Drug Database
MR

MR vaccine (Mebella)

✓ Approved

Indian Immunologicals · Vaccine · Vaccine

What is MR vaccine?

MR vaccine is a vaccine developed by Indian Immunologicals. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesMebella
CompanyIndian Immunologicals
Drug ClassVaccine, Large Molecules
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Indian Immunologicals

Therapeutic Indications

MR vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsMeasles✓ Approved

Related Research Articles

PubMedChemical science2026-07-25

Pure-green OLEDs with CIEy over 0.7 via employing multi-resonance thermally activated delayed fluorescence sensitizers.

Nie Yufang Y, Jiang Chao C, Cao Chi C, Liang Jie J et al.

Multiple-resonance thermally activated delayed fluorescence (MR-TADF) materials have emerged as key candidates for next-generation ultra-high-definition (UHD) display organic light-emitting diodes (OLEDs) owing to their narrowband emission and high efficiency. Due to their long delayed fluorescence lifetimes, most MR-TADF devices suffer from severe efficiency roll-off at high brightness. Incorporating sensitizers into the emissive layer has been proven to be the most feasible and effective solution. Nevertheless, many sensitized devices suffer from incomplete energy transfer, which compromises the color purity of electroluminescence. Herein, we propose an ultra-low concentration doping MR-TADF-sensitized fluorescence (MR-TSF) strategy. Three new MR-TADF sensitizers exhibit reverse intersystem crossing rates (k RISC) of 1.42-1.58 × 105 s-1, along with radiative decay rates (k r) exceeding 108 s-1, endowing them with nearly unity photoluminescence quantum yields (PLQYs). When the doping concentration of the sensitizer is only 3.0 wt%, the external quantum efficiency (EQE) roll-offs of the sensitized devices at 1000 cd m-2 are reduced from the original values of 49.2%, 40.7%, and 40.7% to 22.5%, 23.2%, and 23.1%, respectively. Meanwhile, the MR-TSF devices have a minimal impact on the intrinsic color purity of the emitters.

PMID 42499572
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PubMedMedicine2026-07-25

Cognitive function and knee osteoarthritis: A bidirectional Mendelian randomization study with BMI mediation.

Zhang Yuping Y, Lin Qiuxiang Q, Yu Debiao D, Lu Tianxiang T et al.

This study investigated the causal relationship between cognitive function and knee osteoarthritis (KOA) and whether body mass index (BMI) mediates this effect. A bidirectional Mendelian randomization (MR) analysis was conducted using genome-wide association study summary statistics. The primary analysis used the inverse-variance weighted method, with MR-Egger, weighted median, robust adjusted profile score, and MR-PRESSO applied for sensitivity analyses. Forward MR analyses showed a significant inverse causal effect of cognitive function on KOA risk, with intelligence (OR = 0.843, 95% CI: 0.755-0.941, P = .002) and cognitive performance (OR = 0.850, 95% CI: 0.771-0.937, P = .001) associated with reduced risk. Reverse MR analyses found no evidence that KOA causally affects cognitive function (Intelligence: β = -0.020, 95% CI:-0.048 to 0.008, P = .167; Cognitive performance: β = -0.006, 95% CI:-0.032-0.020, P = .661). Mediation analysis showed that BMI partially mediated the effect of intelligence on KOA (indirect β = -0.047, 95% CI:-0.110 to-0.006, P = .023), accounting for 27.29% of the total effect. In conclusion, these findings support a unidirectional causal effect of cognitive function on KOA, partially mediated by BMI, highlighting the relevance of cognitive function and weight management in high-risk individuals.

PMID 42499075
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PubMedFood chemistry2026-07-25

Online monitoring of Maillard reaction dynamics using a custom reaction-transfer device and direct analysis in real time mass spectrometry.

Qiu Zhichen Z, Xu Liping L, Geng Xin X, Li Hongli H et al.

Controlling the Maillard reaction (MR) is critical for producing food flavor and color, yet real-time monitoring of its dynamics remains challenging. We developed an online monitoring system by integrating a custom reaction-transfer device with a Direct Analysis in Real Time (DART) ion source and high-resolution mass spectrometry. The system continuously transfers volatile MR products from the reaction headspace via a heated transfer line, enabling real-time, high-resolution analysis. The system successfully captured time-resolved molecular profiles, from early-stage sugar degradation intermediates to late-stage formation of nitrogen-containing heterocycles. Substrate-dependent kinetics and products were clearly differentiated. Elemental composition analysis via Van Krevelen plots further revealed distinct reaction pathways. The method was applied to monitor 12 MR model reactions and 5 real food samples, and correlation analysis linked complex food flavors to specific precursor reaction systems. Method validation confirmed the method's precision and robustness, establishing a simple and informative platform for online MR monitoring.

PMID 42497706
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PubMedMedicine2026-07-25

Association between pelvic inflammatory disease and ovarian cancer: A bidirectional Mendelian randomization study.

Qin Kaiyun K, Jiang Yan Y, Gao Xingshuang X, Liu Weilan W et al.

Some observational studies have suggested an association between pelvic inflammatory disease (PID) and ovarian cancer (OC), but the causality between PID and OC remains unclear. To investigate the causal association between PID and 7 OCs, we performed two-sample bidirectional Mendelian randomization (MR) analyses using genetic variants associated with PID. Pooled data on OC were obtained from the Ovarian Cancer Association Consortium. Effect estimates were obtained by inverse-variance weighting, the weighted median method, MR-Egger regression, and MR pleiotropy residual sum and outlier (MR-PRESSO) tests. The results of the inverse-variance weighting analysis showed that PID incidence risks were not significantly associated with OC, mucinous OC, low malignant potential OC, low-grade serous OC, high-grade serous OC, endometrioid OC, or clear cell OC. In this study, the causalities between PID and 7 OCs were comprehensively assessed, but the identified genetic evidence suggested no possible causalities between PID and 7 OCs in European populations.

PMID 42499052
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PubMedMedicine2026-07-25

Causal association between hip osteoarthritis and the risk of pancreatic cancer: A bidirectional two-sample Mendelian randomization study.

Li Wei W, Hu Bo B, Zhuang Hongyu H

The potential causal relationship between hip osteoarthritis (HOA) and pancreatic cancer (PC) is not well understood. To investigate this, our study utilized a two-sample Mendelian randomization (MR) method to examine a possible causal link between HOA and an increased risk of PC. Genome-wide association study summary data for both HOA and PC were sourced from the Integrative Epidemiology Unit OpenGWAS database (https://gwas.mrcieu.ac.uk/datasets/). The single-nucleotide polymorphisms associated with these conditions at a statistically significant level (P value <5 × 10-8) were identified as instrumental variables for subsequent analysis. We conducted bidirectional two-sample MR analyses employing inverse-variance weighting (IVW), weighted median, MR-Egger regression, and weighted mode methods. The robustness of the findings was assessed through sensitivity testing. The IVW analysis indicated that HOA elevated the risk of PC (odds ratio = 1.788; 95% confidence interval: 1.166-2.742; P = .008). Conversely, in the reverse MR analysis, the IVW analysis provided no evidence that PC increased the risk of HOA (odds ratio = 1.016; 95% confidence interval: 0.973-1.060; P = .475). In addition, the weighted mode, weighted median, and MR-Egger regression methods did not uncover a causal relationship. There was no heterogeneity or horizontal pleiotropy among the instrumental variables. The "leave-one-out" analysis revealed that no single-nucleotide polymorphism significantly influenced the overall results. Genetically predicted HOA is significantly associated with an increased risk of PC. However, we found no evidence that PC leads to an increased risk of HOA.

PMID 42499097
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PubMedJournal of the International AIDS Society2026-07-25

Behavioural and Structural Determinants of Mpox Vaccine Awareness and Uptake Among People With HIV in the Dominican Republic: A Cross-Sectional Study.

Paulino-Ramirez Robert R, Matias Wilfredo R WR, Chaumette Alexandre A, Lora-Rodríguez Hector H et al.

Mpox disproportionately affects people with HIV (PWH), yet little is known about mpox vaccine awareness and uptake in low- and middle-income countries. We evaluated mpox-related knowledge, attitudes and practices (KAP) among PWH in the Dominican Republic to identify determinants of vaccine awareness and uptake. We conducted a cross-sectional online survey of 98 PWH recruited through HIV clinics, community-based organizations and social networks (January-May 2025). The questionnaire assessed sociodemographic characteristics, mpox-related KAP, structural barriers and vaccination status. Univariable and multivariable logistic regression were used to examine factors associated with mpox vaccine awareness. Half of the participants (49/98) were aware of the mpox vaccine. Individuals aged 31-40 years had significantly lower odds of awareness compared with those aged 21-30 years. Despite high levels of formal education, 79% rated their mpox knowledge as low, and most perceived minimal personal risk. Among participants aware of the vaccine, 71% had been vaccinated. Structural barriers, including inconvenient site locations and logistical challenges, were frequently reported, even among vaccinated individuals, indicating that access limitations rather than hesitancy were the dominant constraints. Trust in vaccinating organizations was high overall, and healthcare providers and community organizations were the primary sources of vaccine information. Peer and community influence emerged as notable facilitators of uptake, while lack of reliable information and concerns about vaccine safety contributed to hesitancy. Mpox vaccine awareness among PWH in the Dominican Republic was low, but willingness to vaccinate was high when individuals were informed and able to access services. Strengthening mpox preparedness will require expanding accessible vaccination sites, improving disease-specific health literacy, and leveraging trusted community and clinical networks. Integrating mpox vaccination into routine HIV care delivery and enhancing community-led outreach may substantially improve uptake in this and similar low-middle income countries (LMIC) settings.

PMID 42499164
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