Drug Database
OF

ofloxacin (Floxin Otic)

✓ Approved

Daiichi Sankyo Company Limited · Small Molecule · Small Molecule

What is ofloxacin?

ofloxacin is a small molecule developed by Daiichi Sankyo Company Limited. It is approved for therapeutic indications via others or topical.

Drug Profile

Brand NamesFloxin Otic
CompanyDaiichi Sankyo Company Limited
Drug ClassSmall Molecule
RouteOthers, Topical
StatusApproved
Sources: ClinicalTrials.gov, Daiichi Sankyo Company Limited

Therapeutic Indications

ofloxacin is developed for 4 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsOtitis externa✓ Approved
Infections and infestationsOtitis media✓ Approved
Ear and labyrinth disordersExternal ear inflammation✓ Approved
Ear and labyrinth disordersMiddle ear inflammation✓ Approved

Related Research Articles

PubMedEnvironmental geochemistry and health2026-10-20

Suppressing radiocesium uptake and root-to-shoot translocation in crops: Molecular, agronomic, and ecological strategies.

Rahman Ismail I, Khan Bayezid M BM, Hossen Iqbal I, Rahman Zinnat Z

Radiocesium (r-Cs: 137Cs) from the Fukushima Daiichi accident and earlier nuclear fallout remains a long-term contaminant in agricultural soils. It poses an ongoing threat to global food safety because crops readily absorb it as a potassium analog. This review synthesizes a decade of mechanistic, agronomic, and ecological advances in suppressing r-Cs uptake and root-to-shoot translocation. First, the impact of soil mineralogy, particularly clay fixation, on initial r-Cs bioavailability is examined. At the molecular level, r-Cs influx is governed by a shared calcium-signaling hub linked to potassium status. Consequently, optimizing potassium fertilization can transcriptionally silence the principal uptake genes. Furthermore, controlling xylem loading and managing internal sodium interactions directly restrict r-Cs translocation, protecting edible plant parts. Supplementary countermeasures, including plant-microbe symbioses, porous soil amendments, and targeted genetic exclusions, are also evaluated. To ensure long-term agricultural resilience, multi-site field trials and the molecular dissection of translocation pathways must be prioritized in future research. Ultimately, sustainable crop production requires integrating biological and agronomic strategies rather than relying solely on intensive potassium fertilization.

PMID 42900253
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PubMedJournal of environmental radioactivity2026-10-19

A spatiotemporally corrected radiological contamination mapping platform for multi-scenario nuclear and radiological emergencies.

Kim Hyunsung H, Shin Myeongsik M, Kang Ku K

Rapid, quantitative assessment of the environmental consequences of radioactive contamination (and protection of responders operating within it) requires reconstructing continuous contamination fields from heterogeneous reconnaissance measurements. We present an automated platform that converts geo-referenced dose-rate data from ground and airborne assets into hazard-consequence maps. This study presents the platform architecture and quantitatively validates its spatial-reconstruction and decision-support modules; the altitude-correction and temporal-normalization modules are formalized as architecture components whose empirical validation is identified as future work. Airborne measurements are first converted to ground-equivalent dose rates through an altitude-dependent air-to-ground correction factor (AGCF) modeled as a segmented broken power-law (SBPL), then normalized to a common reference time using radionuclide half-life decay for radiological accidents or the Kaufmann power law for nuclear detonations. Normalized data are reconstructed into continuous 2-D fields by interpolation. Five methods, namely inverse distance weighting (IDW), ordinary kriging (OK), universal kriging (UK), anisotropic OK, and thin-plate spline (TPS), were evaluated in two scenarios: a 2000 kT nuclear surface burst (HotSpot 3.1.2) and the Fukushima Daiichi nuclear power plant accident (JAEA airborne surveys, 2011-2025). Performance was strongly scenario-dependent: for the detonation, TPS and anisotropic OK far outperformed isotropic OK (R2=0.866 and 0.849 vs. 0.256), a gap robust across resampling (95% CIs non-overlapping), whereas all methods converged in the Fukushima field (mean R2=0.938-0.957) under random hold-out; under spatially-independent block cross-validation this convergence is weaker and accuracy is lower (R2≈0.70-0.75), yet the anisotropy-aware advantage in the detonation field is reinforced. No single method is universally optimal; scenario-adaptive selection is essential for consequence estimation, exclusion-zone delineation, and minimum-dose routing in operational platforms.

PMID 42896493
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PubMedThe Annals of otology, rhinology, and laryngology2026-10-18

Acute Otitis Externa-Antimicrobial Resistance in the US and Canada: Phase III Study Outcomes.

Bentley Christine C, Lückermann Mark M, Dalhoff Axel A, Vente Andreas A

The goal of this investigation was to characterize the microbiological profile and antimicrobial susceptibility patterns of pathogens isolated from AOE patients of 2 vehicle-controlled Phase III clinical trials and evaluate pathogen eradication rates achieved with finafloxacin otic suspension. In vitro MIC comparisons to other fluoroquinolones (ciprofloxacin, ofloxacin) are reported as supplementary susceptibility data and do not reflect direct randomized clinical comparisons. A total of 2683 bacteria isolated from 1234 AOE patients enrolled in 2 Phase III clinical studies in the United States, Puerto Rico, and Canada were analyzed. Specimens were collected from the external ear of subjects with AOE. Species-level identification for each bacterial isolate recovered was obtained by combining phenotypic and genotypic data. End point minimum inhibitory concentration (MIC) testing was performed using Clinical and Laboratory Standards Institute recommended methods. 72.7% of the pre-therapy bacteria were Gram-positive and 27.3% Gram-negative. Most frequent bacterial isolates were Staphylococcus spp. (46.7%) followed by Pseudomonas spp. (19.5%). Methicillin resistance was detected in 17.0% of S. aureus (MRSA) and 33.2% of S. epidermidis (MRSE) isolates. Ciprofloxacin resistance was identified in 12.5% of S. aureus and 14.0% of S. epidermidis isolates. Finafloxacin eradicated 86.4% of the MRSA isolates and 80.6% of the MRSE isolates. Finafloxacin eradicated ciprofloxacin-resistant Staphylococcus spp. in 74.4% and ciprofloxacin-resistant Pseudomonas spp. in 87.5% of treated patients. Finafloxacin demonstrated high eradication rates in AOE patients with methicillin-resistant S. epidermidis and S. aureus, as well as in patients with ciprofloxacin-resistant Staphylococcus spp.- and Pseudomonas spp., irrespective of the pathogen's resistance profile. These in vitro findings, together with observed eradication rates in the vehicle-controlled trials, suggest that finafloxacin may offer advantages in the treatment of resistant organisms, particularly under acidic pH conditions. However, direct clinical trial comparisons have not been conducted. Clinical trial registry name: ClinicalTrials.gov. URL: https://clinicaltrials.gov/. Identifier: NCT01535599 and NCT01535560.

PMID 42892712
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PubMediScience2026-10-17

Resveratrol-mediated Fe(III)/peroxydisulfate activation for ofloxacin degradation at circumneutral pH.

Wu Yanlin Y, Yang Wenyu W, Zeng Yilan Y, Huang Dingfeng D et al.

Iron-mediated peroxydisulfate (PDS) activation is limited by slow Fe(III)/Fe(II) redox cycling under circumneutral conditions. Here, resveratrol (RES), a natural stilbene polyphenol, was introduced as a low-dose redox mediator to promote Fe(II) formation from Fe(III) for enhanced PDS activation. The Fe(III)/RES/PDS system showed higher ofloxacin (OFL) degradation than the corresponding single-reagent and binary systems and achieved approximately 90% OFL degradation at pH 6.5. Chemical quenching and competition-kinetic analysis indicated that sulfate radical (SO4 ·-) was the major contributor to OFL degradation, while hydroxyl radical (·OH) played a secondary role. Matrix experiments showed that Cl- and NO3 - had minor effects, whereas NO2 - strongly inhibited OFL degradation. This work provides a case study of RES-mediated Fe(III)/PDS activation for antibiotic degradation under near-neutral conditions.

PMID 42890338
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PubMedCase reports in infectious diseases2026-10-17

Concurrent Middle Ear and Vertebral Tuberculosis Secondary to Mycobacterium Africanum in an Immunocompetent Young Adult in a Low-Incidence Setting: Diagnostic Value of Middle Ear Biopsy.

Kasule Sabirah N SN, Zacharia George S GS, Desrosiers Abelard C AC, Penikilapate Shalini S et al.

Otic tuberculosis is an exceedingly rare manifestation of extrapulmonary tuberculosis (EPTB) and typically mimics more common otologic conditions, leading to delayed diagnosis and treatment. This report discusses a case of middle ear tuberculosis in a New York City-born-and-raised young woman. She presented with ear drainage, hearing loss, generalized weakness, and a painful lump on her posterior neck. She was subsequently diagnosed with multiple abscesses along the cervical and thoracic spine and a large mass in her middle ear that protruded through her tympanic membrane into the external auditory canal. Biopsy of the protruding part of the ear mass revealed non-necrotizing granulomatous inflammation and acid-fast bacilli on pathology. Mycobacterium tuberculosis (MTB) complex PCR was positive, and mycobacterial cultures grew Mycobacterium africanum. She was promptly initiated on rifampin, isoniazid, pyrazinamide, and ethambutol (RIPE) with clinical improvement of her symptoms.

PMID 42890672
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PubMedInternational journal of molecular sciences2026-10-16

Photobiomodulation as a Potential Regenerative Signal in the Inner Ear: Linking Mitochondrial Redox Signaling to Cell-Fate Regulation.

Lee Min Young MY

Photobiomodulation (PBM) is a non-thermal therapeutic modality in which low-intensity red or near-infrared light is used to modulate biological activity. Experimental inner-ear studies report preservation of auditory neurons, attenuation of vestibular injury, improved survival of transplanted stem cells, and changes in otic organoid differentiation. These observations raise the possibility that PBM may influence differentiation-associated cellular states in addition to providing cytoprotection. The classical mechanistic model proposes that photons interact with mitochondrial chromophores, particularly cytochrome c oxidase, leading to changes in respiration, ATP, reactive oxygen species (ROS), nitric oxide, calcium, and downstream signaling; however, a universal primary photoreceptor has not been established. In a 2020 mouse embryonic-stem-cell-derived otic-organoid study, PBM was associated with more organoid-like structures, increased hair-cell-associated markers, increased ROS, and lower Hes5 expression. The RNA-sequencing comparison pooled five embryoid bodies into one sample per condition, limiting biological replication and statistical inference. Accordingly, the Hes5 result should be regarded as exploratory and does not demonstrate direct Notch inhibition. Studies in other regenerative tissues show that PBM can engage ROS-dependent PI3K/AKT/GSK3β/β-catenin signaling, providing a mechanistic precedent rather than proof for the inner ear. This review therefore presents a testable working model in which PBM may connect mitochondrial and redox responses to Wnt/β-catenin and Notch/HES5 pathways during otic differentiation, while emphasizing that mature hair-cell regeneration, new SGN generation, and hearing restoration have not yet been established.

PMID 42883688
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