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iontophoretic system (Smart patch / Actyve)

✓ Approved

Vyteris · therapeutic agent

What is iontophoretic system?

iontophoretic system is a therapeutic agent developed by Vyteris. It is approved for therapeutic indications via transdermal.

Drug Profile

Brand NamesSmart patch, Actyve
CompanyVyteris
RouteTransdermal
StatusApproved
Sources: ClinicalTrials.gov, Vyteris

Therapeutic Indications

iontophoretic system is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedJMIR formative research2026-10-22

Physicians' Perceptions of Information Quality and Access in a New Cross-Institutional Electronic Health Record (EHR) System: Mixed Methods Design.

Golburean Olga O, Melby Line L, Pedersen Rune R, Lohmann-Lafrenz Signe S et al.

Physicians rely on electronic health record (EHR) systems to make informed decisions and deliver high-quality care. Although the introduction of EHR systems has created significant opportunities for improving patient care, it has also introduced challenges related to information overload and increased cognitive demands. This study aimed to assess physicians' perceptions of a newly implemented cross-institutional EHR system regarding (1) the quality, access, and presentation of patient data and (2) the EHR's effectiveness at supporting cooperation and communication with patients. This study used a cross-sectional mixed methods descriptive research design. Data were gathered through a closed-ended questionnaire, participant observations, and interviews with physicians at a university hospital in central Norway, which transitioned to a new EHR system in November 2022. Qualitative data were gathered from September 2023 to January 2024 and analyzed using reflexive thematic analysis, while quantitative data were collected from January 2024 to July 2024 and analyzed using descriptive statistics. The quantitative data showed that most surgical and nonsurgical physicians disagreed on the following: (1) that the patient's current medication list is presented in a clear format, (2) that the system provides a comprehensive summary view of patients' health status, and (3) that the system supports cooperation and communications with patients. These results were supported by the qualitative data, indicating that the physicians stressed the necessity of improving the presentation and organization of data and voiced concerns about the overwhelming volume of information. However, physicians also emphasized the benefits of enhanced access to patient data, the usefulness of the timeline function for monitoring hospitalized patients, and the efficiency of communication among health care professionals through the chat function. Additionally, some informants reported favorable experiences with the patient health portal, which facilitated more efficient communication with patients. This study revealed a complex landscape regarding physicians' experiences with the newly implemented cross-institutional EHR system. Physicians stressed the need for improved organization and presentation of patient health data while also highlighting the positive impact of a cross-institutional EHR system on enhanced access to data. Although quantitative data showed that most physicians disagreed on whether the new EHR enhances cooperation and communication with patients, some informants in the qualitative part of the study highlighted positive experiences related to the patient health portal in improving communication. Based on qualitative findings, adding a feature that allows users to confirm if the patient has received or read messages could further improve the usefulness of the patient portal. Our qualitative findings also emphasized that enhancing system usability must be accompanied by comprehensive training on EHR use to achieve meaningful use. Future evaluations of the EHR system should focus on examining its long-term effects on access to patient data.

PMID 42902907
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PubMedFrontiers in veterinary science2026-10-22

Assessment of radiographic healing after tibial plateau leveling osteotomy in young and older dogs using the modified RUST scoring system.

Anderson Bridget L BL, Frederick Steven W SW, Popovitch Catherine C

To compare radiographic osteotomy healing scores after tibial plateau leveling osteotomy (TPLO) in young (2-5 years) and old (8-12 years) dogs using the modified Radiographic Union Score for Tibial fractures (mRUST) system, and to evaluate agreement between large language model-assisted interpretation (LLM), surgeon, and surgical resident scoring. Client-owned, 20-40 kg dogs treated with unilateral TPLO at ages 2-5 or 8-12 years between 2023 and 2025 were retrospectively identified. Dogs with endocrinopathy or atypical TPLO or recovery were excluded. Dogs were assigned to Group 1 (2-5 years) or Group 2 (8-12 years). 8-week postoperative radiographs were scored independently by an LLM, a surgeon, and a surgical resident using the 4-point mRUST system. Scores were compared between age groups using the Wilcoxon rank-sum test, and interrater agreement was assessed using an intraclass correlation coefficient (ICC). Group 1 had 49 dogs; Group 2 had 51 dogs. Group 1 had a mean (SD) age of 3.82 (1.11) years, while Group 2 had a mean (SD) age of 9.24 (0.99) years. mRUST scores did not differ between age groups across LLM (p = 0.352), surgeon (p = 0.908), or resident assessments (p = 0.588). LLM, surgeon, and resident scores had only fair agreement (ICC = 0.4504, p < 0.001). Chronological age was not associated with mRUST score following TPLO at the 8-week postoperative evaluation. The mRUST system demonstrated moderate agreement between human observers. LLM scoring showed promise; further refinement is needed for clinical application.

PMID 42903056
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PubMedJournal of materials chemistry. B2026-10-22

3D printing of an E7 peptide-functionalized biomimetic cartilage composite scaffold for auricular reconstruction.

Li Sijie S, Huang Jingting J, Li Huan H, Wang Xihao X et al.

Auricular cartilage reconstruction for microtia remains limited by insufficient shape maintenance, restricted cell migration, and inconsistent quality of the regenerated cartilage-like matrix. To improve the regenerative performance of tissue-engineered auricular cartilage, this study developed an E7 peptide-functionalized biomimetic composite scaffold. Through dual-nozzle 3D printing, a mechanically reinforced polycaprolactone (PCL) scaffold was spatially integrated with an E7 peptide-functionalized gelatin methacryloyl (GelMA)/carboxylated nanocellulose (CNC) composite hydrogel to provide support for complex shapes, a hydrated matrix microenvironment, and local bioactive cues. In vitro results showed that 0.10 mg mL-1 E7 peptide effectively promoted chondrocyte migration while maintaining good cytocompatibility, adhesion, and spreading. Based on this, further incorporation of perichondrial stem/progenitor cells (PSPCs) into a chondrocyte co-culture system enhanced overall cell migration, spatial proximity, and cellular interactions. In vivo, a rabbit dorsal subcutaneous implantation model was applied for the PGCE + CC + PC system. Results indicated that this system induced more sustained and homogeneous cartilage-like tissue formation than the scaffold-only and chondrocyte-only groups, as evidenced by enhanced SOX9 and COL2 expression, as well as increased proteoglycan and acidic glycosaminoglycan depositions. Transcriptomic analysis further proved that this system enhanced molecular programs related to cell adhesion, intercellular junctions, mechanotransduction, and cartilage matrix synthesis, while reducing inflammatory and matrix degradation-related responses. RT-qPCR confirmed increased relative mRNA expression levels of SOX9, COL2A1, ACAN, and ELN in this group. This study demonstrates that the E7 peptide-functionalized composite scaffold combined with co-culture of chondrocytes and PSPCs provides a promising biomimetic construction strategy for auricular cartilage regeneration.

PMID 42902903
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PubMedEpidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil2026-10-22

National Guidelines for Public Health Emergency Surveillance within the Brazilian Unified Health System.

Proença Raquel R, Nunes Camila Cunha Maia Nogueira CCMN, Romano Alessandro Pecego Martins APM, da Silva Camila Pinto CP et al.

To describe the national guidelines for public health emergency surveillance within the Brazilian Unified Health System (Sistema Único de Saúde, SUS). The increasing frequency of health, environmental, and technological events has led to more public health emergencies, requiring systems capable of early threat detection, risk assessment, and timely response. Public health emergency surveillance is an integral component of health surveillance and encompasses strategies such as indicator-based, event-based, hospital-based epidemiological, mass gathering, wastewater, community-based, and participatory surveillance. These strategies are complementary and should be supported by continuous monitoring and systematic risk assessment, while incorporating multisectoral approaches, risk communication, and One Health. Strengthening public health emergency surveillance involves integrating information systems, building workforce capacity, institutionalizing contingency plans and standard operating procedures, activating situation rooms and emergency operations centers, conducting timely outbreak investigations, communicating risks, and conducting intra-action and after-action reviews. Factors such as territorial inequalities, social vulnerabilities, and population-specific characteristics influence risk exposure, detection capacity, and the impacts of emergencies, underscoring the need to incorporate equity into surveillance explicitly. The guidelines help consolidate public health emergency surveillance as a core component of preparedness and response within the Unified Health System, reinforcing participatory, integrated, and equity-oriented approaches to protect health and reduce harm.

PMID 42903059
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PubMedNature chemical engineering2026-10-22

Elevating CO2 electrolyzer temperature accelerates the viability of chemical electrification.

Spiekermann Lukas L, Lee Mi Gyoung MG, Wicks Joshua J, Peng Bosi B et al.

Climate change mitigation has spurred interest in producing chemicals from CO2. CO2 reduction by electrochemistry can be driven directly by green electricity, yielding even multi-carbon (C2+) products. However, the resulting processes still suffer from high electrolyzer losses and substantial energy demands. This study evaluates the environmental and economic benefits of integrating optimized electrolyzers into complete processes. For CO2 electroreduction to ethylene and dimerization to 1-butene, elevated-temperature electrolysis effectively utilizes waste heat. Challenging the ambient-temperature paradigm, this strategy achieves system-wide savings in energy (10%), climate impacts (9%) and overall cost (11%). Generalizing these findings across various CO2 electroreduction pathways identifies energy savings of up to 25% and the heating system as a key design variable affecting electrolyzer design targets. Our study demonstrates how process integration can guide CO2 electrolyzer development toward sustainable processes.

PMID 42903136
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PubMedMalawi medical journal : the journal of Medical Association of Malawi2026-10-22

Conflict of Interest vs Conflict of Incentives: Rethinking Dual Practice in Light of Malawi's Presidential Executive Order No. 1 of 2026.

Patel Parth K PK, Nair Supriya S

Dual practice-where health professionals simultaneously participate in public and private healthcare markets-is common in many health systems but presents complex governance challenges. In 2026, the Government of Malawi issued Presidential Executive Order No. 1 of 2026, prohibiting public health workers from soliciting informal payments in public facilities and restricting their ownership or financial interests in private healthcare establishments. The policy has generated significant national debate regarding its implications for health system governance and workforce incentives. This commentary examines the policy rationale and potential implications of the Executive Order, focusing on the tension between addressing conflicts of interest and maintaining appropriate incentives for health workforce retention. Drawing on international literature and comparative policy experiences, the commentary situates Malawi's reform within the broader global discourse on dual practice regulation. Evidence from multiple health systems indicates that physician ownership of private facilities can introduce structural conflicts of interest that undermine public sector performance through patient diversion, reduced public sector effort, and erosion of public trust. However, outright restrictions on private sector engagement may also carry unintended consequences in settings where public sector remuneration is limited and specialist workforce shortages are acute. International experiences demonstrate that successful regulation of dual practice requires careful alignment of governance mechanisms, workforce incentives, and health system accountability. Malawi's Executive Order represents a decisive attempt to strengthen the integrity of public healthcare delivery by addressing ownership-based conflicts of interest. Its long-term effectiveness will depend on balanced implementation, transparent regulatory guidance, and complementary reforms that address workforce incentives and health system capacity. The current debate offers an opportunity to move beyond polarized narratives and instead focus on building a governance framework that simultaneously protects public trust and supports a sustainable health workforce.

PMID 42902984
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