Drug Database
TJ

TJ-114 (Sai)

✓ Approved

Tsumura · IL1RN

What is TJ-114?

TJ-114 is a therapeutic agent developed by Tsumura. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesSai
CompanyTsumura
Molecular TargetIL1RN
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Tsumura

Mechanism of Action

Molecular Targets

TJ-114 acts on 1 molecular target:

IL1RNinterleukin 1 receptor antagonist (IL1F3, IL-1RN)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

TJ-114 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersNephritis✓ Approved

Related Research Articles

PubMedMethods in molecular biology (Clifton, N.J.)2026-11-12

Large Insertion Using Template-Jumping Prime Editing.

Zheng Chunwei C, Xue Wen W

Prime editors (PEs) are advanced gene-editing tools capable of a wide spectrum of genomic modifications, offering significant potential for gene therapy. The template-jumping prime editing (TJ-PE) system employs template-jumping prime editing guide RNAs (TJ-pegRNAs) with a dual primer binding site (PBS) sequence. One PBS anneals to the DNA flap generated by the TJ-pegRNA, while the other binds to the DNA flap generated by the nicking sgRNA, enabling the accurate insertion of large DNA fragments.

PMID 43015547
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PubMedGlobal change biology2026-11-12

Intensive Agriculture and Erosion Affect Composition of Soil Organic Matter.

He Yanxing Y, Zhang Fengbao F, Li Xuantian X, Deng Lei L et al.

Land-use changes induced by human activities usually accelerate soil erosion, leading to losses of soil organic matter (SOM). The mechanisms by which cultivation-associated degradation affects SOM composition via changes of content and quality of particulate (POM), mineral-associated (MAOM), dissolved organic matter (DOM), and microbial biomass are not elucidated. We investigated the C:N stoichiometry of these fractions, and erosion (using 137Cs activity) along a chronosequence of cultivation-associated degradation (0-114 years) in Mollisols. Two-pool and Bayesian three-source mixing models estimated contributions of microbial biomass, DOM, and POM to MAOM to the total SOM. Erosion intensity ranged locally from 440 to 4800 t km-2 year-1, resulting in cumulative soil losses of 11,000 to 320,000 t km-2 over 114 years of cultivation. As cultivation duration and eroded amounts increased, the C/N ratios of POM, MAOM, and DOM declined owing to (i) the faster loss of C than N, (ii) a decrease in C/N with soil depth involved in tillage horizon, and (iii) N input by fertilization. These higher C than N losses reflect that erosion is not the sole process leading to the decline of C stocks, but intensive cultivation also accelerates organic matter mineralization and CO2 release to the atmosphere. As the C/N ratios of POM and MAOM declined but microbial C/N increased, the estimated contribution of microbial inputs to MAOM increased from 6% to 32%. The Bayesian model partitioned MAOM sources into DOM (8%), microbial (11%), and POM (81%), reinforcing that POM dominates MAOM formation in croplands. Cultivation-associated degradation led to SOC losses by reducing POM-C/N and MAOM-C/N ratios, while erosion strongly accelerated these effects. Furthermore, cultivation-associated degradation is also based on the limited inputs of organic C as the precursors for MAOM formation by depleting POM. These results from a > 100-year chronosequence indicate that cultivation-induced degradation reduces SOM content, while also shifting the MAOM composition progressively towards a greater contribution of microbial C.

PMID 43015263
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PubMedBMC psychology2026-11-12

Adaptation of the partner acceptance scale to turkish: its associations with forgiveness, trust, and relationship satisfaction in romantic relationships.

Çaktı Saide Umut Zeybek SUZ

The ability to accept one's partner as they have recently gained prominence as an important construct for understanding mental health and relationship quality. However, empirical studies directly focusing on partner acceptance remain limited. Addressing this gap, the present research comprises two studies examining the construct. In Study I (N = 387), confirmatory factor analysis supported the five-item, single-factor structure of the Partner Acceptance Scale (χ²(5) = 8.88, p = .114, CFI = 0.979, RMSEA = 0.045, SRMR = 0.029), and its psychometric properties were comprehensively evaluated. Item Response Theory analyses indicated that all items had moderate discrimination levels, while multiple reliability coefficients supported the scale's overall reliability. Criterion-related validity analyses showed that partner acceptance had small associations with relationship satisfaction, perceived romantic relationship quality, and romantic jealousy (rs ranging from |0.18| to |0.20|). In Study II (N = 492), the relationships among partner acceptance, forgiveness, trust, and relationship satisfaction were examined using structural equation modelling. The structural model demonstrated an acceptable, although partly borderline, fit to the data (χ²/df = 4.48, CFI = 0.964, RMSEA = 0.083, SRMR = 0.082). Findings revealed that forgiveness and trust were sequentially associated with the relationship between partner acceptance and relationship satisfaction. Overall, the results suggest that the Partner Acceptance Scale is a valid and reliable instrument within the Turkish cultural context and further indicate that partner acceptance has modest positive associations with forgiveness, trust, and relationship satisfaction.

PMID 43015871
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PubMedAnnals of the American Thoracic Society2026-11-12

Prognostic value of right atrial pressure to cardiac output slope in patients undergoing exercise right heart catheterization.

Müller Julian J, Douschan Philipp P, Mayer Laura L, Lichtblau Mona M et al.

This study aimed to evaluate the prognostic value of the right atrial pressure to cardiac output relationship (RAP/CO-slope) from rest to end exercise in patients undergoing exercise right heart catheterization for suspected or confirmed pulmonary hypertension (PH). The analysis used data from the retrospective arm of the Pulmonary Hemodynamics during Exercise Network (PEX NET), a multicenter collaboration involving 23 PH centers. Patients were included if resting and exercise measurements were obtained in the same body position and if RAP/CO-slopes were available. Cox proportional hazard models adjusted for age, sex, and hemoglobin were applied. Time dependent ROC curves were used to identify a prognostic cut off. A total of 856 patients were included (median age 59 years; 67% female), of whom 336 had PH. Over a median follow up of 6.5 years, 114 patients (13%) died. Higher RAP/CO-slopes were independently associated with increased mortality, even after adjusting for established resting and exercise hemodynamics (hazard ratio 1.08, 95%CI: 1.03-1.13, p < 0.001). Among patients with manifest PH at rest, a RAP/CO-slope ≥1.0 mmHg·min·L⁻¹ was linked to a 2.2 fold higher mortality risk (hazard ratio: 2.20; 95% CI: 1.1-4.5; p = 0.032) compared with slopes <1.0 mmHg·min·L⁻¹. In a multivariable model including NT proBNP, 6 minute walking distance, and WHO functional class, the RAP/CO-slope remained the strongest predictor of mortality. The RAP/CO-slope is a strong, independent prognostic marker across a spectrum of RV afterload stress. A RAP/CO slope ≥1 mmHg·min·L⁻¹ was identified as particularly predictive in manifest PH.

PMID 43016357
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PubMedVector borne and zoonotic diseases (Larchmont, N.Y.)2026-11-12

Pediculosis Capitis Among Primary School Children in Delvar, Southern Iran: Prevalence, Clinical Characteristics, and Associated Factors.

Boroomand Mitra M, Sanei-Dehkordi Alireza A, Sedigh Atefeh A, Shahabi Saeed S et al.

Pediculosis capitis is one of the most common parasitic infestations among school-aged children worldwide. This study investigated the prevalence, clinical characteristics, and associated factors of pediculosis capitis among primary school children in Delvar, Bushehr Province, southern Iran. A cross-sectional study was conducted from September 2024 to March 2025 among primary school children aged 7-12 years using multistage cluster sampling. A total of 715 students were examined. Head lice infestation was assessed through systematic visual inspection and fine-toothed comb examination by trained personnel. Clinical characteristics, including scalp itching, itching location, and developmental stages of lice, were also recorded. Sociodemographic, household, and behavioral information was collected using a structured questionnaire. Univariable and multivariable analyses were conducted to identify factors associated with infestation. Among 715 students, 146 were infested, yielding an overall prevalence of 20.4%. Infestation prevalence was similar among boys (20.5%) and girls (20.3%). Scalp itching was reported by 128 students (17.9%), of whom 114 (89.1%) were infested. Among infested students, the recorded developmental stages were adults (34.9%), nymphs (24.7%), nits (13.0%), and mixed nit and louse infestation (27.4%). In multivariable analysis, sharing personal items (adjusted odds ratio [AOR] = 10.68), paternal unemployment (AOR = 5.86), and larger family size (AOR = 3.12) showed the strongest positive associations with infestation. Higher paternal education and greater hair-combing frequency were associated with lower odds of infestation. Pediculosis capitis was common among primary school children in Delvar, with scalp itching frequently reported among infested students. Sharing personal items, paternal unemployment, and larger family size were important correlates of infestation. These findings support targeted school-based screening, early identification of symptomatic children, preventive education, and greater attention to children from larger or socioeconomically disadvantaged households.

PMID 43015993
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PubMedJournal of the American Heart Association2026-11-12

Side Effects of Low-Dose Colchicine in Chronic Coronary Disease: A Post Hoc Analysis of the LoDoCo2 Trial.

Jannink Jalina J, van der Veen Jenny J, Mohammadnia Niekbachsh N, van der Bijl Marte F MF et al.

Low-dose colchicine reduces cardiovascular events in patients with chronic coronary disease. However, side effects may compromise compliance and lead to discontinuation of treatment. Therefore, we aimed to assess the incidence of side effects leading to discontinuation of treatment in the LoDoCo2 (Low-Dose Colchicine 2) trial. The LoDoCo2 trial was a randomized controlled trial evaluating colchicine versus placebo in patients with chronic coronary disease. Participants entered a 30-day open-label run-in phase during which all participants received colchicine 0.5 mg once daily, followed by randomization to colchicine or placebo. Tolerability-related side effects leading to treatment discontinuation were evaluated at the end of the 30-day run-in phase and during the randomized phase (median follow-up, 29.5 [interquartile range, 21.6-47.4] months). Cumulative incidence of side effects was presented using Kaplan-Meier curves and compared by treatment arm using Cox proportional hazards models. During the 30-day run-in phase, 618 of 6519 (9.5%) participants reported side effects. Women had a higher risk of side effects than men during the 30-day run-in phase (odds ratio, 1.53 [95% CI, 1.23-1.89]). After randomization, 114 participants (4.2%) in the colchicine group and 120 (4.4%) in the placebo group discontinued treatment due to side effects (hazard ratio [HR], 0.95 [95% CI, 0.73-1.22]). Gastrointestinal symptoms were most common (colchicine 2.0% versus placebo 1.7%) followed by myalgia (colchicine 1.2% versus placebo 1.6%). No differences in the risk of side effects between colchicine and placebo were seen for any of the subgroups. Women did have a higher risk of reporting side effects compared with men, regardless of assigned treatment (HR, 1.66 [95% CI, 1.22-2.25]). In patients with chronic coronary disease that tolerated initial treatment with low-dose colchicine, long-term discontinuation due to side effects was uncommon and did not differ between colchicine and placebo. URL: https://www.anzctr.org/au; Unique identifier: ACTRN12614000093684.

PMID 43018060
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