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MV

MV-130 (Bactek / MV130)

✓ Approved

Inmunotek · Cell-based Therapies · Cell-based Therapies

What is MV-130?

MV-130 is a cell-based therapies developed by Inmunotek. It is approved for therapeutic indications via oral (po) or sublingual (sl)/oral transmucosal.

Drug Profile

Brand NamesBactek, MV130
CompanyInmunotek
Drug ClassCell-based Therapies, Vaccine
RouteOral (PO), Sublingual (SL)/Oral Transmucosal
StatusApproved
Sources: ClinicalTrials.gov, Inmunotek

Therapeutic Indications

MV-130 is developed for 11 unique indications across 4 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsViral upper respiratory tract infection✓ Approved
Infections and infestationsLower respiratory tract infectionPhase III
Infections and infestationsOtitis mediaPhase II
Infections and infestationsPneumoniaPhase II
Infections and infestationsSinusitisPhase II

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Related Research Articles

PubMedAnnals of pediatric cardiology2026-07-25

Lung ultrasound-driven improvements in pneumonia detection, antibiotic stewardship, and ventilation outcomes: A three-era study in a pediatric cardiac surgical intensive care unit.

Gopalakrishnan Rajesh Madavathazathil RM, Meghalakshmi A R AR, Dhar Rohini R, Bijukumar Sandra Chaithanyam SC et al.

Postoperative pneumonia significantly prolongs mechanical ventilation (MV) and intensive care unit (ICU) stay after pediatric cardiac surgery. Lung ultrasound (LUS) offers superior diagnostic accuracy compared with chest radiography, but its longitudinal impact on clinical outcomes remains unclear. We evaluated the effect of structured LUS implementation on pneumonia detection, antibiotic stewardship, and ventilatory outcomes in a pediatric cardiac surgical ICU (PCSICU). This retrospective three-era study included all bronchoalveolar lavage (BAL) episodes performed for suspected postoperative pneumonia between 2019 and 2025. Patients were grouped as pre-LUS (2019-2020), LUS introduction (2021-2022), and established LUS (2023-2025). Outcomes included BAL positivity, antibiotic escalation, reintubation, and MV duration. In the established LUS era, pneumonia severity was classified using a structured 12-zone protocol into low-, moderate-, and high-yield categories. Categorical variables were compared using Chi-square tests and MV duration using Kruskal-Wallis with Bonferroni correction. A total of 313 BAL episodes were analyzed (48, 125, and 140 across the three eras). BAL positivity declined significantly from 70.8% in the pre-LUS era to 42.4% and 43.6% in the later eras (P = 0.0018). Among BAL-positive cases, antibiotic escalation increased progressively (52.9%, 62.3%, and 88.5%; P = 0.00027), while blind escalation among BAL-negative patients decreased markedly (50.0%, 20.8%, and 8.9%; P = 0.00060). Median MV duration decreased significantly from 95.5 h to 46.5 h across three eras (P = 0.00030). Higher LUS yield categories were strongly associated with BAL positivity (P < 0.001), reintubation (P = 0.0336), and Tier-3 antibiotic escalation. Structured LUS adoption improved early pneumonia detection, antibiotic stewardship, and postoperative ventilatory outcomes. Routine LUS integration may significantly improve multidomain outcomes in PCSICUs.

PMID 42499825
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PubMedJournal of plastic, reconstructive & aesthetic surgery : JPRAS2026-07-25

Reinnervation assessment using a modified nerve conduction study protocol following end-to-side anterior interosseous nerve transfer in advanced cubital tunnel syndrome: A case series and proof of concept study.

Chun Sung Ha SH, Hong Wan Kee WK, Hwang Ji Sup JS, Ryu Ju Seok JS et al.

Supercharge end-to-side (SETS) anterior interosseous nerve (AIN) transfer augments motor recovery in advanced cubital tunnel syndrome (CuTS). However, standard electrodiagnostic studies cannot differentiate between native ulnar nerve regeneration and reinnervation via AIN transfer. We aimed to establish a proof-of-concept for a modified nerve conduction study (NCS) protocol by employing median nerve stimulation to electrophysiologically isolate and evaluate AIN-mediated motor recovery. We retrospectively analyzed 13 patients with advanced CuTS who underwent AIN SETS transfer (mean follow-up duration: 1.6 years). Postoperative NCS was performed by stimulating the median nerve at the elbow and recording compound muscle action potentials (CMAPs) from the first dorsal interosseous (FDI) and abductor digiti minimi (ADM). Contralateral measurements were obtained at the follow-up for comparative reference. All 13 patients demonstrated FDI CMAPs upon median nerve stimulation. Among the 8 patients with longitudinal data, 6 showed a progressive increase in the median nerve-stimulated CMAP amplitudes over time. The mean median nerve-stimulated FDI CMAP was 3.1 mV on the operative side versus 2.3 mV on the contralateral side; however, the difference was not statistically significant. Notably, no median nerve-stimulated CMAP responses were recorded from the ADM in any patient. This modified NCS protocol demonstrated median nerve-stimulated CMAP at the FDI, confirming reinnervation after AIN SETS transfer. The selective CMAP recovery in the FDI, but not in the ADM, reflects a site-specific reinnervation pattern resulting from AIN coaptation to FDI-specific ulnar fibers. Therefore, future prospective studies in larger cohorts are warranted to refine this protocol as a standard clinical assessment.

PMID 42497569
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PubMedJournal of colloid and interface science2026-07-25

Enabling stable lattice oxygen mechanism in RuO2 via low-electronegativity Cs doping for enhanced acidic water oxidation.

Li Lingxiao L, Wang Fangqing F, Zhang Tianpeng T, Tang Liyao L et al.

RuO2 undergoes overoxidation at high oxidation potentials, involving the lattice oxygen oxidation mechanism (LOM) that leads to severe Ru dissolution. The current state-of-the-art strategy suppresses the kinetically favored LOM pathway by triggering conventional adsorbate desorption mechanisms, but this approach sacrifices activity for enhanced stability. To address this challenge, this work reports a Cs-doped RuO2 (Cs0.05-RuO2) catalyst. The low electronegativity of Cs enables electron transfer to Ru via Cs-O-Ru bridges, achieving high LOM activity while avoiding Ru overoxidation and thus maintaining high stability. Cs0.05-RuO2 exhibits a low overpotential of 169 mV@10 mA cm-2 under acidic conditions. Furthermore, the Cs0.05-RuO2||Pt/C electrode pair operates stably for ∼1800 h@500 mA cm-2 in an anion-exchange membrane water electrolysis cell. Advanced in situ spectroscopic techniques and density functional theory calculations confirm that the introduction of low-electronegativity Cs strengthens the RuO bond and suppresses the overoxidation of Ru.

PMID 42497688
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PubMedSmart molecules : open access2026-07-25

Oxophilic Yb2O3 nanoparticles as radical scavengers to enhance the durability of Fe-N-C oxygen reduction catalysts.

Liu Jiayu J, Li Shuang S, Li Huijuan H, Wan Xin X et al.

The practical application of Fe-N-C catalysts in proton exchange membrane fuel cells is substantially limited by their susceptibility to radical-induced degradation of the active Fe-N4 sites, which severely compromises long-term durability. To address this issue, we report a strategy of immobilizing Yb2O3 nanoparticles as efficient radical scavengers adjacent to Fe-N4 sites. The remarkable scavenging capability of Yb2O3, surpassing that of conventional cerium oxide, is attributed to its favorable oxophilicity, which facilitates radical capture and conversion. The resulting Fe-NC/Yb2O3 catalyst exhibits outstanding oxygen reduction reaction performance, featuring an initial half-wave potential of 0.809 V and a negligible decay of only 19 mV after 10,000 cycles. In H2-air fuel cell tests, it retains 87.1% of its initial current density at 0.5 V over 20 h. Theoretical calculations indicate that the performance enhancement stems from strengthened radical adsorption and an optimized d-band center of the Fe-N4 sites induced by Yb2O3. This work pioneers the use of a lanthanide sesquioxide for fuel cell catalyst protection, offering an effective strategy to overcome the activity-stability trade-off in non-precious metal catalysts.

PMID 42500720
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PubMedArthroscopy techniques2026-07-25

Cancellous Autograft Transfer From Screw-Hole to the Proximal Tibial Osteotomy Opening Gap for Early Bone Consolidation Without Donor-Site Morbidity.

Akasaki Yukio Y, Kurakazu Ichiro I, Kitamura Kenji K, Kawahara Shinya S et al.

Autologous bone grafting can enhance gap healing after medial open-wedge high tibial osteotomy and open-wedge distal tibial tuberosity osteotomy, but iliac-crest harvest adds donor-site morbidity and is therefore not routinely performed. We describe a bone autografting technique, termed cancellous autograft transfer from screw-hole, which leverages routinely drilled locking plate screw pilot holes as a local donor source to obtain cancellous autograft without a separate donor-site or additional incision. During plate fixation, cancellous bone is cored from the proximal screw pilot holes using a coring device (4.9 mm outer diameter, 4.5 mm inner lumen), and each harvested hole is then secured with a 5.5 mm locking screw. The cylindrical cores are transferred into the hinge-side portion of the opening gap. In the initial 8 cases, mean cumulative core length is approximately 80 mm (range, 60-130 mm), and computed tomography at 1 month shows early consolidation with bony bridging despite a lateral hinge fracture. The cancellous autograft transfer from screw-hole technique is a simple adjunct to plate fixation that provides local cancellous autograft while fully avoiding donor-site morbidity.

PMID 42499931
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PubMedEnvironmental research2026-07-25

Cooperative microorganisms in nitrification-denitrification sludge as the hidden helper for rapid anammox enrichment.

Dong Yongen Y, Wu Guanqi G, Xu Ying Y, Yuan Mengjun M et al.

Nitrification-denitrification sludge is widely used as the seed sludge for anammox bacteria enrichment, yet little is known about which microorganisms it harbors can metabolically support the growth of anammox bacteria. This study focused on exploring the above-mentioned issue during the enrichment of anammox bacteria from nitrification-denitrification sludge collected from a wastewater treatment plant. After 88 days of cultivation in an upflow biological filter reactor, the removal efficiencies of ammonium and nitrite reached 95%, and the relative abundances of Candidatus Brocadia on day 130 were 9.7% in the polypyrrole-modified carrier biofilm (M-PPy), 7.1% in the blank carrier biofilm (B-BC), and 8.8% in the flocculent sludge (B-FS). Unexpectedly, even though the removal efficiencies of ammonium and nitrite remained stably above 95% for 42 days, the most abundant genus across all microbial samples was the heterotrophic bacterium Candidatus Promineifilum, which was also the dominant microorganism in the seed sludge (relative abundance 1.9%). Candidatus Promineifilum exhibited the capacity for folate and molybdopterin cofactor synthesis, as well as nitrite reduction to NO, which were consistent with the characteristics of a cooperative microorganism. Given the auxotrophic nature of anammox bacteria for certain nutrients and the significant positive correlation observed between Candidatus Promineifilum and anammox bacteria, it is plausible that Candidatus Promineifilum is involved in a metabolic interdependency with anammox bacteria and seed sludge enriched with cooperative microorganisms, such as Candidatus Promineifilum, may favor anammox enrichment.

PMID 42498106
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