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triamcinolone acetonide + moxifloxicin + vancomycin

✓ Approved

Harrow Health, Inc. · NR3C1 · Small Molecule

What is triamcinolone acetonide + moxifloxicin + vancomycin?

triamcinolone acetonide + moxifloxicin + vancomycin is a small molecule developed by Harrow Health, Inc.. It is approved for therapeutic indications via injectable (others) or intraocular injection.

Drug Profile

CompanyHarrow Health, Inc.
Drug ClassSmall Molecule
Molecular TargetNR3C1, ,
RouteInjectable (Others), Intraocular Injection
StatusApproved
Sources: ClinicalTrials.gov, Harrow Health, Inc.

Mechanism of Action

Molecular Targets

triamcinolone acetonide + moxifloxicin + vancomycin acts on 3 molecular targets:

NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
()
DNA gyrase subunit A, Staphylococcus aureus MRSA ()
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Therapeutic Indications

triamcinolone acetonide + moxifloxicin + vancomycin is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Eye disordersCataract✓ Approved
Infections and infestationsEye infection✓ Approved
Eye disordersGlaucoma✓ Approved

Related Research Articles

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High-Potency Depigmenting Mask Delivered via 1,927-nm Fractional Laser in Refractory Melasma: A Pilot Case Series.

Piquero-Casals Jaime J, Mir-Bonafé Juan Francisco JF, Rozas-Muñoz Eduardo E, Piquero-Casals Vanesa V et al.

Melasma is a chronic, relapsing hyperpigmentation disorder and may remain refractory despite multiple topical agents and procedural approaches. We report a case series of six women with Fitzpatrick skin types III-V and longstanding, treatment-resistant facial melasma managed with a multimodal protocol consisting of (1) a 16-week home regimen (twice-daily depigmenting cosmeceutical serum and daily high-protection sunscreen) and (2) two sessions of low-energy, low-density 1,927-nm fractional thulium laser at 4-week intervals, immediately followed by laser-assisted delivery of a compounded depigmenting mask (hydroquinone, retinoic acid, kojic acid, triamcinolone acetonide, vitamins C and E). Clinical response was assessed using the Melasma Severity Scale (MSS), standardized photography, and patient satisfaction. At week 16, all patients improved: 4 achieved >75% clinical improvement and 2 achieved 50-75% improvement, with high satisfaction and no significant adverse events beyond transient darkening and mild desquamation. Clinical benefits remained stable 12 weeks after the final laser session. This case series suggests that 1,927-nm fractional thulium laser-assisted delivery of a high-potency depigmenting compound, supported by topical priming and strict photoprotection, may be a feasible option for selected patients with refractory melasma.

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Antimicrobial resistance in post-cataract endophthalmitis: a systematic review on resistance pattern and treatment outcomes.

Yan Martin Chi Kit MCK, Rees Amelia A, Saleki Mohammad M

To systematically review the microbiological spectrum, antimicrobial resistance (AMR) patterns, management strategies, and outcomes in culture-positive endophthalmitis, a rare vision-threatening complication of cataract surgery increasingly challenged by resistance. A comprehensive literature search was conducted in PubMed, Embase, Scopus, and the Cochrane Central Register of Controlled Trials from 1 January 1990 to 30 June 2025. Eligible studies included culture-positive cases of acute Post-Cataract Endophthalmitis reporting antimicrobial susceptibility and outcomes. Data were extracted on organisms, resistance profiles, treatment strategies and visual acuity. Risk of bias was assessed using the ROBINS-I tool. Six studies (five retrospective, one prospective) from Europe, Asia, and North America met inclusion criteria. Coagulase-negative staphylococci predominated, with frequent methicillin and fluoroquinolone resistance; Staphylococcus, Streptococcus, and Pseudomonas were less common. An Indian cohort described multidrug-resistant Pseudomonas with near-universal resistance to fluoroquinolones, aminoglycosides, and cephalosporins but susceptibility to colistin, piperacillin, and imipenem. While vancomycin remained active against Gram-positive organisms, emerging resistance was reported in the United Kingdom. Visual outcomes varied: tap-and-inject was comparable to early pars plana vitrectomy (PPV), except in Gram-negative infections where PPV conferred benefit. Amikacin resistance correlated with poorer outcomes, whereas vancomycin or moxifloxacin resistance did not. Systemic antibiotics and intravitreal corticosteroids showed no consistent benefit. AMR in Post-Cataract Endophthalmitis is an escalating concern with marked geographic variation. Prompt intravitreal therapy remains the key determinant of prognosis, but empiric regimens must reflect local resistance trends, particularly for Gram-negative coverage. Current evidence is limited by retrospective design and regional variability; multicentre prospective studies are needed to refine prophylaxis and treatment protocols, reducing visual and economic burden.

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PubMedCureus2026-07-25

Malignant External Otitis Complicated by Severe Allergic Reaction to Antibiotic Therapy.

Fejza Jetmira J

Malignant external otitis (MEO), also known as necrotizing otitis externa, is an aggressive infection of the external auditory canal and skull base, typically affecting elderly diabetic or immunocompromised patients. We present a case of an 88-year-old non-diabetic woman diagnosed with MEO whose management was complicated by a severe allergic reaction to systemic antibiotic therapy. The patient initially presented with severe otalgia and purulent otorrhea of the right ear, unresponsive to conventional treatment. Otoscopic examination revealed granulation tissue at the osseocartilaginous junction of the external auditory canal. Computed tomography (CT) confirmed temporal bone osteomyelitis consistent with MEO. During hospitalization, the patient developed a severe generalized allergic dermatitis requiring discontinuation of all antibiotics and temporary transfer to the dermatology department. Following stabilization, treatment was resumed with intravenous ciprofloxacin and vancomycin, resulting in progressive clinical improvement and complete recovery after prolonged outpatient therapy. This case highlights the importance of individualized therapeutic strategies in MEO, particularly in elderly patients with atypical presentations and treatment-limiting complications.

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Label- and wash-free electrochemical nucleic acid detection via a LAMP platform coupled with silver ion aptamer probes.

Lee Sangmo S, Lee Soobin S, Ju Yong Y, Kim Hyoyong H et al.

We present a novel electrochemical nucleic acid detection strategy based on loop-mediated isothermal amplification (LAMP) coupled with silver ion (Ag+) aptamer probes. The strategy employs specially designed hairpin-shaped probes comprising an Ag+-binding aptamer sequence in the stem region and a target-complementary sequence in the loop region. In the presence of the target nucleic acid, the LAMP reaction is initiated, and the resulting amplicons hybridize with the loop region of the probe. This interaction disrupts the hairpin structure, leading to the release of Ag+ from the stem region. The liberated Ag+ subsequently participates in a redox reaction at the electrode surface, producing an enhanced electrochemical signal proportional to the amount of LAMP amplicons. Using this approach, we achieved highly sensitive detection of the vanA gene from the genomic DNA of Enterococcus faecium, a key marker of vancomycin-resistant Enterococci, with a detection limit of 10 copies in a 50 μL reaction volume within 45 min from amplification to electrochemical detection, while maintaining high specificity. Owing to its label-free, wash-free, and one-step detection capability, this strategy shows strong potential as a practical platform for electrochemical molecular diagnostics in point-of-care settings.

PMID 42497544
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PubMedBioorganic chemistry2026-07-25

Design, synthesis, antimicrobial evaluation, and molecular dynamics-based computational investigation of novel imidazole-based FabI-targeted derivatives with antioxidant, DNA nicking, and cytotoxicity studies.

Devliya Bhargav B, Patel Bimalkumar B, Chauhan Shreya S, Nagapara Jaykumar J et al.

Antimicrobial resistance (AMR) continues to challenge global healthcare by reducing the effectiveness of existing antibacterial therapies. Resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) pose significant therapeutic challenges, underscoring the need for new antimicrobial candidates with improved antibacterial potential. The present study aimed to design, synthesize, characterize, and biologically evaluate a series of novel imidazole-thiol conjugates containing aminopyridine, chlorinated aromatic, nitroaromatic, and heteroaromatic moieties. The chemical structures of the synthesized compounds were characterized using FTIR, 1H NMR, 13C NMR, and mass spectrometry. The synthesized derivatives exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria, including resistant strains such as MRSA and VRE. Among the synthesized derivatives, BS2 and BS3 exhibited the lowest minimum inhibitory concentration (MIC) values against the tested resistant strains. Computational studies, including molecular docking against Staphylococcus aureus enoyl-acyl carrier protein reductase (SaFabI; PDB ID: 4ALL), molecular dynamics (MD) simulations, and MM/GBSA analyses, supported the predicted interaction of BS3 with the active site of SaFabI under the simulated conditions. In addition, BS3 exhibited moderate antioxidant activity, protected plasmid DNA against oxidative damage in the Fenton reagent-mediated DNA nicking assay, and demonstrated concentration-dependent cytotoxicity with acceptable cell viability at lower concentrations. In silico ADMET and toxicity analyses indicated acceptable drug-like and toxicity characteristics. Overall, BS3 was identified as a potential lead compound for further optimization as an antimicrobial agent.

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PubMedFrontiers in medicine2026-07-25

Right forearm wound and soft tissue abscess complicated with sepsis due to Streptococcus suis: a case report.

Ding Hua H, Lei Chao C, Liu Desheng D, Tian Qing Q

Streptococcus suis (S. suis) is an opportunistic zoonotic bacterial pathogen that is typically transmitted to humans through injured skin or mucous membranes, or through consumption of undercooked contaminated pork. It primarily causes meningitis, septicemia, arthritis, and endocarditis. Reports describing wound infection as the predominant clinical manifestation of S. suis infection are rare. We report a case of S. suis wound infection complicated by sepsis. A 49-year-old woman presented to the emergency department with swelling and pain in her right forearm following wound debridement. According to her history, after wound debridement, she consumed pork soup at a local eatery, where the serving container may have been in contact with contaminated with raw pork. Both blood and wound pus cultures indicated infection with S. suis. Vancomycin and metronidazole were used to control the infection, while plasma transfusion was administered to improve coagulation. Multiple debridements, skin grafting, and vacuum sealing drainage (VSD) were performed. At the 1-year follow-up, the patient achieved a satisfactory recovery and remained free of complications. S. suis infections are commonly associated with individuals who consume raw or undercooked pork and occupational exposure in high-risk groups, including farm workers and butchers. However, trauma-associated infections are more commonly attributed to Staphylococcus aureus. This report draws attention to a possible association between wound infections in trauma patients and S. suis exposure, suggesting that this factor may be considered during clinical evaluation. Therefore, timely wound secretion and blood cultures play a critical role in accurate diagnosis and effective treatment.

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