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TR

trospium chloride (Retardkapseln / Urivesc / Sanctura XR)

✓ Approved

Shire · Small Molecule · Small Molecule

What is trospium chloride?

trospium chloride is a small molecule developed by Shire. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesRetardkapseln, Urivesc, Sanctura XR
CompanyShire
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Shire

Therapeutic Indications

trospium chloride is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersHypertonic bladder✓ Approved

Related Research Articles

PubMedHeart (British Cardiac Society)2026-08-25

Prognostic and exploratory neurohormonal correlates of hypochloraemia in heart failure: a multicentre cohort study.

Inukai Kohei K, Takefuji Mikito M, Kazama Shingo S, Ito Ryota R et al.

Hypochloraemia has emerged as a prognostic marker in heart failure, although the mechanisms underlying chloride dysregulation remain incompletely understood. We evaluated the prognostic significance of serum chloride levels and explored clinical and biochemical correlates of hypochloraemia including circulating urocortin 2 (UCN2). This multicentre prospective cohort study included 3941 patients discharged after hospitalisation for acute or worsening heart failure with available serum chloride measurements. Patients were categorised according to discharge chloride levels as hypochloraemia, normochloraemia or hyperchloraemia. Associations between chloride status and 2-year outcomes were assessed using multivariable Cox proportional hazards and competing risk models. Exploratory analyses of circulating UCN2 concentrations were performed in a predefined subset of 499 patients. Hypochloraemia was independently associated with adverse outcomes after multivariable adjustment, including all-cause mortality (adjusted HR, 2.09; 95% CI 1.64 to 2.67; p<0.001), cardiovascular mortality (adjusted HR, 2.29; 95% CI 1.64 to 3.20; p<0.001), heart failure rehospitalisation (adjusted HR, 1.30; 95% CI 1.02 to 1.67; p=0.04) and the composite outcome (adjusted HR, 1.46; 95% CI 1.20 to 1.78; p<0.001). Competing risk analyses demonstrated that the excess mortality risk associated with hypochloraemia was predominantly cardiovascular. In models including both serum chloride and sodium, chloride remained independently associated with all-cause mortality whereas sodium did not. In exploratory analyses, circulating UCN2 concentrations showed a modest inverse association with serum chloride levels after adjustment for sodium, renal function, nutritional status and clinical severity (B=-0.37; 95% CI -0.72 to -0.02; p=0.04). Hypochloraemia identified patients with heart failure at substantially increased cardiovascular risk independent of established prognostic markers. Exploratory analyses suggested a potential association between circulating UCN2 and chloride homeostasis that warrants mechanistic investigation.

PMID 42638074
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PubMedNature communications2026-08-25

Near-unity near-infrared emission from Mo6 cluster doped hybrid halide glasses via halide-ligand and matrix engineering.

Feng Xuhui X, Cai Peiqing P, Lei Da D, Liu Keyuan K et al.

Efficient and air-stable near-infrared emitters are needed for compact optical systems, but translating highly emissive molecular triplet emitters into processable bulk solids remains challenging because aggregation, molecular motion and oxygen deactivate long-lived excited states. Here we show that a molecular hybrid halide glass can serve as a protective and regulating host for the triplet emission of molybdenum cluster. By comparing isostructural cluster salts with chloride, bromide and iodide terminal ligands, we establish how apical halide chemistry controls electronic structure and near-infrared radiative dynamics. The chloride-terminated cluster shows the highest efficiency among the molecular salts. When incorporated into a cadmium chloride-based molecular hybrid glass, the clusters become molecularly dispersed, while matrix-dictated halide redistribution and amorphous confinement suppress aggregation, vibrational deactivation and oxygen accessibility. The optimized glass achieves 96.95% internal quantum efficiency and 91.43% external quantum efficiency in air, enabling compact near-infrared illumination for imaging applications.

PMID 42637738
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PubMedNanoscale advances2026-08-25

Two-dimensional molybdenum disulfide nanoparticles intercalated between graphite layers: TEM observation and desulfurization behaviour.

San-Yoshi Koya K, Sasaki Takehiko T, Kubota Takeshi T, Sakaguchi Norihito N et al.

Two-dimensional molybdenum disulfide nanoparticles were formed in graphite interlayers by sulfurization and reduction-sulfurization treatments of a molybdenum chloride-intercalated graphite compound (MoCl5-GIC). When MoCl5-GIC was treated at 623 or 823 K under a flowing mixed gas of hydrogen sulfide and hydrogen, molybdenum disulfide nanosheets (MoS2-GIC(i)) with a thickness of 1-2 layers and lateral dimensions extending over several hundred nanometers were obtained. In contrast, when MoCl5-GIC was first reduced at 873 K under a hydrogen flow and subsequently sulfurized at 823 K under a mixed gas of hydrogen sulfide and hydrogen, molybdenum disulfide clusters (MoS2-GIC(ii)) with lateral dimensions of several tens of nanometers and consisting of 4-5 stacked layers were formed in the graphite interlayers. MoS2-GIC(i) and MoS2-GIC(ii) exhibited comparable catalytic activities for the hydrogenation of naphthalene; however, in the hydrodesulfurization of dibenzothiophene, MoS2-GIC(ii) showed higher desulfurization selectivity.

PMID 42639430
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PubMedCurrent microbiology2026-08-25

Wallemia orionensis sp. nov., a Xerophilic and Halotolerant Fungus Isolated from Air Environment.

Zhang Jingjing J, Bai Feirong F, Zhang Tianci T, Wu Tuhuan T et al.

A novel xerophilic fungus, Wallemia orionensis sp. nov., was isolated from air samples collected in a cake production environment and is described here based on a polyphasic approach, including molecular phylogenetics, morphology, and physiological traits. Phylogenetic analyses using concatenated ITS and SSU rDNA sequences revealed that the three strains form a distinct and well-supported clade within the genus Wallemia, clearly separated from all currently recognized species. Colonies of W. orionensis exhibit slow to moderate growth on media supplemented with high concentrations of glucose or sodium chloride, but fail to grow on media lacking such solutes, confirming its obligate xerophilic nature. The species demonstrates remarkable halotolerance and osmophily, growing optimally in media containing 50% glucose or 10-17% NaCl. Microscopic examination reveals that it exhibits the characteristic morphological features of the genus Wallemia, with arthroconidia formed by the fragmentation of hyphae, appearing as short cylindrical, barrel-shaped, or bluntly rounded structures. The isolation of W. orionensis from air samples in a cake production environment expands the known diversity of the genus Wallemia and contributes to a better understanding of fungal adaptation to high-solute, low-water-activity conditions.

PMID 42637874
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PubMedMicrosystems & nanoengineering2026-08-25

Portable microwave sensor system for real-time detection of microplastics in seawater.

Hou Yuxuan Y, Wang Qingzhou Q, Zhang Qilong Q, Liu Jiaxu J et al.

With the rapid development of the global plastic industry, microplastic pollution has become an increasingly serious environmental concern. However, standardized technologies for convenient, accurate, and real-time microplastic detection are limited. To address this challenge, a microwave resonant sensor with a complete microplastic detection system equipped with a Bluetooth module for remote real-time monitoring of microplastic concentrations was developed. Microplastic concentrations were measured in deionized water containing polyvinyl chloride powder (particle size: 6.5 ± 1 μm), simulated artificial seawater, and real seawater samples. The integration of the microfluidic system mitigated the interference caused by the complex seawater matrix, thereby ensuring stable and reliable microwave-based detection of microplastic concentrations. The system demonstrated high repeatability for predicting the concentration of microplastics in seawater samples. The proposed method demonstrated a recognition rate of over 96% with a tolerance of ±0.01 mg/mL, while maintaining a minimum detection limit of 48.72 ng/mL. To improve the prediction accuracy, a convolutional neural network algorithm was employed to predict microplastic concentrations based on the test results, with the predicted and actual concentrations being highly consistent. Finally, a compact and portable seawater microplastic monitoring system was developed by integrating the microwave sensor with Bluetooth and embedded systems, enabling real-time microplastic concentration monitoring in marine environments.

PMID 42637727
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PubMedBeilstein journal of organic chemistry2026-08-25

The surprising reaction of (chloro- and methanesulfonyloxy)(phenyl)methylphosphonates and -(phenyl)methylphosphine oxides with potassium diphenylphosphide followed by oxidation.

Szalai Zsuzsanna Z, Bednárik Janka J, Miskó András A, Takács Angéla A et al.

α-Hydroxyphosphonates and α-hydroxyphosphine oxides are important intermediates for additional biologically active species. While (hydroxy(phenyl)methyl)(diphenyl)phosphine oxide did not even undergo chlorination with thionyl chloride, the reaction of diethyl chloro(phenyl)methylphosphonate with potassium diphenylphosphide followed by oxidation with hydrogen peroxide resulted in the expected bis(>P(O)-functionalized) product only as a minor component. The similar reaction of the analogous (methanesulfonyloxy)(phenyl)methyl derivative afforded a mixture of a diethyl (diethoxyphosphonyl)(phenyl)methyl phosphate, a diethyl (diphenylphosphinyl)(phenyl)methyl phosphate, and a ((diphenylphosphinyl)(phenyl)methyl) diphenylphosphinate. The formation of the unexpected products was explained assuming rearrangements and reversible formation of the hydroxymethylene-bis(>P(O)-functionalized) intermediate. Contrary to the earlier experiences, the reaction of ((methanesulfonyloxy)(phenyl)methyl)(diaryl)phosphine oxides with potassium diphenylphosphide followed by oxidation took place in a clear-cut manner providing, with one exception, the corresponding α-phosphinylated α-hydroxyphosphine oxides that could also be synthesized by direct phosphinylation of the starting α-hydroxyphosphine oxide. Cell viability assays performed on U266 myeloma cells revealed concentration-dependent antiproliferative effects of the synthesized compounds on U266 myeloma cells, highlighting the key role of the phosphinoyloxy moiety in the cytotoxic activity, which may be enhanced further by 4-methyl groups in the P-phenyl rings.

PMID 42638896
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