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lamotrigine orally disintegrating tablet (lamotrigine ODT / lamictal ODT / EUR1048)

✓ Approved

Adare Pharma Solutions · SCN1A · Small Molecule

What is lamotrigine orally disintegrating tablet?

lamotrigine orally disintegrating tablet is a small molecule developed by Adare Pharma Solutions. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand Nameslamotrigine ODT, lamictal ODT, EUR1048
CompanyAdare Pharma Solutions
Drug ClassSmall Molecule
Molecular TargetSCN1A, SCN2A, SCN3A
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Adare Pharma Solutions

Mechanism of Action

Molecular Targets

lamotrigine orally disintegrating tablet acts on 3 molecular targets:

SCN1Asodium voltage-gated channel alpha subunit 1 (DEE6B, FEB3)
SCN2Asodium voltage-gated channel alpha subunit 2 (Na(v)1.2, BFNIS)
SCN3Asodium voltage-gated channel alpha subunit 3 (Nav1.3, NAC3)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

lamotrigine orally disintegrating tablet is developed for 4 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Nervous system disordersGeneralised tonic-clonic seizure✓ Approved
Nervous system disordersLennox-Gastaut syndrome✓ Approved
Psychiatric disordersBipolar disorder✓ Approved
Nervous system disordersPartial seizures✓ Approved

Related Research Articles

PubMedThe Journal of the Association of Physicians of India2026-10-22

An Epidemiological Study to Assess the Prevalence of Anemia and Its Determinants in Women of Reproductive Age Group (15-49 Years) in an Urban Slum of a Metropolitan City.

Deshmukh Kshitij Rajesh KR, Chavhan Smita Santosh SS, Tupe Sagar Dhondiram SD, Vakilna Roshni R et al.

Anemia is a serious public health concern among women of reproductive age (WRA) 15-49 years in India. The prevalence of anemia in WRA in Mumbai and the Mumbai suburban district was 45%-50%, respectively, as per National Family Health Survey-5 (NFHS-5) data. This study was done to assess the prevalence of anemia and its determinants in WRA in the urban slums of Mumbai. A total of 1,500 WRA were enrolled in this community-based cross-sectional study by the convenience sampling method. A structured validated questionnaire was used to record sociodemographic variables and determinants. Hemoglobin (Hb) estimation was done with a digital hemoglobinometer. SPSS v.18, Chi-square test, and binary logistic regression were used for analysis. The study was approved by the Institutional Ethics Committee of HBT Medical College and Dr. RN Cooper Hospital (Approval No. HBTMC/IEC/025-2025/RP/0/330/07072025/26) on 07/07/2025, and written informed consent was obtained from all participants. Prevalence of anemia in WRA was 57.9%. Significant associations were found between anemia and education level (p = 0.004), socioeconomic class (p < 0.001), gravida status (p < 0.001), spacing between pregnancies (p < 0.001), iron tablet consumption in the past 1 year (p = 0.014), duration of menses (p = 0.019), and pad changes per day (p = 0.013). Determinants such as education level, socioeconomic class, number of pregnancies, spacing between pregnancies, iron tablet consumption, duration of menses, and pad changes per day affect the Hb level of WRA.

PMID 42902642
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PubMedJournal of microbiology and biotechnology2026-10-22

Live and Heat-Killed Lactiplantibacillus plantarum HY7715 Attenuate D-Galactose-Induced Aging-Related Brain Changes and Blood-Brain Barrier Disruption with Gut Microbiota Modulation in Mice.

Baik Jimin J, Gwon Hyeonjun H, Kim Joo-Yun JY, Shim Jae-Jung JJ et al.

Aging is associated with changes in systemic homeostasis, intestinal barrier integrity, and brain function. This study investigated the effects of Lactiplantibacillus plantarum HY7715 on aging-related alterations in a D-galactose-induced accelerated aging mouse model. Male C57BL/6J mice were administered D-galactose for 8 weeks and orally treated with live or heat-killed HY7715. D-galactose increased circulating advanced glycation end products (AGEs), blood-brain barrier (BBB) permeability, hippocampal inflammation, and aging-related molecular changes, while impairing cortical and colonic tight junction-associated markers. Both live and heat-killed HY7715 reduced serum AGE levels, Evans blue leakage, and hippocampal inflammatory responses, while restoring CLDN5 immunoreactivity, tight junction-associated gene expression, and antioxidant-related gene expression. HY7715 also attenuated senescence- and apoptosis-related changes in the hippocampus and colonic tight junction- and inflammation-related gene expression changes. Gut microbiota analysis showed taxon-specific changes following HY7715 treatment, including significant increases in Bifidobacterium in both HY7715-treated groups, whereas live HY7715 was associated with significant changes in microbial community structure. Several microbial taxa were correlated with serum AGEs, BBB permeability, and neuroinflammation-related parameters. Together, these results show that both live and heat-killed HY7715 attenuated multiple aging-related changes in the D-galactose-induced accelerated aging model, accompanied by changes in gut microbiota composition.

PMID 42902892
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PubMedImmunologic research2026-10-21

Otorhinolaryngological manifestations of systemic autoimmune and autoinflammatory diseases: a comprehensive review.

Bayar Muluk Nuray N, Cingi Cemal C

In many autoimmune and autoinflammatory diseases, the head and neck are the first sites of symptom manifestation. Recognizing these early signs is crucial to prevent diagnostic delays and fatal consequences. This review addresses: (1) specific otorhinolaryngological (ENT) manifestations indicating systemic diseases (2), evidence for differentiating these from isolated ENT disorders, and (3) the multidisciplinary role in patient management. A comprehensive narrative literature review was conducted utilizing established scientific databases, including PubMed/Medline, Scopus, Web of Science, and Embase, covering articles published from 1983 up to 2026. A structured search strategy applied keywords like "systemic disorders," "ENT symptoms," "granulomatosis with polyangiitis," and "Sjögren syndrome." Peer-reviewed clinical trials, mechanistic studies, and authoritative guidelines were included to synthesize current evidence regarding the clinical detection and management of systemic diseases through ENT manifestations. ENT symptoms typically manifest locally before systemic organ involvement. Sensorineural hearing loss (SNHL) frequently accompanies autoinflammatory diseases. Auricular chondritis strongly indicates relapsing polychondritis (RP). Granulomatosis with Polyangiitis (GPA) and RP classically present with refractory rhinosinusitis, nasal crusting, and saddle-nose deformities. Orally, Sjögren syndrome causes severe sicca syndrome, while Behçet's disease leads to mucosal ulcerations. Furthermore, GPA (developing in 2-20% of cases) and RP are common causes of potentially fatal laryngeal involvement, including progressive subglottic stenosis. ENT manifestations frequently herald severe systemic diseases. Early detection by otolaryngologists is vital. Implementing a multidisciplinary strategy that integrates rheumatology and internal medicine ensures timely diagnosis, facilitates appropriate systemic immunosuppression, and significantly improves patient survival and overall quality of life.

PMID 42902115
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PubMedJournal of clinical monitoring and computing2026-10-20

A tablet-based augmented reality system to reduce preoperative anxiety in pediatric patients: a quasi-experimental pilot study.

Narisawa Ayuka A, Hayasaka Tatsuya T, Sato Kazunori K, Honda Yuka Y et al.

Preoperative anxiety in pediatric patients remains a significant clinical challenge, yet existing interventions are limited by resource requirements and inconsistent effectiveness. The aim of this pilot study was to evaluate the feasibility and preliminary effects of a tablet-based augmented reality (AR) system integrated into routine perioperative patient transfer on preoperative anxiety in pediatric patients. In this single-center, quasi-experimental pilot study, 27 pediatric patients aged 3-10 years were assigned to an AR (n = 13) or control (n = 14) group based on surgery month. The AR system, implemented on a standard tablet device, overlaid virtual characters onto real-world surroundings to guide patients from the surgical center entrance to the operating room. The primary outcome was preoperative anxiety assessed using the modified Yale Preoperative Anxiety Scale (mYPAS) at operating room entry. Secondary outcomes included guardian-rated comfort visual analog scale scores and postoperative agitation. The AR group was younger than the control group. Median mYPAS scores at operating room entry were lower in the AR group than in the control group (28.3 [23.3-36.7] vs. 40.0 [36.7-52.9]; median difference - 11.7; 95% CI, - 18.4 to - 1.60; p = 0.01). No significant differences were observed in secondary outcomes. This pilot study demonstrates the feasibility of integrating a tablet-based AR system into perioperative workflows. Preliminary findings also indicate that this approach may help reduce preoperative anxiety in this population. Given the pilot nature of the study, non-randomized allocation, and baseline imbalances between groups, validation in larger, well-controlled, randomized trials is required.

PMID 42900299
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PubMedSchizophrenia research. Cognition2026-10-20

Establishment of age- and sex-stratified normative data for the Brief Assessment of Cognition (BAC) app in healthy Japanese individuals.

Kubota Ryotaro R, Izumi Shoki S, Oba Mari S MS, Sanji Shohei S et al.

The Brief Assessment of Cognition in Schizophrenia (BACS) and its Japanese version are widely used instruments for the brief and efficient assessment of cognitive domains commonly impaired in schizophrenia. A tablet-administered version, the Brief Assessment of Cognition (BAC) App, has been developed; however, normative data for the BAC App have not yet been established for the general Japanese population. This cross-sectional study aimed to establish normative data for the Japanese version of the BAC App in healthy Japanese individuals. A total of 120 participants aged 12-69 years were recruited, with 10 male and 10 female participants in each of six age groups. Cognitive performance was assessed using BAC App subtests, and mean scores and standard deviations were calculated for each age- and sex-defined subgroup. Most subtests showed stable performance distributions across age groups. No notable differences between forms were observed for the Tower of London Task. In contrast, a substantial difference between forms was observed for the Verbal Memory Task, with higher recall performance for Form 3. Structural characteristics of the word lists may contribute to form-dependent differences; therefore, form-related effects should be considered when interpreting verbal memory performance. Overall, this study provides age- and sex-stratified normative data for the Japanese version of the BAC App, supporting its standardized use as a digital cognitive assessment tool.

PMID 42898053
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PubMedProceedings of the National Academy of Sciences of the United States of America2026-10-20

Gut microbiota vesicle reprogramming by Ganoderma lucidum polysaccharide alleviates mycoplasmal pneumonia via the gut-lung axis.

Zhang Zimu Z, Gong Hanfei H, Zhang Zhenzhen Z, Ying Ping P et al.

Respiratory infections remain a major global health challenge, further compounded by antibiotic resistance. Among these, mycoplasmal pneumonia represents a particularly prevalent and refractory form. Here, using targeted enzymatic fragmentation combined with multidimensional NMR analysis, we resolved the structure of a homogeneous Ganoderma lucidum polysaccharide, GLFP2, and identified β-(1→6)-linked galactosyl motifs as key structural features. Despite minimal systemic absorption, oral GLFP2 alleviated mycoplasmal pneumonia in mice. Instead, GLFP2 reshaped the gut microbiota and functionally reprogrammed gut microbiota-derived extracellular vesicles (GMEVs), whose transplantation alone was sufficient to confer pulmonary protection. Orally administered GMEVs remained bioactive, showed systemic exposure, associated with the lung, and were preferentially taken up by alveolar macrophages. These vesicles activated AMP-activated protein kinase (AMPK) signaling, suppressed the S100A8/A9 inflammatory axis, and limited neutrophil-driven immunopathology. Collectively, these findings identify microbiota-derived vesicles as effectors of gut-lung communication and use a defined polysaccharide to uncover a remote protective mechanism against pneumonia.

PMID 42900711
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