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isosorbide mononitrate (Mono Mack 50D / Mono Mack)

✓ Approved

Novartis AG · Small Molecule · Small Molecule

What is isosorbide mononitrate?

isosorbide mononitrate is a small molecule developed by Novartis AG. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMono Mack 50D, Mono Mack
CompanyNovartis AG
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Novartis AG

Therapeutic Indications

isosorbide mononitrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Cardiac disordersAngina pectoris✓ Approved

Related Research Articles

PubMedChemSusChem2026-09-16

Highly Efficient Vapor-Phase Dehydration of Bio-Derived Sorbitol Over a Sulfur-Intercalated Two-Dimensional Vanadium Phosphate Catalyst.

Dhiman Neha N, Kumar Arvind A, Acharya Dolan D, Jeyakumar Karthikeyan K et al.

Biorefinery technologies that convert sorbitol into platform chemicals like isosorbide without the use of inorganic acids are essential for sustainability and environmentally friendly green chemicals. Here, we investigate mineral acid-free vapor-phase dehydration of sorbitol over a sulfur-intercalated vanadium phosphate (VPO) catalyst. The roles of Brønsted and Lewis acid sites were studied to understand their effect on sorbitol dehydration and adsorption energy. Intercalating sulfur enhances the relative concentration of Brønsted acid sites on the lamellar VPO surface. Density functional theory results indicate that sorbitol adsorption is thermodynamically favorable on VPO catalysts. However, sulfur-intercalated VPO catalysts exhibit a reduced adsorption energy (Ead) of -0.64 eV, which is approximately 1.5 times lower than that of regular VPO catalysts, as corroborated by kinetic analysis. Notably, the resulting improvement in catalytic performance results in ≥99% bio-derived sorbitol conversion with ≥94% isosorbide selectivity, limiting other anhydrohexitol intermediate.

PMID 42745410
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PubMedAmerican journal of veterinary research2026-09-15

Cardiac pacemakers in dogs: programming parameters.

Oyafuso Mônica Kanashiro MK, Triches Dornbusch Peterson P, Moreno Juan Carlos Duque JCD, Hamamura Caio C et al.

To report the behavior of the main parameters used in the evaluation of cardiac pacemakers (PMs) in dogs, associated complications, and survival times. This retrospective cohort study evaluated dogs that received PMs (from 2016 through 2023) at a veterinary teaching hospital. Dogs of various breeds, ages, and sexes with at least 1 baseline assessment were included. The PM parameters pacing threshold amplitude, impedance (or conductance), and estimated battery life were assessed immediately after PM insertion and at reevaluation times (≤ 7, ≤ 90, ≤ 547, ≤ 912, and ≥ 912 days). Complications and survival rates were also evaluated. The median survival time of 11 dogs was 30 months. Two complications were recorded: seroma and suture dehiscence. A reduction in impedance over time was further validated by a significant Skillings-Mack test (χ2 = 12.692; P = .0054). Pacing threshold amplitude and estimated battery life did not significantly change. PM implantation in dogs is safe and eliminates clinical signs. A reduction in myocardial impedance (or increased conductance) is expected, but impedance assessment should consider individual baselines, observing the behavior rather than just the normal range or isolated values. Baseline pacing threshold amplitude also varies between individuals and tends to decrease over time. No significant reduction in estimated battery life was observed during the study period, probably due to high device longevity. This study provides the first data for PM parameters in dogs. The results suggest that clinical interpretation should focus on longitudinal parameter behavior relative to baseline values rather than solely on the reference range.

PMID 42743987
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PubMedInorganic chemistry2026-09-07

Sustainable Recovery of Dibutyl Terephthalate from Aromatic Polyester Waste via Solvothermal Alcoholysis.

Matuszak Karolina K, Petrus Rafał R, Lis Tadeusz T

In this work, a series of homometallic and heterometallic aryloxides, including [M'6(sal-Me)6] (M'+ = Li+ (1), Na+ (2), K+ (3)), [M'(sal-Me)]n (M'+ = Rb+ (4), Cs+ (5)), [Mg2(sal-Et)4(EtOH)2] (6), [Zn4(sal-Me)8] (7), [Ca3(sal-Me)6(EtOH)2] (8), [M2M'2(sal-Me)6(X)x] (where M2+ = Mg2+ and M'+ = Li+ (9), Na+ (10), K+ (11); M2+ = Zn2+ and M'+ = Li+ (13), Na+ (14), K+ (15); or M2+ = Ca2+ and M'+ = Li+ (16), Na+ (17), K+ (18) with X = THF or MeOH and x = 0, 2, 4), [MgRb(μ-H2O)(sal-Me)3(H2O)0.5]n (12), [Mg4Na2(sal-Me)6(sal)2(THF)4] (19), [CaLi6(sal-Me)8] (20), [Ca4M'(μ5-OH)(sal-Et)8(EtOH)] (M'+ = Na+ (21), K+ (22)), [ZnLi2(sal-Me)4(THF)2] (23), and [ZnM'2(sal-R)4]n (for M' = Na and R = Et (24), M' = K and R = Me (25)), were investigated as catalysts for the chemical recycling of postconsumer poly(ethylene terephthalate) (PET) and poly(ethylene-co-isosorbide-co-1,4-cyclohexanedimethylene terephthalate) (PEICT) waste. The catalytic performance of metal aryloxides was evaluated in relation to their chemical composition, solid-state structures, and solution behavior, allowing general trends in the catalytic activity of alkali metal and divalent metal aryloxides (Mg2+, Ca2+, Zn2+) and their heterometallic combinations to be established. Key factors governing catalytic activity, reaction mechanisms, and the formation of reaction intermediates are also discussed.

PMID 42704149
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PubMedInternational journal of surgery case reports2026-09-06

Controlled hypotension therapy with isosorbide dinitrate for postoperative bleeding of transurethral resection of the prostate.

Li Zihao Z, Li Hongliang H, Chen Zhenzhuo Z, Wang Li L et al.

Postoperative bleeding is a well-known complication of transurethral resection of the prostate (TURP). This study aims to evaluate the efficacy and safety of controlled hypotension using isosorbide dinitrate (ISDN) as a treatment for refractory postoperative bleeding after TURP when conventional non-surgical treatments have failed. A retrospective analysis was conducted of eight patients who experienced postoperative bleeding following TURP and did not respond to standard non-surgical interventions. Patients were treated with an intravenous infusion of ISDN to induce controlled hypotension. The hemostatic effect was subsequently observed and evaluated once the mean arterial pressure was lowered to a target range of 66-73 mmHg. Hemostasis was achieved rapidly in all eight patients following the induction of controlled hypotension. The treatment demonstrated a highly satisfactory clinical effect, and no severe adverse events or complications were observed during or after the intervention. Controlled hypotension via intravenous ISDN is a safe, rapidly effective, and promising therapeutic alternative for managing refractory postoperative bleeding after TURP when conventional non-surgical measures fail.

PMID 42699463
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-03

Bio-Based Transparent Self-Healable Polyimides Enabled by Isosorbide-Derived Dianhydride Design and Aliphatic Chain-Mobility Regulation.

Jang Jisu J, Kang Woojin W, Seo Yeongseok Y, Bae Gyu Hyoung GH et al.

Transparent self-healable polyimides are attractive for flexible, wearable, and sustainable electronic devices, but achieving high transparency, rapid healing, and mechanical robustness within a single material remains challenging. Herein, we report a bio-based aliphatic-aromatic polyimide platform that addresses this challenge through the cooperative molecular design of an isosorbide-derived dianhydride (ISSDA), 4,4'-oxydiphthalic anhydride, cystamine, and a bio-based long-chain aliphatic diamine (DDA). Unlike conventional aromatic polyimides, the nonplanar and nonconjugated ISSDA structure reduces charge-transfer complex formation and prevents compact chain packing, enabling high optical transparency in a self-healable polyimide network. The DDA segment further introduces controlled chain flexibility, lowers the effective healing barrier, and improves segmental mobility required for dynamic disulfide exchange. As a result, the optimized film achieved over 95% transmittance above 650 nm, thermal healing within 4 min at 150°C, and only a 7.8% loss in toughness after healing. DFT/TD-DFT analyses confirmed that ISSDA suppresses and blueshifts the near-UV electronic transitions relevant to visible transparency, while WAXD analysis revealed enlarged interchain d-spacing and increased amorphous packing. This study provides a bio-derived and structurally tunable route to transparent, tough, and rapidly self-healable engineering polyimides.

PMID 42689332
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-08-30

Isosorbide-Based Optically Clear Adhesives With Ultrahigh Transparency and Rapid Strain Recovery for Flexible Displays.

Choi Yoonji Y, Lee Geonwoo G, Kim Yeonseo Y, Jin Dahyun D et al.

Flexible and foldable displays require optically clear adhesives (OCAs) that combine ultrahigh optical transparency with mechanical resilience under repeated deformation. However, conventional acrylic-based OCAs often fail to achieve both properties simultaneously. Herein, we synthesized a polyurethane diacrylate (PUDA) crosslinker incorporating biomass-derived isosorbide and photostable 1,3-bis(isocyanatomethyl)cyclohexane (H6XDI) for flexible display adhesives. The segmented polyurethane architecture forms a mechanically flexible yet robust network, enabling rapid strain recovery while maintaining ultrahigh optical transparency. Furthermore, the incorporation of an isosorbide-based PUDA crosslinker introduces a biomass-derived component and preserves excellent optical properties due to its intrinsically low birefringence. As a result, the PUDA crosslinked OCA exhibits exceptional optical transmittance (99.8%) and maintains high transparency (98.6%) even at 50% tensile strain, alongside low modulus, stable adhesion, and clean debonding behavior. These results highlight the potential of PUDA OCAs for high-performance and energy-efficient foldable display applications.

PMID 42669159
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