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carteolol (OPC1085 / Ocupress / Mikelan, ophthalmic)

✓ Approved

CSL Vifor · ADRB1 · Small Molecule

What is carteolol?

carteolol is a small molecule developed by CSL Vifor. It is approved for therapeutic indications via others or topical.

Drug Profile

Brand NamesOPC1085, Ocupress, Mikelan, ophthalmic
CompanyCSL Vifor
Drug ClassSmall Molecule
Molecular TargetADRB1, ADRB2
RouteOthers, Topical
StatusApproved
Sources: ClinicalTrials.gov, CSL Vifor

Mechanism of Action

Molecular Targets

carteolol acts on 2 molecular targets:

ADRB1adrenoceptor beta 1 (B1AR, RHR)
ADRB2adrenoceptor beta 2 (B2AR, ADRBR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

carteolol is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Eye disordersGlaucoma✓ Approved

Related Research Articles

PubMedJournal of ophthalmology2026-08-25

Models Estimating the Effects of Changes in the Concentration of Specific Climatic Pollutants and Temperature on the Prevalence of Acute Ophthalmic Inflammatory Conditions: A Retrospective Cross-Sectional Observational Study.

Sarnat-Kucharczyk Monika M, Wyględowska-Promieńska Dorota D, Patel Sudi S

Air pollution is a major environmental health risk linked to systemic and ocular diseases, including conjunctivitis, keratitis, and dry eye disease. Pollutants such as particulate matter, nitrogen oxides, and diesel exhaust particles have been associated with an increased prevalence of acute ophthalmic inflammatory conditions (AOICs). Identifying key pollutants may help reduce the prevalence of AOICs. The aim of this study was to investigate the relationship between atmospheric pollution and AOICs by identifying pollutants with the most consistent impact on AOIC prevalence, developing predictive models to estimate their composite effect, and assessing model accuracy. This retrospective study analyzed cases of AOICs from the Eye Emergency Department in Katowice (2011-2019). Diagnoses were classified into subgroups using ICD-10 codes and ophthalmologic evaluation. Annual prevalence was correlated with average pollutant levels and temperature via linear and multiple regression. Significant associations informed predictive models, assessed for accuracy using limits of agreement (±1.96 × SD), with p < 0.05 as the significance threshold. Between 2011 and 2019, over 60,000 cases of AOICs were identified among nearly 95,000 emergency visits. The most frequent diagnoses included conjunctivitis (46.8%), keratitis (26.4%), and blepharitis (14.1%). Multiple regression analyses revealed that the prevalence of several AOIC subtypes was significantly associated with mean annual concentrations of specific pollutants and/or temperature. Formaldehyde, CO, SO2, PM2.5, and PM10 were significantly linked to inflammatory ocular conditions, with stronger associations after excluding noninflammatory cases and conjunctivitis. These findings highlight the role of environmental monitoring in predicting or reducing serious eye inflammation, supporting further large-scale research.

PMID 42639289
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PubMedAdvanced healthcare materials2026-08-25

Light-Mediated Transfection of the Ocular Surface Using an Ophthalmic YAG Laser.

Byun Junho J, Wels Mike M, Vanmeerhaeghe Bernd B, Paoletti Luca L et al.

Diseases of the ocular surface, such as dry eye disease (DED), can significantly impair vision and reduce the quality of life. Current treatments rely primarily on conventional approaches, including artificial tears, antibiotics, and anti-inflammatory drugs. However, advances in nucleic acid (NA) therapeutics have opened new avenues for treating ocular surface disorders, with growing interest in small interfering RNA (siRNA) and messenger RNA (mRNA) as potential drugs. A key challenge remains the efficient delivery of these macromolecules into cells of the ocular surface, where both extracellular and intracellular barriers hinder their cellular uptake and activity. To address this limitation, we explore the use of photoporation, a laser-based physical transfection technique, to enhance mRNA delivery into ocular surface cells. Photoporation employs pulsed-laser irradiation of photosensitizers to generate vapor nanobubbles (VNBs), whose rapid expansion and implosion produce mechanical forces that transiently permeabilize cell membranes, thereby promoting intracellular delivery of co-administered nucleic acids. Using polydopamine nanoparticles (PD NPs) as biocompatible photosensitizers for photoporation, we demonstrate mRNA transfection in the corneal epithelium with both an experimental and a clinically approved pulsed-laser system. Our results highlight the potential of laser-based approaches for noninvasive engineering of the ocular surface.

PMID 42638266
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PubMedInternational journal of ophthalmology2026-08-25

Utility of 3D-display surgical videos for better educational effects in pediatric persistent fetal vasculature for trainees.

Liu Jing-Hua JH, Yuan Ming-Zhen MZ, Li Song-Feng SF, Deng Guang-Da GD et al.

To compare the educational benefits of three-dimensional (3D) surgical videos compared with two-dimensional (2D) surgical videos as a training tool for trainees in pediatric persistent fetal vasculature (PFV). Trainees were stratified into three tiers by retinal surgery exposure and independent operating experience: Level 1 (≤5y, no independent cases), Level 2 (5-10y, ≤5 independent years), Level 3 (>10y, >5 independent years). Trainees viewed 3D and 2D surgical videos of pediatric PFV in a randomized order and immediately completed a questionnaire to provide educational assessments. Twelve trainees viewed 9 paired 3D and 2D surgical videos from 9 pediatric PFV patients (9 3D videos and 9 2D videos), resulting in 216 completed questionnaires. For pediatric PFV cases, trainees demonstrated a higher accuracy rate when watching 3D surgical videos compared to 2D surgical videos in discerning the depth of the anterior chamber (85.2% vs 70.4%, χ²=6.857, P=0.009), the location of lens opacity (86.1% vs 69.4%, χ²=8.679, P=0.003), and vitreous strips (89.8% vs 78.7%, χ²=5.027, P=0.025). Trainees believed that, compared to 2D surgical videos, 3D surgical videos significantly improved their ability to discriminate shallow anterior chambers (5.70±1.58 vs 3.92±1.14, P<0.001), the location of lens opacity (6.80±1.60 vs 4.36±1.35, P<0.001), vitreous strips (9.06±2.02 vs 7.16±2.42, P<0.001), complicated tractional retinal detachment (9.31±2.13 vs 7.99±2.63, P<0.001), and macular involvement (8.47±2.62 vs 6.91±2.84, P<0.001) in pediatric PFV cases. Trainees found 3D surgical videos to be significantly more satisfactory than 2D surgical videos in terms of image magnification (8.90±1.61 vs 7.17±1.65, P<0.001), clarity (9.21±2.11 vs 7.42±2.27, P<0.001), and depth of field (8.31±2.38 vs 6.78±2.79, P<0.001). Trainees regarded 3D surgical videos as significantly more suitable for ophthalmic surgical teaching (9.23±0.83 vs 5.75±0.93, P<0.001) and implementation (8.83±2.69 vs 6.15±2.83, P<0.001) compared to 2D surgical videos. 3D-display surgical videos offer superior educational benefits for trainees earning pediatric PFV vitrectomy surgery compared to 2D videos.

PMID 42638902
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PubMedCureus2026-08-25

A Prospective Observational Study Comparing Hybrid Acrylic and Collamer Posterior Chamber Phakic Intraocular Lenses for High Myopia.

Pande Gaurav G, Singh Virendra P VP, Priyanka, Maurya Rajendra P RP et al.

To evaluate clinical outcomes following implantation of two types of posterior chamber phakic intraocular lenses: a reinforced hydrophilic acrylic implantable phakic contact lens IPCL (model V2.0; Care Group, Baroda, India) and a Collamer implantable phakic contact lens Visian ICL (model V4c; Staar Surgical Co., Monrovia, CA) for the treatment of high myopia (more myopic than -5.00 Dioptre) in adults. To compare visual and refractive outcomes and postoperative complications between a reinforced hydrophilic acrylic implantable phakic contact lens IPCL and a Collamer implantable phakic contact lens Visian ICL for the treatment of high myopia and myopic astigmatism in adults. This is a prospective, observational study in a tertiary ophthalmic care centre in Varanasi, India. Fifty-five eyes from 55 patients with high myopia or myopic astigmatism were included in the study. Group A (27 eyes) received implantable phakic contact lens IPCLs, and Group B (28 eyes) received implantable Collamer lens ICLs. All patients underwent preoperative assessments, including optical biometry, keratometry, axial length, central corneal thickness, and white-to-white measurement. Postoperative evaluations were conducted at 1, 6, and 12 months, assessing uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), refractive stability, and adverse effects. Both groups showed statistically significant improvement in visual acuity over 12 months. Preoperative mean LogMAR BCVA was 0.411 ± 0.191 (Group A) and 0.366 ± 0.277 (Group B). At 12 months, mean postoperative LogMAR UCVA was 0.268 ± 0.202 (Group A) and 0.146 ± 0.133 (Group B). Anterior uveitis with intraocular pressure elevation occurred in four eyes (14.8%) in Group A and four eyes (14.3%) in Group B at one week. Glare and halos were reported in eight eyes (29.6%) in Group A and six eyes (21.4%) in Group B during late follow-up. Both the IPCL and ICL are effective and safe options for correcting high myopia. ICL showed superior visual outcomes as compared to IPCL with comparable complication rates. Though affordability was not assessed, the reinforced acrylic lens remained a potentially lower-cost material, offering meaningful refractive correction.

PMID 42639070
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PubMedJournal of neuroradiology = Journal de neuroradiologie2026-08-24

Visual complication after middle meningeal artery embolization in a patient with an ophthalmic artery originating solely from the middle meningeal artery: an underrecognized pitfall.

Kitamura Satoshi S, Koyama Junichi J, Kakizawa Yukinari Y, Kobayashi Hideki H et al.

Middle meningeal artery embolization (MMAE) has emerged as an effective treatment for chronic subdural hematoma (CSDH). Although generally considered safe, rare but potentially devastating visual complications have been reported, most often attributed to embolic migration through angiographically occult anastomoses between the middle meningeal artery (MMA) and the orbital circulation. A 75-year-old man with recurrent left-sided CSDH underwent MMAE using 12.5% n‑butyl cyanoacrylate (NBCA). Preprocedural angiography revealed a rare vascular anatomy in which the ophthalmic artery originated exclusively from the MMA, with complete absence of internal carotid artery-derived ophthalmic flow. The microcatheter was positioned in a wedged configuration within the MMA during embolization. Immediately after NBCA injection, the patient developed a unilateral superior visual field defect. Postprocedural findings were consistent with embolic diversion into the orbital circulation via angiographically occult meningo-orbital microanastomoses. This case highlights a rare but clinically important high-risk anatomical and hemodynamic scenario during MMAE. Absence of internal carotid artery-derived ophthalmic flow, together with the use of low-concentration NBCA and local hemodynamic alterations associated with microcatheter wedging, may increase the risk of unintended embolization into occult orbital pathways. Careful preprocedural evaluation of ophthalmic artery origin and individualized embolization strategies are essential, particularly when low-viscosity liquid embolic agents such as low-concentration NBCA are considered.

PMID 42636677
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PubMedScientific reports2026-08-24

Evaluation of a novel multi-purpose ophthalmic block simulator amongst ophthalmology trainees.

Choo Jessica Q H JQH, Lim Elizabeth W L EWL, Tan Chelsea Q L CQL, Lee Jordan J et al.

Training to perform ophthalmic blocks is often done on actual patients by trial and error. Higher complication rates and poor patient experience occur from suboptimal blocks. We assess the efficacy of a novel ophthalmic block simulator via a pilot study. The production process involved 3D-printing and improvisation with readily available materials that provided excellent reproducibility of a real-life experience. A prospective pilot study on ophthalmology trainees in a single centre via a 3-pronged approach before and after a supervised training workshop on the simulator was performed. Outcomes include procedural confidence, competence, accurate needle positioning during peribulbar block and degree of post-procedural akinesia. There were significant improvements in trainee self-ranked confidence (7.57 ± 1.27 to 8.57 ± 1.13, p = 0.018) and competence (7.71 ± 0.95 to 8.43 ± 0.98, p = 0.047) (n = 7). There was improvement in consultant-rated akinesia, competence and confidence (38.1% ± 29.9% to 34.8% ± 20.7% p = 0.766, 7.63 ± 1.51 to 7.90 ± 0.66 p = 0.585, and 7.57±1.64 to 7.80±0.92 p = 0.698) (18 assessments pre-workshop, 20 assessments post-workshop), and mean accuracy in blocks performed on the simulator after training with the simulator (4.17 ± 1.27 to 4.83 ± 0.389, n = 12, p = 0.054) although all these were statistically insignificant. In summary, this is a useful, portable and low-cost ophthalmic block simulator that allows trainees to gain confidence and competence in performing these procedures.

PMID 42634018
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