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doxycycline hyclate (Targadox)

✓ Approved

Fortress Biotech, Inc. · Small Molecule · Small Molecule

What is doxycycline hyclate?

doxycycline hyclate is a small molecule developed by Fortress Biotech, Inc.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesTargadox
CompanyFortress Biotech, Inc.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Fortress Biotech, Inc.

Therapeutic Indications

doxycycline hyclate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersAcne✓ Approved

Related Research Articles

PubMedPharmacological research2026-07-25

Targeting KLF4 Degradation by Doxycycline Restores Peroxisome Lipid Metabolism and Mitochondrial Energy Production in Acute Kidney Injury.

Feng Ji J, Yao Zhi-Sheng ZS, Li Yu-Hong YH, Bai Yan Y et al.

Acute kidney injury (AKI) is a life‑threatening condition with limited preventive medications. While the transcription factor Krüppel-like factor 4 (KLF4) is critical to AKI pathophysiology, its underlying molecular mechanisms remain incompletely understood. This study investigates KLF4 from a metabolic perspective and explores the renoprotective potential of doxycycline, an FDA-approved antibiotic. In murine models of ischemia‑reperfusion (IR)‑ and cisplatin (CDDP)‑induced AKI, doxycycline administered significantly attenuated kidney injury and protected renal tubular cells from glucose deprivation- and oxygen‑glucose deprivation-induced stress in vitro. Integrative transcriptomic and metabolomic profiling revealed that AKI progression involves profound metabolic dysfunction, characterized by the downregulation of peroxisomal Acyl-CoA oxidase 3 (ACOX3) and mitochondrial Isocitrate dehydrogenase 2 (IDH2). We identified KLF4 as a dual transcriptional repressor of ACOX3 and IDH2. Mechanistically, molecular docking, surface plasmon resonance, and co-immunoprecipitation assays demonstrated that doxycycline directly binds KLF4 and promotes its ubiquitin-mediated degradation via the E3 ligase FBXO32, which restores ACOX3/IDH2-mediated fatty acid oxidation and the TCA cycle, enhancing cellular resilience against ischemic crisis. These findings define a novel KLF4‑ACOX3/IDH2 metabolic axis and highlight doxycycline as a promising repositioning candidate for AKI prevention.

PMID 42498145
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PubMedFrontiers in health services2026-07-25

Patient pathways to PrEP persistence: a qualitative resilience-focused journey mapping study with cisgender Black and Latino men who have sex with men and clinical PrEP staff at a federally qualified health center.

Meanley Steven S, Arnold Emily A EA, Listerud Louis L, Burgese Tyler T et al.

Persistence in pre-exposure prophylaxis (PrEP) use remains inequitably implemented among cisgender Black and Latino men who have sex with men (BLMSM) who could benefit from PrEP. Despite multilevel social barriers across the PrEP care continuum, many BLMSM mitigate or overcome these barriers to sustain their PrEP use, suggesting underlying resiliencies that can strengthen PrEP programs and policies. We conducted qualitative journey mapping interviews with 16 PrEP-sustained BLMSM and 7 clinical PrEP staff (medical and social/outreach services) at a federally-qualified health center (FQHC) in Philadelphia, Pennsylvania (United States). Interviews explored BLMSM's PrEP trajectories, elucidating which processes and resources supported BLMSM's ability to overcome barriers (e.g., job transitions, health insurance coverage). PrEP trajectories included cyclical knowledge-building and contemplation, immediate linkage upon learning about PrEP when accessing health services, brand and modality transitions, and periods of disengagement followed by re-linkage. Structural barriers related to cost, insurance coverage, pharmacy access, clinic hours, housing and employment instability, and medical burnout and fatigue were identified. BLMSM and PrEP staff identified key facilitators supporting barrier reduction, such as affirming provider communication, co-located phlebotomy, transportation assistance, and problem-solving adherence challenges. Participants emphasized PrEP coordinators as being central to support PrEP service navigation, outreach for PrEP discontinuers, problem-solving financial challenges, and liaising between insurance companies and pharmacies. Our findings illuminate how resilience processes (i.e., overcoming barriers) and patient-centered, team-based support within an FQHC can transform common disruptions into opportunities for sustained or renewed PrEP engagement, advancing resilience-informed PrEP engagement models that advocate for practice-oriented solutions and future implementation research.

PMID 42500465
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PubMedIDCases2026-07-25

A case report of acute kidney injury due to the use of rifampicin in Brucella induced spondylodiscitis.

Bakar Lena L, Yağcı Çağlayık Dilek D

Brucellosis is the most frequently encountered zoonotic disease in regions like Turkey. Osteoarticular involvement is the most common complication, and standard treatment involves doxycycline and rifampicin. Rifampicin is generally well tolerated; however, hepatotoxicity is a known side effect, and acute kidney injury (AKI) has rarely been reported in the literature. We present a 79-year-old male with Brucella spondylodiscitis who developed progressive AKI (creatinine rising from 0.99 to 2.14 mg/dL) following 14 days of rifampicin therapy. Renal function fully recovered after rifampicin discontinuation and supportive hydration over three months. Clinicians should monitor renal function closely during rifampicin therapy and consider drug-induced AKI early, doxycycline was discontinued prior to any renal deterioration, and ciprofloxacin was continued throughout recovery, strongly implicating rifampicin as the causative agent.

PMID 42500331
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PubMedFrontiers in veterinary science2026-07-25

Development of a welfare assessment protocol for dromedary camels during road transport.

Padalino Barbara B, Faraz Asim A, Meyer-Glitza Patrick P, Zohra Anam A et al.

Transporting dromedary camels, like other farm animals, may be stressful and impair their welfare and health. The lack of standardized practices regarding loading and unloading, vehicle design and size, journey duration, and space allowance complicates camel transportation, leading to greater welfare compromise and risk. The study aimed to develop a protocol for assessing the welfare of dromedary camels during road transportation. A group of researchers and experts (n = 10) conducted an extensive literature search and frequent meetings, during which several unstructured expert knowledge elicitation (EKE) sessions were conducted to develop the protocol. The literature search was conducted in Scopus and Web of Science databases; additionally, a snowball search was conducted to locate relevant literature. Overall, 24 articles from the databases, 10 initial articles, and 20 articles from the snowball search were used. Due to limited research on the transportation of dromedary camels, the authors primarily considered studies on the welfare assessment of other species during transport, such as horses, pigs, and ruminants. Accordingly, the checklists were prepared to assess the welfare of dromedary camels at five stages during transportation: before loading (24 indicators), after loading (18 indicators), during the journey (14 indicators), upon arrival (24 indicators), and 1 h after arrival (22 indicators). Additionally, a checklist was prepared to assess the loading and unloading process (28 indicators), the journey, and the vehicle (17 indicators). This is the first protocol to assess the welfare of dromedary camels during road transportation. It uses non-invasive methods and practically applicable welfare measures suitable for field conditions. However, it needs to be applied to refine and validate the proposed animal-based and environmental welfare indicators.

PMID 42500394
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PubMedFrontiers in microbiology2026-07-25

Advancing the diagnosis of scrub typhus with targeted next-generation sequencing.

Qin Weijuan W, Guo Yuni Y, Lei Ming M, Wei Huanhuan H et al.

Scrub typhus has nonspecific symptoms, making it easy to miss or underdiagnose. This retrospective study evaluated targeted next-generation sequencing (tNGS) for the early diagnosis of acute Orientia tsutsugamushi infection in terms of feasibility and application value. This retrospective study included 49 patients with suspected scrub typhus as the case group. Among them, 28 patients with eschar or ulcers were assigned to the clinical diagnosis group. The remaining 21 patients without eschar or ulcers formed the clinically suspected group. Additionally, 48 patients with nonscrub typhus bloodstream infections during the same period were included in the negative control group. Clinical data and tNGS results were collected for all the patients. No significant differences were found between the clinical diagnosis group and the clinically suspected group in sex, age, time from onset to sampling, season of onset, complications, or clinical prognosis (p > 0.05). The sensitivity of tNGS for diagnosing scrub typhus was 91.8% (45/49), and the specificity was 100.0% (48/48). No significant differences were observed between the clinically diagnosed group and the clinically suspected group regarding the positivity rate of O. tsutsugamushi detected by tNGS or the therapeutic response to doxycycline (p > 0.05). Significant changes were observed in the median eosinophil count (EOS), platelet count (PLT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) before and after doxycycline treatment in the case group (p < 0.001). TNGS demonstrated high sensitivity and specificity for the detection of O. tsutsugamushi. It facilitates the early diagnosis of scrub typhus, particularly in suspected cases without eschars. However, prospective studies are needed for validation.

PMID 42499666
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PubMedGlomerular diseases2026-07-25

Renal Histopathology and Outcomes of Anti-Neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis: The Qatar Experience.

Aqeel Faten F, Fituri Omar O, Nauman Awais A, Alkadi Mohamad M MM et al.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe small-vessel vasculitis with substantial morbidity. Data from the Gulf region are limited, restricting understanding of disease patterns and outcomes. This study describes the epidemiology, clinical features, kidney pathology, and management of ANCA-associated glomerulonephritis (ANCA-GN) in Qatar. We performed a retrospective cohort study of adults diagnosed with ANCA-GN between 2015 and 2025 at Hamad Medical Corporation. Demographic, clinical, serologic, histopathologic, and therapeutic data were extracted from electronic records. Primary outcomes were end-stage kidney disease (ESKD) and death; secondary outcomes included kidney function trends, proteinuria, ANCA titers, relapse, and infections. Statistical analyses included Student's t test, chi-square, Fisher's exact test, and Kaplan-Meier survival. Twenty-eight patients were followed for a median of 16 months (IQR 16-43). Median age was 49 years, 71% were male, and 54% were of South Asian origin. Seasonal peaks occurred in winter (43%) and summer (32%). GPA and MPA accounted for 54% and 43% of cases; 57% had pulmonary involvement. PR3-ANCA was positive in 43% and MPO-ANCA in 36%, and 18% had atypical ANCA. Mixed (50%) and crescentic (25%) histologic classes predominated. Despite 61% having low-to-moderate ANCA Kidney Risk Score (AKRiS), 39% developed ESKD and 14% died. Maintenance therapy was given to only 54%. Infection-related mortality accounted for most deaths. Lack of hematuria resolution, failure of early proteinuria reduction, and absence of maintenance therapy were significantly associated with ESKD (p < 0.05). ANCA-GN in Qatar demonstrates seasonal clustering and high ESKD rates, pointing to opportunities for improved monitoring, timely therapy, and more consistent care pathways.

PMID 42499763
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