Drug Database
TJ

TJ-15 (OGT)

✓ Approved

Tsumura · therapeutic agent

What is TJ-15?

TJ-15 is a therapeutic agent developed by Tsumura. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesOGT
CompanyTsumura
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Tsumura

Therapeutic Indications

TJ-15 is developed for 5 unique indications across 5 therapeutic areas.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersEczema✓ Approved
Gastrointestinal disordersGastritis✓ Approved
Vascular disordersHypertension✓ Approved
Psychiatric disordersObsessive-compulsive disorder✓ Approved
Nervous system disordersCerebral cyst haemorrhage✓ Approved

Related Research Articles

PubMedAddiction (Abingdon, England)2026-10-22

Nicotine pouch use characteristics, self-perceived addiction and regret among Danish youth.

Arp Stine S, Pisinger Charlotta C, Lund Lisbeth L, Bast Lotus Sofie LS

Use of nicotine pouches is increasing among youth worldwide. A subsequent increase in the prevalence of youth becoming addicted is therefore expected. We sought to estimate current prevalences of self-perceived addiction and regret, as well as the association between nicotine pouch characteristics and self-perceived addiction. As regretting ever starting to use nicotine pouches may reflect motivation to quit, we additionally aimed to estimate the association between self-perceived addiction and regret. Cross-sectional national population-based survey (§SMOKE). The invited population (n = 37 500) was selected randomly through the Danish national Civil Register, and 9801 responded (26.3%). Analyses were weighted for non-response according by age and sex. Denmark (2025). Danish 15-29-year-olds with a current daily or occasional use of nicotine pouches (n = 1201). Primary outcomes were reporting being very addicted compared to not or somewhat addicted, and regret of nicotine pouch initiation was defined as not wanting to start using nicotine pouches, if having the chance to do it over again. Outcomes were self-reported. A total of 14.0% [95% confidence interval (CI): 13.3%; 14.7%] of Danish youth aged 15-29 years use nicotine pouches either daily or occasionally. Among these, approximately 82.2% reported self-perceived addiction (36.4% [95% CI: 33.6%; 39.3%] somewhat addicted and 44.8% [95% CI: 41.9%; 47.8%] very addicted), while 79.0% [95% CI: 76.1%; 81.6%] reported regretting nicotine pouch initiation. Adjusting for age, sex and education, daily use (adjusted odds ratio (aOR): 40.68 [18.41;89.88]), more than one year since initiation (2-4 years, aOR: 2.79 [1.88;4.16]; 5-9 years, aOR: 3.68 [2.36;5,72]; 10 years or more, aOR: 3.02 [1.45;6.31]), using menthol and mint flavors (aOR: 1.59 [1.18;2.15], nicotine strength of 5 or more mg (5-9 mg, aOR: 1.93 [1.32;2.83]; 10-14 mg: aOR 2.45 [1.70;3.54]; 15 mg or more, aOR: 1.80 [1.13;2.85]) and using for more than 15 minutes (15-30 minutes, aOR: 1.66 [1.24;2.23] and 30 minutes or more, aOR: 1.69 [1.10;2.58]) were associated with reporting being very addicted to nicotine pouches. Further, being very addicted was positively associated with regretting initiation (aOR: 1.97, 95%CI [1.17;3.31]). The prevalence of self-perceived addiction to nicotine pouches and regret with starting to use them appears to be high among Danish youth. Several nicotine pouch use characteristics appear to be positively associated with reporting being very addicted, which were further associated with regret.

PMID 42902826
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PubMedFrontiers in neurology2026-10-22

Development of the LARyNGTH score to predict central neurogenic respiratory failure in lateral medullary infarction.

Kim Yoon Sub YS, Park So Young SY, Park Ji Hyun JH, Park Bumhee B et al.

Central neurogenic respiratory failure (CNRF) is a fatal complication associated with lateral medullary infarcts (LMI). Its detection may be critical for timely intervention and to reduce the risk of mortality. This study aimed to identify the clinical predictors of CNRF in patients with LMI. This study included patients with LMI who were admitted to a university hospital between 2010 and 2022. CNRF was defined as unexpected intubations due to hypercapnia, cardiopulmonary resuscitation owing to respiratory causes, or clinical detection of CNRF. Clinical, neurological, and imaging data were also collected. Univariable and multivariable analyses were performed to identify the clinical predictors of respiratory complications. Among the 214 patients, 12 (5.6%) developed CNRF. Hypertension (91.7% vs. 55.9%, p = 0.033) and diabetes mellitus (58.3% vs. 26.2%, p = 0.04) were more common in the CNRF group. Patients with CNRF exhibited higher National Institutes of Health Stroke Scale (NIHSS) scores (6.0 [4.25-7.0] vs. 2.0 [1.0-4.0], p < 0.001) and lower modified Gugging Swallowing Screen (GUSS) test scores (9.0 [3.5-13.75] vs. 15 [13-15], p = 0.014). Imaging showed a higher rate of large rostral infarcts (83.3% vs. 9.4%, p < 0.001) and combined extramedullary lesions (50.0% vs. 13.4%, p < 0.001). Multivariable analysis identified the LARyNGTH score, which included the above variables. A score >5.5 predicted CNRF with an AUROC of 0.968 (95% CI: 0.940-0.996), a sensitivity of 91.7%, a specificity of 94.6%, and an accuracy of 94.4%. In patients with LMI, a combined predictive model can predict CNRF and facilitate preemptive intervention.

PMID 42903130
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PubMedThe Journal of the Association of Physicians of India2026-10-22

An Epidemiological Study to Assess the Prevalence of Anemia and Its Determinants in Women of Reproductive Age Group (15-49 Years) in an Urban Slum of a Metropolitan City.

Deshmukh Kshitij Rajesh KR, Chavhan Smita Santosh SS, Tupe Sagar Dhondiram SD, Vakilna Roshni R et al.

Anemia is a serious public health concern among women of reproductive age (WRA) 15-49 years in India. The prevalence of anemia in WRA in Mumbai and the Mumbai suburban district was 45%-50%, respectively, as per National Family Health Survey-5 (NFHS-5) data. This study was done to assess the prevalence of anemia and its determinants in WRA in the urban slums of Mumbai. A total of 1,500 WRA were enrolled in this community-based cross-sectional study by the convenience sampling method. A structured validated questionnaire was used to record sociodemographic variables and determinants. Hemoglobin (Hb) estimation was done with a digital hemoglobinometer. SPSS v.18, Chi-square test, and binary logistic regression were used for analysis. The study was approved by the Institutional Ethics Committee of HBT Medical College and Dr. RN Cooper Hospital (Approval No. HBTMC/IEC/025-2025/RP/0/330/07072025/26) on 07/07/2025, and written informed consent was obtained from all participants. Prevalence of anemia in WRA was 57.9%. Significant associations were found between anemia and education level (p = 0.004), socioeconomic class (p < 0.001), gravida status (p < 0.001), spacing between pregnancies (p < 0.001), iron tablet consumption in the past 1 year (p = 0.014), duration of menses (p = 0.019), and pad changes per day (p = 0.013). Determinants such as education level, socioeconomic class, number of pregnancies, spacing between pregnancies, iron tablet consumption, duration of menses, and pad changes per day affect the Hb level of WRA.

PMID 42902642
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PubMedEmergency medicine Australasia : EMA2026-10-22

Trainee Access to Major Procedures in an Academic Emergency Department: Are We Doing Enough?

Jones Christopher L CL, Rienks Sylvia S, Verbossche Femke F

The Australasian College for Emergency Medicine requires trainee competency in many procedures; however, real-world practicalities may not align with expectations. The objective of this study was to record the number of procedures performed by trainees in an academic emergency department (ED). Any gaps identified in exposure to procedures could help guide alternative forms of training. A prospective observational study was conducted in a tertiary ED in Perth, Western Australia, between 1 February 2024 and 31 January 2025. Data were collected on 14 procedures via self-reporting using a QR code linked to a Microsoft form. Procedure numbers, median per trainee, and range of procedures are reported. Full-time versus part-time rates were compared. Six-monthly sub-analyses were performed to account for changes in personnel mid-year. Of 1413 procedures, 771 (54.6%) were performed by trainees. The median number performed was 10.5 (IQR = 6-23). There was no significant difference between those working full-time versus part-time (median = 15, IQR = 9-23 vs. median = 8, IQR = 4-16; p = 0.11). There was no significant difference between the two 6-month periods (median = 8.5, IQR = 4.3-13.8 vs. median = 9, IQR = 5.75-15, p = 0.51). Procedures commonly performed were sedation (207/405, 51.1%), intubation (121/193, 62.7%) and arterial lines (90/150, 60%). Access to procedures is limited. Alternative forms of training should be incorporated into education programmes. A lack of exposure has wider implications for assessing competency in emergency medicine and should be considered in any future curriculum update.

PMID 42902873
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-22

Elastic Graphene-Shell Architectures Enable Stress Regulation in High-Capacity Lithium-Ion Battery Electrodes.

Li Luwen L, Shi Qitao Q, Wang Zhipeng Z, Zhang Cheng C et al.

Silicon-based anodes are limited by large volume changes, stress accumulation, and sluggish kinetics during cycling. Porous electrode designs can alleviate these problems, but conventional approaches often rely on multistep processing or sacrificial pore formers. Here, hollow graphene-shell (GS) spheres are introduced as slurry-compatible pore-engineering additives. In a 5-60-5 MPa pressure cycle, the SiOx/GS electrode shows greater thickness recovery than pristine SiOx, with thickness-recovery indices of 4.18 and 1.24 percentage points, respectively. Individual GS particles show a largely recoverable response within the small-displacement range probed by atomic force microscopy (AFM), with an apparent modulus of approximately 114 MPa. Upon full lithiation, the through-plane thickness of the SiOx/GS electrode increases by 15%, compared with 94% for pristine SiOx. The SiOx/GS electrode also retains approximately 702 mAh g-1 after 400 cycles at 1.6 A g-1. GS improves the performance of the tested SiOx/graphite, Si@C, and LiNi0.8Co0.1Mn0.1O2(NCM811) formulations as well. These results demonstrate a simple, slurry-compatible strategy for accommodating electrode deformation while maintaining electrochemical performance.

PMID 42902913
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PubMedPhysical chemistry chemical physics : PCCP2026-10-22

Dual-guest-metal control of stability and superconductivity in ambient-pressure B-C clathrates X0.5Y0.5B2C8.

Yang Yuting Y, Su Zhangmin Z, Chen Ruijie R, Guo Hongying H et al.

Phonon-mediated superconductivity in boron-carbon clathrates has become an active area of research, but how mixed guest-metal occupancy affects stability and superconductivity is still unclear. Using high-throughput first-principles calculations, we study quaternary X0.5Y0.5B2C8 clathrates (X, Y = Li, Na, K, Rb, Cs, Mg, Ca, Sr, and Ba) at ambient pressure. We identify 15 dynamically stable phases, all involving combinations of two large-radius guest metals. Fourteen of these phases are predicted to be superconducting: compounds with an average formal oxidation state at the metal sites of +1.5 and +1 show Tc of 34 to 42 K and 78 to 90 K, respectively, whereas the remaining +2 phase is semiconducting. The contrast in Tc fits a rigid-band picture in which lower guest formal oxidation states increase the B-C density of states at the Fermi level and enhance coupling to mid-frequency B-C phonons. Ab initio molecular dynamics at 300 K reveals no structural transformation, indicating that these dual-guest clathrates are viable candidates for further study.

PMID 42902693
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