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colistin methanesulfonate sodium (GW402007A / Oldoreb / Aldreb)

✓ Approved

GSK · Small Molecule · Small Molecule

What is colistin methanesulfonate sodium?

colistin methanesulfonate sodium is a small molecule developed by GSK. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesGW402007A, Oldoreb, Aldreb
CompanyGSK
Drug ClassSmall Molecule
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, GSK

Therapeutic Indications

colistin methanesulfonate sodium is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsPneumonia pseudomonal✓ Approved

Related Research Articles

PubMedDanish medical journal2026-10-22

Early discrimination of preterm prelabour rupture of foetal membranes in nulliparous women.

Kirk Mille M, Koch Milos M MM, Nathan Nina O NO, Budtz-Jørgensen Esben E et al.

Biologic therapies for chronic rhinosinusitis with nasal polyps (CRSwNP) have been approved in Denmark since 2022. Chest X-ray (CXR) was implemented by the Global Airways Steering Group as pre-treatment screening to identify pulmonary conditions and monitor adverse effects. This study evaluates the utility of routine CXR screening before initiating biological therapy in patients with CRSwNP. Baseline data, including chest X-ray, were collected prospectively in the nationwide Global Airways Registry (approved by the Danish Research Ethics Committee R. no.: H-21020685) and analysed in May 2025. A total of 511 patients (335 males, 176 females; mean age 46.5 ± 14.6) years were identified and included in this study; 247 patients were initiated on biologic therapy. In the treatment group, 136 (55%) had normal CXRs, and 12 (5%) had abnormal findings. Among the 264 patients who did not receive biologic treatment, 143 (54%) had normal CXRs and ten (4%) demonstrated abnormal findings. Routine baseline CXR screening before biologic therapy in patients with CRSwNP identified few abnormal findings. Accordingly, routine CXR is likely to offer limited clinical benefit. The Global Airways database is funded by GlaxoSmithKline, Sanofi and Astra Zeneca. None of the pharmaceutical companies has access to data. Not relevant.

PMID 42902751
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PubMedThe Journal of the Association of Physicians of India2026-10-22

A Retrospective Study of Clinical, Microbiological, and Ulcer Severity Patterns of Diabetic Foot Presenting to a Tertiary Care Hospital.

Jafri Asif Dabeer AD, Dhar Srikant Kumar SK, Singh Muktesh M, Singh Ratender Kumar RK

Diabetic foot ulcers (DFUs) are a major complication of diabetes and are frequently associated with infection, antimicrobial resistance, and limb amputation. Regional Indian data on microbiological patterns and antimicrobial resistance remain limited. This retrospective observational study evaluated 40 patients with DFUs presenting to a tertiary care hospital over a 12-month period. Clinical and laboratory parameters, including glycated hemoglobin (HbA1c), C-reactive protein (CRP), total leukocyte count (TLC), and serum albumin, were analyzed. Ulcer severity was graded using the Wagner classification, and wound cultures with antibiotic susceptibility testing were performed. Most patients were male (70%) and aged 40-60 years. Mean HbA1c was significantly higher in male than in female patients (13.99 ± 1.40 vs 10.45 ± 1.41; p < 0.05). Monomicrobial infections predominated, with Gram-negative organisms accounting for 70.3% of isolates, followed by Gram-positive bacteria (22.2%) and fungi (7.4%). Polymicrobial infections occurred in 12.5% of cases. Gram-negative isolates showed universal sensitivity to colistin, whereas Acinetobacter spp. demonstrated high resistance to other antibiotics. Higher Wagner grades were significantly associated with elevated HbA1c and CRP levels. All amputations occurred in male patients with polymicrobial infections. Gram-negative pathogens predominated in DFUs in this setting, contrasting with the Gram-positive predominance reported in Western literature. Poor glycemic control and elevated inflammatory markers were associated with increasing ulcer severity and amputation risk.

PMID 42902668
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PubMedThe Journal of the Association of Physicians of India2026-10-22

Etiological Spectrum of Hyponatremia in Tuberculous Meningitis: Insights from Referral Institute in Northern India.

Singla Neeraj N, Nc Meiherishankar M, Sharma Kusum K, Modi Manish M et al.

Tuberculous meningitis (TBM) causes death or severe disability in 50% of afflicted patients. Among the various complications, such as hydrocephalus, hyponatremia, cranial nerve palsies, seizures, and myeloradiculopathy, hyponatremia occurs more frequently, affecting 35-65% of patients with central nervous system (CNS) tuberculosis. To study the prevalence of hyponatremia in patients with TBM and its correlation with the clinical profile, severity of illness, and outcome. In suspected TBM patients with low sodium levels, serum and urine osmolality were measured by an osmometer [Advanced Instruments, Inc. (2020)] to evaluate the possible causes. Patients underwent brain imaging to look for hydrocephalus, vasculitic infarcts, and basal exudates. They were followed up with serum sodium levels until the completion of treatment and repeat brain imaging during follow-up to assess radiological recovery. A total of 100 suspected TBM patients with a mean age of 32.6 years and predominantly female (57%) were included. The most common symptoms were fever, headache, altered sensorium, and seizures. The VI cranial nerve was most frequently involved. A total of 31% of patients presented in stage III, with a significant association with mortality (p = 0.002). Hyponatremia was seen in 57% of patients. The GeneXpert Ultra-based polymerase chain reaction (PCR) test for tuberculosis was positive in 41% of patients. Basal exudates (p = 0.001) and tuberculomas (p = 0.004) on brain imaging had a significant association with mortality. On follow-up, 41% of patients had improvement, 35% expired, and 10% had a static condition. Repeat sodium levels along with brain imaging were assessed (p = 0.001). There was a high prevalence of hyponatremia in TBM patients, as seen in 57% of patients, which occurred most frequently due to syndrome of inappropriate antidiuretic hormone secretion (SIADH), followed by cerebral salt-wasting syndrome (CSWS), and was related to the severity of TBM.

PMID 42902663
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PubMedDrug testing and analysis2026-10-22

Doping Control Analysis of Darbepoetin Alfa Biosimilars in Human Urine, Serum, Plasma, and Dried Blood Spots.

Akiyama Kentaro K, Sakurai Hikaru H, Sato Mitsuhiko M, Momobayashi Atsushi A et al.

Following the patent expiration of the originator darbepoetin alfa, three biosimilar products have been marketed in Japan; however, their detectability by current anti-doping methods has not yet been verified. The present study assessed whether these biosimilars can be detected in human urine, serum, plasma, and dried blood spots (DBS) using the established initial testing procedure and confirmation analysis for erythropoietin-receptor agonists. The originator product and three biosimilars (5 μg, i.v.) were administered to healthy male volunteers. Samples collected up to 72 h postdose were subjected to immunopurification followed by sodium N-lauroyl sarcosinate polyacrylamide-gel electrophoresis (SAR-PAGE) as the initial testing procedure. Confirmation was performed by SAR-PAGE with double blotting for serum and plasma. DBS and urine samples were confirmed by SAR-PAGE using an alternative antibody, and urine samples were further examined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). SAR-PAGE analysis of the pharmaceutical preparations revealed product-specific electrophoretic profiles: two biosimilars migrated slightly above one originator product as diffused smears, whereas the third produced a sharp band comparable to that of another originator product. Similar profiles were observed in postdose samples from all biological matrices, and all biosimilars remained detectable in urine, serum, plasma, and DBS for at least 72 h. Although some biosimilars showed distinct SAR-PAGE banding patterns, product attribution remained limited. LC-MS/MS confirmed administered darbepoetin alfa in the 24 h urine samples but did not detect analyte in lower concentration samples, indicating that its performance was concentration-dependent. Accordingly, SAR-PAGE should incorporate reference standards beyond the originator product, particularly those with different band morphologies.

PMID 42902912
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PubMedTherapeutic hypothermia and temperature management2026-10-21

Renin-Aldosterone Activation and Enhanced Urinary Potassium Excretion in Asphyxiated Newborns Treated with Therapeutic Hypothermia: A Prospective Study.

Baştuğ Osman O, İnan Bahadır B, Özdemir Ahmet A, Baştuğ Funda F et al.

Hypoxic-ischemic encephalopathy (HIE) is a critical neonatal condition for which therapeutic hypothermia (TH) remains the cornerstone of neuroprotective intervention. Clinical observations and prior studies note that electrolyte imbalances-particularly hyponatremia and hypokalemia-frequently emerge during TH. Therefore, this study explores how activation of the renin-angiotensin-aldosterone system (RAAS) may contribute to sodium (Na) and potassium (K) disturbances in asphyxiated neonates receiving TH. In this prospective study, 38 newborns with HIE treated with TH and 21 healthy term newborns were enrolled. Serum renin, aldosterone, Na, K, and urinary electrolyte levels were measured at 24, 48, and 72 hours postnatally. Receiver operating characteristic analyses assessed the diagnostic performance of renin and aldosterone. Renin and aldosterone levels were significantly elevated in the TH group compared with controls (p < 0.05). Serum sodium levels were consistently lower at all time points (p = 0.001), while potassium levels were significantly reduced at 24 and 72 hours (p < 0.05). Fractional excretion of sodium was increased at 24 hours, and potassium excretion remained elevated throughout the TH period (p < 0.05). Among the biomarkers, aldosterone demonstrated excellent diagnostic performance at 24 hours (AUC = 0.919). Activation of the RAAS is evident in asphyxiated neonates undergoing TH, with aldosterone playing a pivotal role in electrolyte disturbances. These results highlight the clinical importance of vigilant monitoring and timely correction of serum sodium and potassium levels during the hypothermia protocol.

PMID 42902593
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PubMedNature communications2026-10-21

High-risk antimicrobial resistance genomic traits in multidrug-resistant Salmonella across China's food chain: projections to 2050.

Baker Michelle M, Lu Xin X, Luo Chengchang C, Wu Ge G et al.

Antimicrobial resistance (AMR) is rising globally, yet factors shaping its genomic evolution remain poorly understood. We investigated how socioeconomic, climate, and health factors are associated with AMR spread in multi-drug resistant (MDR) Salmonella enterica across China's food chain, mapped hotspots and forecasted genomic trait prevalence to 2050. We analysed 2,536 MDR genomes from 15 provinces over 16 years, covering patients, food and non-food workers, meat, livestock, and environmental sources. A machine learning framework integrated genomic surveillance with risk assessment to identify high-risk AMR traits (clinically relevant, MDR, mobile). Regression models linked trait prevalence to socioeconomic, climate, health, and antimicrobial consumption data, informing projections to 2050. Eighty-four high-risk traits, including carbapenem, colistin, and β-lactam resistance, are projected to rise, with antibiotic use, population growth, healthcare spending, and urbanisation. Projections were trait-specific: blaCTX-M-64 and blaTEM-1 may increase up to 20%, while blaCTX-M-65 and blaCTX-M-14 remain below 5%. A mechanistic shift in fluoroquinolone resistance is projected: mutation-based resistance (gyrA 87) declines while plasmid-mediated genes (qnrB17, qnrS1) rise. Food workers emerged as a potential reservoir, showing higher trait prevalence than food sources, uniquely carrying last-resort antibiotic-resistance genes (blaTEM-30, blaNDM-5, blaCTX-M-64). Integrating genomic with socioeconomic surveillance could shift AMR interventions from reactive to preventive.

PMID 42901977
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