Drug Database
QL

QL-1209 (QL1209 / QL 1209)

✓ Approved

Qilu Pharmaceutical · ERBB2 · Monoclonal Antibodies

What is QL-1209?

QL-1209 is a monoclonal antibodies developed by Qilu Pharmaceutical. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesQL1209, QL 1209
CompanyQilu Pharmaceutical
Drug ClassMonoclonal Antibodies, Antibody
Molecular TargetERBB2
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Qilu Pharmaceutical

Mechanism of Action

Molecular Targets

QL-1209 acts on 1 molecular target:

ERBB2erb-b2 receptor tyrosine kinase 2 (NEU, CD340)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

QL-1209 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Breast cancer✓ Approved

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PubMedAIDS care2026-07-23

Beyond viral suppression: determinants of health-related quality of life in a national HIV cohort in Turkiye.

Karacaer Zehra Z, Bozdag Merve M, Asar Erdogan E, Bastug Aliye A et al.

This multicentre study evaluated Health-related Quality of Life (HRQoL) and identified sociodemographic and clinical determinants of physical and mental health outcomes in a large national HIV cohort in Turkiye. This cross-sectional study included 1303 adults across 23 centres. HRQoL was assessed using the Turkish MOS-HIV Health Survey, yielding Physical Health Summary (PHSS) and Mental Health Summary (MHSS) scores. HRQoL scores were dichotomised into "higher" (>50) and "lower" (≤50) groups. Data were analysed via univariate tests and multivariable logistic regression. Participants (88.6% male; median age: 38) were primarily single, employed, and university graduates. The median CD4+ T-cell count and HIV RNA level were 627 cells/mm3 and <50 copy/mL, respectively. Median PHSS and MHSS were 57.25 and 50.57, respectively. While social/role functioning scored highest, health transition scored lowest. Lower PHSS was identified in 22.7% of participants, whereas 47.9% reported lower MHSS. Low education and high daily pill burden significantly increased the risk of lower HRQoL. Interestingly, lower income was independently associated with better HRQoL, while older age and psychiatric treatment correlated with better MHSS. Despite robust physical HRQoL, mental health remains a significant challenge. To achieve "Fourth 90" targets, interventions should prioritise health literacy and integrated mental health services within HIV care.​​Abbreviations: ART: antiretroviral therapy; CF: cognitive functioning; CI: confidence interval; EF: energy/fatigue; GH: general health perception; HAART: highly active antiretroviral therapy; HD: health distress; HIV: human immunodeficiency virus; HL: Hosmer-Lemeshow; HRQoL: health-related quality of life; HT: health transition; MHS: mental health summary; MHSS: mental health summary score; MOS-HIV: medical outcomes study HIV health survey; OR: odds ratio; P: pain; PF: physical functioning; PHS: physical health summary; PHSS: physical health summary score; PLWH: people living with HIV; QL: quality of life; RF: role function; RNA: ribonucleic acid; SF: social function; UNAIDS: joint United Nations programme on HIV/AIDS.

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PubMedAmerican journal of obstetrics & gynecology MFM2026-07-23

Characteristics and clinician perspectives associated with fetal autopsy completion and counseling.

Page Jessica M JM, Allshouse Amanda A AA, Carlson Lindsey L, Krong Jake J et al.

Fetal death certificate data reflect low fetal autopsy rates despite evidence-based recommendations that autopsy be performed in nearly all stillbirths. Data are lacking regarding clinical characteristics associated with fetal autopsy counseling and completion as well as clinician perspectives. To identify (1) patient factors and (2) clinician beliefs and opinions associated with clinician counseling and performance of fetal autopsy STUDY DESIGN: A retrospective cohort study was performed including fetal deaths at 16w0d and greater across 20 hospitals in a geographically diverse healthcare system. Deliveries between 2014-2019 were included to minimize the potential effect of the COVID-19 pandemic on results. Pregnancies that ended due to elective or indicated termination were excluded. The primary analysis included stillbirths at 20w0d and greater with an exploratory analysis of fetal deaths between 16w0d-19w6d. Demographic, medical and obstetric data were obtained by medical record abstraction. Performance of counseling regarding fetal autopsy was determined by documentation of fetal autopsy as an evaluation option in the medical record. Rate of fetal autopsy, clinician counseling regarding fetal autopsy and additional components of the stillbirth evaluation are reported overall, patient characteristics are then compared by these categories with between-group differences tested with chi-square. Obstetric clinicians from the same medical system as the retrospective cohort were surveyed over a 10-week period in 2023 to assess beliefs, perceptions, and considerations regarding the use of fetal autopsy in stillbirth evaluation. Clinician responses were summarized descriptively, and compared by clinician-reported perception of autopsy utility, and clinician-reported autopsy counseling completion with differences tested using chi-square. Overall 1209 stillbirths were recorded during the study period with 840 meeting criteria for analysis. 558 (66%) were included in the primary analysis with a mean gestational age of 29.4 weeks. Fetal autopsy was performed following 126 (22.6%) of stillbirths and autopsy was offered to 368 (65.9%) patients experiencing stillbirth. Higher maternal level of care was associated with fetal autopsy performance and clinician counseling for fetal autopsy (p=0.024 and p=0.008 respectively). No other patient characteristics were significantly associated with fetal autopsy performance or counseling. Among 383 invited clinicians, 131 (34.2%) responded to the survey; the majority were OB/GYN physicians (61.5%) followed by CNMs (23.0%). Most clinicians reported counseling >75% their patients on fetal autopsy (79.2%) but 54.6% also felt that it was helpful <25% of the time. Despite being a valuable tool in identifying causes of stillbirth, fetal autopsy was completed in a minority of patients. Efforts are needed to improve clinician education on fetal autopsy as this may increase counseling regarding the benefits of autopsy, performance of autopsy and lead to better understanding of causes of stillbirth. Additional research into barriers and facilitators as well as the motivations of patients who pursue or decline fetal autopsy will enable designing more effective counseling on options for stillbirth evaluation.

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PubMedBMC medical research methodology2026-07-22

Robust power and sample size calculations in quasi-likelihood models: methods and practice.

Yuan Shijie S, Cochran Amy A, Rathouz Paul P

Accurate power and sample size calculations are essential in study planning, yet they are often difficult to carry out for quasi-likelihood (QL) models. Traditional power and sample size (PSS) approaches often rely on restrictive distributional assumptions, limiting their applicability when responses have non-standard distributions, variance functions are misspecified, or when covariates exhibit complex dependence structures. We examine whether two effect size measures-2 Standard Deviations in the Linear Predictor (2SLiP) and Pseudo-Partial [Formula: see text] (P2R2)-originally developed for Wald tests involving generalized linear models, are effective at power and sample size calculations in the QL framework. Through extensive simulations across diverse outcome types, link functions, and variance structures, we assess their performance under Wald tests and explore whether they remain useful for score tests. To illustrate practical utility, we apply these effect size measures to survey data on frontline health care workers to quantify the association between perceived personal protective equipment (PPE) adequacy and burnout risk during the COVID-19 pandemic, adjusting for covariates. We show that the two generalized linear model (GLM)-based effect sizes are fundamentally moment-based objects, and therefore extend directly to QL models. Across all simulation settings, both measures remained accurate, with sample size and power estimates within 3% and 2% of the target, respectively. In the case study, the estimated effect sizes for perceived PPE adequacy (2SLiP = 0.096 and P2R2 = 0.020) correspond to small but meaningful associations with burnout risk after adjustment for demographic and occupational covariates; both yielded accurate recommendations for sample size. Both 2SLiP and P2R2 offer robust alternatives for power and sample size calculation in QL settings. By requiring minimal distributional assumptions, these measures enhance the flexibility and reliability of power and sample size calculations for realistic study designs commonly encountered in medical and public health research.

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PubMedScience bulletin2026-07-21

A dual-functional single-crystalline layer boosts operational stability of organic light-emitting diodes.

Ye Gao-Da GD, Wang Guan-Ran GR, Wang Xue-Peng XP, Li Su-Heng SH et al.

The extreme sensitivity to the environment and inherent instability of organic materials have posed persistent challenges to achieving long-term operational stability of organic light-emitting diodes (OLEDs). Herein, a dual-functional single-crystalline layer of 1,4-bis(4-methylstyryl)benzene (BSB-Me) is introduced into the OLED structure, simultaneously serving as both an intrinsically stable hole-transporting layer (HTL) and an effective barrier layer, to improve device stability. Systematic characterizations are conducted to gain an insight into the stability property of BSB-Me single crystals (SCs), confirming their robust thermal, morphological, and electrochemical stabilities. The SCs also exhibit desirable barrier property with a low water vapor transmission rate (WVTR) of approximately 3.58 × 10-4 g m-2 day-1, which is comparable to that of a 50-nm-thick monolayer Al2O3 barrier layer. In consequence, highly efficient and stable single-crystal OLEDs (SC-OLEDs) can be successfully fabricated by introducing the dual-functional BSB-Me SC layer. The blue SC-OLEDs present extended operational lifetimes (LT75) of over 1209 h at an initial luminance of 1000 cd cm-2, which is notably more than thirty times enhanced compared to that of conventional OLEDs with amorphous HTLs. Our findings suggest that the introduction of a dual-functional single-crystalline layer presents a promising advancement for improving the operational stability of OLEDs.

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PubMedJournal of cellular and molecular medicine2026-07-20

Qiliqiangxin Improves Cardiac Glucose Metabolism After Myocardial Infarction Through a HIF-1α/MIF/AMPK Axis.

Wang Zimu Z, Xie Zhonglei Z, Zhao Hanqing H, Li Chaofu C et al.

Cardiac glucose metabolism is critically involved in the pathophysiology of myocardial infarction. This study investigated whether Qiliqiangxin (QL), a traditional Chinese medicine, improves myocardial glucose uptake and aerobic oxidation after myocardial infarction (MI) and explored the underlying mechanisms. QL treatment significantly increased LVEF, enhanced myocardial glucose uptake, reduced fibrosis, apoptosis, ROS production and elevated ATP generation along with activity of pyruvate dehydrogenase (PDH) and citrate synthase (CS). These effects were abolished by HIF-1α-shRNA transduction. QL also upregulated the expression of HIF-1α, MIF, p-AMPKα, GLUT-4, hexokinase 2 (HK2), PDH and CS, which were similarly attenuated by HIF-1α knockdown. In conclusion, our study demonstrated that QL enhances myocardial glucose uptake and aerobic oxidation in a murine model of post-MI heart failure. Genetic inhibition of HIF-1α reverses these beneficial effects, suggesting the involvement of the HIF-1α/MIF/AMPK signalling axis.

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PubMedSurgical and radiologic anatomy : SRA2026-07-16

Layer-specific neuroanatomical architecture of the quadratus lumborum: a quantitative study using 3D micro-CT and immunofluorescence staining.

Lee Hyung-Jin HJ, Kim Soo-Jung SJ, Lee Jisu J, Yeo In-Seung IS

The quadratus lumborum (QL) is increasingly recognized as an anatomically important component of the posterior abdominal wall, yet its internal organization remains incompletely defined. This study aimed to characterize the layer-specific architecture of the QL and to quantitatively analyze the distribution of immunolabeled axonal components across its layers. Ten embalmed adult cadavers (mean age, 82.1 ± 9.9 years) were examined. Gross dissection and morphometric analysis were performed in eight cadavers (16 sides) to identify layer-specific organization and measure width and thickness at standardized anatomical landmarks; measurement reliability was assessed using intraclass correlation coefficients. Non-destructive three-dimensional reconstruction was performed in four phosphotungstic acid-enhanced block specimens using micro-computed tomography (micro-CT; voxel size, 72 μm). Histological and immunofluorescence analyses were performed in six sides using Masson's trichrome staining and double labeling for NF200 combined with choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), or calcitonin gene-related peptide (CGRP). Marker-positive axons were quantified relative to NF200-positive axons. Gross dissection and micro-CT consistently demonstrated a three-layer organization of the QL, comprising the lumbocostal (LC), iliocostal (IC), and iliolumbar (IL) layers. Morphometrically, the LC was the smallest layer, the IC was the thickest, and the IL was the widest. Neural branches arose mainly from the ventral rami of T12-L4 and entered the muscle along its anterior and lateral aspects as neurovascular bundles. Intramuscular nerves were multifascicular, and mean axonal diameter was greatest in the IC (572.9 ± 41.8 μm) and IL (556.1 ± 38.4 μm) and smallest in the LC (276.9 ± 65.2 μm). Immunofluorescence analysis demonstrated layer-dependent differences in marker distribution: the IC showed the highest proportions of ChAT-positive (26.4%) and TH-positive (32.4%) axons, whereas the LC showed the highest proportion of CGRP-positive axons (24.5%). The IL showed lower proportions of ChAT-, TH-, and CGRP-positive axons and the highest residual NF200-positive fraction (39.7%). The quadratus lumborum is a reproducible multilayered structure with layer-specific morphometric and immunolabeled neural heterogeneity. These findings provide quantitative anatomical evidence of layer-specific structural and neuroanatomical heterogeneity within the quadratus lumborum.

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