates proximally toward the tibial plateau and joint surface. We describe a simple maneuver that reuses the 2 K-wires routinely employed to guide the osteotomy plane. Once the osteotomy cut is complete, the wires are withdrawn and reinserted horizontally into the proximal metaphyseal tibia, just above the osteotomy gap. Acting as a temporary metaphyseal block, the wires stabilize the epiphyseal-metaphyseal unit and limit upward fracture propagation into the joint during gradual gap opening. This simple technique is cost-neutral, reproducible, and complements existing hinge-protection methods by specifically protecting the articular extension pathway.

PMID 42499948
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