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sumatriptan succinate (sc) (DFN 11 / Zembrace SymTouch / DFN11)

✓ Approved

Upsher-Smith Laboratories, LLC. · HTR1B · Small Molecule

What is sumatriptan succinate (sc)?

sumatriptan succinate (sc) is a small molecule developed by Upsher-Smith Laboratories, LLC.. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesDFN 11, Zembrace SymTouch, DFN11
CompanyUpsher-Smith Laboratories, LLC.
Drug ClassSmall Molecule
Molecular TargetHTR1B, HTR1D
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Upsher-Smith Laboratories, LLC.

Mechanism of Action

Molecular Targets

sumatriptan succinate (sc) acts on 2 molecular targets:

HTR1B5-hydroxytryptamine receptor 1B (HTR1DB, 5-HT1DB)
HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

sumatriptan succinate (sc) is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersMigraine✓ Approved

Related Research Articles

PubMedFrontiers in neuroscience2026-08-25

Bidirectional structural-functional connectivity coupling reorganization in obstructive sleep apnea.

Chao Baoting B, Han Gang G, Chen Xueqing X, Chen Jie J

Obstructive sleep apnea (OSA) is associated with widespread cognitive and neural dysfunction; however, how chronic intermittent hypoxia and sleep fragmentation reshape the relationship between structural and functional brain connectivity remains unclear. Structural-functional connectivity (SC-FC) coupling provides a multimodal framework for characterizing the correspondence between anatomical architecture and functional communication. Fifty patients with moderate-to-severe OSA and fifty matched healthy controls (HCs) underwent overnight polysomnography and multimodal MRI scanning, including resting-state functional MRI and diffusion tensor imaging. Regional SC-FC coupling was calculated using SC and FC matrices derived from the Brainnetome Atlas. Group differences in regional SC-FC coupling were examined across 246 regions, and exploratory correlation analyses were performed with cognitive and clinical measures. Compared with HCs, patients with OSA showed significantly increased SC-FC coupling in frontal-insular, posterior default-mode, sensorimotor, and visual regions. In contrast, significantly decreased SC-FC coupling was observed in temporal-associative, limbic, and subcortical regions. Increased SC-FC coupling in the superior frontal gyrus, precuneus, and insula was associated with poorer psychomotor vigilance performance, including prolonged reaction times and increased lapse frequency. Reduced hippocampal and subcortical coupling was associated with nocturnal hypoxia burden, including increased percentage of sleep time spent below 90% oxygen saturation and lower minimum oxygen saturation. Inferior parietal lobule coupling showed a weaker association with apnea-hypopnea index severity. OSA is associated with bidirectional regional SC-FC coupling reorganization, characterized by hypercoupling in attention-related systems and hypocoupling in limbic-subcortical regions. These exploratory findings suggest that distinct coupling patterns may relate to different clinical dimensions of OSA, including vigilance impairment and nocturnal hypoxic burden.

PMID 42639103
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PubMedJournal of endourology2026-08-25

Characterizing Neurogenic Bladder Patients Undergoing Percutaneous Nephrolithotomy: Examining Concordance of Preoperative Urine and Stone Cultures.

Siron Nicolas N, Hafeez Zaki Z, Samala Vishwasree V, Dalton David D et al.

Percutaneous nephrolithotomy (PCNL) is associated with a significant risk for postoperative urinary tract infection (UTI) and sepsis. Prevention of post-PCNL UTI is dependent on appropriate antibiotic prophylaxis (AP), which relies on preoperative urine cultures. However, studies have demonstrated that preoperative urine cultures are not always concordant with stone cultures (SC), the latter most closely representing the bacterial burden. Accuracy of urine cultures is even more critical in the neurogenic bladder (NB) subpopulation, as they often have infected or infectious stones. In this study, we aim to assess the concordance of preoperative urine cultures and SC in NB patients as compared to non-neurogenic bladder (non-NB) patients undergoing PCNL. We performed a retrospective chart review of all patients ≥18 years old undergoing PCNL at our institution between 2022 and 2024. Baseline characteristics, preoperative urine culture, stone culture, concordance rates, perioperative complication, and urosepsis rates were collected and compared between NB and non-NB patients. Numeric variables were compared using t-test and categorical variables using chi-square. A total of 333 patients underwent PCNL between 2022 and 202 were non-NB patients. NB patients had a lower concordance rate between preoperative urine culture and SC compared to non-NB patients (37.7% vs 64.3%, p = < 0.05). Rates of urosepsis were comparable in both groups in the perioperative period (1.8% vs 1.4%, p = 0.51). Enterococcus faecalis was the most common pathogen found in NB SC. NB patients are more likely to have discordant preoperative urine culture and SC compared to non-NB patients. Gram-positive organisms such as Enterococcus faecalis also represent a high number of positive SC in this population. Given the high discordance rate and positivity with Enterococcus faecalis in SC, consideration for a larger spectrum AP is warranted in NB patients.

PMID 42638265
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PubMedJournal of the science of food and agriculture2026-08-25

Comparative analysis of supercritical CO2, hexane and isopropanol extraction methods for rice bran oil: cultivar-specific assessment for bioactive compound preservation.

Abd El Salam Khaled M H KMH, Ammar Gamal A G GAG, Shaalan Ahmed M AM, Zayed Bassiouni A BA et al.

Rice bran, a valuable rice milling by-product, is rich in edible oil with γ-oryzanol, tocopherols, tocotrienols and phenolics. However, the effectiveness of extraction methods in maximizing oil recovery at the same time as preserving these bioactives across rice cultivars remains unclear. This study compared the extraction of five Egyptian rice cultivars using supercritical CO2, hexane and isopropanol. Rice bran from Giza 179, Giza 178, Super 300, Sakha 108 and Egyptian Yasmine harvested during the 2023 and 2024 seasons was extracted using a split-plot design with three replications. Cultivar, extraction method and their interaction significantly affected crude oil yield, iodine value, saponification number, total phenolic content, γ-oryzanol, tocopherols, tocotrienols and total tocols. Sakha 108 exhibited the highest crude oil content (21.93%) and superior bioactive compound concentrations among the cultivars. SC-CO2 extraction produced the greatest oil yield (24.64%), which was approximately 27% higher than hexane extraction, at the same time as preserving the highest concentrations of total phenolics (22.21 mg gallic acid equivalents g-1 oil), γ-oryzanol (27.64 mg g-1 oil), tocopherols (324.76 mg g-1 oil), tocotrienols (518.54 mg g-1 oil) and total tocols (843.29 mg g-1 oil). Strong positive correlations were observed among vitamin E compounds (r = 0.995) and between bioactive compounds and oil quality traits. SC-CO2 extraction, when paired with the Sakha 108 cultivar, achieved the best balance between oil recovery and the preservation of bioactive compounds. These findings underscore the importance of cultivar-specific extraction strategies and support SC-CO2 as a promising green technology for producing high-quality rice bran oil. © 2026 Society of Chemical Industry.

PMID 42638262
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-08-25

A Microenvironment-Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells.

Zhan Ning N, Tian Lixin L, Peng Lianjie L, Zhang Jingyu J et al.

Repairing peripheral nerve injury remains a clinical challenge due to its limited regenerative capacity and the situation is further compounded with age. In this study, we identified the dysregulated repair program of Schwann cells (SCs) as a key feature of the aging-dependent impairment of nerve regeneration, mediated by dual influence of ferroptosis. The ferroptosis-stressor-rich microenvironment inhibits SC function in regenerating nerves. Moreover, the persistent intracellular ferroptosis stressor accumulation could accentuate senescence-associated secretory phenotype (SASP) expression in SCs, culminating in the disruption of redifferentiation trajectory and repair programs of SCs. Herein, a composite nerve conduit integrating microenvironment-responsive Ga-PTA nanoparticles and maxillofacial-derived mesenchymal stem cells (Mmscs) is developed by melt electrospinning writing (MEW). Mechanistically, Ga-PTA nanoparticles competitively inhibited excessive ferroptosis to establish a pro-regenerative niche. Meanwhile, Mmscs was induced to differentiate into SC-like cells which bypassed the redifferentiation impairment of resident SASP-expressing SCs, offering promising therapeutic strategies for peripheral nerve and other tissue injuries during aging.

PMID 42640138
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PubMedFrontiers in microbiology2026-08-25

Colorectal laterally spreading tumors exhibit a distinct carcinogenic eco-metabolic shift defined by multi-omics profiling.

Liu Wenming W, Liu Jie J, Chen Yudai Y, Lu Guijun G et al.

Colorectal laterally spreading tumors (LSTs) are clinically important premalignant lesions with distinctive endoscopic morphology and malignant potential. Although microbiome and metabolome alterations have been reported in colorectal cancer and conventional adenomas, the microbial and metabolic features associated with LSTs remain insufficiently characterized. We investigated whether LSTs are associated with a coordinated carcinogenic eco-metabolic shift (CES) involving stool microbial, metagenomic functional, and circulating metabolic alterations, hereafter referred to a CES, a finding consistent with its high-risk premalignant biology. Building on our LST multi-omics cohort, we focused on stool metagenomic, serum metabolomic, and paired stool-serum datasets from 35 LST patients and 35 healthy controls. LST-associated microbial taxa, serum metabolites, and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional features were organized into CES modules according to their biological direction and functional themes. Cross-layer Spearman's analyses, functional pathway analyses, and sign-aligned CES scores were used to assess coordination across microbial, functional, and metabolic layers. Publicly available MetaGenoPolis stool metagenomic data were used as a reference cohort for comparisons across healthy controls, adenoma, and colorectal cancer (CRC) disease sequences. LST patients showed a CES characterized by the depletion of protective anaerobe-associated taxa; enrichment of facultative/pathobiont-associated taxa; remodeling of dicarboxylate/TCA axis metabolism; alterations in amino acid and choline/glycerophospholipid metabolism; and enrichment of microbial functions related to carbohydrate uptake, central carbon metabolism, transport, and biofilm-associated adaptation. In paired stool-serum samples, four cross-layer associations were retained, including an exploratory inverse Roseburia-succinate relationship. In the MetaGenoPolis cohort, the matched microbial component of the CES showed a CRC-oriented pattern: CRC patients had higher microbial CES scores than healthy controls and adenoma patients, whereas the microbial CES scores of healthy controls and adenoma patients were not significantly different. Sign-aligned CES scores were higher in LST patients than in healthy controls across stool, serum, and paired multi-omics analyses; the paired integrated CES score showed a rank-biserial effect size of 0.952. A compact five-anchor CES representation, based on Roseburia depletion, succinate elevation, phosphotransferase system (PTS) elevation, 3-hydroxybutyric acid depletion, and Escherichia enrichment, preserved the main signal. LSTs are associated with a coordinated CES involving stool microbial, microbial functional, and serum metabolic alterations. These findings support the CES as a testable framework for understanding high-risk premalignant colorectal biology and warrant validation in larger cohorts with adenoma and serrated lesion comparators.

PMID 42638748
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PubMedDrug development research2026-08-25

Tricin Inhibits Human Osteosarcoma Cell Metastasis via Suppression of ZNF503 and the PI3K-PIP3-Akt Pathway.

Chou Chia-Hsuan CH, Yang Jia-Sin JS, Chen Pei-Ni PN, Hsieh Yi-Hsien YH et al.

Osteosarcoma is the most common primary malignant bone tumor and is associated with a high mortality rate due to its pronounced metastatic potential. Although tricin has been proposed as a chemosensitizer in various malignancies, its anti-metastatic effect in osteosarcoma remains poorly characterized. This study investigated whether tricin suppresses metastasis in human osteosarcoma cells and explored the underlying molecular mechanisms. Our results revealed that tricin significantly inhibited the migration and invasion of U2OS and Saos-2 osteosarcoma cells and downregulated ZNF503 expression at both the mRNA and protein levels. Similarly, siRNA-mediated knockdown of ZNF503 suppressed cell migration, as confirmed by immunofluorescence analysis. Tricin treatment also reduced phosphorylation of PI3K and Akt, without affecting the activation of ERK1/2, JNK1/2, or p38. Additionally, intracellular levels of PIP3 were diminished following tricin exposure. Notably, the Akt activator SC-79 significantly reversed tricin-induced suppression of both ZNF503 expression and cell migration in U2OS and Saos-2 cells. In conclusion, these findings suggest that ZNF503 inhibits osteosarcoma cell motility via the PI3K-PIP3-Akt signaling axis and that tricin exerts anti-metastatic effects by targeting this pathway. Tricin may therefore represent a promising therapeutic agent for inhibiting osteosarcoma metastasis.

PMID 42638601
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