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calcium hopantothenate (Hopate / hopantenate calcium)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · Small Molecule · Small Molecule

What is calcium hopantothenate?

calcium hopantothenate is a small molecule developed by Mitsubishi Tanabe Pharma Corporation. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesHopate, hopantenate calcium
CompanyMitsubishi Tanabe Pharma Corporation
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

Therapeutic Indications

calcium hopantothenate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Psychiatric disordersAttention deficit hyperactivity disorder✓ Approved

Related Research Articles

PubMedCardio-oncology (London, England)2026-11-12

Cardiac calcification and radiation dose to cardiac substructures as predictors of survival in breast cancer patients undergoing thoracic radiotherapy.

Montoya Julio J, Salas Ana María AM, Caprile Paola P, Cornejo María Daniela MD et al.

Cardiac toxicity remains a relevant concern in breast cancer radiotherapy. Both incidental dose to specific cardiac substructures and pre-existing coronary calcifications may impact long-term outcomes. This study evaluated the prognostic significance of these two complementary predictors in a Chilean cohort of breast cancer patients undergoing thoracic radiotherapy. This retrospective cohort study included 375 breast cancer patients treated at UC-Christus Health Network (1985-2022), comprising 61 deceased and 314 non-deceased patients. Cardiac substructures were automatically segmented using an open-source algorithm. Cardiac calcium burden was quantified from non-contrast planning computed tomography (CT) using a 130 HU threshold. Dose distributions were converted to equivalent dose in 2 Gy fractions. Univariate Cox regression with false discovery rate correction and graph-based collinearity selection were applied, followed by multivariable Cox models adjusted for relevant clinical covariates and cardiac calcium burden. Cardiac calcium burden was independently associated with OS after adjustment for clinical covariates. Among dosimetric parameters, three metrics survived collinearity elimination and remained independently associated with overall survival (OS) in separate multivariable models: composite cardiac base region (C1) mean dose, right ventricle (RV) mean dose, and RV-V10Gy. Kaplan-Meier analyses confirmed progressive survival differences across calcium burden catefum burden and radiation dose to the C1 region and RV were independently associated with OS in breast cancer patients receiving thoracic radiotherapy. Cardiac calcium quantification from routine planning CT represents a clinically actionable tool for cardiovascular risk stratification within the existing radiotherapy workflow. This study also provides the first Latin American validation of an open-source automated cardiac segmentation tool in a breast cancer radiotherapy cohort. gories and RV-based dosimetric risk groups, while no statistically significant separation was observed for C1 mean dose groups, when restricting the minimum group size. Automated segmentation demonstrated high accuracy for whole-heart delineation, while geometric accuracy for left anterior descending artery segmentation was limited. Pre-treatment cardiac calcium burden and radiation dose to the C1 region and RV were independently associated with OS in breast cancer patients receiving thoracic radiotherapy. Cardiac calcium quantification from routine planning CT represents a clinically actionable tool for cardiovascular risk stratification within the existing radiotherapy workflow. This study also provides the first Latin American validation of an open-source automated cardiac segmentation tool in a breast cancer radiotherapy cohort.

PMID 43015874
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PubMedHistology and histopathology2026-11-12

TRPC3 regulates STIM1-mediated calcium homeostasis in protection against intervertebral disc degeneration.

Gao Yingchao Y, Zhang Ning N, Zhang Jun-Fei JF, Lu Rong R

Intervertebral disc degeneration (IDD) is a leading cause of low back pain and dysfunction that severely affects patients' quality of life. This study aimed to investigate the role of TRPC3 in IDD, with particular emphasis on apoptosis, inflammatory responses, calcium homeostasis, and its interaction with STIM1. An IDD model was established in Sprague-Dawley rats, which were divided into sham, model, shRNA NC, and shRNA TRPC3 groups. Co-immunoprecipitation, real-time quantitative PCR, immunohistochemistry, and ELISA were used to evaluate protein expression, gene transcription, and histopathological changes associated with IDD. The results showed that shRNA TRPC3 significantly reduced collagen fiber content and inhibited apoptosis in IDD rats. TRPC3 silencing decreased the levels of TNF-α, IL-6, and IL-1β and reduced the release of inflammatory factors. Co-immunoprecipitation confirmed that TRPC3 could directly bind to STIM1 and affect its expression and function in IDD. TRPC3 silencing inhibited the increase in calcium ion content and regulated the expression of IP3R2 and SERCA in IDD model rats. This study demonstrated the multifaceted role of TRPC3 in IDD, including the regulation of apoptosis and calcium homeostasis, inhibition of inflammatory responses, and interaction with STIM1. TRPC3 silencing had a significant protective effect and may serve as a potential target for the treatment of IDD.

PMID 43016296
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PubMedJACC. Case reports2026-11-12

Intravascular Lithotripsy in Calcific Fontan Conduit Stenosis: Between a Rock and a Hard Place.

Pinsker Bret L BL, Djomaleu Manuella M, Wang David D, Lin C Huie CH

Dilation and stenting of stenotic Fontan conduits may be limited by circumferential calcific stenosis. Few options exist for calcium modification in this study group. A 29-year-old woman with an extracardiac Fontan was found to have a severely stenotic, circumferentially calcified Fontan conduit (approximately 8 mm). She was brought to the catheterization laboratory for balloon dilation and stent placement. Calcium modification was performed before stenting using intravascular lithotripsy, allowing restoration of the lumen diameter to 20-22 mm. Hemodynamics following lithotripsy and stent placement confirmed the absence of a gradient across her conduit. High-pressure balloons have traditionally been used to facilitate stent expansion in calcified Fontan conduits. However, circumferential calcification may lead to suboptimal results. This case highlights the efficacy of prestent calcium modification with intravascular lithotripsy in a Fontan conduit. Intravascular lithotripsy may facilitate optimal dilation and stenting in circumferentially calcified Fontan obstruction.

PMID 43018189
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PubMedFrontiers in physiology2026-11-12

Correction: Commentary: Calcium arrhythmogenicity of Purkinje fibers: importance of the animal model.

Chaigne Sebastien S

[This corrects the article DOI: 10.3389/fphys.2026.1970067.].

PMID 43017442
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PubMedBMC medical education2026-11-12

Calcium hydroxide placement by preclinical dental students using three delivery techniques: a CBCT-based volumetric and radiographic study.

Çiçek Medine M, Pertek Hatipoğlu Fatma F, Magat Guldane G, Kanik Furkan F et al.

Effective calcium hydroxide (CH) placement is essential for intracanal disinfection, but achieving homogeneous filling without apical extrusion may be challenging for preclinical dental students. This in vitro study aimed to compare the effectiveness of CH placement performed by preclinical dental students via manual file, Lentulo spiral, and injector-type application techniques via cone-beam computed tomography (CBCT) analysis and to evaluate the presence of apical extrusion associated with each technique. A total of 264 extracted mandibular single-rooted premolar teeth were allocated to three experimental groups according to the calcium hydroxide delivery technique: manual file, Lentulo spiral, and injector-type application (n = 88/group). Following standardized root canal preparation, each preclinical dental student applied calcium hydroxide using all three techniques. CBCT and three-dimensional volumetric analysis were used to compare medicament volume, fill ratio, homogeneity, and apical reach among the groups. Apical extrusion was evaluated using periapical radiographs. Repeated-measures statistical analyses were performed to account for the within-student study design (α = 0.05). The injector-type technique produced significantly greater medicament volume, fill ratio, and homogeneity than the manual file and Lentulo spiral techniques (p<0.001). No significant differences were observed in apical extrusion, apical reach, or optimal placement (p>0.05). Apical extrusion rates were low across all groups. The injector-type technique improved CH filling volume, fill ratio, and homogeneity; however, none of the techniques consistently achieved ideal intracanal placement. These findings highlight the importance of both application technique and structured preclinical training.

PMID 43015783
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PubMedJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026-11-12

EXPRESS: Persistent cerebrovascular dysfunction and altered mural cell calcium signaling after sepsis recovery in female mice.

Stobart Michael M, Sontag David D, Bland Catherine C, Meza-Resillas Jessica J et al.

Sepsis is associated with long-term cognitive impairment, yet the cerebrovascular mechanisms underlying these deficits remain poorly understood, particularly after clinical recovery. Although cerebral blood flow abnormalities are well documented during acute sepsis, whether microvascular dysfunction persists and how mural cells contribute to these changes remain unknown. We used longitudinal in vivo two-photon imaging in a fecal-induced peritonitis model to examine pericyte calcium signaling, microvascular hemodynamics, vasomotion, and neurovascular coupling before and after sepsis in the same female mice. Two weeks after sepsis, when mice no longer exhibited clinical signs of illness, both ensheathing and thin-strand pericytes displayed persistently elevated basal Ca2⁺ activity. In the arteriole-capillary transition zone, elevated ensheathing pericyte Ca2⁺ was paradoxically associated with vessel dilation and diminished vasomotor activity. These abnormalities were accompanied by altered red blood cell distribution and attenuated vascular responses during neurovascular coupling. Together, these findings demonstrate that clinically recovered mice exhibit persistent abnormalities in pericyte calcium signaling, microvascular blood flow regulation, and neurovascular coupling-associated vascular responses, identifying pericyte dysfunction as a potential contributor to long-term cerebrovascular impairment after sepsis.

PMID 43015638
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