Drug Database
AP

aP vaccine (aP vaccine, NAVA)

✓ Approved

Baxter International, Inc. · Vaccine · Vaccine

What is aP vaccine?

aP vaccine is a vaccine developed by Baxter International, Inc.. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesaP vaccine, NAVA
CompanyBaxter International, Inc.
Drug ClassVaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved

Therapeutic Indications

aP vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsPertussis✓ Approved

Related Research Articles

PubMedThe American journal of managed care2026-08-25

Potential Role for Assistant Physicians in Addressing the Physician Shortage.

Schwartzman David D, Fendrick A Mark AM

Given the fixed supply of residency training slots, pathways to increasing physician supply are limited. We assess use of the novel assistant physician (AP) status and the early impact of regulatory changes in Missouri. We find limited impacts of APs on supply, with a substantial majority (80.2%) of licensed APs not reporting a practice address and declining numbers of new licenses in recent years. We discuss implications and potential changes to increase health care supply through an AP pathway.

PubMedAngewandte Chemie (International ed. in English)2026-08-25

Paired Electrocatalytic Valorization of Phenolic Pollutants Into p-Benzoquinone and p-Aminophenol.

Song Yankai Y, Li Yanchao Y, Gan Xue X, Jia HongBao H et al.

Electrocatalytic valorization of organic pollutants into value-added chemicals offers a sustainable strategy for wastewater treatment and resource recovery; however, achieving high Faradaic and energy efficiency remains challenging. Herein, we report a bipolar electrocatalytic strategy integrating anodic phenol oxidation (PhOR) with cathodic p-nitrophenol reduction (NPRR) for simultaneously producing p-benzoquinone (p-BQ) and p-aminophenol (p-AP). The tailored Ni(OH)2/CeF3 anode and Cu(OH)2/Ni(OH)2 cathode achieve p-BQ and p-AP yields of 84.5% and 96.3%, respectively. Specifically, incorporation of CeF3 induces the interfacial charge redistribution of Ni site and then facilitates Ni(OH)2 reconstruction into active NiOOH. Operando x-ray absorption fine structure (XAFS) reveals that the potential-driven dynamic Ni-O evolution optimizes the binding strength of reaction intermediates to boost PhOR performance. The cathode with Cu and Ni sites favors the surface-adsorbed H* formation for efficient NPRR via an indirect electron transfer pathway. The PhOR||NPRR system achieves an exceptional Faradaic efficiency of 129.3% with a low energy consumption of 1.06 kWh kg- 1. The practical applicability was validated through the successful production of high-purity p-BQ and p-AP from phenolic pollutants with respective recovery efficiency of 83.1% and 87.9%. This work provides a viable approach for facilitating a sustainable recovery of phenolic wastewaters.

PubMedScientific reports2026-08-25

High-throughput in silico multi-epitope reverse vaccine design against hydatidosis.

Skhal Dania D, Al Nahhas Samar S, Skhal Osama O, Abbady Abdul Qader AQ

The Middle East is a significant hotspot for human hydatidosis caused by Echinococcus granulosus, a complex multi-stage pathogen exhibiting antigenic variation with diverse epitopes. Multi-epitope vaccines, designed using immunoinformatics, represent a promising approach to effectively control this challenging parasite. A total of 1150 secreted, non-toxic, antigenic proteins were obtained from database and analyzed for their immunogenic potential, leading to the identification of 1024 CTL, 80 HTL, and 172 LBL prioritized epitopes, which were then ranked and clustered to prefer the most immunogenicity epitopes to include in novel vaccine construct. The chosen Construct (Con2) was modified for dual-plasmid insertion, facilitating the expression of three different vaccine constructs which were predicted by C-ImmSim to stimulate robust IFN-γ/IL-2 production and enhance IgM/IgG antibody secretion. Utilizing in silico, next-generation vaccine design, we propose several vaccine candidates that warrant further validation through in vitro laboratory testing and in vivo studies to assess their immunological efficacy.

PubMedChaos, solitons, and fractals2026-08-25

Wobble board instability enhances proactive postural control.

Kelty-Stephen Damian G DG, Deligiannis Theodore T, Fujimoto Yudai Y, Kiyono Ken K et al.

Rehabilitating a stable, upright posture requires tailoring therapeutic training to the multiscale dynamics of postural control. Wobble board training offers a unique approach to postural rehabilitation by fostering safe, shorter-scale variability, scaffolding an individual's exploration of longer-scale multijoint coordination between the center of mass (CoM) situated within the midsection of the standing body and the postural center of pressure (CoP) located on the support surface. We tested 48 healthy young adults standing on a wobble board, inducing mediolateral (ML) instability, to examine how wobble board training influences multijoint coordination. Detrended Moving Average (DMA) analysis of CoM and CoP fluctuations yielded fluctuation functions showing that wobble board training caused CoM and CoP variability to diverge at shorter timescales and converge at longer timescales. Specifically, crossovers along the anteroposterior (AP) axis fluctuations occurred later for CoM fluctuations and earlier for CoP fluctuations, suggesting that reflex activity persists over longer timescales for CoM fluctuations in the AP direction, whereas CoP fluctuations showed the reverse, that is, the extension of longer-timescale intentional resetting of equilibrium. Wobble board training reduced temporal correlations for CoM fluctuations while enhancing them for CoP fluctuations without compromising shorter-scale temporal correlations, even during a secondary visual search task. So, wobble board training promotes robust postural control strategies, shifting control from CoM to CoP into proactive, AP-oriented variability-an approach that could help tailor wobble board training to individualize postural rehabilitation. Multiscale modeling of posture thus advances understanding of the physical-therapeutic application of wobble boards to posture, amounting to effective rehabilitative training of CoP response to CoM excursion.

PubMedJournal of applied clinical medical physics2026-08-25

Reproducibility and positioning sensitivity of CT beam width measurements using a pencil ionization chamber and radiopaque mask.

Aire Morgan M, Meyer Hunter C HC, Kirby Krystal K

To evaluate the reproducibility and precision of CT beam width measurements using a pencil ionization chamber and radiopaque mask and to assess the robustness of the technique against clinically realistic setup errors in the superior-inferior (SI) and anterior-posterior (AP) directions. Beam width was measured on a GE Discovery RT590 CT scanner at three nominal collimations (10, 15, 20 mm), three tube potentials (80, 100, 120 kV), and three tube currents (50, 100, 150 mA). Three repeated exposures per setting were acquired using a Radcal Accu-Gold pencil ionization chamber with a radiopaque mask to calculate beam width. Coefficients of variation and Levene's test were used to test precision. To assess the robustness to setup error, the chamber was offset from the isocenter at 0, 1, 3, and 5 mm in the SI direction at 20-mm collimation across all kV/mA combinations and at 0 and 5 mm in the AP direction at 10- and 20-mm collimation. A linear mixed-effects model was used to test the sensitivity of beam width to SI setup errors across kV/mA combinations. Slopes of the overall deviance from the global mean vs offset were obtained for each combination with 95% confidence intervals, and pairwise slope differences were evaluated using a Tukey-adjusted statistical test. Confidence intervals were used to assess AP setup errors at two different nominal collimations. Across all kV/mA combinations, mean measured radiation beam width was 13.04, 16.90, and 20.60 mm for nominal 10-, 15-, and 20-mm collimations, with inter-protocol coefficients of variation of 0.57%, 0.48%, and 0.25%, respectively. Intra-protocol standard deviations across triplicate exposures were 0.04 to 0.09 mm. SI offset slopes from 0 - 3 mm ranged from -0.07 to -0.12 mm (per mm of offset) with overlapping 95% confidence intervals. There was no significant interaction with kV/mA (p > 0.05). AP offsets of 5 mm produced beam-width changes of 0.09 mm at 10 mm collimation and 0.15 mm at 20 mm collimation. The pencil ionization chamber and radiopaque mask technique produced highly reproducible CT beam width estimates for potentials up to 120 kV and at or above 50 mA that were independent of tube potential, tube current, and robust to clinically plausible setup inconsistencies.

PubMedYing yong sheng tai xue bao = The journal of applied ecology2026-08-25

Soil extracellular enzyme activities and stoichiometric characteristics in a warm-temperate-subtropical mixed coniferous and broad-leaved forest under nitrogen addition and drought conditions.

Yu-Die Lin L, Zhi-Jie Chen C, Shi-Zhe Wang W, Min-Hui X U XU et al.

We focused on soils from coniferous-broadleaf mixed forests in the transition zone between warm tempe-rate and subtropical climates. Based on a 9-year field manipulative experiment with factorial treatments of nitrogen addition (50 kg N·hm-2·a-1) and drought (50% precipitation reduction). Soil extracellular enzyme activities involved in carbon, nitrogen, and phosphorus cycling and their stoichiometric characteristics were determined. Results showed that nitrogen addition significantly increased the activity of soil β-glucosidase (βG), soil enzyme stoichiometric carbon-nitrogen ratio (EC:N) and soil enzyme stoichiometric carbon-phosphorus ratio (EC:P) by 113.1%, 158.5%, and 126.8%, respectively. Drought significantly reduced the activity of soil acid phosphatase (AP) by 69.3%, while EC:N and EC:P increased significantly by 125.9% and 133.0%. Nitrogen addition combined with drought treatment significantly increased soil βG activity and EC:P by 106.5% and 129.8%, respectively. Additionally, nitrogen addition combined with drought treatment significantly increased soil AP and β-N-acetylglucosaminidase (NAG) activities, whereas drought attenuated the positive effects of nitrogen addition on soil βG, EC:N, and EC:P. Soil cellulose hydrolase (CBH) activity was significantly positively correlated with soil water content. Soil βG activity was significantly positively correlated with dissolved organic carbon, nitrate, and ammonium. Soil AP activity was significantly positively correlated with ammonium. Soil NAG activity was significantly positively correlated with dissolved organic carbon and ammonium. In conclusion, nitrogen addition and drought interactively affected soil extracellular enzyme activities and their stoichiometric characteristics in a warm-temperate to subtropical mixed coniferous and broad-leaved forest, indicating that drought may alter the influence of nitrogen addition on soil microbial enzymatic strategies for nutrient acquisition.

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