Drug Database
HY

hyaluronic acid (Hyalein / Sanlein / Hialid)

✓ Approved

Santen Pharmaceutical Co., Ltd. · therapeutic agent

What is hyaluronic acid?

hyaluronic acid is a therapeutic agent developed by Santen Pharmaceutical Co., Ltd.. It is approved for therapeutic indications via others.

Drug Profile

Brand NamesHyalein, Sanlein, Hialid
CompanySanten Pharmaceutical Co., Ltd.
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, Santen Pharmaceutical Co., Ltd.

Therapeutic Indications

hyaluronic acid is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Eye disordersDry eye✓ Approved
Eye disordersKeratitis✓ Approved

Related Research Articles

PubMedClinical, cosmetic and investigational dermatology2026-08-25

Perceived User Experience, Comfort, and Ergonomics of an Add-on Backstop for Hyaluronic Acid Filler Injections: A Simulated-Use Study in Aesthetic Healthcare Professionals.

Combedazou Anne A, Brunet-Manquat Laurie L, Giri Jayant R JR, Girgis Haymen H et al.

Hyaluronic acid (HA) fillers are widely used in cosmetic dermatology. These products exhibit viscoelastic properties and often high viscosity, which may require substantial injection forces during injection. In clinical practice, repeated injections and sustained manual force may increase operator effort and contribute to hand fatigue. Device ergonomics may therefore influence perceived comfort and control during HA filler administration. To assess the perceived aspiration and injection experience, comfort, satisfaction, and perceived ergonomics of an investigational add-on device consisting of a redesigned backstop and reinforced plunger rod for use with prefilled hyaluronic acid syringes during simulated aesthetic injection tasks. In a late formative Human Factors study, 30 aesthetic healthcare professionals in China and Korea performed simulated HA injections using the investigational add-on device with both needle and cannula on facial training models. The primary evaluation focused on perceived user experience with the investigational add-on under simulated-use conditions. A separate exploratory contextual comparison was then conducted using the investigational add-on configuration and a standard backstop/plunger-rod configuration with needle only. The exploratory contextual comparison was open because the configurations were visually and physically distinguishable; the order of configurations was randomized. Outcomes included task observation, first impression, injection and aspiration experience assessed using visual analogue scales, comfort and perceived ergonomics assessed using user-reported Likert scales, overall satisfaction, and qualitative feedback. Data were analyzed descriptively. Participants had a mean of 8.6 years of aesthetic practice. During simulated injections with the investigational add-on device, mean injection experience scores ranged from 8.6 to 8.9/10, and comfort scores from 5.3 to 5.4/6 for needle and cannula use. Ergonomics was rated positively by most participants, with a mean score of 5.5/6. Qualitative feedback frequently mentioned improved grip stability and reduced perceived needle-tip movement during aspiration in the simulated-use setting. In this simulated-use late formative study, experienced aesthetic healthcare professionals reported high perceived user experience, comfort, and perceived ergonomics with the investigational add-on device. These findings should be interpreted as immediate subjective user feedback and require confirmation in studies using objective biomechanical measures and clinical-use conditions.

PMID 42639158
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PubMedRSC advances2026-08-25

Crosslinking strategies govern the morphology and biological performance of decellularized extracellular matrix particle-tyramine-modified hyaluronic acid hydrogels.

Xu Jiangyao J, Wychowaniec Jacek K JK, D'Este Matteo M, Jiang Nan N et al.

Decellularized extracellular matrix (dECM) particle-based hydrogels hold promise for cartilage repair. Due to its chondropermissive properties, tuneable viscoelastic profile, and the potential to form covalent bonds with ECM proteins, tyramine-modified hyaluronic acid (THA) is an ideal candidate as a binder for dECM particles. However, the incorporation of the dECM particles into a viscoelastic hydrogel may interfere with its crosslinking. The goal of this study was to compare two crosslinking methods: (1) horseradish peroxidase/Eosin (HRP/Eo) with H2O2 and (2) sodium persulfate/ruthenium (SPS/Ru) for fabricating THA hydrogels containing dECM particles, and to investigate their biological and biomechanical effect for cartilage tissue engineering. Incorporation of dECM markedly enhanced the mechanical properties of the composites in both crosslinking methods, increasing the storage modulus by 10-fold, while leaving the linear viscoelastic region unchanged. Chondrocyte-laden dECM hydrogels demonstrated sustained cytocompatibility over 14 days, evidenced by stable DNA content throughout the culture period. Compared with SPS/Ru, hydrogels showed more effective incorporation of dECM particles into the HRP/Eo-crosslinked network, as indicated by a lower I ∼1630/I ∼1030 ratio from FTIR analysis, clear morphological changes in confocal microscopy, higher glycosaminoglycan (GAG) and collagen retention, as well as slower GAG and collagen release. HRP/Eo-dECM hydrogels promoted stronger gene expression of type II collagen (COL2) and higher compressive modulus compared with SPS/Ru-dECM hydrogels. In summary, HRP/Eo crosslinked dECM hydrogels demonstrated improved mechanical performance and chondrocyte redifferentiation effect compared to SPS/Ru, attributed to the difference in hydrogel morphology. These findings identify the HRP/Eo crosslinking method as a favorable strategy for engineering dECM particle-THA hydrogels for cartilage regeneration.

PMID 42639416
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PubMedHand (New York, N.Y.)2026-08-25

Perineural Scar Prevention in Brachial Plexus Decompression Surgery: Clinical Outcomes Using a Bioresorbable Hydrogel Implant.

Cervantes Valadez Samantha S, Harris Peyton P, Cato Liam L, Tanas Yousef Y et al.

Perineural scarring after peripheral nerve surgery is a known cause of persistent pain and reoperation. Brachial plexus decompression for neurogenic thoracic outlet syndrome (nTOS) carries a particularly high risk given the extent of dissection, scalenectomy, and the constant motion of the cervicothoracic region. Recurrence rates after complete decompression range from 7% to 30%. VersaWrap (Alafair Biosciences) is a bioresorbable hyaluronic acid/alginate hydrogel that physically blocks fibroblast access while allowing nutrient diffusion to the nerve. Its use has not previously been reported in brachial plexus surgery. We reviewed 94 patients who underwent supraclavicular brachial plexus decompression for nTOS at a single institution between 2014 and 2025. Forty-nine received VersaWrap around the brachial plexus trunks after neurolysis; 45 underwent the same procedure without a wrap. Primary outcomes were persistent neuropathic pain and reintervention for nTOS. Secondary outcomes included paresthesias, opioid use past 5 days, wound complications, and device-related adverse events. Mean follow-up was 12 months for the entire cohort. Persistent neuropathic pain occurred in 2 VersaWrap patients (4.1%) versus 3 controls (6.7%). Reintervention was required in 1 VersaWrap patient (2%) versus 2 controls (4.4%). Postoperative paresthesias were noted in 4 VersaWrap patients (8.2%) versus 3 controls (6.7%). Opioid use beyond 5 days occurred in 2 VersaWrap patients (4.1%). No device-related complications were observed. VersaWrap was safe and well tolerated. Rates of persistent pain and reoperation were numerically lower in the VersaWrap group, though the study was not powered to detect significant differences. These results support further prospective evaluation of hydrogel barriers in high-risk peripheral nerve surgery.

PMID 42640026
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PubMedFrontiers in surgery2026-08-25

Antigliotic guiding regenerative gel: a bioactive hydrogel platform for peripheral nerve and spinal cord repair.

Rochkind Shimon S, Almog Mara M, Goldlust Arie A

Peripheral nerve injury (PNI) and spinal cord injury (SCI) impose a major burden of traumatic neurological disability worldwide. Autologous nerve grafting, the current gold standard, achieves meaningful recovery in only 81.6% of repairs (2023 meta-analysis, n = 1,559), while hollow nerve graft conduits achieve only 62.2% (p < 0.05), with performance declining sharply beyond 20-30 mm gaps. Passive scaffolds cannot counter the inhibitory post-injury microenvironment of reactive gliosis, chondroitin sulfate proteoglycan (CSPG) deposition, oxidative stress, and myelin-associated inhibitors, which actively collapse regenerating axon growth cones. This review traces the conceptual and developmental logic of a family of bioactive hydrogels, "neurogels", designed as active modulators of the regenerative microenvironment rather than passive bridges. We organize the review around the scientific problem: the biological barriers that passive scaffolds cannot address; the design rationale for a hyaluronic acid (HA)-based neurogel bearing a biomimetic laminin-derived peptide (LDP-916), an antioxidant, and an antigliotic immunomodulator; the formulation evolution from the original Guiding Regenerative Gel (GRG; HA + LDP-916 + recombinant superoxide dismutase 1, SOD1) to the current Antigliotic Guiding Regenerative Gel (AGRG; HA + LDP-916 + DL-α-tocopherol + glatiramer acetate); and the preclinical evidence base. An in vitro 35S-glycosaminoglycan candidate-selection screen in activated astrocytes identified several antigliotic agents; translational barriers of the top-ranked biologics (bacterial origin and thermolability of chondroitinase ABC; blood-brain barrier impermeability of anti-NogoA antibody) motivated selection of glatiramer acetate, the active copolymer of Copaxone (a clinically validated multiple sclerosis drug), and replacement of SOD1 by DL-α-tocopherol for manufacturing and stability reasons. AGRG increased neurite length by approximately 78% in vitro relative to control, showed electrophysiological performance comparable to or exceeding autograft in a 25 mm chronic rabbit PNI model at 40 weeks, and promoted myelinated axon regrowth in acute and chronic rat SCI. A recently completed 15 mm rat sciatic critical-gap study comparing AGRG to autograft provides supportive internal data; because this dataset has not yet completed independent peer review, its findings are described in general terms and are not used as a basis for definitive efficacy claims. Regulatory-enabling studies are being pursued by Maxonis Ltd. in preparation for an FDA pre-IND interaction.

PMID 42639068
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PubMedJournal of experimental botany2026-08-25

Hijacking the auxin highway: Substrate Recognition of Phenoxyacetic Acid Herbicides.

Schulz Lukas L, Bech Frederik Bonderup FB, Koutnik-Abele Sarah S, Mueller Thomas D TD et al.

Auxins are central for plant growth and development and this has been exploited to design herbicides that hijack the auxin transport machinery and signal transduction pathways. Among these auxin herbicides are phenoxyacetic acid herbicides which have been used for decades. Accumulating structural, biochemical, and physiological evidence converges on a model in which phenoxyacetic acid herbicides exploit the endogenous auxin transport machinery, with both AUXIN-RESISTANT1/LIKE-AUX1 (AUX/LAX) importers and PIN-FORMED (PIN) exporters recognizing and transporting these compounds in a manner closely resembling indole-3-acetic acid. Substrate recognition is governed by conserved interactions with the carboxyl group, while affinity and specificity are modulated by hydrophobic interactions with the aromatic moiety, particularly influenced by halogen substitution. Despite this mechanistic similarity, the comparatively low mobility of phenoxyacetic acid herbicides in planta highlights the importance of additional processes such as intracellular sequestration, metabolic conversion, and conjugation, which limit their systemic distribution. Together with the high conservation of the auxin perception machinery, these findings explain why resistance to synthetic auxins predominantly arises through transport- and metabolism-based mechanisms rather than target-site alterations, and they underscore the central role of auxin transporters as key determinants of herbicide activity and selectivity.

PMID 42639942
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PubMedYing yong sheng tai xue bao = The journal of applied ecology2026-08-25

Effects of simulated acid rain on leaf structure and photosynthetic physiology in Michelia shiluensis.

Shuai-Jie L U LU, Ruo-Yong Yin Y, Bao-Jin Zhang Z, Meng-Ling Wen W et al.

Michelia shiluensis is a rare tree species in the family Magnoliaceae endemic to southern China. Its natural distribution regions frequently affected by acid rain, exposing it to a high risk of acid rain stress. In this study, 3-year-old seedlings of M. shiluensis were subjected to simulated acid rain treatments at pH 2.5, 3.5, 4.5, and 5.0, with purified water (pH 7.0) as control, for a 50-day experiment. We investigated changes in plant growth, leaf anatomical structure, and photosynthetic physiological parameters. The results showed that acid rain stress significantly inhibited plant growth, and that the effect became more severe with decreasing pH. Under the pH 2.5 treatment, plant height and ground diameter decreased by 82.3% and 87.4%, respectively. All the treatments with pH≤4.5 significantly increased stomatal area, with that of individual stomata being increased by 47.6% and 76.6% under pH 3.5 and pH 2.5 treatments, respectively. Under pH≤3.5, the thickness of all leaf anatomical tissues increased significantly, and the mesophyll became more compact. During the stress period, net photosynthetic rate continuously declined, while the intercellular CO2 concentration increased during the middle and late stages of stress. Under pH≤3.5, the maximum photochemical efficiency of PSⅡ remained relatively stable, whereas the photochemical quenching coefficient and electron transport rate increased transiently during the early stage of stress but gradually declined thereafter. In contrast, both parameters remained suppressed under the pH 2.5 treatment. In conclusion, acid rain reduced net photosynthetic rate and inhibited the growth of M. shiluensis by disrupting stomatal structure, increasing the resistance to CO2 diffusion within the mesophyll, and suppressing the photochemical activity of photosystem Ⅱ. Photosynthetic activity was markedly inhibited at pH≤3.5, whereas severe damage to both leaf structure and photosynthetic capacity occurred under the pH 2.5 treatment.

PMID 42639891
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