Drug Database
HU

human albumin (Kedbumin)

✓ Approved

Kedrion · Cell-based Therapies · Cell-based Therapies

What is human albumin?

human albumin is a cell-based therapies developed by Kedrion. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesKedbumin
CompanyKedrion
Drug ClassCell-based Therapies
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Kedrion

Therapeutic Indications

human albumin is developed for 4 unique indications across 3 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersAcute respiratory distress syndrome✓ Approved
Metabolism and nutrition disordersHypoalbuminaemia✓ Approved
Injury, poisoning and procedural complicationsTraumatic shock✓ Approved
Injury, poisoning and procedural complicationsThermal burn✓ Approved

Related Research Articles

PubMedBioconjugate chemistry2026-10-22

Systematic Evaluation of Washing Conditions to Preserve Low Affinity Binders in DEL Selections.

Fabbri Mosè M, Campari Lorenzo L, Puglioli Sara S, Alvigini Laura L et al.

DNA-encoded chemical libraries (DELs) accelerate ligand discovery by combining combinatorial synthesis with parallel affinity selection of DNA-tagged compounds. Conventional DEL selection protocols involve the immobilization of protein targets on a solid support such as magnetic beads. Several washes are performed on the beads after library incubation to remove non-binder library members and to enrich for binding compounds. However, excessive washing could also deplete weak or rapidly dissociating binders. Here, we systematically study the impact of the number of washing steps on DEL hit enrichment during screening of a newly synthesized library named THPP-DEL and based on a central 2-amino-3-(4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl)propanoic acid scaffold and containing ∼8 million compounds. THPP-DEL was screened against Carbonic Anhydrase IX (CAIX), Prostate-Specific Membrane Antigen (PSMA), and Human Serum Albumin (HSA) by systematically varying the number of washing steps from 0 to 20. High-throughput sequencing revealed enriched chemotypes against the three targets, with affinities ranging from low nanomolar to low micromolar concentration values. For all hits, total counts and enrichment factors depended on washing conditions and stabilized after three washing steps. The results presented in this paper define practical selection conditions that preserve micromolar binders, control background levels, and reduce unnecessary hit resynthesis of false positives.

PMID 42902950
Read full article →
PubMedZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026-10-22

[Preliminary evaluation of the efficacy and safety of telitacicept in children with IgA nephropathy].

Chen Jie J, Yu Xiao-Xia XX, Shi Xiao-Song XS, Chen Bing B et al.

To preliminarily assess the efficacy and safety of telitacicept in pediatric IgA nephropathy (IgAN). Clinical data of 11 children with IgAN who received telitacicept in the Department of Pediatrics, Provincial Hospital Affiliated to Fuzhou University, from January 2024 to October 2025 were retrospectively collected. Parameters compared before and after treatment included 24-hour urinary protein, serum albumin, immunoglobulins (IgG, IgA, IgM), peripheral blood CD19+ cells, estimated glomerular filtration rate (eGFR), and glucocorticoid dosage. Adverse events were recorded. At 4, 12, 24, 36, and 48 weeks after treatment, 24-hour urinary protein was significantly lower than baseline (all P<0.05), with the greatest reduction at 12 weeks (P<0.001). Serum albumin increased compared with baseline, reaching statistical significance at 12, 24, and 36 weeks (all P<0.05). IgG and IgA levels decreased significantly at all time points (all P<0.05), and IgM showed an overall downward trend (P<0.05). CD19+ cell counts showed no significant change (P>0.05). Glucocorticoid dosage was significantly reduced (P<0.05), while eGFR showed no significant change (P>0.05). A total of 6 adverse event episodes were recorded, predominantly mild respiratory infections; no serious adverse events occurred. Telitacicept can effectively reduce proteinuria in children with IgAN and demonstrates an overall favorable safety profile.

PMID 42902722
Read full article →
PubMedThe Journal of the Association of Physicians of India2026-10-22

A Retrospective Study of Clinical, Microbiological, and Ulcer Severity Patterns of Diabetic Foot Presenting to a Tertiary Care Hospital.

Jafri Asif Dabeer AD, Dhar Srikant Kumar SK, Singh Muktesh M, Singh Ratender Kumar RK

Diabetic foot ulcers (DFUs) are a major complication of diabetes and are frequently associated with infection, antimicrobial resistance, and limb amputation. Regional Indian data on microbiological patterns and antimicrobial resistance remain limited. This retrospective observational study evaluated 40 patients with DFUs presenting to a tertiary care hospital over a 12-month period. Clinical and laboratory parameters, including glycated hemoglobin (HbA1c), C-reactive protein (CRP), total leukocyte count (TLC), and serum albumin, were analyzed. Ulcer severity was graded using the Wagner classification, and wound cultures with antibiotic susceptibility testing were performed. Most patients were male (70%) and aged 40-60 years. Mean HbA1c was significantly higher in male than in female patients (13.99 ± 1.40 vs 10.45 ± 1.41; p < 0.05). Monomicrobial infections predominated, with Gram-negative organisms accounting for 70.3% of isolates, followed by Gram-positive bacteria (22.2%) and fungi (7.4%). Polymicrobial infections occurred in 12.5% of cases. Gram-negative isolates showed universal sensitivity to colistin, whereas Acinetobacter spp. demonstrated high resistance to other antibiotics. Higher Wagner grades were significantly associated with elevated HbA1c and CRP levels. All amputations occurred in male patients with polymicrobial infections. Gram-negative pathogens predominated in DFUs in this setting, contrasting with the Gram-positive predominance reported in Western literature. Poor glycemic control and elevated inflammatory markers were associated with increasing ulcer severity and amputation risk.

PMID 42902668
Read full article →
PubMedZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026-10-22

[Post-discharge fortified human milk feeding in preterm infants with moderate-to-high nutritional risk: a retrospective cohort study].

Wang Yun-He YH, Yao Yi Y, Chi Yun-Qian YQ, Zhang Zi-Han ZH et al.

To investigate the effects of post-discharge fortified human milk feeding on growth, common complications, and neuropsychological development in preterm infants with moderate-to-high nutritional risk. Clinical data were retrospectively collected from 320 preterm infants with moderate-to-high nutritional risk who were discharged from the Department of Neonatology, Provincial Hospital Affiliated to Shandong First Medical University between January 2021 and December 2023 and completed a 6-month follow-up. Infants were classified into four groups by nutritional risk level and feeding method: moderate-risk fortified human milk, moderate-risk formula, high-risk fortified human milk, and high-risk formula. Comparisons were conducted between fortified human milk and formula within the same risk level, and between moderate- and high-risk groups within the same feeding method. Within the same feeding method, gestational age at birth and birth weight differed significantly between moderate- and high-risk infants (P<0.001). Within the same nutritional risk level, no significant differences were found between fortified human milk and formula groups in gestational age at birth and birth weight (P>0.05). In the fortified human milk groups, corrected gestational age at discharge differed significantly between moderate- and high-risk infants (P<0.05). No significant differences were noted among the four groups in discharge weight, length, or head circumference (P>0.05). Analysis of covariance, adjusting for discharge weight, length, head circumference, and corrected gestational age at discharge, showed no significant differences among the four groups during the 6-month follow-up in growth velocities of weight, length, or head circumference, nor in hemoglobin, 25-hydroxyvitamin D, or alkaline phosphatase measured at 1, 3, and 5 months (P>0.05). Multivariable logistic regression indicated that fortified human milk feeding did not increase the risk of infection (OR=0.66, 95%CI: 0.40-1.08, P=0.097) or feeding intolerance (OR=0.70, 95%CI: 0.45-1.08, P=0.107). At 6 months' corrected age, mental, motor, and behavioral scores did not differ significantly among groups (P>0.05). In preterm infants at moderate-to-high nutritional risk, post-discharge fortified human milk feeding does not increase the risk of infection or feeding intolerance, does not differ significantly from formula feeding in short-term catch-up growth or neuropsychological development, and appears clinically feasible and safe.

PMID 42902717
Read full article →
PubMedFrontiers in nutrition2026-10-22

LVEF-defined septic cardiomyopathy modifies the association between the prognostic nutritional index and mortality in adults with sepsis: a 72-h landmark analysis.

Wang Xianju X, Cheng Min M, Ruan Fengqi F, Chen Chong C et al.

The prognostic nutritional index (PNI) combines albumin and lymphocyte count and may capture nutrition-related immune-inflammatory status in sepsis. Whether its association with mortality differs by left ventricular ejection fraction (LVEF)-defined septic cardiomyopathy (SCM) is unclear. We conducted a retrospective 72-h landmark study of MIMIC-IV adults with Sepsis-3 who survived to the landmark, had clinically indicated pre-landmark echocardiographic LVEF assessment, and had calculable early PNI. The prespecified primary analysis tested the lower-PNI-by-LVEF-defined-SCM interaction for 28-day mortality in an adjusted Cox model. Ninety-day and sensitivity analyses were supportive or exploratory. A single-center cohort was examined separately, not as formal validation. Among 1,976 patients, 240 had LVEF-defined SCM; 506 and 633 died by 28 and 90 days, respectively. Each 5-point lower PNI was associated with higher 28-day mortality without SCM (adjusted hazard ratio [HR], 1.18; 95% CI, 1.11-1.24) but not with LVEF-defined SCM (HR, 0.96; 95% CI, 0.87-1.05); the ratio of HRs was 0.82 (95% CI, 0.73-0.91; p < 0.001). The secondary 90-day ratio was 0.84 (95% CI, 0.76-0.94; nominal p = 0.001). Absolute-risk and restricted-mean-survival-time analyses supported attenuation, whereas same-calendar-day PNI pairing and some alternative LVEF definitions attenuated the interaction estimates toward the null. The external estimate was imprecise and statistically inconclusive (ratio of odds ratios, 0.89; 95% CI, 0.51-1.55). Among selected 72-h survivors with clinically indicated pre-landmark echocardiography, the association between lower PNI and 28-day mortality was attenuated with LVEF-defined SCM. PNI should not be used alone for nutritional or clinical decision-making.

PMID 42903086
Read full article →
PubMedFrontiers in immunology2026-10-22

Transcriptomics-guided serum podoplanin and interpretable machine learning for early risk stratification of necrotizing enterocolitis in preterm infants.

Peng Hanghang H, Liu Xue X, Li Yihui Y, Zhou Minqian M et al.

To evaluate podoplanin (PDPN) as a circulating biomarker for early necrotizing enterocolitis (NEC) risk stratification and to determine whether an interpretable machine-learning framework integrating PDPN with prediagnostic clinical and inflammatory variables could improve individualized risk estimation. PDPN expression was examined in two public NEC intestinal transcriptomic datasets. Serum PDPN was then measured by enzyme-linked immunosorbent assay in a nested case-control cohort of 132 preterm infants (66 with NEC and 66 gestational-age- and birth-weight-matched controls). All candidate predictors were obtained before NEC onset in cases and before the matched reference time in controls. Restricted cubic spline, receiver operating characteristic, precision-recall, LASSO, multivariable logistic regression, 11 machine-learning algorithms, SHAP, and nomogram analyses were performed. PDPN was upregulated in NEC intestinal tissue. Serum concentrations were higher in infants who developed NEC than in controls (48.36 ± 22.89 vs 19.75 ± 6.26 ng/mL, P < 0.001) and in Bell stage III than in Bell stage II NEC [69.43 (58.91-77.95) vs 30.59 (24.06-42.79) ng/mL, P < 0.001]. PDPN correlated weakly with the C-reactive protein-to-albumin ratio and high-sensitivity C-reactive protein, achieved an area under the receiver operating characteristic curve of 0.905 and an area under the precision-recall curve of 0.925, and remained independently associated with NEC after multivariable adjustment. CatBoost showed the most favorable internal performance among 11 models, with PDPN as the leading SHAP contributor. The nomogram achieved an internally assessed area under the curve of 0.974. Prediagnostic serum PDPN, particularly when combined with routinely available variables, may support early individualized NEC risk stratification. Prospective multicenter validation and mechanistic studies are warranted.

PMID 42903119
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about human albumin