Drug Database
TE

teriparatide (Xinfutai Pro)

✓ Approved

Shenzhen Salubris Pharmaceuticals Co., Ltd. · PTH1R · Recombinant Proteins

What is teriparatide?

teriparatide is a recombinant proteins developed by Shenzhen Salubris Pharmaceuticals Co., Ltd.. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesXinfutai Pro
CompanyShenzhen Salubris Pharmaceuticals Co., Ltd.
Drug ClassRecombinant Proteins
Molecular TargetPTH1R
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Shenzhen Salubris Pharmaceuticals Co., Ltd.

Mechanism of Action

Molecular Targets

teriparatide acts on 1 molecular target:

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

teriparatide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

Related Research Articles

PubMedJournal of the American Pharmacists Association : JAPhA2026-07-25

Artificial intelligence and machine learning in pharmaceutical research and healthcare: Ethical challenges and a framework for responsible implementation.

Hajjo Rima R, Abusara Osama H OH, Sabbah Dima A DA, Zidan Rahaf R et al.

Artificial intelligence (AI) and machine learning (ML) are transforming pharmaceutical research and healthcare by enabling analysis of large-scale biomedical data and supporting data-driven decision-making. However, their rapid integration has introduced significant ethical, governance, and implementation challenges that remain insufficiently synthesized within a unified framework. This work aims to synthesize the central ethical challenges and paradoxes associated with AI and ML in pharmaceutical and healthcare contexts and to develop a structured, actionable governance framework to guide responsible implementation. We conducted a narrative review using structured searches of PubMed/MEDLINE and Google Scholar (January 2015-February 2026). We screened peer-reviewed, English-language publications addressing AI/ML applications or associated ethical considerations and synthesized evidence thematically. A total of 127 studies were synthesized, revealing interconnected ethical challenges, including bias, accountability, privacy, and equity, affecting patient safety and trust. The literature clustered across pharmaceutical research, clinical decision support, and governance, informing a structured, ethics centered framework with three pillars including technical excellence and safety, robust governance and trust, and human-centered values, along with cross-cutting enablers. Successful integration of AI/ML into pharmaceutical research and healthcare requires addressing its inherent ethical paradox. By linking interconnected challenges to a structured, actionable governance framework, this study provides practical guidance for implementing trustworthy, equitable, and human-centered AI, with direct implications for patient safety, clinical practice, and policy.

PMID 42498132
Read full article →
PubMedJournal of environmental sciences (China)2026-07-25

Does the use of pharmaceuticals for bullfrog farming pose health risks to humans?

Sun Qiongping Q, Zhan Han H, Li Yiyin Y, Liu Junxian J et al.

As global food demand is projected to rise in the future due to population growth, animal husbandry has been increasingly promoted worldwide. Yet, pharmaceuticals are extensively used for animal husbandry to prevent disease outbreaks, possibly posing human health risks via consumption of pharmaceutical-contaminated animals. Using a typical bullfrog farm as the study site, this study assessed the accumulation of pharmaceuticals in bullfrogs at different ages (juveniles vs. adults) from different origins (cultured vs. wild). The health risk of bullfrog consumption was then evaluated with the consideration of different cooking methods (steaming, pan-frying and deep-frying). Different types of pharmaceuticals were detected in the culture ponds, where sulfonamides (SAs) and fluoroquinolones (FQs) were predominant in water and sediment (> 60 % of total pharmaceutical concentration), respectively. Regardless of ages and origins, the intestine and stomach of bullfrogs had higher pharmaceutical concentrations than their muscle, skin and liver. Wild bullfrogs tended to accumulate more pharmaceuticals, particularly FQs, than cultured bullfrogs. Nevertheless, the health risk of bullfrog consumption was low (HR < 1), especially when the bullfrogs were well cooked by steaming that reduced pharmaceutical concentrations. This risk can be further lowered by avoiding the consumption of internal organs. Taken together, this study provides useful guidance for the public to minimize dietary intake of persistent pollutants and suggests that proper use of pharmaceuticals is promising for producing safe animal food products on a large scale, possibly serving as an important solution to the future increase in global food demand.

PMID 42498404
Read full article →
PubMedJournal of pharmaceutical sciences2026-07-25

Efficacy of ultraviolet irradiation of pharmaceutical excipients in mitigating N-nitrosamine generation.

Minamioka Saki S, Matsuzawa Shun S, Yoshihara Naoki N, Oikawa Michinori M et al.

The generation of N-nitrosamine compounds (NOCs) in drugs presents a critical regulatory challenge owing to their potential mutagenicity and exceptionally strict acceptable intake limits required for patient safety. These impurities arise primarily from the reaction between amine-containing active pharmaceutical ingredients and trace amounts of nitrosating agents (reactive NOx), which contribute to N-nitrosation. Reactive NOx species are frequently found in pharmaceutical excipients. Therefore, efficiently reducing reactive NOx is essential for robust management of the risk posed by NOCs. In this study, we employed ultraviolet (UV) irradiation of excipients as a novel preemptive strategy to reduce reactive NOx levels. Desloratadine was used as a secondary amine model to evaluate the generation of N-nitrosamine in physical mixtures with various excipients. The excipients were exposed to different UV wavelengths (248, 313, and 365 nm), and N-nitrosodesloratadine (NDLRT) generation was quantified after storage under stress conditions. We found that 365 nm UV irradiation was the most effective in reducing reactive NOx under all conditions. In a formulation study, 365 nm UV irradiation successfully reduced NDLRT generation in the tablet by 54-68% compared with the control. Overall, the novel strategy described herein should be useful for reducing NOCs without affecting the quality of drugs.

PMID 42497957
Read full article →
PubMedJournal of environmental sciences (China)2026-07-25

Non-target screening of toxic contaminants in secondary effluents (from several sources) using SPE-LC-Orbitrap mass spectrometry.

Jin Yifan Y, Ye Bei B, Wang Wen-Min WM, Cen Mei-Feng MF et al.

Toxic contaminants are widely present in aquatic environments; however, many contaminants cannot be eliminated during wastewater treatment. The identification of these contaminants using traditional targeted methods requires considerable effort, time, and specialized reference standards. In this study, a non-target screening method was developed. Samples were analyzed using ultra-high-performance liquid chromatography-Q Exactive Orbitrap mass spectrometry (UHPLC-Q Exactive Orbitrap MS). Data were processed through the small molecule screening software Compound Discoverer 3.3, and the identified toxic contaminants were ranked according to certain scoring rules. The pollutant ranking rules in this study primarily consider the software matching results, detection frequencies, and relative peak areas of detected contaminants. Each maximum value is assigned 100 points, with the remaining points distributed proportionally. The characteristics of contaminants in secondary effluents from individual locations were evaluated to identify surrogate parameters for the detected contaminants. These parameters were used to propose a list of potentially toxic contaminants (PTCs). A total of 229 PTCs, including pesticides, plasticizers, and pharmaceutical and personal care products (PPCPs), were identified in effluent streams from eight wastewater treatment plants (WWTPs) in China. The number of PTCs detected in the secondary effluent positively correlated with several surrogate parameters, including pH, total organic carbon content, excitation emission matrix (EEM), and others, with EEM displaying the strongest correlation. A computational toxicity assessment indicated that these potential priority contaminants are highly toxic, genotoxic, and mutagenic to Daphnia magna.

PMID 42498396
Read full article →
PubMedThe International journal of risk & safety in medicine2026-07-25

Heavy metal contamination in pharmaceuticals: A narrative review of prevalence, health risks, and regulatory gaps in Nigeria.

Ogungbe Blessing Abraham BA, Atanda David Ololade DO, Bepo Janet Adedoyin JA, Akinyemi Adedamola Akin AA

Pharmaceutical quality and safety are critical to public health, yet low- and middle-income countries such as Nigeria remain vulnerable to medicine safety challenges due to weak regulatory enforcement and limited market surveillance. A major concern is contamination of pharmaceutical products with toxic heavy metals, including lead, cadmium, mercury, arsenic, nickel, and chromium. These metals can bioaccumulate and cause adverse health effects even at low concentrations, such as neurodevelopmental impairment, renal and hepatic dysfunction, reproductive toxicity, and cardiovascular complications. This narrative review synthesised evidence on the prevalence of heavy metal contamination in pharmaceuticals marketed in Nigeria, associated health risks, and the adequacy of existing regulatory frameworks.Relevant literature published between 2005 and 2025 was identified through a comprehensive literature search of major databases such as PubMed, Google Scholar, African Journals Online, and Scopus, supplemented with reports from the National Agency for Food and Drug Administration and Control, the World Health Organisation, and grey literature. Studies assessing industrially manufactured or over-the-counter medicines for heavy metal contamination in Nigeria were included.The findings reveal recurrent contamination across several pharmaceutical categories, particularly syrups, locally manufactured analgesics, and herbal preparations. Lead and cadmium were the most frequently reported contaminants, with some products containing multiple metals and exceeding pharmacopeial limits. Heavy metal exposure induces oxidative stress and cellular damage, contributing to kidney injury, neurotoxicity, haematological effects, and endocrine disruption. Children, pregnant women, individuals with renal impairment, and frequent users of herbal medicines were identified as particularly vulnerable. Overall, heavy metal contamination remains a significant medicine safety concern in Nigeria, highlighting the need for stronger regulation, improved analytical capacity, and risk-based surveillance.

PMID 42499143
Read full article →
PubMedJournal of colloid and interface science2026-07-25

Sub-50 nm colloidal nanoparticle quantification via liquid-to-aerosol conversion through control of non-volatile residue artifacts.

Pan Zhengyuan Z, Wang Shibo S, Troolin Daniel D, Romay Francisco J FJ et al.

Quantitative measurement of silica nanoparticles (NPs) in liquid, particularly below 20 nm, remains fundamentally constrained by background artifacts and detection limits that are poorly understood. Here, we identify and systematically resolve a commonly underrecognized limitation in liquid-to-aerosol nanoparticle metrology: interference from dissolved non-volatile residues (NVRs) that generate artifact aerosol modes and easily interfere with NP measurements. Through mechanistic analysis of droplet formation, NVR-derived size scaling, transport losses, and charge efficiency, we establish a quantitative framework that defines the measurable concentration and size limits of aerosolization-based nanoparticle characterization. By integrating droplet-size control (via impactor coupling and electrospray tuning) with liquid-phase purification, NVR-derived artifacts are largely suppressed, enabling clear resolution of target nanoparticle peaks down single-digit nanometer range. Unified correlation equations for silica and gold NPs are developed to account for transport losses and sample feeding rate, defining practical concentration limits. An aerosolization-CPC method that avoids particle loss in DMA classification was further evaluated. Finally, the aerosolization-based method with effective NVR control is validated in membrane filtration tests where bimodal 10/20 nm silica peaks are resolved for membrane retention quantification. This work establishes a transferable metrological framework that extends liquid-phase nanoparticle quantification beyond current limitations, providing operating guidelines for reliable sub-50 nm measurements using aerosolization-based techniques.

PMID 42497684
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about teriparatide