Drug Database
EL

elastase (elastase / Elaszym)

✓ Approved

Eisai Co., Ltd. · therapeutic agent

What is elastase?

elastase is a therapeutic agent developed by Eisai Co., Ltd.. It is approved for therapeutic indications.

Drug Profile

Brand Nameselastase, Elaszym
CompanyEisai Co., Ltd.
StatusApproved
Sources: ClinicalTrials.gov, Eisai Co., Ltd.

Therapeutic Indications

elastase is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersArteriosclerosis✓ Approved

Related Research Articles

PubMedFrontiers in plant science2026-11-12

Methyl jasmonate elicitation increases vitexin production in protocorm-like body-derived cultures of Grammatophyllum speciosum Blume.

Rungruang Rittipun R, Ratanathavorn Wittawat W, Panichakul Tasanee T, Kongruang Sasithorn S

Grammatophyllum speciosum Blume (Orchidaceae) is a giant orchid that accumulates phenolic glucosides and C-glycosylflavones, including the bioactive flavone vitexin. Vitexin is a pharmaceutically and cosmetically valuable compound obtained mainly from aerial tissues of wild-harvested plants, motivating controlled in vitro production. Methyl jasmonate (MeJA) is a widely used elicitor of phenylpropanoid and flavonoid biosynthesis; however, its effects on vitexin accumulation in protocorm-like bodies (PLBs) of G. speciosum in liquid culture systems have not yet been investigated. This study aimed to establish a PLB-derived liquid culture of G. speciosum and to evaluate the effects of MeJA (0, 50, 75, and 100 µM) on culture growth, phenolic and flavonoid accumulation, vitexin production, phenylalanine ammonia-lyase (PAL) activity, antioxidant capacity, and enzyme inhibitory activities. The cultures showed a sigmoidal growth profile with the highest dry growth index (DGI, 0.72 ± 0.09) on Day 32. MeJA elicitation for 12 days reduced biomass in a concentration-dependent manner (DGI 0.066 ± 0.007 to 0.050 ± 0.001 at Day 12 versus 0.089 ± 0.002 in untreated cultures), whereas the PLB clusters remained morphologically intact. Treatment with 75 µM MeJA gave the highest total phenolic (14.267 ± 0.273 mg GAE/g CDW) and total flavonoid (27.093 ± 0.504 mg QE/g CDW) contents. Vitexin was quantified by HPLC-DAD and its identity confirmed by LC-ESI-QTOF-MS; cultures treated with 75 µM MeJA contained 420.05 ± 9.96 µg vitexin/g culture dry weight, approximately twofold higher than untreated controls (208.33 ± 2.69 µg/g CDW). PAL activity was rapidly and transiently induced, peaking 12 h after 75 µM MeJA treatment. The same treatment also produced the highest DPPH (5.30 ± 0.20 mg TE/g CDW) and ABTS (10.64 ± 0.25 mg TE/g CDW) radical-scavenging and copper-chelating (6.54 ± 0.29 mg EDTA/g CDW) activities, and the strongest inhibition of collagenase (55.62 ± 0.34%), elastase (42.40 ± 0.63%), and tyrosinase (36.01 ± 1.71%). These results indicate that MeJA is associated with activation of the phenylpropanoid pathway and enhanced vitexin, phenolic, and flavonoid accumulation in G. speciosum. Overall, MeJA-elicited PLB-derived liquid cultures represent a controlled in vitro system for producing vitexin-containing extracts with antioxidant and enzyme-inhibitory activities.

PMID 43017238
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PubMedLife sciences2026-11-11

Oral angiotensin-(1-7) formulation attenuates structural alterations in established emphysema and protects against subsequent allergic airway inflammation.

Magalhaes Giselle Santos GS, Cardoso Lucas P LP, Villacampa Alicia A, Gregório Juliana Fabiana JF et al.

Chronic obstructive pulmonary disease and asthma can coexist, increasing disease burden and complicating treatment. We investigated whether oral angiotensin-(1-7) [Ang-(1-7)] treatment initiated after emphysema establishment attenuates pulmonary structural alterations and protects against subsequent ovalbumin (OVA)-induced allergic airway inflammation. C57BL/6 mice were randomly assigned to experimental groups with or without elastase-induced emphysema. Emphysema was induced by three weekly intratracheal instillations of porcine pancreatic elastase. The mice subsequently received an oral formulation of Ang-(1-7) one week later, for four weeks. Treatment was discontinued before the subsequent OVA sensitization and challenge. The groups were sensitized and challenged with either OVA or PBS. Lung morphometry, inflammation, collagen deposition, pulmonary Ang II levels, and gene expression were assessed. Elastase caused persistent alveolar enlargement and reduced septal density. Oral Ang-(1-7) attenuated these abnormalities. Treatment reduced elevated pulmonary angiotensin II levels and increased ACE2 mRNA expression in an independent emphysema experiment. OVA induced eosinophilic inflammation, airway remodeling, and increased inflammatory gene expression in emphysematous mice. Following the OVA challenge, previously treated emphysematous mice exhibited reduced pulmonary eosinophilia, inflammatory scores, epithelial thickening, and collagen deposition, alongside improved alveolar morphometry. Ang-(1-7) also decreased the gene expression of CD206, arginase-1, NLRP3, caspase-1, p53, and p16. These protective effects occurred without significant changes in OVA-specific IgE levels. Oral Ang-(1-7) provided structural and anti-inflammatory benefits after establishing emphysema, with protection also evident following an allergic challenge despite treatment withdrawal before sensitization. These findings support prior modulation of the injured pulmonary microenvironment as a promising therapeutic strategy to limit allergic inflammation and airway remodeling in structurally compromised lungs.

PMID 43014695
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PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Clinical efficacy and mechanism of Liniao Tonglin decoction in treating UU-infected oligoasthenospermia with dampness-heat pouring down syndrome].

Zhu Fanyu F, Li Ninghua N, Yang Wentao W

Objective To explore the clinical effect and mechanism of Liniao Tonglin decoction on oligoasthenospermia caused by Ureaplasma urealyticum (UU) infection with dampness-heat pouring down syndrome. Methods Eighty-eight patients were randomly divided into control group and observation group, with 44 cases in each group. The patients in control group were treated with doxycycline hydrochloride enteric-coated capsules and doxycycline tablets. While the patients in observation group were treated with Liniao Tonglin decoction on the basis of the treatment given to the control group. Both groups were treated for 14 days. Sperm concentration, total sperm count, progressive motility sperm rate(PR%), sperm motility rate（［PR+NP］%）, seminal plasmic elastase, interleukin-6(IL-6), interleukin-17(IL-17) levels TCM syndrome score and negative conversion rate of UU were compared between the two groups before and after the treatment. Results The overall efficacy rate of the observation group was significantly higher than that in the control group (86.05% vs 66.67% , χ2=4.435, P<0.05). UU negative conversion rate was also superior in the observation group (95.35% vs 88.10%，P>0.05). The increases in sperm concentration, total count, PR%, and （PR+NP）% (P<0.05) exhibited in both of two groups after the treatment, with significantly greater improvements in the observation group (P<0.05). The levels of seminal elastase, IL-6, IL-17 and TCM syndrome scores declined in both groups (P<0.05), with greater improvements in the observation group as well (P<0.05). Conclusion Liniao Tonglin decoction combined with antibiotics improves the count and motility of sperm and TCM syndrome score of oligoasthenospermia induced by UU infection with dampness-heat pouring down syndrome, increases the negative rate of UU, inhibits the expression of inflammatory factors, and changes the patency of reproductive tract and the living environment of sperm.

PMID 43012219
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PubMedFrontiers in medicine2026-11-11

Efficacy and safety of sivelestat in sepsis-induced acute respiratory distress syndrome: an updated meta-analysis based on disease severity and treatment strategy subgroups.

Haibier Abduwupuer A, Ma Jiawei J, Wang Yuanyuan Y, Wu Tong T

Sivelestat sodium hydrate is a selective neutrophil elastase inhibitor that attenuates neutrophil-mediated alveolar-capillary injury and is used in some East Asian countries for acute lung injury/ARDS. We evaluated the efficacy and safety of sivelestat in sepsis-induced acute respiratory distress syndrome (ARDS) and explored whether disease severity, baseline mortality risk, and treatment background modify the mortality effect. We searched PubMed/MEDLINE, Embase, Cochrane CENTRAL, Web of Science, CNKI, Wanfang, and ClinicalTrials.gov from database inception to August 27, 2026. Eligible studies were adult studies of sepsis-induced ARDS comparing a sivelestat-containing regimen with an otherwise comparable regimen without sivelestat. COVID-19-only cohorts, non-septic ARDS, mixed-etiology studies without a separable sepsis subgroup, and comparisons in which both groups received sivelestat were excluded. The primary outcome was all-cause mortality; secondary outcomes included P/F ratio, duration of mechanical ventilation, ICU length of stay, organ-function scores, inflammatory markers, and adverse events. Mortality was pooled as odds ratios (ORs) using a random-effects model with restricted maximum likelihood; Hartung-Knapp intervals were used for the primary and study-design analyses. This review was prospectively registered in PROSPERO. Fourteen studies were eligible for qualitative synthesis, and 10 studies (943 patients) provided extractable 2 × 2 mortality data. Deaths occurred in 73/431 patients receiving sivelestat and 125/512 controls. Sivelestat was associated with lower mortality (OR=0.55, 95% CI 0.36-0.84; I2 = 0%). The signal persisted in randomized trials (OR=0.37, 95% CI 0.16-0.86; I2 = 0%). Study-level point estimates appeared more favorable in cohorts with baseline P/F < 100 mmHg and control mortality >30%; however, interaction tests were not statistically significant and severity analyses were ecological. Leave-one-out analyses were stable. Egger testing did not detect significant small-study asymmetry (P = 0.197), although power was limited. Baseline-stratified treatment effects by IL-6, PCT, CRP, or neutrophil elastase were unavailable for quantitative effect-modification analyses. In an updated and etiologically strict evidence synthesis, sivelestat was associated with lower mortality in sepsis-induced ARDS, including in randomized trials. Severe hypoxemia and high baseline risk remain plausible enrichment factors, but current aggregate evidence is insufficient to support a validated phenotype-guided prescribing rule. Co-intervention reporting was sparse, and residual confounding by prone positioning, sedation, neuromuscular blockade, and steroid background cannot be excluded. PROSPERO CRD420261541158.

PMID 43011073
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PubMedFrontiers in pharmacology2026-11-11

Enhanced mitochondrial respiratory metabolism in UV-damaged HDF cells based on metabolomics analysis of fermented Galla rhois gallnut extract.

Wu Jiaying J, Wang Ning N, Chen Denghui D, Zhang Yi Y et al.

UV-induced photoaging disrupts mitochondrial homeostasis in skin cells, which in turn exacerbates skin aging. In this study, we developed a novel fermented Galla rhois gallnut extract (FGRE) using Lactiplantibacillus plantarum with mitochondrial respiratory homeostasis amelioration. Biochemical assays showed that FGRE exhibited stronger antioxidant and anti-elastase activities than the unfermented extract. Using Seahorse XF Cell Mito Stress Test, 1% FGRE significantly enhanced mitochondrial respiratory function in UVB-irradiated human dermal fibroblast (HDF) cells compared to that with the unfermented extract. In addition, 1% FGRE increased the ATP content and NAD+/NADH ratio and regulated the transcription level of fusion and fission genes in UVA-induced HDFs. Furthermore, the non-targeted metabolomics analysis revealed that differential metabolites were predominantly enriched in amino acid metabolic pathways, and 24 differential metabolites were putatively identified. Among these, the differential metabolites leucinic acid, urolithin A, and urolithin M5 were quantitatively determined. Notably, 1 μg/mL leucinic acid (equivalent to the concentration in 1% FGRE) ameliorated mitochondrial respiratory dysfunction and promoted the ATP production in UV-induced HDFs. Therefore, leucinic acid was considered as one of the potentially bioactive metabolites of FGRE.

PMID 43011815
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PubMedProtoplasma2026-11-11

Comprehensive evaluation of Crambe orientalis subsp. orientalis var. orientalis: phytochemistry, anatomy, and biological activities.

Aydın Bilge B, Yuca Hafize H, Özbek Hilal H, Bona Gülnur Ekşi GE et al.

This study investigated the phytochemical composition, biological activities, and morphological and anatomical characteristics of Crambe orientalis subsp. orientalis var. orientalis (Brassicaceae). Extracts and solvent fractions obtained from different plant parts were evaluated for their total phenolic, flavonoid, and tannin contents, antioxidant activities, enzyme inhibitory effects, and mutagenic potential. Essential oil and fatty acid compositions were investigated using chromatographic techniques. Essential oil yields were low (0.00017-0.0083%), with glucosinolate-derived volatile constituents, particularly methallyl cyanide and β-3-butenyl isothiocyanate, identified among the major components. Ethyl acetate and n-butanol fractions generally exhibited higher phenolic and flavonoid contents and stronger ABTS and DPPH radical scavenging activities. Spearman correlation analysis revealed weak but statistically significant positive correlations between both total phenolic content (TPC) and ABTS activity (ρ = 0.356, p = 0.042) and total flavonoid content (TFC) and ABTS activity (ρ = 0.356, p = 0.042). However, neither TPC nor TFC showed a statistically significant correlation with DPPH radical scavenging activity (p > 0.05). Enzyme inhibitory activities were generally weak to moderate, with α-amylase inhibition reaching 43.94% and butyrylcholinesterase inhibition reaching 34.59%. The leaf methanol extract exhibited pronounced hyaluronidase inhibition (97.90%), compared with 86.40% for the reference inhibitor EGCG under the tested conditions; however, relative inhibitory potency could not be established without concentration-response analysis. The aerial-part methanol extract showed moderate elastase inhibition (40.09%), whereas α-glucosidase, acetylcholinesterase, tyrosinase, and collagenase inhibition remained limited. In the Ames/Salmonella assay conducted without metabolic activation, the aerial-part essential oil produced a dose-dependent increase in revertant colonies in the TA1537 and TA97a strains, indicating potential mutagenicity under the investigated conditions. Morphological and anatomical examinations revealed diagnostic characteristics, including amphistomatic, bifacial leaves, multicellular trichomes, a Y-shaped petiole, and distinct vascular and supporting tissues. Overall, these findings provide an integrated characterization of C. orientalis and identify the leaf methanol extract as a candidate for further investigation of hyaluronidase inhibitory constituents, while emphasizing the need for additional toxicological evaluation of the aerial-part essential oil.

PMID 43012963
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