Drug Database
TJ

TJ-15 (OGT)

✓ Approved

Tsumura · therapeutic agent

What is TJ-15?

TJ-15 is a therapeutic agent developed by Tsumura. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesOGT
CompanyTsumura
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Tsumura

Therapeutic Indications

TJ-15 is developed for 5 unique indications across 5 therapeutic areas.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersEczema✓ Approved
Gastrointestinal disordersGastritis✓ Approved
Vascular disordersHypertension✓ Approved
Psychiatric disordersObsessive-compulsive disorder✓ Approved
Nervous system disordersCerebral cyst haemorrhage✓ Approved

Related Research Articles

PubMedPostgraduate medicine2026-10-15

Identification of perioperative risk factors for retrograde type A dissection after thoracic endovascular aortic repair for type B dissection.

Li Jiajun J, Zhang Yucong Y, Chen Xuegui X, Tan Xinyu X et al.

To identify risk factors and develop a predictive model for retrograde type A dissection (RTAD) following thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD). We analyzed TBAD patients who underwent TEVAR from 2014 to 2024 (IRB:No. TJ-IRB20230805). Patients developing RTAD within 1 year were matched with controls by age, sex, operation date, and location. Logistic regression identified risk factors, and a nomogram was constructed. Model performance was assessed using ROC curves. Of 2383 patients, 76 (3.19%) developed RTAD within one year. 65 RTAD cases and 195 matched controls were analyzed. RTAD patients had a greater horizontal distance of the ascending aorta (HDAA) than controls (53.34 mm vs. 43.05 mm, p < .001). Multivariate analysis identified younger age (OR = 0.95, p = .008), larger HDAA (OR = 1.14, p < .001), aortic root dilatation (OR = 2.85, p = .006), shorter stent length (OR = 0.99, p = .029), and absence of postoperative bradycardic drug use (OR = 0.31, p = .005) as independent RTAD risk factors. The model showed good discrimination (AUC = 0.85). Younger age, larger HDAA, aortic root dilatation, shorter stent length, and no bradycardic drugs postoperatively are independent predictors of RTAD after TEVAR. For TBAD patients with a high risk of RTAD, clinicians should consider the possibility of having connective tissue diseases, select stents appropriately, and optimize postoperative treatment with strict follow-up.

PMID 42876259
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PubMedVeterinary and animal science2026-10-15

Effects of early dietary inclusion of untreated or extruded Chlorella vulgaris, with pancreatin supplementation of the extruded biomass, on broiler performance and meat quality.

Mendes Ana R AR, Carvalho Daniela F P DFP, Spínola Maria P MP, Madacussengua Obete O et al.

This study evaluated the effects of early dietary inclusion of Chlorella vulgaris, either untreated or extruded and with or without pancreatin supplementation, on growth performance, carcass traits, gastrointestinal responses, and meat quality in broilers. A total of 120 male Ross 308 broilers were assigned from day 7 to day 35 of age to one of four dietary treatments (10 pens per treatment, 3 birds per pen): a maize-soybean meal control diet (CTR), a diet containing 15% C. vulgaris (CV), a diet containing 15% extruded C. vulgaris (CVEX), and the CVEX diet supplemented with 0.30% pancreatin (CVEXEN). Final body weights, overall feed conversion ratios, and digesta viscosity were not affected by dietary treatment. Average feed intake was lower in birds fed CV than in those fed CVEXEN, whereas all microalgae-based diets increased carcass yields relative to the control. Visual assessment indicated higher beak feed adhesion and poorer excreta consistency in birds fed microalgae-containing diets. Concerning meat quality, microalgae inclusion increased breast meat yellowness and markedly improved oxidative stability. In addition, the fatty acid profile of breast and thigh meat was modified, particularly by reducing the n-6/n-3 ratio. Overall, C. vulgaris, even without pre-treatment, can be included at 15% in broiler diets from 7 days of age without impairing overall growth performance, while improving carcass yield and selected meat quality traits. However, the effects on external condition indicators and meat colour warrant further evaluation under practical production conditions.

PMID 42876629
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PubMedBMC musculoskeletal disorders2026-10-15

Factors associated with 1-year health-related quality of life after neck-specific exercise in chronic whiplash-associated disorders: an exploratory secondary analysis of a randomized controlled trial.

Peolsson Anneli A, Ljunggren Stefan S, Peterson Gunnel G

Factors associated with changes in health-related quality of life (HRQoL) outcomes in neck disorders have not been investigated after internet-based support for exercise. The purpose of the study was to investigate baseline and short-term outcome factors associated with changes in HRQoL (EQ-5D-3L and EQ-VAS) at 3 and 15 months, respectively, after a neck-specific exercise programme (NSE) for individuals with chronic whiplash-associated disorders grades 2 and 3. This was a secondary analysis of a prospective randomized controlled multi-centre trial with concealed allocation. Participants (n = 140) were randomized to NSE at a physiotherapy clinic or internet-based NSE with four physiotherapy visits (NSEIT). Assessor-blinded investigators obtained measurements at baseline and at 3- and 15-month follow-up. Orthogonal partial least square (OPLS) and OPLS discriminant statistical analyses (OPLS-DA) were used. There were no significant differences between the exercise programmes. Improvement in psychosocial measures, pain, disability and several objective measures were associated with improvements in HRQoL in OPLS models (R2 = 0.20 to 0.27, Q2 = 0.06 to 0.12, p < 0.05 to < 0.001). Higher baseline score on adverse psychosocial measures and disability, together with lower dizziness, self-efficacy, and neck-muscle endurance in extension, were associated with clinically relevant improvement in EQ-5D-3L at 15-month follow-up (R2 = 0.26, Q2 = 0.13, p < 0.01). The other models were non-significant. Several factors, including adverse psychosocial measures, may be clinically relevant for HRQoL after neck-specific exercise interventions. Given the models' weak predictive ability, the findings should be regarded as exploratory and hypothesis-generating. The study was registered before data collection started, ClinicalTrials.gov Protocol ID: NCT03022812, initial release 12/20/2016. The study was approved by the regional ethical review board in Linköping, Sweden (Dnr 2016/135-31; 2016/526-32; 2017/45-32).

PMID 42875773
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PubMedFrontiers in medicine2026-10-15

A preliminary study on the assessment of bone age in children and adolescents in frigid-zone regions by the CHN-05 method.

Qi Yue Y, Li Xinyi X, Lv Dongmei D, Zhang Xiaoyue X et al.

Bone age assessment is a key tool for monitoring growth and development in children and adolescents. This study analyzes bone age development characteristics among children and adolescents aged 6-18 years, to provide reference data for improving regional bone age standards. Bone age data were retrospectively collected and assessed using the CHN-05 method. The correlation and differences between bone age and chronological age were analyzed, developmental patterns were compared by gender, and regression equations were established. The CHN-05 method showed a strong correlation between bone age and chronological age (R = 0.952, p < 0.001). A higher proportion of females had advanced bone age compared to males, whereas a higher proportion of males had delayed bone age. In males, mean bone age was slightly lower than chronological age before age 14 and slightly higher after 14, with significant differences at ages 7, 8, and 12 (p < 0.05). In females, mean bone age was slightly higher before age 15 and slightly lower after 15, No statistically significant differences were observed among individual age strata. (p > 0.05). Gender-specific linear regression equations were established: males: y = 0.886x + 1.445 (R = 0.96, p < 0.001); females: y = 0.893x + 1.082 (R = 0.95, p < 0.001). The CHN-05 method is reasonably suitable for bone age assessment in children and adolescents and provides valuable reference data for refining regional bone age standards.

PMID 42876737
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PubMedWellcome open research2026-10-15

The genome sequence of the Yellow Meadow Ant, Lasius flavus (Fabricius, 1782) (Hymenoptera: Formicidae).

Broad Gavin R GR, Natural History Museum Genome Acquisition Lab, Darwin Tree of Life Barcoding Collective, Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team et al.

We present a genome assembly from an individual female Lasius flavus (Yellow Meadow Ant; Arthropoda; Insecta; Hymenoptera; Formicidae). The assembly contains two haplotypes with total lengths of 314.61 megabases and 325.88 megabases. Most of haplotype 1 (95.46%) and haplotype 2 (92.16%) are each scaffolded into 15 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 21.36 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces genomes for eukaryotic species found in Britain and Ireland.

PMID 42876508
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PubMedFrontiers in chemistry2026-10-15

Development of alkyd-based copper sorbate coatings for anti-corrosion and anti-biofouling applications.

Thiyagarajan Manikandan M, Angaiah Subramania S, Yan Chao C, Punniyakotti Parthipan P

Biofouling is a serious problem in various industrial sectors such as shipping infrastructure, cooling water systems, and aquaculture. Biofilm formation by different types of microorganisms plays a very crucial role in this biofouling process. Biofouling on metallic surfaces accelerates aggressive corrosion processes. Therefore, it is essential to develop antifouling coatings with corrosion resistance for effective protection. In the present study, copper sorbate (CS) and copper oxide (CuO) were synthesized as antifouling pigments and characterized using a UV-vis spectrometer, Fourier transform infrared spectroscopy, X-ray diffraction, and field emission scanning electron microscopy. Both pigments in different ratios were used for the formulation of antifouling and anti-corrosion paints. Salt spray test and anti-corrosion test were performed in the presence of 3.5% NaCl solution for 30 days. Electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization were recorded for all the tested specimens. The results indicate that CS-rich coatings (15%20% of CS) display higher corrosion resistance than CuO-rich coatings. The antifouling potential of the coated mild steel was evaluated by immersing them in the marine estuarine water, and surface changes were monitored at regular intervals. All coatings exhibited considerable antifouling effects up to 60 days of immersion. Notably, the CS-II coating, containing only 5% CuO with 15% of CS, showed significant fouling resistance up to 90 days. At the end of 120 days, SEM analysis confirmed that a huge number of marine microorganisms (mostly diatoms) settled on CS-I, CS-III, CS-IV, and CS-V, but minimal microorganisms were only noticed on CS-II. This could be due to the antimicrobial activity and controlled leaching behavior of both pigments in marine conditions.

PMID 42876747
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