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amphotericin B (Ampholip)

✓ Approved

Bharat Serums and Vaccines Limited · Small Molecule · Small Molecule

What is amphotericin B?

amphotericin B is a small molecule developed by Bharat Serums and Vaccines Limited. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesAmpholip
CompanyBharat Serums and Vaccines Limited
Drug ClassSmall Molecule
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Bharat Serums and Vaccines Limited

Therapeutic Indications

amphotericin B is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Cardiac disordersEndocardial disease✓ Approved
Infections and infestationsCandida infection✓ Approved
Infections and infestationsAspergillus infection✓ Approved

Related Research Articles

PubMedClinical, cosmetic and investigational dermatology2026-09-20

Post-Traumatic Primary Cutaneous Cryptococcosis Presenting as a Chronic Refractory Forearm Ulcer with Polymicrobial Coinfection: An mNGS-Assisted Case Report and Literature Review.

Lian Chengxiang C, Feng Bin B, Su Jiaguang J

Primary cutaneous cryptococcosis (PCC) is a rare infection caused by direct inoculation of Cryptococcus through disrupted skin. We report a 52-year-old male farmer with type 2 diabetes but no HIV infection or known major immunosuppressive disease who developed chronic refractory ulcers on the right forearm following suspected insect-bite trauma. Cryptococcus neoformans was isolated from cutaneous specimens. Probe-capture metagenomic next-generation sequencing (MetaCAP) of the ulcer tissue additionally detected C. neoformans at 202 reads per million (RPM), accounting for 91.98% of the fungal sequences, with a reported confidence of 99%. Histopathology demonstrated an infectious granuloma, while bacterial culture identified methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase-producing Escherichia coli. Chest computed tomography and cerebrospinal fluid investigations did not support pulmonary or central nervous system cryptococcosis. Liposomal amphotericin B was discontinued because of acute kidney injury, and subsequent fluconazole plus flucytosine treatment resulted in reduced exudation, granulation tissue formation, and partial ulcer healing. PCC should be considered in chronic post-traumatic ulcers, with systematic evaluation for extracutaneous involvement before establishing a primary cutaneous diagnosis.

PMID 42763741
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PubMedGenes & diseases2026-09-20

High-throughput chemical screen identifies epothilone B in modulating inflammatory bowel disease by triggering neutrophil apoptosis.

He Zhenting Z, Deng Ziling Z, Zhang Huan H, Xiang Yiming Y et al.

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract characterized by a complex interplay of genetic, environmental, and immunological factors. Neutrophils, as a key component of the innate immune system, play a critical role in IBD pathogenesis due to their dysregulated infiltration, impaired apoptosis, and resultant epithelial damage during the disease process. Conventional approaches aimed at suppressing neutrophil activity have achieved only modest clinical efficacy and highlight the need for strategies that recalibrate neutrophil responses without compromising their essential antimicrobial functions. In this study, we employed high-throughput chemical screening using neutrophil-specific transgenic zebrafish larvae to identify compounds capable of modulating neutrophil homeostasis, and subsequently evaluating their efficacy in a dextran sodium sulfate (DSS)-induced IBD model. We identified epothilone B (Epo B), a traditional chemotherapeutic drug, as a potential therapeutic candidate for IBD. Our findings demonstrate that Epo B protects against IBD by promoting intestinal epithelial recovery, alleviating inflammatory responses, and rebalancing the gut microbiota. Mechanistically, Epo B selectively stimulates neutrophil apoptosis by targeting and enhancing Caspase-3 cleavage, thereby inhibiting neutrophilic inflammation. This study underscores the utility of in vivo high-throughput drug screening in IBD and highlights Epo B as a promising candidate for drug repurposing in IBD treatment, offering a novel therapeutic strategy by targeting neutrophil apoptosis.

PMID 42763496
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PubMedAnesthesiology and pain medicine2026-09-20

Effectiveness of Apneic Oxygenation During Induction of General Anesthesia in Children Undergoing Adenotonsillectomy: A Prospective Randomized Controlled Study.

Ragab Safaa Gaber SG, Ali Lotfy Ahmed A, Botros Joseph Makram JM, Hashem Hasnaa Mohsen HM et al.

Children undergoing adenotonsillectomy often have partial airway obstruction due to hypertrophic tonsils and adenoids, increasing their risk of oxygen desaturation during anesthesia induction. This study aimed to evaluate whether apneic oxygenation via nasal cannula prevents oxygen desaturation during tracheal intubation in children aged 3 - 10 years undergoing adenotonsillectomy while assessing its effects on intubation conditions and hemodynamic stability. In this prospective, single-blinded, randomized controlled trial, 140 children scheduled for adenotonsillectomy were allocated to either standard intubation (group A, n = 70) or apneic oxygenation (group B, n = 70; 0.2 L/kg/min via nasal cannula). The primary outcome was the lowest peripheral oxygen saturation (SpO₂) during intubation. Peripheral SpO₂ was significantly lower during intubation in group A (97.40 ± 2.96) than in group B (99.91 ± 0.28) (P < 0.001). Group B also maintained significantly higher SpO₂ immediately after intubation (99.91 ± 0.28%) than group A (97.77 ± 2.24%; P < 0.001). No episodes of desaturation occurred in group B during the procedure (P < 0.001). In group A, 21.43% of patients desaturated to ≤ 95% (P < 0.001). Severe desaturation (SpO₂ < 92%) occurred in 7.14% of controls but was absent in group B (P = 0.023). Intubation time, intubation attempts, and bradycardia rates were comparable between groups (P > 0.05). Apneic oxygenation during intubation in children undergoing adenotonsillectomy effectively prevented desaturation without compromising safety or procedural efficiency.

PMID 42763625
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PubMedMycoKeys2026-09-20

Taxonomy and phylogeny of the lichen genus Bunodophoron (Sphaerophoraceae, Lecanorales) in New Caledonia, with the description of two new species.

Borg Nora Helene NH, Wedin Mats M, Timdal Einar E, Prieto María M et al.

This study presents a taxonomic revision of Bunodophoron in New Caledonia. Extensive fieldwork was conducted in the region, particularly in the montane rainforests of Grande Terre. An integrative approach was employed, in which specimens underwent morphological assessment, chemical analysis via thin-layer chromatography, and DNA sequencing for four molecular markers: ITS, β-tubulin, MCM7, and RPB1. Phylogenetic analyses were performed within a global framework, incorporating morphologically similar and related taxa from Australasia, the Neotropics, and the Paleotropics, including previously unsequenced taxa analyzed for the first time in this study. Using this approach, four species of Bunodophoron lichens were identified in New Caledonia, including two new to science, B. flagellare Ant.Simon, N.Borg & Wedin, sp. nov. and B. imbricatum Ant.Simon, N.Borg & Wedin, sp. nov.

PMID 42763634
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PubMedCase reports in hematology2026-09-20

Intravascular Large B-Cell Lymphoma Presenting as Recurrent Cryptogenic Strokes: A Diagnostic Challenge.

Krishnan Veena V, Dessie Habtemariam H, Stogner Kimberly K, Baldwin Jakita J et al.

Intravascular large B-cell lymphoma (IVLBCL) is a rare malignancy and is a challenging diagnosis to make given its varied clinical presentation. Here, we present the case of a 69-year-old male who presented with multiple cryptogenic strokes. Despite multiple hypercoagulable and malignancy workups, no etiology was identified, with multiple CT scans negative for any masses. Ultimately, a vascular abnormality was noted on a CTA of the head and neck, and IVLBCL was diagnosed on biopsy. The patient was initiated on R-CHOP and had improvement in his neurological status after the initiation of chemotherapy, and his ClonoSeq MRD testing is negative. This case is of interest given the lack of imaging findings for this patient prior to diagnosis as all of his CT scans were negative, making it a challenge to diagnose him as well as monitor his response to treatment. Additionally, his case highlights the importance of ClonoSeq MRD testing, which allows for the detection of even minimal amounts of disease in tracking response to treatment.

PMID 42763545
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PubMedVeterinary research2026-09-20

Mapping of three novel linear B-cell epitopes on the VP7 protein of epizootic hemorrhagic disease virus with monoclonal antibodies.

Hu Xinbing X, Zhong Yunru Y, He Yingjuan Y, Zhang Mingxin M et al.

Epizootic hemorrhagic disease virus (EHDV) is an important Orbivirus transmitted by culicoides midges. EHDV poses a significant threat to ruminant production worldwide. The VP7 protein is a highly conserved, group-specific antigen of EHDV, which serves as a key target for serological diagnosis. In this study, the recombinant VP7 (r-VP7) protein of EHDV-1 was expressed in an Escherichia coli expression system and used to immunize BALB/c mice. Four hybridoma cell lines secreting monoclonal antibodies (mAbs) against VP7 were successfully generated by the hybridoma technique, and named 5D1, 6A7, 7B11, and 7C4. Indirect ELISA, western blot analysis, and immunofluorescence assays demonstrated that all four mAbs specifically recognized both the r-VP7 protein and the native VP7 protein in EHDV-1-infected BHK-21 cells, with favorable reactivity and specificity. The VP7 protein was progressively truncated and expressed as a series of GST fusion proteins, and the linear B-cell epitopes recognized by these mAbs were precisely identified by western blotting. The results showed that 5D1 and 7B11 recognized the epitope 83DYIQNLATIGVLATPEI99, 7C4 recognized 121PDRQPFGYFL130, and 6A7 recognized 229APVNVNNPGQ238. Sequence alignment and cross-reactivity assays revealed that the three epitopes were highly conserved among EHDV serotypes and showed no cross-reactivity with the VP7 proteins of African horse sickness virus (AHSV) or bluetongue virus (BTV). Three-dimensional structural analysis indicated that all three epitopes were exposed on the surface of the VP7 trimer and were located in distinct structural domains. In summary, this study successfully generated four specific mAbs against the EHDV VP7 protein and identified three novel linear B-cell epitopes, providing a foundation for the development of specific EHDV serological diagnostic methods and epitope-based vaccines.

PMID 42763396
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