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Tc 99m nofetumomab merpentan (Verluma)

✓ Approved

Poniard Pharmaceuticals · Small Molecule · Small Molecule

What is Tc 99m nofetumomab merpentan?

Tc 99m nofetumomab merpentan is a small molecule developed by Poniard Pharmaceuticals. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesVerluma
CompanyPoniard Pharmaceuticals
Drug ClassSmall Molecule, Imaging Agents
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Poniard Pharmaceuticals

Therapeutic Indications

Tc 99m nofetumomab merpentan is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Small cell lung cancer recurrent✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

Related Research Articles

PubMedFood & function2026-08-25

Bidirectional fermentation of Tremella fuciformis and Acanthopanax trifoliatus alleviates lipid accumulation in LO2 cells.

Wu Yuxiao Y, Chen Sini S, Chen Yueqiu Y, Yu Qian Q et al.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder with limited intervention. This study developed a bidirectional fermentation system combining Tremella fuciformis and Acanthopanax trifoliatus (TF-AT) to enhance metabolite biotransformation and bioactivity. TF-AT showed stronger lipid-lowering effects than the unfermented controls in the free fatty acid (FFA)-induced human normal hepatocyte cell line (LO2 cells). Network pharmacology and targeted metabolomics were used to identify key phenolic metabolites and potential signaling pathways. The TF-AT fermentation product was fractionated into free phenolic fractions (TF-AT-1-TF-AT-6) and a crude polysaccharide fraction (TF-AT-PS). In vitro assays were performed in FFA-induced LO2 cells to assess lipid accumulation, cell viability, triglyceride (TG), total cholesterol (TC), and mRNA expression of MAPK pathway-related genes. Ten phenolic metabolites, including quercetin, myricetin, and luteolin, were identified, and the MAPK pathway was predicted as a potential signaling pathway associated with TF-AT activity. TF-AT, TF-AT-1, and TF-AT-PS significantly improved the cell viability, reduced lipid droplets, and lowered TG and TC levels in FFA-induced LO2 cells, suggesting that bidirectional fermentation contributed to enhanced bioactivity. qPCR analysis showed that these effects were accompanied by downregulation of JNK1, ASK1, p38, ELK-1, and p53 mRNA, indicating the possible involvement of MAPK/JNK/p38-related transcriptional responses. Overall, TF-AT attenuated FFA-induced lipid accumulation in LO2 cells and may serve as a promising fermented multi-component functional ingredient for hepatic steatosis-related intervention, although further protein-level and in vivo validation is required.

PMID 42640247
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PubMedIndian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine2026-08-25

Study of Subclinical Hypothyroidism and its Association with Lipid Profile Among the Rural Population of Chamarajanagara District-A Hospital-Based Study.

Sumanth B V BV, Thoyaj K J KJ, Shashank N N

Subclinical hypothyroidism (SCH) patients are at an increased risk of coronary artery disease and cerebrovascular disease complications. The association between SCH and dyslipidemia is still controversial. To study the prevalence of SCH in Chamarajanagara district and to find its association with lipid profile. A prospective cross-sectional study was carried out at Chamarajanagara Institute of Medical Sciences hospital, Chamarajanagar. Age group of more than 18 years and less than 75 years were included in the study. All patients serum samples were processed for thyroid function tests and lipid profile. A total of 496 rural subjects were enrolled. Among them, six had T4/T3 values above the normal levels and were excluded. Out of 490 subjects, 16.3% had thyroid-stimulating hormone (TSH) values more than 5 μIU/ml and were considered as the SCH group. The remaining 410 subjects, grouped as the euthyroid group (EUT). Median values of total cholesterol (TC) and triglycerides (TG) were increased and statistically significant in the SCH group compared with EUT group. There was no difference between the groups with respect to high-density lipoprotein and low-density lipoprotein. Dyslipidemia was common in the SCH group compared to the EUT group (P = 0.0308). In the SCH group, TG levels were elevated in 68.7% vs 29.7% in the EUT group (P < 0.0001) and TC levels were increased in 26.2% of subjects in the SCH group compared to 13.6% in the EUT group (P = 0.0046). SCH is an important endocrinological health problem in India. Dyslipidemia is more common in the SCH group and the consequences can be detrimental, leading to complications. Therefore, routine serum TSH estimation to detect SCH in clinical practice as a screening test is recommended.

PMID 42639636
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PubMedJACC. Case reports2026-08-25

Incidental Atrial Amyloid on Surgical Pathology Revealing Transthyretin Cardiac Amyloidosis.

Wright Jonathan J, Haroun Fadi F, Potter Adam A, Vallakati Ajay A et al.

Atrial amyloid is frequently encountered incidentally on surgical specimens and often attributed to isolated atrial amyloidosis. However, atrial amyloid may also represent early transthyretin amyloid (ATTR) cardiac amyloidosis (CA), a treatable condition. A 70-year-old man presented with worsening dyspnea, lower-extremity edema, and atrial fibrillation. He underwent coronary artery bypass grafting with MAZE procedure and left atrial appendage ligation. Pathology of the atrial appendage revealed Congo red-positive amyloid deposits. Mass spectrometry confirmed transthyretin-type amyloid. Transthyretin gene sequencing was negative, and technetium-99m pyrophosphate scintigraphy demonstrated significant cardiac uptake, confirming wild-type ATTR CA. He was treated with tafamidis and spironolactone, maintained sinus rhythm after cardioversion, and remained clinically stable at 1-year follow-up. This case highlights the diagnostic value of atrial tissue histopathology in detecting occult ATTR amyloidosis. Further, it emphasizes the importance of comprehensive evaluation and early initiation of disease-modifying therapy. Proper evaluation of atrial amyloid can alter management and improve patient outcomes. Atrial amyloid identified on surgical pathology should prompt comprehensive evaluation for CA. Atrial amyloid should not be assumed to represent isolated atrial amyloidosis, as it may provide an opportunity for early diagnosis and initiation of disease-modifying therapy.

PMID 42640236
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PubMedThe Eurasian journal of medicine2026-08-25

Predicting Failure of Conventional Imaging in Primary Hyperparathyroidism: The Impact of Parathyroid Hormone Levels and Thyroid Nodules.

Erdoğan Eroğlu Ceren C, Açık Şeyma Ş, Kalan Sarı Işılay I

Primary hyperparathyroidism (PHPT) is an endocrine disorder caused by excessive parathyroid hormone (PTH) secretion. Accurate localization remains essential for the clinical evaluation of patients; however, successful localization cannot be achieved in all patients. This study aimed to evaluate clinical and biochemical factors associated with unsuccessful localization using conventional imaging in patients with PHPT. This retrospective cross-sectional study analyzed data from 174 patients diagnosed with PHPT between January 1, 2015, and October 1, 2024. Localization was performed using technetium-99m MIBI scintigraphy and ultrasonography; fine-needle aspiration with PTH washout was used selectively. Patients were grouped as localized (n = 127) or non-localized (n = 47) according to conventional imaging findings. Demographic characteristics, biochemical parameters, imaging results, and clinical findings were compared. The localized group had significantly higher intact PTH (iPTH) levels (143.0 vs 115.0 pg/mL, P < .001) and serum calcium levels (11.6 vs 11.2 mg/dL, P = .004). The non-localized group had higher age (P = .012), higher 25-hydroxyvitamin D levels (21.8 vs 17.0 ng/mL, P = .024), and more frequent thyroid nodules (74.5% vs 54.3%, P = .016). In multivariable analysis, iPTH level (OR: 1.011, 95% CI:1.002-1.020, P = .021) and thyroid nodules (OR:0.391, 95% CI:0.174-0.879, P = .023) were identified as independently associated with localization success. Receiver operating characteristic (ROC) analysis showed moderate discriminative ability of iPTH cut-off: 146.5 pg/mL (area under the curve = 0.693, sensitivity = 45.7%, specificity = 87.2%). Higher serum iPTH levels were associated with successful localization, whereas the presence of thyroid nodules was associated with unsuccessful localization using conventional imaging. These findings may help identify patients who require more cautious interpretation of conventional imaging results and individualized consideration of additional imaging modalities. Cite this article as: Erdoğan Eroğlu C, Açık Ş, Kalan Sarı I. Predicting failure of conventional imaging in primary hyperparathyroidism: The impact of parathyroid hormone levels and thyroid nodules. Eurasian J Med. 2026, 58(4), 1492, doi: 10.5152/ eurasianjmed.2026.261492.

PMID 42639806
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PubMedPharmaceutical nanotechnology2026-08-25

Moringa Peregrina-derived Selenium Nanoparticles: Potent Inhibitor of Key Inflammatory Pathways in Aluminum-exposed Rats.

Mohei Eldeen Toka R TR, Hussein Mohammed A MA, Mostafa Nasser Y NY, Abdelsalam Sally M F SMF

Human exposure to aluminium, due to its high availability, can lead to nephrotoxicity. This exposure generates reactive oxygen species and triggers apoptosis, contributing to mitochondrial dysfunction and oxidative damage. Moringa peregrina, a plant valued for its traditional, nutritional, industrial, and medicinal properties, has been studied for its pharmacological benefits. Selenium nanoparticles synthesized using plant extracts have garnered attention for their potential medicinal importance. This study aims to investigate the nephroprotective effects of Moringa peregrinaselenium nanoparticles (MPE-SeNPs) on aluminium-induced renal injury. Dried powdered seeds of M. peregrina (100 g) were extracted in distilled water to evaluate total phenolics and flavonoids and prepare the targeted MPE-SeNPs. These nanoparticles were characterized using TEM, UV-Vis, and FTIR. The LD50 of MPE-SeNPs was estimated to prepare 1/50 and 1/20 LD50 doses for evaluating renal protective activity against renal fibrosis in rats. The phenolic and flavonoid content of Moringa peregrina was approximately 76.42 mg of GAE/g DE and 15.55 mg of QE/g DE, respectively. TEM analysis showed that the nanoparticles had a size of around 64.5 ± 5.5 nm with a zeta potential value of 28.57 mV. The UV-Vis profile of the nanoparticles showed two specific peaks at 268 and 277 nm. At the same time, FTIR spectral data revealed the presence of OH, CH-arom., CH-aliph., and C=O groups, characterizing phenolics and flavonoids. The LD50 of the nanoparticles was 773 mg/kg b.w. Oral administration of M. peregrina extract (150 mg) and MPE-SeNPs (15.46 and 38.65 mg/kg b.w.) daily for 7 days significantly improved blood selenium levels as well as plasma levels of urea, creatinine, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), and phospholipids, as well as renal malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione reductase (GR), interleukin-2 (IL-2), interleukin-4 (IL-4), and interleukin-10 (IL-10) in aluminium-intoxicated rats. Furthermore, M. peregrina and its selenium nanoparticles downregulated renal transforming growth factor-β1 (TGF-β1), inducible nitric oxide synthase (iNOS), and tumor necrosis factor-α (TNF-α) gene expression in aluminium-exposed rats. The antioxidant and anti-inflammatory activity in rats treated with MPE-SeNPs was more pronounced than in those treated with M. peregrina extract alone. Histopathological results indicated that MPE-SeNPs improved renal tissue by enhancing antioxidant enzymes and anti-inflammatory cytokines (IL-4 and IL-10), suppressing pro-inflammatory IL-2, and scavenging free radicals. The seeds of M. peregrina are rich in phenolic compounds, including flavonoids, glucosides, and glucosinolates. MPE-SeNPs show promise as a protective agent against aluminiuminduced renal injury, with their ability to mitigate oxidative stress, inflammation, and apoptosis underscoring their potential therapeutic value.

PMID 42638233
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PubMedUpdates in surgery2026-08-24

Subtotal colectomy with antiperistaltic caecorectal anastomosis versus total colectomy with ileorectal anastomosis for refractory slow-transit constipation: a comparative analysis.

Grossi Ugo U, Pecorino Alice A, Valiyeva Sayali S, Passuello Nicola N et al.

In selected cases of slow-transit constipation (STC), total colectomy with ileorectal anastomosis (TC-IRA) remains the standard surgical treatment but is associated with heterogeneous outcomes and relevant functional sequelae. Subtotal colectomy with caecorectal anastomosis (SCCRA) has been proposed as an alternative approach aiming to preserve the ileocaecal junction and improve postoperative bowel function. A prospective bicentre cohort of patients undergoing minimally invasive SCCRA for refractory STC was analysed and compared with a retrospective cohort of patients undergoing TC-IRA. Primary outcome was change in PAC-QOL score at 6 months. Secondary outcomes included PAC-SYM, St Mark's incontinence score, bowel movement frequency, and postoperative outcomes. Histopathological findings from colectomy specimens in the SCCRA cohort were also evaluated. Eleven patients underwent SCCRA and 21 underwent TC-IRA. In the SCCRA cohort, PAC-QOL and PAC-SYM scores significantly improved at 6 months (p < 0.001 and p = 0.004, respectively), with bowel movements increasing from a median of 1 to 7 per week (p = 0.003), without deterioration in continence. One anastomotic leak required reoperation. Compared with SCCRA, TC-IRA patients had higher baseline disease burden (PAC-QOL 3.88 vs. 2.00, p < 0.001) and greater absolute improvement in PAC-QOL (Δ3.28 vs. 1.54, p < 0.001). However, TC-IRA was associated with significantly higher postoperative bowel frequency (21 vs. 7/week, p = 0.002). Operative time and baseline characteristics were comparable. Histopathological evaluation of the SCCRA cohort revealed a heterogeneous spectrum of pathological alterations. Minimally invasive SCCRA provides significant functional improvement while maintaining a more physiological bowel frequency. However, direct comparison with TC-IRA is limited by differences in baseline disease burden and study design, and these findings should be confirmed in prospective comparative studies.

PMID 42635704
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