Drug Database
AC

acetylsalicylic acid + dipyridamole (Asasantin / Asasantin Retard / Asasantine LP)

✓ Approved

Boehringer Ingelheim International GmbH · PTGS1 · Small Molecule

What is acetylsalicylic acid + dipyridamole?

acetylsalicylic acid + dipyridamole is a small molecule developed by Boehringer Ingelheim International GmbH. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesAsasantin, Asasantin Retard, Asasantine LP
CompanyBoehringer Ingelheim International GmbH
Drug ClassSmall Molecule
Molecular TargetPTGS1
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Boehringer Ingelheim International GmbH

Mechanism of Action

Molecular Targets

acetylsalicylic acid + dipyridamole acts on 1 molecular target:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

acetylsalicylic acid + dipyridamole is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Nervous system disordersDelayed ischaemic neurological deficit✓ Approved
Infections and infestationsCOVID-19Phase III

Related Research Articles

PubMedZhonghua nan ke xue = National journal of andrology2026-11-12

[Chlorogenic acid combined with vitamin D inhibits tumor growth in castration-resistant prostate cancer mice by regulating the STAT3/PPARγ pathway].

Wang Chenghao C, Wang Xing X, Feng Rui R

Objective Based on the signal transducers and activator of transcription 3 (STAT3)/peroxisome proliferator-activated receptor γ(PPARγ) pathway, the inhibitory effect of chlorogenic acid combined with vitamin D on tumor growth in castration-resistant prostate cancer mice was investigated. MethodsCastration-resistant prostate cancer mice were constructed by axillary injection of 0.1 mL of 1×107 cells /mL PC-3 cell suspension. Subsequently, 28 castration-resistant prostate cancer mice were randomly divided into the control group, chlorogenic acid group, vitamin D group and chlorogenic acid + vitamin D group, with 7 mice in each group. Tumor quality was measured in each group of mice. TUNEL staining was used to detect apoptosis of tumor tissue cells. Immunohistochemistry was used to detect the expression of Ki67 protein in tumor tissue. The fatty acid uptake in tumor tissue was detected by kit. RT-qPCR was used to detect the expression of fatty acid uptake-related proteins leukocyte differentiation antigen 36 (CD36) and fatty acid binding protein 4 (FABP4) mRNA in tumor tissues. Western blot was used to detect the expression of CD36, FABP4, p-STAT3/STAT3, PPARγ and nerve growth factor inducible gene B (Nur77) protein in tumor tissue. ResultsThe tumor mass, fatty acid uptake capacity, and expression levels of Ki67, CD36, FABP4, p-STAT3/STAT3, and PPARγ in mice of the chlorogenic acid group, vitamin D group, and chlorogenic acid + vitamin D group were significantly lower than those of the control group (P<0.05), while the tumor tissue cell apoptosis rate and Nur77 expression levels were significantly higher than those of the control group (P< 0.05). In the chlorogenic acid + vitamin D group, the tumor mass, fatty acid uptake cpacity, and expression levels of Ki67, CD36, FABP4, p-STAT3/STAT3, and PPARγ were significantly lower than those in the chlorogenic acid group and vitamin D group (P< 0.05), while the tumor tissue cell apoptosis rate and Nur77 expression levels were significantly higher than those in the chlorogenic acid group and vitamin D group (P< 0.05).Conclusion Chlorogenic acid combined with vitamin D inhibits the proliferation and promotes apoptosis of androgen receptor -independent castration-resistant prostate cancer mice by inhibiting tumor fatty acid uptake in tumors, and the mechanism may be related to the inhibition of STAT3/PPARγ signaling pathway and activation of Nur77 signaling molecule.

PMID 43017712
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PubMedAnnals of medicine and surgery (2012)2026-11-12

Severe upper gastrointestinal corrosive injury following intentional muriatic acid (HCl) ingestion: a case report.

Acharya Bimarsh B, Yadhav Aryan Kumar AK, Tamrakar Kritika K, Kharel Kushal K et al.

Corrosive poisonings usually occur from accidental or intentional ingestion of acidic solutions, with hydrochloric acid (HCl) being the most commonly misused acid. A case study from a teaching hospital in Spain reported on 21 patients who developed massive necrosis of the upper gastrointestinal tract following acid ingestion over a 14-year period. Although HCl ingestion resulting in death is rare, the morbidity associated with survival is significant. A 22-year-old female presented with a history of intentional ingestion of approximately 375 mL of Harpic (containing 10% hydrochloric acid) following a domestic quarrel. She presented with hematemesis, nausea, and severe burning epigastric pain radiating to the chest. Endoscopy revealed extensive necrotic mucosa and ulceration consistent with Zargar Grade IIIA corrosive injury. Laboratory findings showed neutrophilic leukocytosis (white blood cell count: 22 950 cells/mm3). Severe upper gastrointestinal injury from hydrochloric acid ingestion can lead to life-threatening complications, including Zargar Grade IIIA damage. Early endoscopic evaluation within 12-24 hours aids diagnosis and guides management. Supportive therapy, endoscopic dilation for stricture, and long-term surveillance are essential to prevent and monitor late complications such as stricture formation and malignant transformation. This case highlights the severe gastrointestinal damage caused by acid ingestion and underscores the importance of early endoscopic evaluation, comprehensive supportive care, psychiatric assessment, and long-term follow-up in managing corrosive acid injuries.

PMID 43017309
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PubMedACS applied materials & interfaces2026-11-12

A Rutin-Glycyrrhizic Acid Self-Assembled Nanohydrogel Promotes Early Osteogenic Differentiation Potential and Antioxidant Activity via Synergistic Inhibition of the IL-1β/NF-κB Axis.

Wang Hongyu H, Zhou Mengjiao M, Xiao Mintao M, Kang Jianqing J et al.

Plant-derived natural compounds have gained increasing attention in biomaterial development due to their intrinsic bioactivity and favorable biocompatibility. The anti-inflammatory, antioxidant, and osteogenic properties of rutin and glycyrrhizic acid have rendered them increasingly attractive candidates for therapeutic biomaterial development. However, their poor bioavailability significantly restricts their broad biomedical applications. Inspired by a supramolecular self-assembly strategy, we successfully constructed a rutin-glycyrrhizic acid nanohydrogel (RU-GA). The microstructure and formation mechanism were investigated through experimental characterization and computational simulations. Rutin (RU) and glycyrrhizic acid (GA) self-assemble into a carrier-free hydrogel in aqueous solution via hydrogen bonding and π-π stacking interactions, exhibiting favorable injectability, shapeability, and stability. RU-GA can disperse in water and release rutin-glycyrrhizic acid nanoparticles (RG NPs) with homogeneous particle sizes, while the hydrogel material possesses degradation and sustained-release properties. The bioavailability of RU and GA is synergistically improved through size effects and continuous release. Notably, the RU-GA hydrogel significantly promotes antioxidant activity and early osteogenic differentiation potential relative to the individual monomer components. Bioinformatics analysis further suggested that these bioactivities are associated with IL1B. Il1b knockdown experiments validated that RU and GA may synergistically suppress IL-1β-mediated NF-κB activation, thereby reducing oxidative stress and enhancing early osteogenic differentiation potential. Collectively, the rutin-glycyrrhizic acid nanohydrogel (RU-GA) represents a promising functional biomaterial, providing a strategy for the broad application of natural compounds in biomedical and related fields.

PMID 43017866
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PubMedRSC advances2026-11-12

Push-pull luminescent imidazole derivatives: ICT enables efficient picric acid sensing.

Dey Mayuri M, Bhattacharyya Arghyadeep A, Roy Swarup S, Majumdar Swapan S

Two push-pull fluorophores (3a-b) based on a tri-substituted imidazole core appended with donor-acceptor groups were successfully synthesized by the catalysis of Amberlite IR 120H+ and were fully characterized by NMR and mass spectral analyses. The synthesized compounds exhibit strong luminescent properties due to their donor-acceptor (push-pull) electronic structures and possess pronounced excited-state charge transfer characteristics, as evidenced by steady-state and time-resolved spectroscopic experiments. Imidazole incorporated with donor groups in the phenyl rings at the 4- and 5-positions (3b) shows a greater extent of charge transfer and emits yellow color in polar solvents like DMSO and acetonitrile. Both the fluorophores were found to act as sensors of picric acid in the solution phase with a very low detection level (nM) by static quenching of the fluorescence emission mechanism. The sensitivity of the detection of picric acid by 3b was found to be almost 1000 fold higher than that by 3a, and the response time of 3b towards picric acid was ∼3 times faster than that of 3a.

PMID 43017050
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PubMedCurrent organic synthesis2026-11-12

A Green Suzuki-Miyaura Cross-coupling Reaction of N-(4-Bromophenyl) Ureas with Phenylboronic Acid using Palladium Nanoparticles as a Catalyst.

da Cunha Sindra Haryadylla H, Sanabria Carlos Mario CM, de Mattos Marcio C S MCS

The N-biphenyl urea framework is of particular importance due to its relevant pharmacological activities, such as antitumour, antithrombotic, and herbicidal activities. Here, we present our results on the preparation of N-biphenyl ureas using a green Suzuki-Miyaura cross-coupling reaction of N-(4-bromophenyl) ureas with phenylboronic acid. Several N-(4-bromophenyl) ureas with different substitution patterns were prepared in excellent yields by the reaction of 4-bromophenylisocyanate with primary and secondary amines in hexane at room temperature. Their Suzuki-Miyaura cross-coupling reaction with phenylboronic acid was accomplished at room temperature in aqueous ethanol using a catalytic system composed of Na2PdCl4 (2 mol%) as a source of palladium and 2-hydroxypropyl-β-cyclodextrin as a reductant/ stabiliser of palladium nanoparticles. The Suzuki-Miyaura cross-coupling reaction of N-(4-bromophenyl) and N-(4- bromobenzyl) ureas with phenylboronic acid, catalysed by palladium nanoparticles, gave the corresponding N-biphenyl ureas in up to 93% yield. We have developed a convenient synthesis of N-4-biphenyl ureas from the corresponding N-(4-bromophenyl) or N-(4-bromobenzyl) ureas and phenylboronic acid using palladium nanoparticles as a catalyst. The methodology also proved suitable for the Suzuki-Miyaura crosscoupling reaction using N-(4-bromobenzyl)-N'-butylurea as the substrate. The reaction conditions are mild and consistent with the principles of green chemistry. N-biaryl ureas are potentially pharmacologically active, and our approach opens the possibility for the preparation and study of new substances.

PMID 43016275
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PubMedFrontiers in pharmacology2026-11-12

Safety of long-term use of potassium-competitive acid blockers: a narrative review.

Bao Yuqi Y, Chen Junkang J, Han Jiayu J, Le Jingying J et al.

Potassium-competitive acid blockers (P-CABs) reversibly inhibit gastric H+/K+-ATPase, providing rapid and potent acid suppression. They are increasingly used for gastroesophageal reflux disease, peptic ulcer disease, and Helicobacter pylori eradication. As maintenance therapy expands, long-term safety has drawn growing attention. To evaluate the available evidence on the long-term safety of P-CABs, distinguishing established findings from potential safety signals. This narrative review drew on searches of PubMed, Embase, Cochrane Library, and ClinicalTrials.gov through 30 June 2026. Studies with at least 24 weeks of treatment or follow-up formed the longer-term human evidence base. Evidence was synthesized by safety outcome, considering the specific agent and study design. Available comparative evidence, predominantly for vonoprazan, has not shown a substantially higher overall adverse event incidence than with proton pump inhibitors (PPIs). Sustained acid suppression can induce hypergastrinemia, which may be accompanied by parietal-cell hyperplasia, fundic gland dilatation, and other endoscopic mucosal changes. Evidence remains insufficient to determine the risks of rare or long-latency outcomes or to generalize long-term findings to all P-CABs. Long-term prescribing should include periodic reassessment of the indication and individualized monitoring.

PMID 43017358
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