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IV

IVIG (Privigen / IVIG, liquid, CSL / IgPro10)

✓ Approved

CSL Behring · Polyclonal Antibodies · Polyclonal Antibodies

What is IVIG?

IVIG is a polyclonal antibodies developed by CSL Behring. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesPrivigen, IVIG, liquid, CSL, IgPro10
CompanyCSL Behring
Drug ClassPolyclonal Antibodies, Antibody
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, CSL Behring

Therapeutic Indications

IVIG is developed for 9 unique indications across 6 therapeutic areas.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersPurpura✓ Approved
Immune system disordersImmunodeficiency✓ Approved
Nervous system disordersMultifocal motor neuropathy✓ Approved
Musculoskeletal and connective tissue disordersScleroderma✓ Approved
Nervous system disordersGuillain-Barre syndrome✓ Approved

+4 more indications available with a free account

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Related Research Articles

PubMedCancer science2026-10-22

Diagnostic Performance of cfDNA-Based Liquid Biopsy for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

Liu Jiwei J, Zhang Yangyu Y, Yang Shuo S, Wu Yanhua Y et al.

Conventional surveillance tools for hepatocellular carcinoma (HCC) have limited sensitivity. Circulating cell-free DNA (cfDNA)-based liquid biopsy is a promising minimally invasive approach; however, its overall diagnostic performance remains unclear. This meta-analysis aimed to comprehensively evaluate the diagnostic accuracy of cfDNA-based liquid biopsy in HCC. Following PRISMA-DTA guidelines, we searched PubMed, EMBASE, and Web of Science until July 2026. Diagnostic accuracy data were pooled using bivariate random-effects models. Methodological quality was assessed using QUADAS-2 and NOS. A total of 29 studies (4250 HCC patients, 7982 controls) were included. Pooled sensitivity and specificity of cfDNA-based testing were 0.82 (95% CI: 0.76-0.86) and 0.91 (95% CI: 0.88-0.93). The area under the summary receiver operating characteristic curve (AUC) was 0.93 (95% CI: 0.91-0.96). Subgroup analyses showed higher sensitivity in advanced HCC 0.91 (95% CI: 0.85-0.95) than early HCC 0.77 (95% CI: 0.71-0.83). Methylation profiling yielded relatively higher sensitivity 0.84 (95% CI: 0.77-0.89), whereas fragmentomics showed relatively favorable specificity 0.93 (95% CI: 0.88-0.96). Combining cfDNA-based testing with alpha-fetoprotein (AFP) significantly improved sensitivity compared with cfDNA alone (0.78 vs. 0.65). No significant publication bias was detected (p = 0.83). cfDNA-based liquid biopsy achieves high diagnostic accuracy for HCC. As exploratory observations, methylation-based assays with relatively higher sensitivity may have potential value for screening high-risk populations, while fragmentomics-based assays with relatively favorable specificity may aid differential diagnosis. Combining cfDNA-based liquid biopsy with AFP further improves diagnostic performance, supporting cfDNA as a promising noninvasive tool for HCC detection. Trial Registration: This systematic review was registered on PROSPERO: CRD420261293877 (https://www.crd.york.ac.uk/PROSPERO/).

PMID 42902833
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PubMedEnvironmental technology2026-10-22

Extraction and separation of phosphorous and heavy metals from freshwater sediment - influence of experimental variables on the electrodialytic treatment.

Paradkar Aishwarya S AS, Ottosen Lisbeth M LM, Jensen Pernille E PE, Pedersen Kristine B KB

This study explores the influence of experimental variables on the electrodialytic (ED) treatment of freshwater sediment for extraction and separation of phosphorus (P) and heavy metals (Cd, Cu, Pb, Zn). The overall idea is to extract an uncontaminated P product and an unpolluted sediment fit for recycling. The influence of the experimental variables, current, liquid-to-solid ratio (L/S), duration, stirring rate, suspension liquid (distilled/tap water), was studied in 11 ED experiments with the help of a multivariate analysis tool, projection to latent structures (PLS). In the experimental domain studied, current and L/S had the most influence on P extraction (50%), and the extracted P was uncontaminated with heavy metals. The stirring rate and current had the most influence on the extraction of Zn (90%) > Cd   (87%) > Cu  (60%) > Pb  (48%). The concentration of heavy metals was compared with the limits for soil improvers because that is one of the options for sediment recycling. Cd and Zn in the treated sediment met the standards for soil improvers, whereas optimization is necessary for Cu and Pb. The multivariate analysis revealed that the extracted Cd and Zn were mostly associated with the exchangeable and reducible fractions of the sediment. It was also revealed that the extracted Cu was mostly associated with the oxidizable fraction, whereas for Pb, no clear relationship could be established. The optimization for improving the extraction of Cu and Pb associated with the oxidizable fraction could be done by treating the sediment at a high stirring rate, high current, and long duration.

PMID 42902632
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PubMedJournal of the science of food and agriculture2026-10-22

Impact of different ultrasonication strategies on the structural, rheological, and functional properties of mung bean protein isolate-gum arabic conjugates formed via the Maillard reaction.

Odabaş Halil İbrahim Hİ, Karabulut Esra E, Türk Asena A, Tunç Merve Tuğçe MT et al.

The impact of different ultrasound (US) strategies on the formation of mung bean protein isolate-gum arabic (MBPI-GA) conjugates formed by the Maillard reaction was investigated to overcome the techno-functional limitations of native mung bean protein isolate (MBPI). Two primary sonication strategies - pre-sonication of protein (P100, P200) and co-sonication of the protein-polysaccharide mixture (PG100, PG200) - were compared with traditional wet-heating controls. High-intensity ultrasound (200 W) significantly accelerated Maillard reaction kinetics, resulting in the highest degrees of grafting (44% to 47%) compared with wet-heated MBPI-GA conjugates without ultrasound treatment. Fourier transform infrared (FTIR) spectroscopy and reactive sulfhydryl group analyses confirmed that ultrasonic cavitation induced structural unfolding, as evidenced by a significant reduction in β -sheet fractions and a concomitant increase in random coil content, exposing buried reactive sites. All sonicated conjugates exhibited more than a twofold increase in protein solubility compared with the native protein. The PG200 strategy maximized emulsifying activity index (EAI) and water-holding capacity (8.5 g g-1), and PG100 yielded the highest in vitro protein digestibility (approximately 60%) and improved thermal stability. The denaturation temperature ( T d ) increased from 81.32 °C (native MBPI) to 82.65-83.63 °C in the co-sonicated conjugates, accompanied by a pronounced reduction in denaturation enthalpy ( Δ H ) from 15.7 to 5.5 J g-1. Rheological assessments revealed that the conjugates formed a heat-stable, liquid-like network in which the loss modulus ( G ″ ) consistently exceeded the storage modulus ( G ' ), thereby preventing thermal gelation and precipitation during processing. These findings suggest that co-sonication of MBPI-GA mixtures is a highly effective green modification strategy for producing homogeneous, functional, and highly digestible plant-based biomacromolecules. The resulting conjugates show considerable potential for use in liquid food formulations and high-temperature industrial processes. © 2026 Society of Chemical Industry.

PMID 42902841
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PubMedBioconjugate chemistry2026-10-22

Development of a Hyaluronic Acid-Retinol Conjugate for Enhanced Photostability and Transdermal Delivery.

Park Chaeheon C, Lee Seungchan S, Jung Seung Oh SO, Lee Yujin Y et al.

Despite its potent anti-aging efficacy, the practical application of retinol (ROH) remains highly restricted by its poor photostability, low aqueous solubility, and concentration-dependent cytotoxicity. Herein, we report the synthesis of a hyaluronic acid-retinol (HA-ROH) conjugate to overcome these limitations and improve transdermal delivery. The successful conjugation was confirmed via proton nuclear magnetic resonance (1H NMR) spectroscopy, high-performance liquid chromatography (HPLC) and Fourier-transform infrared spectroscopy (FT-IR). Notably, the HA-ROH conjugate exhibited remarkable photostability under UVA irradiation compared to free retinol. HA-ROH presented a sustained, hyaluronidase-responsive ROH release profile, indicating its potential as an enzyme-responsive controlled delivery system. Furthermore, the conjugation significantly mitigated the cytotoxicity of retinol in both HaCaT keratinocytes and human dermal fibroblasts. The conjugate suppressed matrix metalloproteinase-1 (MMP-1) expression more effectively than free ROH. In vitro cellular uptake and ex vivo skin permeation studies demonstrated enhanced transdermal delivery of the HA-ROH conjugate. Taken together, these results suggest that the HA-ROH conjugate is a highly promising, stable, and safe candidate for advanced dermatologic and cosmetic applications.

PMID 42902956
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PubMedBioconjugate chemistry2026-10-22

Facile Gram-Scale Solution Phase Synthesis of a Universal Cathepsin B-Cleavable Antibody-Drug Conjugate Linker.

Ringaci Alina A, Hamoud Aladin A, Colson Yolonda L YL, Grinstaff Mark W MW

Antibody drug conjugates (ADCs) are a key therapy in the cancer treatment arsenal. Critical to the success of the ADC is the release of the drug cargo at the desired site, and thus, enzymatically or chemically responsive linkers, connecting the drug to the antibody, play a central role. Linkers containing the peptide sequence Glu-Val-Cit are particularly important as cleavage of this peptide occurs by both murine and human cathepsin B enzymes. Additional linker design considerations include components for free drug release via the self-immolative moiety para-aminobenzyl alcohol (PABOH), copper-free click conjugation to an azide-functionalized antibody using dibenzocyclooctyne (DBCO), and aqueous solubility via a polyethylene glycol spacer (PEG). To facilitate widespread use and translation, we describe the 9-step gram-scale synthesis of the linker DBCO-PEG4-Glu-Val-Cit-PABOH conjugated to monomethyl auristatin E (MMAE). Using only liquid-phase synthesis protocols and chromatography-free, precipitation-based intermediate isolations gives the drug-linker conjugate in 36% overall yield, and this method is an improvement over prior methods (yield < 1%). Finally, we prepare the corresponding MMAE-linked ADC and validate its target-dependent potency across ErbB2/Her2-high (MDA-MB-453) and ErbB2/Her2-low (MDA-MB-231) human breast cancer cell lines.

PMID 42902954
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PubMedDrug development and industrial pharmacy2026-10-22

Synthesis, characterization, and in vivo evaluation of desvenlafaxine decanoate, a new long-acting injectable antidepressant.

Santos Maria Luiza Ferreira Dos MLFD, Oliveira Campos Philipe Raphael PR, Machado Renes Resende RR, Jardim Filho Nilo Edgar NE et al.

The aim of this study was to design, synthesize, and characterize a novel long-acting injectable antidepressant prodrug, desvenlafaxine decanoate. Long-acting injectable drugs represent a useful approach for the treatment of mental illnesses, since these formulations extend dosing intervals and are beneficial for patients unable to self-administer oral medication or to maintain adherence to treatment. Although some antipsychotic depot formulations are used in clinical practice, there is a lack of studies on long-acting injectable antidepressants. This prodrug was synthesized by esterifying desvenlafaxine with decanoic acid, affording the target compound in 75% yield. Structural characterization was performed by 1H and 13C NMR, high-resolution mass spectrometry (HRMS), and high-performance liquid chromatography (HPLC). An in vivo proof-of-concept study was conducted in mice following intramuscular administration of desvenlafaxine decanoate. A selective HPLC-DAD method was developed to separate desvenlafaxine succinate and desvenlafaxine decanoate, achieving retention times 6.08 and 15.70 min, respectively. LC-MS/MS analysis of plasma samples collected 2 hours after administration demonstrated significant levels of desvenlafaxine in systemic circulation. The plasma detection was a proof-of-concept for the in vivo hydrolysis of the ester prodrug. These findings support the feasibility of desvenlafaxine decanoate as a promising long-acting injectable antidepressant for patients requiring prolonged maintenance therapy.

PMID 42902977
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