Drug Database
ME

measles (Tresivac)

✓ Approved

Serum Institute of India Pvt. Ltd. · Vaccine · Vaccine

What is measles?

measles is a vaccine developed by Serum Institute of India Pvt. Ltd.. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesTresivac
CompanySerum Institute of India Pvt. Ltd.
Drug ClassVaccine
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Serum Institute of India Pvt. Ltd.

Therapeutic Indications

measles is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsMeasles✓ Approved

Related Research Articles

PubMedThe Journal of the Association of Physicians of India2026-10-22

Clinical Profile of Patients Presenting with Scrub Typhus at a Tertiary Care Center in Eastern India: A Cross-sectional Study.

Prakash Jyoti J, Kumar Anjani A, Prasad Janmeshwar J, Modi Pratibha P

Scrub typhus is a reemerging rickettsial infection in India and remains an important cause of acute febrile illness with the potential for severe multi-organ involvement if diagnosis and treatment are delayed. Data from eastern India remain limited. To delineate the clinical and laboratory profile of patients diagnosed with scrub typhus admitted to a tertiary care center in eastern India. A retrospective cross-sectional study was conducted at All India Institute of Medical Sciences (AIIMS) Patna, including adult patients (>15 years) with serologically confirmed scrub typhus admitted between January and December 2023. Demographic details, clinical features, laboratory parameters, and complications were retrieved from medical records. Descriptive statistics were used for analysis. A total of 69 patients were included; 58.0% were male. Fever was the most common presenting symptom (94.2%), followed by headache (66.7%) and myalgia (53.6%). Eschar was identified in 10.1% of patients. Thrombocytopenia was present in 82.6%, hyperbilirubinemia in 65.2%, and acute kidney injury in 20.3%. Meningoencephalitis occurred in 13.0%, while hypotension/shock and acute respiratory distress syndrome (ARDS) were infrequent (4.3 and 1.4%, respectively). Scrub typhus commonly presents as acute febrile illness with significant hematological and hepatic involvement. Eschar, though specific, was infrequently observed. High clinical suspicion and early recognition are crucial to prevent complications.

PMID 42902639
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PubMedThe Journal of the Association of Physicians of India2026-10-22

Etiological Spectrum of Hyponatremia in Tuberculous Meningitis: Insights from Referral Institute in Northern India.

Singla Neeraj N, Nc Meiherishankar M, Sharma Kusum K, Modi Manish M et al.

Tuberculous meningitis (TBM) causes death or severe disability in 50% of afflicted patients. Among the various complications, such as hydrocephalus, hyponatremia, cranial nerve palsies, seizures, and myeloradiculopathy, hyponatremia occurs more frequently, affecting 35-65% of patients with central nervous system (CNS) tuberculosis. To study the prevalence of hyponatremia in patients with TBM and its correlation with the clinical profile, severity of illness, and outcome. In suspected TBM patients with low sodium levels, serum and urine osmolality were measured by an osmometer [Advanced Instruments, Inc. (2020)] to evaluate the possible causes. Patients underwent brain imaging to look for hydrocephalus, vasculitic infarcts, and basal exudates. They were followed up with serum sodium levels until the completion of treatment and repeat brain imaging during follow-up to assess radiological recovery. A total of 100 suspected TBM patients with a mean age of 32.6 years and predominantly female (57%) were included. The most common symptoms were fever, headache, altered sensorium, and seizures. The VI cranial nerve was most frequently involved. A total of 31% of patients presented in stage III, with a significant association with mortality (p = 0.002). Hyponatremia was seen in 57% of patients. The GeneXpert Ultra-based polymerase chain reaction (PCR) test for tuberculosis was positive in 41% of patients. Basal exudates (p = 0.001) and tuberculomas (p = 0.004) on brain imaging had a significant association with mortality. On follow-up, 41% of patients had improvement, 35% expired, and 10% had a static condition. Repeat sodium levels along with brain imaging were assessed (p = 0.001). There was a high prevalence of hyponatremia in TBM patients, as seen in 57% of patients, which occurred most frequently due to syndrome of inappropriate antidiuretic hormone secretion (SIADH), followed by cerebral salt-wasting syndrome (CSWS), and was related to the severity of TBM.

PMID 42902663
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PubMedFrontiers in immunology2026-10-22

Integrated immunoreactivity analysis of MHC-I epitopes derived from the Marburg virus glycoprotein.

Yang Yulin Y, Wang Jing J, Guan Enqi E, Wei Hengzheng H et al.

Marburg virus (MARV) is a hemorrhagic fever virus, and its glycoprotein (GP) represents an important target for vaccine research. MHC class I (MHC-I)-restricted T cell epitopes are critical for inducing cytotoxic CD8+ T cell responses. In this study, we aimed to identify MHC-I-restricted T cell epitopes derived from the MARV Angola strain GP through an integrated bioinformatics and experimental approach. We retrieved the MARV Angola strain GP sequence and divided it into 673 overlapping 9-mer peptides. By integrating five computational prediction algorithms, immunogenicity scoring tools and BLASTp conservation analysis, we screened 9-mer peptides from the MARV Angola GP. Molecular docking was performed with MHC-I structures using HPEPDOCK and molecular dynamics (MD) analysis. Bidirectional hierarchical clustering was used to analyze binding similarity across MHC-I molecules. Mutations identified in epitope regions were tested for their effect on affinity. Toxicity and allergenicity of the epitopes were predicted using dedicated tools. Finally, BALB/c and C57BL/6 mice were immunized with a DNA vaccine encoding MARV GP. IFN-γ secretion in mouse splenocytes was then measured by ELISpot, serum IgG by ELISA, and CD8+ T cell cytokine production by flow cytometry. Among 673 GP peptides, eight epitopes (GAFFLYDRI, REGDMFPFL, DMFPFLDGL, NENDCDAEL, AGLSWIPFF, NQNNLVCRL, TGWGLGGKW, SDWGVLTNL) were predicted to exhibit high-affinity MHC-I binding, strong immunogenicity, and intraspecies conservation. Bidirectional hierarchical clustering analysis, molecular docking, sequence alignment, and toxicity/allergenicity predictions suggested binding across selected alleles, structural stability, limited impact from identified mutations, and low predicted toxicity. In subsequent ELISpot validation, eight epitopes elicited strong IFN-γ responses. In addition, serum from GP-immunized mice contained IgG that bound the corresponding linear peptide sequences. An integrated computational-experimental pipeline identified eight conserved, immunogenic MHC-I epitopes from MARV GP. These selected epitopes may serve as promising candidates for future vaccine design.

PMID 42903143
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PubMedThe Journal of the Association of Physicians of India2026-10-22

Smartphone Usage Sleep Quality and Behavioral Health in Adolescents: A Cross-sectional Study from Eastern India.

Chatterjee Rupak R, Sarkar Subhajit Dey SD, Mukherjee Shatavisa S, Chatterjee Nandini N

Widespread smartphone use has raised concerns regarding its effects on adolescent health, particularly sleep quality and behavioral outcomes. The associations between smartphone usage patterns, sleep disturbances, and markers of obesity and vision health have yet to be systematically evaluated in India. To assess the prevalence of smartphone usage, bedtime usage patterns, and their association with sleep quality, overweight status, and visual acuity among adolescents in Eastern India. A cross-sectional study was conducted among 140 adolescents aged 13-19 years attending urban and rural schools in Eastern India. Participants completed a structured questionnaire covering demographics, daily and bedtime smartphone use, and sleep quality. Sleep quality was assessed using a modified Pittsburgh Sleep Quality Index (PSQI), and smartphone addiction was estimated using behavioral proxies. Chi-square tests were employed to assess associations, and logistic regression was used to identify predictors of poor sleep quality. The mean age of participants was 16.8 ± 1.9 years, with 55% male participants and 70% from urban areas. Smartphone usage at bedtime was reported by 89.3% of participants, and 42.1% reported poor sleep quality. Longer bedtime smartphone use (>30 minutes) was significantly associated with poor sleep quality (χ2 = 42.5, p < 0.001). Daily usage exceeding 2 hours was significantly associated with overweight status (χ2 = 21.9, p = 0.001). A high prevalence of bedtime smartphone use among adolescents in Eastern India is significantly associated with poor sleep quality. Excessive daily smartphone use is also linked with overweight status. Public health strategies should include digital hygiene awareness and school-based interventions.

PMID 42902647
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PubMedThe Journal of the Association of Physicians of India2026-10-22

Medical Research in India: Bridging the Gaps and Shaping the Future.

Jagtap Nitin N, Chavan Radhika R, Reddy D Nageshwar DN

PMID 42902660
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PubMedThe Journal of the Association of Physicians of India2026-10-22

Efficacy and Tolerability of Tenofovir/Lamivudine/Dolutegravir among Antiretroviral Therapy Naive Human Immunodeficiency Virus Infected Patients of a Tertiary Care Center in Eastern India.

Sengupta Debroop D, Ghosh Sandip S, Pain Shantasil S, Chatterjee Nandini N

PMID 42902680
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