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Tc 99m nofetumomab merpentan (Verluma)

✓ Approved

Poniard Pharmaceuticals · Small Molecule · Small Molecule

What is Tc 99m nofetumomab merpentan?

Tc 99m nofetumomab merpentan is a small molecule developed by Poniard Pharmaceuticals. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesVerluma
CompanyPoniard Pharmaceuticals
Drug ClassSmall Molecule, Imaging Agents
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Poniard Pharmaceuticals

Therapeutic Indications

Tc 99m nofetumomab merpentan is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Small cell lung cancer recurrent✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

Related Research Articles

PubMedPhysical chemistry chemical physics : PCCP2026-10-22

Dual-guest-metal control of stability and superconductivity in ambient-pressure B-C clathrates X0.5Y0.5B2C8.

Yang Yuting Y, Su Zhangmin Z, Chen Ruijie R, Guo Hongying H et al.

Phonon-mediated superconductivity in boron-carbon clathrates has become an active area of research, but how mixed guest-metal occupancy affects stability and superconductivity is still unclear. Using high-throughput first-principles calculations, we study quaternary X0.5Y0.5B2C8 clathrates (X, Y = Li, Na, K, Rb, Cs, Mg, Ca, Sr, and Ba) at ambient pressure. We identify 15 dynamically stable phases, all involving combinations of two large-radius guest metals. Fourteen of these phases are predicted to be superconducting: compounds with an average formal oxidation state at the metal sites of +1.5 and +1 show Tc of 34 to 42 K and 78 to 90 K, respectively, whereas the remaining +2 phase is semiconducting. The contrast in Tc fits a rigid-band picture in which lower guest formal oxidation states increase the B-C density of states at the Fermi level and enhance coupling to mid-frequency B-C phonons. Ab initio molecular dynamics at 300 K reveals no structural transformation, indicating that these dual-guest clathrates are viable candidates for further study.

PMID 42902693
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PubMedMaterials and structures2026-10-22

Durability of MgO-based binders: a critical review from RILEM TC 311-MBC.

Mundra Shishir S, Hallet Vincent V, Bernard Ellina E, Ilango Nirupama Kamala NK et al.

The urgent need to decarbonise the cement industry has motivated global research on MgO-based cements, including magnesium oxychloride (MOC), oxysulfate (MOS), carbonate (MC), and silicate (MS) cements. While this new class of cements may offer material advantages over Portland cement, questions surrounding their long-term durability continue to limit their broader implementation. This critical review, prepared for RILEM TC 311-MBC, evaluates the durability literature on these four types of MgO-based binders. Findings show that while MOC and MOS cements exhibit attractive early-age strength, they suffer rapid strength loss under sustained exposure to moisture because their main hydrates are highly soluble. Field test data is critically needed. MC binders, dominated by hydrous carbonate-bearing brucite, exhibit good resistance to chloride and sulfate environments; however, their strength decreases with increasing humidity, and accelerated carbonation can trigger expansion or micro-cracking, depending on the availability of pore spaces. Contrastingly, MS cements develop dense M-S-H matrices with permeability and frost performance on par with, or better than, PC-based concretes. This promising class of cements resists natural carbonation but remains sensitive to micro-crack formation when nesquehonite precipitates in high CO2 environments. Across all MgO-based binders, reinforcement corrosion is driven by moisture transport rather than by differences in passivation due to the near-neutral pH of their pore solutions. The research community is encouraged to close these gaps so to advance the formulation of durable and environmentally sustainable MgO-based cements.

PMID 42903152
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PubMedFrontiers in public health2026-10-22

Long-term exposure to ambient air pollution and lipid profiles: a longitudinal study in a heavily industrialized region of northern China.

Sun Caiyun C, Li Xiaofeng X, Miao Yuanjia Y, Shen Jiayu J et al.

Dyslipidemia is an important modifiable risk factor for cardiovascular disease, and growing evidence suggests that long-term ambient air pollution exposure may adversely affect lipid metabolism. However, longitudinal evidence from heavily industrialized regions with complex multipollutant exposure remains limited. We conducted a repeated-measures study of 9,040 adults with 19,113 lipid measurements from a health-screening program in Shanxi Province, China, between October 2019 and September 2023. Three-year average exposures to PM2.5, PM10, O3, SO2, NO2, and CO were estimated using the high-resolution ChinaHighAirPollutants (CHAP) dataset based on geocoded residential addresses. Linear mixed-effects models and generalized linear mixed-effects models were used to evaluate associations with lipid profiles and dyslipidemia, respectively. Restricted cubic spline, stratified, sensitivity, and quantile g-computation-style mixed-effects analyses were further conducted. Higher long-term exposure to PM2.5, PM10, O3, NO2, and SO2 was associated with higher triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels and lower high-density lipoprotein cholesterol (HDL-C) levels, whereas CO showed weaker associations. Among pollutants, PM2.5 showed relatively pronounced associations; each 10 μg/m3 increase was associated with 1.85, 1.70, and 1.81% increases in TG, TC, and LDL-C, respectively, and a 1.55% decrease in HDL-C. Similar patterns were observed for dyslipidemia. Stratified analyses suggested potential effect modification by sex, age, and BMI for selected pollutant-lipid associations, with the most robust interaction signals observed for age-stratified HDL-C associations after false discovery rate (FDR) correction. The associations remained consistent in sensitivity analyses. Restricted cubic spline analyses suggested nonlinear exposure-response relationships between PM2.5 and lipid parameters, while the quantile g-computation-style mixed-effects analysis indicated that multipollutant exposure was associated with adverse lipid profiles, with PM2.5 and O3 showing relatively large weights in the overall mixed-exposure association. Long-term ambient air pollution exposure was associated with adverse lipid profiles and may be related to higher odds of dyslipidemia among adults in a heavily industrialized region of northern China. These findings suggest that ambient air pollution may be an important environmental factor associated with lipid metabolism and highlight the need to consider long-term multipollutant exposure in cardiometabolic health research and prevention strategies.

PMID 42903168
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PubMedNature communications2026-10-21

Noncollinear kagome magnet driven by giant antisymmetric exchange.

Tam David W DW, Sibille Romain R, Mazet Thomas T, Roessli Bertrand B et al.

Kagome lattices host exotic phenomena such as quantum spin liquids, topological Weyl nodes, and flat bands. The kagome ferromagnet Co3Sn2S2 has been a focus of debate due to conflicting reports on its magnetic character. Here, using weakly perturbative probes-primarily neutron scattering and Mössbauer spectroscopy-we determine its ground state and magnetic Hamiltonian. The spin wave spectrum is reproduced by a simple Hamiltonian dominated by a large in-plane nearest-neighbor Heisenberg interaction J and an antisymmetric Dzyaloshinskii-Moriya interaction that is roughly one third of J. This Hamiltonian yields a canted, noncollinear ferromagnetic ground state with an umbrella-type structure, which our data show to be the true ground state at all temperatures below TC. Additionally, the spin susceptibility above TC exhibits a reduced critical exponent, akin to other spin-anisotropic systems. Our findings explain the unconventional magnetism in Co3Sn2S2, including the giant anomalous Hall effect and the origin of chiral phonons.

PMID 42901899
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PubMedBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026-10-21

Association between urinary heavy metal(loid)s exposure and dyslipidemia in children from e-waste dismantling areas.

Sun Rui R, Qu Shuhan S, Chen Jieting J, Kang Rongyi R et al.

To assess temporal trends of urinary heavy metal(loid)s burden and lipid levels, and explore the single and joint associations of heavy metal(loid)s exposure with lipid profiles among children in Guiyu, a typical e-waste dismantling area in China. Based on 2016 and 2024 surveys in Guiyu, 197 children (aged 3-7) were enrolled. Urinary concentrations of 13 heavy metal(loid)s were determined using inductively coupled plasma mass spectrometry (ICP-MS). Serum lipid parameters including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured, and non-high-density lipoprotein cholesterol (non-HDL-C) was calculated. To investigate the independent and combined associations between metals and blood lipid profiles, multiple linear regression and Bayesian kernel machine regression (BKMR) models were employed. Urinary concentrations of Chromium (Cr), Nickel (Ni), Copper (Cu), Cadmium (Cd), and Lead (Pb) in 2024 were significantly lower than those in 2016 (all P < 0.05). In adjusted models, Manganese (Mn), Cobalt (Co), Cd, and Pb were positively associated with TC and non-HDL-C, while Cd and Pb were negatively associated with HDL-C (all P < 0.05). BKMR confirmed a significant joint positive effect of a 12-metal mixture on TC and non-HDL-C, and a negative effect on HDL-C. Despite decreased individual metal levels over the eight-year interval, the biological risk from co‑exposure to these metals remains a critical concern These findings highlight the need for vigilance regarding the synergistic cardiovascular toxicity of heavy metals on pediatric lipid homeostasis.

PMID 42902073
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PubMedBMC cardiovascular disorders2026-10-21

The CML/esRAGE ratio as a potential biomarker of early diastolic impairment in asymptomatic type 1 diabetic patients without overt heart disease.

Wang Daiming D, Lin Jing J, Chen Shiyi S

Heart failure is a prevalent complication of diabetic microangiopathy, and early identification of myocardial dysfuntion is crucial. Advanced glycation end products (AGEs) bind to their receptor RAGE and further promote diabetic late complications as well as heart failure. Two soluble RAGE isoforms, endogenous secretory RAGE (esRAGE) and the cleaved extracellular fragment of membrane RAGE (collectively termed sRAGE), are believed to exert cardioprotective effects by acting as RAGE decoy receptors. This pilot study aimed to investigate the associations of AGEs, sRAGE and esRAGE with early cardiac dysfunction identified via advanced echocardiography. We enrolled 29 type 1 diabetic patients without known heart disease(EF ≥ 50%) and 31 healthy controls. Plasma levels of two major AGEs, carboxymethyllysine(CML) and methylglyoxal-derived hydroimidazolone 1(MG-H1), as well as sRAGE and esRAGE were measured using immunoassay. Conventional, tissue Doppler, and speckle-tracking echocardiography were performed. In the diabetic group, global longitudinal strain (GLS) and peak early diastolic velocity at the lateral mitral annulus [e(lat)] were significantly lower, while E/e(lat) was higher. CML levels and CML/esRAGE ratio were increased, and esRAGE was decreased in the diabetic group. Pearson correlation analysis showed GLS was significantly associated with disease duration, total cholesterol (TC), HbA1c, esRAGE, and CML/esRAGE ratio; Univariate linear regression confirmed that higher CML/esRAGE ratio was associated with lower e(lat) (β = -0.006, P = 0.047).Variables with P < 0.1 in univariate regression together with pre-specified clinical covariates including age, gender, HbA1c, disease duration, and heart rate were incorporated into stepwise multiple regression; the model demonstrated that CML/esRAGE was independently associated with e(lat) (β = -0.006, 95%CI: [-0.012, -0.001], P = 0.049). Elevated CML/esRAGE ratio is associated with impaired left ventricular diastolic function, and may represent a candidate biomarker for early diastolic dysfunction. Our study also suggest that CML/esRAGE ratio may not associated with GLS abnormalities reflecting subclinical systolic dysfunction. All observations from this pilot study require further validation in large independent prospective cohorts.

PMID 42902164
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