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calcium acetate (PhosLo Gelcaps / PhosLo Tablets / Phoslyra)

✓ Approved

Vaxart, Inc. · Small Molecule · Small Molecule

What is calcium acetate?

calcium acetate is a small molecule developed by Vaxart, Inc.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesPhosLo Gelcaps, PhosLo Tablets, Phoslyra
CompanyVaxart, Inc.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Vaxart, Inc.

Therapeutic Indications

calcium acetate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHyperphosphataemia✓ Approved

Related Research Articles

PubMedFuture cardiology2026-10-22

The emerging role of orbital atherectomy in the management of heavily calcified lesions in percutaneous coronary intervention.

Helal Ayman A, Cader F Aaysha FA, Hetherington Simon S, Ahmad Nasir N et al.

Severe coronary calcification is a challenge to optimal percutaneous coronary intervention (PCI). Adequate lesion preparation is essential to achieve appropriate stent expansion and improve long-term outcomes. Recently, orbital atherectomy (OA) has emerged as an important tool for calcium modification, offering a unique mechanism of action based on centrifugal sanding and differential cutting. This review summarizes the contemporary evidence supporting OA in heavily calcified coronary disease, compares it to other established calcium modification strategies, and highlights practical scenarios where OA offers distinctive advantages. Several calcium algorithms exist, detailing start points according to balloon crossability and stepwise escalation guided by intravascular imaging. Orbital atherectomy has recently become available across centers in Europe and the United Kingdom, providing an alternative calcium‑debulking toolkit that is of particular use in some indications, with advantages over other techniques. In this review, we look at the emerging role of OA in calcified lesions, with a critical appraisal of the data and highlighting its utility drawing examples from the published literature and our center's experience.

PMID 42902991
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PubMedPediatric endocrinology, diabetes, and metabolism2026-10-22

Refractory hypoparathyroidism in paediatric autoimmune polyglandular syndrome type 1: successful long-term use of teriparatide.

Perez Carolina C, Adarme Nicolas N, Hernandez Catalina C, Sarmiento Maria Paula MP

Autoimmune polyglandular syndrome type 1 (APS-1) is a rare monogenic disorder caused by pathogenic variants in the autoimmune regulator (AIRE) gene. It typically manifests in childhood with at least two features of the classic triad: chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency. We present the case of an 11-year-old girl from a consanguineous family, with severe hypocalcaemia and chronic oral candidiasis. Despite high-dose calcium and calcitriol therapy, she experienced recurrent symptomatic hypocalcaemia requiring multiple hospitalisations. Genetic testing confirmed homozygosity for the pathogenic AIRE variant c.967_979del, establishing the diagnosis of APS-1. Due to poor biochemical control, teriparatide (parathyroid hormone, PTH [1-34]) was initiated at 20 g twice daily, leading to rapid improvement in calcium-phosphate homeostasis, a 75% reduction in oral calcium requirements, and no further hospitalisations over a two-year period. The therapy was well tolerated with no adverse events. This is the first paediatric case reported in Colombia using recombinant PTH (1-34) for APS-1-related hypoparathyroidism, supporting its therapeutic role in refractory cases.

PMID 42902706
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PubMedFrontiers in plant science2026-10-22

Calcium application coordinates seedling heat tolerance and yield-quality formation in ginger under summer high-temperature conditions.

Wang Xingcui X, Ni Xiumei X, Liu Xiaoming X, Li Zhiyu Z et al.

Summer heat stress constrains ginger production. Although calcium (Ca) enhances stress tolerance in various crops, its effects on heat tolerance, yield, and quality in ginger remain unclear. A pot experiment was conducted using Zingiber officinale cv. 'Laiwu Big Ginger' to evaluate Ca effects on plant growth and quality under natural summer high-temperature conditions. Six Ca rates (0, 15.2, 30.5, 45.7, 60.9, and 76.2 mmol Ca2+ plant-1) were established using calcium nitrate tetrahydrate [Ca(NO3)2·4H2O]. Seedling-stage physiological and biochemical parameters were analyzed with linear mixed-effects models; harvest-stage growth, biomass, and quality parameters were analyzed with ANOVA or non-parametric tests. PCA, correlation analysis, and membership function analysis were used for multivariate evaluation. At Day 16, the 60.9 mmol Ca2+ plant-1 treatment significantly improved photosynthetic capacity (chlorophyll +23.3%, Pn +13.0%), antioxidant enzyme activities (SOD, POD, CAT), and proline content, while reducing oxidative damage (MDA, REC) and ROS (O2 ·-, H2O2). These adjustments promoted biomass and rhizome quality, with the highest rhizome fresh weight (727.7 vs. 447.3 g plant-1), dry matter (+3.6%), soluble sugars (+28.1%), soluble protein (+36.5%), free amino acids (+19.1%), and vitamin C (+17.5%). Multivariate analyses confirmed positive correlations among photosynthetic traits, antioxidant activity, biomass, and quality parameters, with the 60.9 mmolCa2+ plant-1 treatment ranking highest in comprehensive evaluation by membership function analysis. Calcium application at this optimal rate, as determined under our experimental conditions, was associated with enhanced heat tolerance and subsequent growth and quality formation. These findings provide practical insights for sustaining ginger productivity under heat stress within the scope of our experimental conditions.

PMID 42903102
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PubMedChannels (Austin, Tex.)2026-10-22

Potential roles for transient receptor potential vanilloid 1 in heart failure with preserved ejection fraction.

Gao Zhicheng Z, Bao Jiaqi J, He Chaojie C, Pan Haihua H et al.

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome in which diastolic dysfunction develops against a background of interacting mechanisms: inflammation, oxidative stress, impaired calcium homeostasis, myocardial fibrosis, coronary microvascular dysfunction, mitochondrial impairment, and neurohumoral activation. Effective mechanism-targeted therapies remain limited. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel expressed in cardiac sensory nerves, vascular endothelial cells, immune cells, and possibly other cardiovascular cell populations. It responds to diverse physical and chemical stimuli and may influence calcium handling, inflammatory signaling, oxidative stress, myocardial fibrosis, mitophagy, and ferroptosis. Preclinical studies have linked altered TRPV1 expression or activity to myocardial remodeling, impaired relaxation, microvascular dysfunction, and heart failure progression, but direct evidence in HFpEF is still sparse. This review summarizes the biological properties of TRPV1, considers how its signaling might intersect with HFpEF pathophysiology, reviews experimental TRPV1-targeted interventions, and identifies the evidence needed before TRPV1 can be evaluated as a potential therapeutic target.

PMID 42902773
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PubMedAging cell2026-10-22

The Senokine Gas6 Promotes Aortic Valve Calcification Through CaMKII-DRP1-Mediated Terminal Scission of Mitochondrial-Derived Vesicles.

Zhang Yaoyu Y, Zhang Jialiang J, Xu Yanjiani Y, Lei Wenhua W et al.

Calcific aortic valve disease (CAVD) is an age-associated valvular disorder in which calcification expands from discrete foci into adjacent tissue. We investigated whether mitochondrial-derived vesicles (MDVs) released by human valvular interstitial cells (hVICs) exert pro-calcific effects on recipient cells and how MDV release is regulated. Using ex vivo hemodynamic perfusion of human CAVD tissue, multi-omics profiling, live-cell single-organelle tracking, MDV transfer assays, and in vivo Gas6 deletion, we found that calcifying hVICs hypersecreted MDVs that exerted pro-calcific effects in recipient hVICs. High-resolution imaging showed that mitochondria remodeled into donut-shaped structures under pro-osteogenic conditions; these structures served as physical platforms for MDV budding. Human CAVD valve tissues and hVICs treated with pro-osteogenic medium also exhibited senescence-associated features. Multi-omics profiling identified growth arrest-specific 6 (Gas6), a senokine, among 36 concordantly upregulated candidates. Functional analyzes showed that Gas6 promoted terminal MDV scission while leaving donut-shaped mitochondrial precursor formation intact. Mechanistically, Gas6 promoted intracellular Ca2+ accumulation, calcium/calmodulin-dependent protein kinase II (CaMKII) activation, and dynamin-related protein 1 (DRP1) phosphorylation at Ser616, supporting a Ca2+-CaMKII-DRP1 axis that facilitates terminal MDV scission. Pharmacological inhibition of CaMKII or DRP1 reduced MDV hypersecretion and subsequent recipient-cell calcification, and Gas6 deletion in vivo attenuated valvular stenosis, calcification, and fibrotic remodeling. These findings identify Gas6-dependent terminal MDV scission as a mechanism contributing to the intercellular propagation of valvular calcification in a CAVD context characterized by senescence-associated features.

PMID 42902865
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PubMedAmerican journal of hypertension2026-10-22

Association of Antihypertensive Medications with Orthostatic Hypotension among OIder Adults.

Khan Md Marufuzzaman MM, Col Hannah H, Larbi Kwapong Fredrick F, Patil Dhrumil D et al.

Orthostatic hypotension (OH) is common among older adults actively prescribed hypertension pharmacotherapy. Associations between antihypertensives and OH are inconsistent, due to differences in drug classes and OH assessment protocols. Three supine and six standing blood pressures (BPs) were measured over 6 minutes, timed to initiate immediately (0 minutes) and 1, 2, 3, 4, and 5 minutes after standing. OH was defined as a drop of systolic/diastolic BP ≥ 20/10 mmHg upon standing from the supine position. OH phenotypes were initial (immediately after standing), early (within 3 minutes), late (after 3 minutes), and sustained (during 6 minutes of standing). Participants were asked about orthostatic symptoms experienced during OH assessment. We investigated associations of antihypertensive classes with OH phenotypes and orthostatic symptoms via multivariable logistic regression. Of 863 participants (mean age 84 years), 41% had initial, 24% early, 18% late, and 17% sustained OH; 81% used antihypertensive medications. First-line antihypertensives (renin angiotensin aldosterone system blockers, dihydropyridine calcium channel blockers, and thiazide diuretics) were not associated with OH or orthostatic symptoms. Among non-first-line, alpha blockers were significantly associated with initial OH (OR 1.80, 95%CI 1.07, 3.01) and orthostatic symptoms during postural change (OR 2.64, 95%CI 1.34, 5.23), whereas combined alpha-beta blockers were significantly associated with early, late, or sustained OH (2.24 [1.15, 4.37], 2.50 [1.21, 5.17], 2.99 [1.41, 6.30], respectively) and experienced symptoms while standing (3.08 [1.10, 8.65]). First-line antihypertensives are not associated with OH among older adults, which does not support their discontinuation in the setting of non-neurogenic OH.

PMID 42902777
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