Drug Database
AC

acetylsalicylic acid + clopidogrel (Copregrel / Coprigrel)

✓ Approved

Chong Kun Dang Pharmaceutical · PTGS1 · Small Molecule

What is acetylsalicylic acid + clopidogrel?

acetylsalicylic acid + clopidogrel is a small molecule developed by Chong Kun Dang Pharmaceutical. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesCopregrel, Coprigrel
CompanyChong Kun Dang Pharmaceutical
Drug ClassSmall Molecule
Molecular TargetPTGS1, PTGS2, P2RY12
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Chong Kun Dang Pharmaceutical

Mechanism of Action

Molecular Targets

acetylsalicylic acid + clopidogrel acts on 3 molecular targets:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
P2RY12purinergic receptor P2Y12 (P2Y(ADP), P2Y(cyc))
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

acetylsalicylic acid + clopidogrel is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersThrombosis✓ Approved

Related Research Articles

PubMedJournal of experimental botany2026-08-25

Hijacking the auxin highway: Substrate Recognition of Phenoxyacetic Acid Herbicides.

Schulz Lukas L, Bech Frederik Bonderup FB, Koutnik-Abele Sarah S, Mueller Thomas D TD et al.

Auxins are central for plant growth and development and this has been exploited to design herbicides that hijack the auxin transport machinery and signal transduction pathways. Among these auxin herbicides are phenoxyacetic acid herbicides which have been used for decades. Accumulating structural, biochemical, and physiological evidence converges on a model in which phenoxyacetic acid herbicides exploit the endogenous auxin transport machinery, with both AUXIN-RESISTANT1/LIKE-AUX1 (AUX/LAX) importers and PIN-FORMED (PIN) exporters recognizing and transporting these compounds in a manner closely resembling indole-3-acetic acid. Substrate recognition is governed by conserved interactions with the carboxyl group, while affinity and specificity are modulated by hydrophobic interactions with the aromatic moiety, particularly influenced by halogen substitution. Despite this mechanistic similarity, the comparatively low mobility of phenoxyacetic acid herbicides in planta highlights the importance of additional processes such as intracellular sequestration, metabolic conversion, and conjugation, which limit their systemic distribution. Together with the high conservation of the auxin perception machinery, these findings explain why resistance to synthetic auxins predominantly arises through transport- and metabolism-based mechanisms rather than target-site alterations, and they underscore the central role of auxin transporters as key determinants of herbicide activity and selectivity.

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PubMedYing yong sheng tai xue bao = The journal of applied ecology2026-08-25

Effects of simulated acid rain on leaf structure and photosynthetic physiology in Michelia shiluensis.

Shuai-Jie L U LU, Ruo-Yong Yin Y, Bao-Jin Zhang Z, Meng-Ling Wen W et al.

Michelia shiluensis is a rare tree species in the family Magnoliaceae endemic to southern China. Its natural distribution regions frequently affected by acid rain, exposing it to a high risk of acid rain stress. In this study, 3-year-old seedlings of M. shiluensis were subjected to simulated acid rain treatments at pH 2.5, 3.5, 4.5, and 5.0, with purified water (pH 7.0) as control, for a 50-day experiment. We investigated changes in plant growth, leaf anatomical structure, and photosynthetic physiological parameters. The results showed that acid rain stress significantly inhibited plant growth, and that the effect became more severe with decreasing pH. Under the pH 2.5 treatment, plant height and ground diameter decreased by 82.3% and 87.4%, respectively. All the treatments with pH≤4.5 significantly increased stomatal area, with that of individual stomata being increased by 47.6% and 76.6% under pH 3.5 and pH 2.5 treatments, respectively. Under pH≤3.5, the thickness of all leaf anatomical tissues increased significantly, and the mesophyll became more compact. During the stress period, net photosynthetic rate continuously declined, while the intercellular CO2 concentration increased during the middle and late stages of stress. Under pH≤3.5, the maximum photochemical efficiency of PSⅡ remained relatively stable, whereas the photochemical quenching coefficient and electron transport rate increased transiently during the early stage of stress but gradually declined thereafter. In contrast, both parameters remained suppressed under the pH 2.5 treatment. In conclusion, acid rain reduced net photosynthetic rate and inhibited the growth of M. shiluensis by disrupting stomatal structure, increasing the resistance to CO2 diffusion within the mesophyll, and suppressing the photochemical activity of photosystem Ⅱ. Photosynthetic activity was markedly inhibited at pH≤3.5, whereas severe damage to both leaf structure and photosynthetic capacity occurred under the pH 2.5 treatment.

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PubMedFood science & nutrition2026-08-25

Association Between the Planetary Health Diet Index and Serum Uric Acid Levels and Incident Hyperuricemia: Findings From an Iranian Prospective Cohort Study.

Kamrani Farzam F, Imannezhad Mobina M, Etesami Elahe E, Karimi Elham E et al.

The EAT-Lancet planetary health diet aims to jointly promote human health and environmental sustainability, yet its relationship with uric acid metabolism remains largely unexplored. We prospectively examined the association between adherence to this dietary pattern and both incident hyperuricemia and serum uric acid levels, and tested whether insulin resistance mediated any observed link. Among 5773 Iranian adults free of hyperuricemia at baseline and followed for approximately five years, dietary intake was assessed using a validated food frequency questionnaire. Adherence to the EAT-Lancet diet was quantified with the Planetary Health Diet Index (PHDI; range 0-150). Hyperuricemia was defined as serum uric acid exceeding 7.0 mg/dL in men and 6.0 mg/dL in women. Multivariable logistic and linear regression models estimated associations, and bootstrapped causal mediation analysis quantified the indirect effect through HOMA-IR. Incident hyperuricemia occurred in 1113 participants (cumulative incidence 19.3%). In the fully adjusted model, the highest versus lowest PHDI quartile was associated with 25% lower odds of hyperuricemia (OR 0.75; 95% CI 0.62-0.91; p-trend < 0.001). Each SD increment in PHDI corresponded to a 0.053 mg/dL lower follow-up serum uric acid after adjustment for baseline levels (p < 0.001). Mediation analysis suggested that HOMA-IR accounted for a large proportion of the association (point estimate 91.0%; 95% CI 48.2%-232.5%), although the wide confidence interval calls for cautious interpretation; the direct effect was non-significant. Findings were robust across sensitivity analyses, alternative EAT-Lancet scoring systems, and further adjustment for established dietary indices including the Mediterranean diet score, Healthy Eating Index 2015, Diet Quality Index Revised, and Dietary Approaches to Stop Hypertension score. Greater adherence to the planetary health diet was prospectively associated with lower serum uric acid and reduced hyperuricemia odds, a benefit that appeared to be mediated largely through insulin sensitivity.

PMID 42639183
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PubMedCell press blue2026-08-25

The hallmarks of protein and amino acid restriction in aging and longevity.

Knopf Bailey A BA, Lamming Dudley W DW

Despite widespread recommendations for higher protein intake during aging, increasing evidence suggests that dietary protein restriction (PR) promotes metabolic health, healthspan, and lifespan across diverse organisms. Mechanistic studies further demonstrate that restriction of specific amino acids, particularly methionine, isoleucine, and valine, recapitulates many of the benefits of PR, highlighting the specific amino acid composition of the diet as a key determinant of aging. Here, we define the hallmarks of PR through the lens of aging, examining how PR and restriction of specific essential amino acids impact metabolic health, nutrient sensing, senescence, mitochondrial function, and the epigenome. We also discuss the known and unknown roles of non-essential amino acids in healthy aging. Overall, this review provides a comprehensive overview of current knowledge regarding the benefits of PR and amino acid restriction for healthy aging and highlights the therapeutic potential of interventions based on these diets to promote healthspan and longevity.

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PubMedMedical gas research2026-08-25

A chlorine gas-derived weapon of the immune system: new developments in hypochlorous acid determination.

Kianpoor Mahsa M, Schiller Jürgen J, Leopold Jenny J

PMID 42638339
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PubMedClinical toxicology (Philadelphia, Pa.)2026-08-25

Transient hepatic portal venous gas and gastric emphysema following ingestion of hydrogen peroxide and peroxyacetic acid.

Yu Guangcai G, Lv Shizhen S, Jian Tianzi T, Li Wei W et al.

PMID 42640224
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