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iontophoretic system (Smart patch / Actyve)

✓ Approved

Vyteris · therapeutic agent

What is iontophoretic system?

iontophoretic system is a therapeutic agent developed by Vyteris. It is approved for therapeutic indications via transdermal.

Drug Profile

Brand NamesSmart patch, Actyve
CompanyVyteris
RouteTransdermal
StatusApproved

Therapeutic Indications

iontophoretic system is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

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Air conditioning and the future electricity system in Great Britain.

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Climate change is driving hotter summers in temperate regions including the United Kingdom, where historically air-conditioning demand has been low and energy-system planning focused on winter peaks. As Great Britain's energy system moves toward renewables-dominated supply, understanding how emerging cooling demand could interact with system adequacy becomes increasingly important. Here, we use a risk-opportunity analysis framework to examine how cooling uptake could affect future planning and adequacy of the electricity system, integrating international ownership data, qualitative analysis of policy, and first principles system-capacity calculations. We aim to identify where cooling creates underexplored risks or opportunities, and what assumptions need revision. We find current official scenario assumptions for residential air conditioning uptake are too narrow, and present ownership is potentially an order of magnitude higher; therefore, the system-level implications of more rapid cooling uptake remain essentially unexplored. While there may be a noon surplus of solar energy in summer, official scenario analysis does not yet examine peak loads in summer and may therefore miss interactions with low-wind periods and declining afternoon solar power, potentially underestimating requirements for storage and flexibility. We recommend summer adequacy analysis be included in planning. Underestimated cooling demand could lead to missed decarbonisation targets or greater operational challenges, but treating low demand assumptions as constraints could lead to missed policy opportunities to protect health from overheating and to make use of reversible heat pumps. Air conditioning needs to be understood within a systemic context of electrification of heating, expansion of renewable energy, and adaptation to higher temperatures.

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Direct air capture enables sustainable methanol production in water-scarce regions.

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Methanol is an essential chemical for the global economy, but its production typically requires substantial water inputs. Here we investigate the techno-economic potential of water-conscious methanol production across more than 20,000 regions worldwide by integrating direct air capture (DAC) with electrolysis, methanol synthesis and a renewable energy supply system. In 97% of these regions, water availability from ambient air is sufficient, and constraints in the remaining regions can be mitigated through adjusted system design and operation. Our results further highlight the importance of modeling DAC's weather dependency, as system energy efficiency fluctuates between 39 to 49%, primarily due to variations in DAC energy demand. Air cooling - often overlooked in prior assessments - is identified as a viable strategy for water-conscious cooling, incurring only minor cost increases. Ultimately, the proposed system enables sustainable methanol production in arid regions worldwide by overcoming the water-energy nexus and sourcing all necessary feedstocks directly from ambient air.

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Portable microwave sensor system for real-time detection of microplastics in seawater.

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With the rapid development of the global plastic industry, microplastic pollution has become an increasingly serious environmental concern. However, standardized technologies for convenient, accurate, and real-time microplastic detection are limited. To address this challenge, a microwave resonant sensor with a complete microplastic detection system equipped with a Bluetooth module for remote real-time monitoring of microplastic concentrations was developed. Microplastic concentrations were measured in deionized water containing polyvinyl chloride powder (particle size: 6.5 ± 1 μm), simulated artificial seawater, and real seawater samples. The integration of the microfluidic system mitigated the interference caused by the complex seawater matrix, thereby ensuring stable and reliable microwave-based detection of microplastic concentrations. The system demonstrated high repeatability for predicting the concentration of microplastics in seawater samples. The proposed method demonstrated a recognition rate of over 96% with a tolerance of ±0.01 mg/mL, while maintaining a minimum detection limit of 48.72 ng/mL. To improve the prediction accuracy, a convolutional neural network algorithm was employed to predict microplastic concentrations based on the test results, with the predicted and actual concentrations being highly consistent. Finally, a compact and portable seawater microplastic monitoring system was developed by integrating the microwave sensor with Bluetooth and embedded systems, enabling real-time microplastic concentration monitoring in marine environments.

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Physicians and the Future of Health Systems.

Carroll A A

Healthcare reform debates often focus on organisational structures and governance arrangements. However, patient outcomes are shaped not only by institutional design but also by how healthcare systems function in practice. Physicians encounter the consequences of system design daily through fragmented services, delays in diagnostics, and challenges coordinating care across sectors. This article argues that modern healthcare systems should be understood as complex adaptive systems in which outcomes emerge from the interactions of clinicians, organisations, and patients. Structural reform alone cannot deliver integrated care. Physicians therefore have an important role in engaging constructively with system improvement through clinical leadership, quality improvement, and professional collaboration. In an era of growing complexity and evolving patterns of illness, engagement with health system design represents an important dimension of professional responsibility.

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Short-term outcomes of robotic-assisted distal pancreatectomy using domestic KangDuo Surgical Robot-2000 System versus Da Vinci Xi system: a two-center prospective observational cohort study.

Weng Guihu G, Cao Zhe Z, Ma Yongsu Y, Luo Wenhao W et al.

Robotic surgery is a transformative approach for abdominal tumors. With the emergence of multiple robotic systems, evidence on their comparative oncological outcomes remains limited. This two-center prospective observational cohort study aimed to compare surgical efficacy and short-term oncological outcomes between the novel KangDuo Surgical Robot System-2000 (KD-SR-2000) and the Da Vinci Xi system in robot-assisted distal pancreatectomy (RDP). This two-center prospective observational cohort study enrolled patients with pancreatic tumors who scheduled for RDP at Peking Union Medical College Hospital and Peking University First Hospital between December 2023 and May 2025. Eligible patients were assigned into either the KD-SR-2000 group (n = 33) or the Da Vinci Xi group (n = 50) in a non-randomized, non-blinded manner. Baseline demographics, perioperative parameters, postoperative complications, ergonomics, and hospitalization costs were prospectively collected and compared between groups. Baseline characteristics were balanced. One case in the Da Vinci Xi group was converted to laparotomy due to severe adhesions and splenic vein bleeding. No significant differences were observed in surgical success, conversion, spleen preservation, or 90-day mortality rates (all P > 0.05). NASA-TLX scores indicated higher physical demand, effort, and total workload in the KD-SR-2000 group, though differences were not significant (all P > 0.05). Major complications (Clavien-Dindo ≥ III) and specific complications showed no significant differences. The KD-SR-2000 group had significantly lower hospitalization costs ($8131.6 [7642.4-9960.7] vs. $9859.6 [9022.4-18,965.8], P < 0.001). Intraoperative blood loss, operation time, and postoperative stay did not differ significantly. In this preliminary prospective observational study, the KD-SR-2000 system demonstrated comparable efficacy and safety to the Da Vinci Xi in the RDP procedure. While further improvements are needed in its ergonomic design, it possesses significant advantages in surgical costs and may be considered a viable alternative to the Da Vinci Xi system.

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Qiu Xingchen X, Wang Bo B, Sun Jun J, Pei Shuang S et al.

Stroke remains a major cause of death, disability, and long-term care burden in China. National policy has expanded from disease-specific prevention and treatment to broader arrangements involving chronic disease governance, emergency care, hierarchical services, rehabilitation, and medical quality improvement. However, the policy design and governance structure remain underexamined. We conducted a multidimensional national policy text analysis of stroke prevention and stroke center development in China. The final corpus comprised 33 national policies issued between 2009 and 2026, including 11 Main policies and 22 Extended policies. Policies were classified by document function, and 1,739 atomic meaning units were coded for policy instruments, governance tasks, strict and contextual actors, policy objects, and policy integration. A stratified sample of 348 units was independently coded, followed by consensus adjudication. The corpus showed a descriptive three-stage progression from early disease-specific screening and quality-control arrangements, through system expansion, to system-embedded and quality-oriented governance. The final adjudicated dataset contained 16,882 code assignments. Among 5,263 policy-instrument assignments, environment-side instruments accounted for 47.0%, supply-side instruments for 32.2%, and demand-side instruments for 20.7%. Standardized diagnosis, treatment, and acute care was the most frequent governance task, followed by quality improvement, system coordination, and risk-factor control. Hospitals, medical institutions, and stroke centers were the most frequently specified strict actors, while other actor groups showed differentiated task profiles. Policy integration connected stroke governance with medical quality and safety, specialty capacity, chronic disease governance, public health, emergency care, rehabilitation, referral, and financing. Cohen's kappa across the six coding dimensions ranged from 0.595 to 0.746. China's national stroke policy has evolved toward system-embedded, task-differentiated, and quality-oriented governance. Future policy design may benefit from stronger demand-side and continuity-oriented instruments, clearer cross-setting responsibilities, and closer alignment between stroke-specific policies and wider health-system arrangements.

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