Drug Database
TJ

TJ-114 (Sai)

✓ Approved

Tsumura · IL1RN

What is TJ-114?

TJ-114 is a therapeutic agent developed by Tsumura. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesSai
CompanyTsumura
Molecular TargetIL1RN
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Tsumura

Mechanism of Action

Molecular Targets

TJ-114 acts on 1 molecular target:

IL1RNinterleukin 1 receptor antagonist (IL1F3, IL-1RN)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

TJ-114 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersNephritis✓ Approved

Related Research Articles

PubMedPlastic and reconstructive surgery. Global open2026-07-25

Does Intraoperative Heparin Administration Reduce Postoperative Complications in Deep Inferior Epigastric Perforator Flap Breast Reconstruction?

Dong Edward T C ETC, Zinner Gauthier G, Giordano Salvatore S, Oranges Carlo M CM

Microsurgical thrombosis is a critical complication of free flap surgery. Evidence evaluating the efficacy of intraoperative thromboprophylaxis in mitigating this complication during deep inferior epigastric perforator (DIEP) flap breast reconstruction remains limited. Here, we report a retrospective analysis of all DIEP flap breast reconstructions performed at our institution during a 6-year period. This single-center analysis offers a retrospective review of all female patients who underwent DIEP flap breast reconstruction from January 2018 to June 2024. Subjects were divided into 2 groups: a control group and a treatment group that received an intraoperative bolus administration of 2000 IU of unfractionated heparin (UFH). Patient characteristics, therapeutic variables, intraoperative details, and postoperative outcomes were extracted and analyzed. Postoperative complications were classified into subgroups: acute complications (≤4 d) and delayed complications (>4 d). This study included 114 patients (141 breasts), corresponding to 48 patients in the control cohort and 66 patients in the UFH cohort. No significant differences were observed in the occurrence of complications in intraoperative (P = 0.226), acute (P = 0.839), or delayed settings (P = 1.00). Notably, the risk of thrombosis and hematoma was comparable. Interestingly, ischemia time and total operative duration were significantly prolonged in the control group (P < 0.05). Intraoperative anticoagulant prophylaxis using UFH did not diminish acute thrombotic complications; however, it was also not associated with an increased risk of hematoma and bleeding. These findings offer valuable insights regarding the clinical relevance and safety profile of perioperative UFH administration.

PMID 42499803
Read full article →
PubMedHCA healthcare journal of medicine2026-07-25

Time for a New Whole-Person Care Pathway for Chest Pain Admissions.

Kajan Dana D, Mirza Sabbir S, Ruiz Alexander M AM, De-Gennaro Anthony A et al.

Emergency department (ED) visits for chest pain are common and costly, and ED workup often shows no clear cardiac etiology in low-risk patients. Emerging evidence suggests that social determinants of health (SDOH) such as loneliness, social isolation, and food insecurity contribute to cardiovascular outcomes and chest pain presentations. We interviewed 114 patients (>18 years) presenting with chest pain and a thrombolysis in myocardial infarction (TIMI) score less than 4 at our community teaching hospital ED. Structured questionnaires assessed the SDOH triad of loneliness, social isolation, and food insecurity. Dependent variables included systolic blood pressure (SBP) at admission, body mass index (BMI), ejection fraction (EF) within 6 months of admission, and 30-day readmissions. Correlation analyses examined significant associations between SDOH and cardiometabolic outcomes. Loneliness was prevalent in 71% of our surveyed participants (mean age of 64, 53% male, 47% female). Loneliness had a strong positive correlation with poorly controlled admission SBP and a negative correlation with EF. Higher social isolation scores had a negative correlation with EF. Food insecurity was prevalent in 71% of participants, and it had a moderate but positive correlation with higher BMI. Thirty-day readmission of patients with a prior ED hospitalization for cardiac examination was 7% across all the etiologies included in this study. Because SDOH are potently present in patients who visit EDs with chest pain, locally designed screening cards should be part of the workup. The rise of the loneliness, social isolation, and food insecurity syndemics should raise our awareness to manage those risk factors individually, institutionally, and systemically.

PMID 42500439
Read full article →
PubMedInternational journal of prison health2026-07-25

An underrecognized population in pediatric emergency care: process challenges for children deprived of liberty.

Unsal Yesim Ece YE, Bicilioglu Yuksel Y, Nalbant Tugce T, Gokalp Gamze G

Children deprived of their liberty represent a vulnerable and underrecognized population in pediatric emergency departments. This study aims to describe the clinical and process-related characteristics of these encounters, identify factors associated with emergency department length of stay (ED-LOS) and evaluate changes observed after workflow interventions. This retrospective study included a process-oriented pre-post evaluation in a tertiary pediatric emergency department. Children deprived of their liberty presenting during the study period were included. The primary outcome was ED-LOS. Prolonged ED-LOS was defined as a stay exceeding 8 h. Secondary outcomes included diagnostic testing, imaging, consultations, hospitalization, repeat visits, reasons for presentation and consent-related workflow barriers. A total of 114 encounters were evaluated. The mean age was 16.04 ± 1.08 years, and 86.0% were male. Foreign body ingestion and trauma were the most common reasons for presentation. ED-LOS exceeded 8 h in 14.9% of encounters. Laboratory testing, imaging, consultations and consent-related workflow barriers were associated with ED-LOS, whereas presentation time and weekday versus weekend arrival were not. The proportion of encounters exceeding 8 h decreased from 20.3% to 6.7% after the interventions (p = 0.046). Hospitalization rates increased. To the best of the authors' knowledge, this study is among the first process-oriented evaluations of pediatric emergency care for children deprived of their liberty in Türkiye. The findings suggest that prolonged ED-LOS may be more closely related to diagnostic processes, consultations, consent and disposition workflows than to temporal characteristics of presentation. Workflow interventions may contribute to reducing prolonged emergency department stays.

PMID 42499173
Read full article →
PubMedPediatric nephrology (Berlin, Germany)2026-07-25

Impact of childhood and parental smoking and substance use on nephrotic syndrome outcomes: a prospective cohort study.

Joshi Tanay T, Robinson Cal H CH, Aman Nowrin N, Banh Tonny H M THM et al.

The impact of environmental exposures such as household and adolescent smoking, alcohol use, and drug use on childhood nephrotic syndrome outcomes is unknown. Our objective was to characterize tobacco, alcohol, and recreational drug use and longitudinal associations. Analyzing data from Insight into Nephrotic Syndrome: Investigating Genes, Health, and Therapeutics, a prospective cohort, we included children (1-18 years) diagnosed with nephrotic syndrome from 1996 to 2023. Tobacco, alcohol, and recreational drug use were self-reported at annual study visits, treated as time-varying exposures. We evaluated prevalence and quantity of exposure to each substance and associations with relapse rate, steroid-sparing medication initiation, and hospitalizations using generalized linear mixed models. We included 732 children with nephrotic syndrome (total of 2065 study visits). Median age at diagnosis was 3.8-years (IQR 2.7-6.3), 461 (73%) were male, and 692 (96%) were steroid-sensitive at diagnosis. Exposure to a household tobacco smoker was reported in 114 (16%) participants. Eight adolescents (1%) reported personal tobacco smoking, 33 (5%) used alcohol, and 10 (1%) used recreational drugs at any time. Personal or household tobacco smoking was not associated with relapse rate (adjusted rate ratio 1.22, 95% CI 0.96-1.54), steroid-sparing medication initiation (adjusted odds ratio 0.97, 95% CI 0.66-1.42), or hospitalization (adjusted odds ratio 0.66, 95% CI 0.31-1.37). Youth alcohol use was also not associated with nephrotic syndrome outcomes. Up to 5% of youth with nephrotic syndrome use tobacco, alcohol, or recreational drugs, and 16% are exposed to a household smoker. While this study was underpowered to evaluate the independent impact of personal tobacco and recreational drug use, no clear association between substance exposure and longitudinal outcomes was identified.

PMID 42498857
Read full article →
PubMedCrohn's & colitis 3602026-07-25

Highlights of the 2026 European Crohn's and Colitis Conference: redefining the IBD care continuum.

Al-Hindawi Ahmed A, Siegel Alexander A, Miranda Clive Jude CJ, Maddineni Gautam G et al.

Inflammatory bowel disease (IBD) care is moving from a symptom-driven step-up model of care toward earlier effective intervention, complication-specific management, and more personalized treatment selection. This review synthesizes selected ECCO 2026 studies and offers an expert appraisal of their clinical relevance, methodological strengths, and remaining uncertainties. Particular emphasis is placed on studies most likely to influence current practice and further research, including late-breaking trials, complication-directed therapy, pediatric evidence, and technology-assisted assessment. Study findings spanned both ulcerative colitis (UC) and Crohn's disease (CD). New therapeutic studies presented included the phase 3 study of vedolizumab in pediatric UC, phase 2 efficacy data for picankibart in UC, and regenerative fistula data of AVB-114 in perianal CD. Real-world data presented included comparative data on different Janus kinase inhibitors in UC. Updates on interleukin-23 included durable extension data in UC, as well as efficacy data in advanced therapy‑exposed patients (mirikizumab in UC and risankizumab in CD). Innovative technologies included transperineal ultrasound for early identification of steroid non-response in acute severe UC, and multimodal artificial intelligence for Mayo endoscopic scoring. Beyond drug therapy, the 10-year LIR! C follow-up provided further data on surgical intervention as an early strategy in selected uncomplicated ileal CD, while the Preventing IBD ONset in Individuals at Risk study investigated potential benefits of a whole-food diet in high-risk first-degree relatives. ECCO 2026 emphasized durable, precision-oriented, multidisciplinary, and technology-enabled IBD care across the full continuum, from prevention to long-term modification. Apart from phase 3 and extension trials, other results remain preliminary and need broader comparative and practice-embedded studies before widespread adoption.

PMID 42499815
Read full article →
PubMedNature medicine2026-07-25

AI-based clinician decision support system for diagnosis of inherited retinal diseases: a multicenter, randomized trial.

Jia Huixun H, Qian Bo B, Qu Yanlin Y, Wang Jinyuan J et al.

The accurate and timely diagnosis of inherited retinal diseases (IRDs) represents an unmet clinical need in ophthalmology, as the current pathways rely on resource-intensive phenotyping, multidisciplinary expertise and genetic testing. Here we developed Retina4IRD, an artificial intelligence (AI)-based clinician decision support system (CDSS) that predicts 17 genotype categories from retina images. Retina4IRD uses a Vision Transformer model pretrained with RETFound. We then trained and validated Retina4IRD using multimodal data with color fundus photographs and optical coherence tomography scans from 1,843 genetically confirmed patients (3,376 eyes) across China, South Korea and Poland. The top-5 prediction accuracy was 0.904 (95% confidence interval (CI): 0.896-0.912) and 0.856 (95% CI: 0.850-0.863) for internal and external validation, respectively. We conducted a randomized controlled trial with 300 participants with suspected IRD randomized 1:1 to either Retina4IRD-assisted specialist arm or specialist-only arm. Of these, 295 participants (median age 33 years, 114 (38.6%) females) with available next-generation sequencing reports were included in the final analysis. The primary outcome was met: top-5 genetic accuracy was significantly higher in the Retina4IRD-assisted specialist arm versus the specialist-only arm (88.5% versus 67.3%, P < 0.001). For secondary endpoints, top-1 to top-4 accuracies all favored the Retina4IRD-assisted specialist arm, with top-1 accuracy of 37.8% versus 22.4% and top-4 accuracy of 81.8% versus 53.1%, respectively. Post hoc analyses demonstrated that, with Retina4IRD assistance, clinicians made better management decisions, and the composite downstream management score indicated significantly higher scores relative to the control group (37.7 versus 28.5, P < 0.001). Our study shows that Retina4IRD is a CDSS tool prior to genetic testing and aligns with clinical workflow for patients with suspected IRDs. ClinicalTrials.gov identifier: NCT06839170 .

PMID 42498742
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about TJ-114