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amphotericin B (Amphotec / Amphocil / ABCD)

✓ Approved

Therametrics · Small Molecule · Small Molecule

What is amphotericin B?

amphotericin B is a small molecule developed by Therametrics. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesAmphotec, Amphocil, ABCD
CompanyTherametrics
Drug ClassSmall Molecule
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Therametrics

Therapeutic Indications

amphotericin B is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsWound infection fungal✓ Approved

Related Research Articles

PubMedInternational journal of dentistry2026-08-25

Using an Analog Multifunctional Model to Develop Cognitive Skills in Dental Implants.

Dos Santos Leal Morbeck M, Neves Ilana Dantas ID, de Souza Fernandes Atson Carlos AC, Medrado Alena Ribeiro Alves Peixoto ARAP

To evaluate the effectiveness of the multifunctional analog model (MAM) as a teaching-learning tool for developing cognitive skills in dental implantology among undergraduate students. This randomized educational trial included 115 students allocated into three groups: group A (theoretical instruction), group B (theoretical instruction plus laboratory practice), and group C (laboratory practice only). Learning was assessed using a five-item objective questionnaire administered before and after the intervention. Students' perceptions were evaluated through two open-ended questions. The percentage of correct answers increased from 33.3% (SD 17.4) to 55.4% (SD 26.1) in group A, from 28.2% (SD 20.4) to 76.9% (SD 20.8) in group B, and from 23.8% (SD 18.2) to 77.3% (SD 17.7) in group C. Posttest performance was significantly higher in groups B and C compared with group A (p < 0.05), with no significant difference between groups B and C. Most participants (99.2%) preferred the applied methodology over traditional lectures, with integration of theory and practice identified as the most relevant aspect (31.9%). The MAM-based methodology was significantly more effective than theoretical instruction alone in promoting cognitive learning. The integration of theory and practice was the key factor underlying its effectiveness.

PMID 42639227
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PubMedPatient preference and adherence2026-08-25

Predicting Medication Adherence in Sickle Cell Disease and Thalassemia in Oman: The Role of Beliefs and Fatigue.

Alshukaili Waleed Issa WI, Al-Noumani Huda H, Al Salmi Nasser N

Patients with sickle cell disease and thalassemia require lifelong pharmacological management yet demonstrate persistently low medication adherence, with limited research on adherence predictors in Oman. This study aimed to assess medication adherence and identify its predictors, including fatigue and beliefs about medicines, among adults with sickle cell disease and thalassemia in Oman. A cross-sectional descriptive correlational study was conducted at the National Hematology Center in Oman. A convenience sample of 233 adult patients completed three validated self-report instruments. Clinical data were extracted from medical records, and multiple linear regression was used to identify predictors of adherence. Most participants (91.8%) demonstrated low adherence (mean score 18.73 ± 3.56 out of 25). The regression model explained 34.5% of the variance in adherence (adjusted R2 = 0.316; F[10, 222] = 11.69; P <0.001). Significant predictors of poorer adherence were medication side effects (B = -1.90; P <0.001), frequency of hospitalization (B = -0.29; P =0.015), fatigue severity (B = -0.42; P =0.027), and harm beliefs about medicines (B = -0.31; P <0.001). A higher hemoglobin level was associated with better adherence (B = 0.44; P =0.004). Medication adherence is critically low among Omani patients with sickle cell disease and thalassemia. Healthcare professionals should address physical and psychosocial factors, including fatigue and misconceptions about medication harm, through individualized patient education and care plans to improve adherence and patient outcomes.

PMID 42638976
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PubMedPublic health action2026-08-25

Uptake of hepatitis B vaccination among nursing students in Cameroon: a mixed-methods study.

Fandie R R, Ngo Likeng J L JL, Douanla S R SR, Noeske J J

Three purposively identified nursing education institutions (Ayos, EITMS/GS, and the Virginia Henderson Foundation) in the Centre Region of Cameroon. To evaluate the psychological, socio-cognitive, economic, and institutional factors associated with hepatitis B (HBV) vaccine uptake among nursing students. A mixed-methods cross-sectional study was conducted between June and July 2025. Quantitative data (n = 325) were collected via self-administered electronic surveys, supplemented by qualitative focus group discussions. Quantitative analysis was performed using SPSS. Qualitative themes were synthesised via a hybrid inductive-deductive thematic analysis, using QCAmap. HBV vaccination was critically low at 29.54%, with only 50.04% of those vaccinated completing the full three-dose series. Multivariate analysis identified female gender, age, advanced study level, a solid knowledge level, high perceived self-efficacy, low vaccine-related anxiety, and encouragement from the educational institution as significant predictors of uptake. Qualitative findings highlighted as primary barriers: prohibitive costs, inadequate information, weak institutional mandates, and traditional prejudices. Immunisation rates among high-risk nursing students are alarmingly insufficient. To mitigate occupational risk, public health policy should mandate HBV vaccination at school matriculation and implement subsidies to facilitate economic access together with systematic sensitisation.

PMID 42639597
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PubMedInfectious diseases of poverty2026-08-25

Contrasting patterns of trematode and host snail dispersal across clusters of tropical crater lakes.

Hammoud Cyril C, Van Bocxlaer Bert B, Tumusiime Julius J, Verschuren Dirk D et al.

Comparing the genetic diversity and population structure of parasites and their hosts can improve understanding of their respective methods of dispersal, demographic histories, and factors driving genetic differentiation. In parasite taxa such as trematodes which have both intermediate and final hosts, comparative population-level analyses may also inform how each host influences gene flow among parasite populations. Here we aimed to assess how intermediate and final hosts influence trematode dispersal by examining the population genetic structure of the aquatic snail Bulinus tropicus and three trematodes that use it as intermediate host. We used high-throughput amplicon sequencing to simultaneously genotype populations of B. tropicus in two clusters of crater lakes in western Uganda (823 snails, 15 lakes) and three infecting trematode taxa (Petasiger sp., Echinoparyphium sp. and Plagiorchioidea sp.). For each taxon, we quantified genetic diversity in three mitochondrial markers and used analyses of molecular variance to test whether populations were genetically differentiated. Populations of B. tropicus were strongly genetically differentiated among individual crater lakes and lake clusters (ΦST = 0.78), indicating limited inter-lake dispersal. Petasiger sp. haplotype diversity was on average twice as high as that of its intermediate snail host and did not display genetic structuring among lakes (ΦST = 0.01). This parasite can therefore overcome the dispersal barriers encountered by its snail host, likely facilitated by mobile avian hosts, resulting in a single 'panmictic' region-wide population. Contrastingly, Echinoparyphium trematodes displayed less genetic diversity and significant genetic differentiation among lakes (ΦST = 0.35), likely due to limited final host mobility. Finally, Plagiorchioidea sp. was restricted to five neighbouring lakes, and a single haplotype was identified in the 217 infected snails analysed, implying recent introduction into the crater lakes. Contrasting patterns of genetic diversity and population structure among three parasitic trematodes and their common intermediate snail host illustrate how multi-host life cycles mediate dispersal dynamics and generate distinct evolutionary outcomes in hydrographically fragmented aquatic habitats. These findings demonstrate how multi-host life cycles shape parasite connectivity and evolution, and show that comparative population genetics can provide valuable insights into the dispersal ecology of understudied parasite species.

PMID 42638150
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PubMedClinical transplantation2026-08-25

HLA-A, -B, and DR Mismatch and Outcomes After Simultaneous Pancreas-Kidney Transplantation in the Modern Era.

Sachdeva Moksh M, Tingle Samuel S, Kourounis Georgios G, Malik Abdullah A et al.

HLA mismatch is known to impact post-transplant outcomes following kidney-alone transplantation. However, the impact on kidney outcomes in the context of simultaneous pancreas-kidney (SPK) transplantation remains uncertain. This study aimed to assess the impact of HLA mismatch on SPK outcomes. Adult SPK recipients in the UNOS STAR registry (2010-2023) were analysed. Re-transplants were excluded. Multivariable nonlinear regression models evaluated the impact of HLA mismatch on outcome. In a cohort of 10,559 SPK recipients overall mismatch was frequent, with only 34 recipients (0.3%) having 0/0/0 mismatches across HLA-A, HLA-B, and HLA-DR. HLA-DR mismatch was not associated with pancreas or kidney graft survival at 5 years; two versus zero HLA-DR mismatches aHR = 1.015 (95% CI 0.828-1.243) for pancreas graft survival, and aHR = 0.946 (0.753-1.188) for kidney graft survival. HLA-DR mismatch was also not associated with pancreas or kidney acute rejection or 12-month eGFR. HLA-A and HLA-B mismatches also showed no association with any pancreas or kidney transplant outcomes. Three-way interaction analyses between HLA-A, B and DR demonstrated no evidence that mismatch at any locus affected outcomes, irrespective of mismatch level at the other loci. In first-time simultaneous pancreas-kidney transplantation, donor-recipient HLA mismatch was not associated with pancreas or kidney graft survival, rejection, or early renal function. These findings contrast with kidney-alone transplantation and suggest that classical HLA mismatch effects may be attenuated in the contemporary SPK setting. Prioritising HLA-based matching, including HLA-DR, is therefore unlikely to improve short- or medium-term post-transplant outcomes in first-time SPK transplantation.

PMID 42638165
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PubMedAnesthesia and pain medicine2026-08-25

An evaluation of transdermal buprenorphine and transdermal fentanyl patch on quality of recovery-15 and analgesic effect following inguinal hernia surgery: a randomized controlled study.

A Chaitanya Pratyusha CP, Ch Rama Krishna Prasad RKP, Garre Sandeep S, S Kalyani Sdl KS et al.

Effective postoperative analgesia is essential for optimizing recovery and patient satisfaction after inguinal hernia surgery. Therefore, we compared transdermal buprenorphine and fentanyl patches with conventional analgesia for pain control and quality of recovery-15 (QoR-15). In this prospective, randomized study 150 patients classified as American Society of Anesthesiologists (ASA) I-III scheduled for elective open inguinal hernia repair were randomized into three groups; (n=50 each) Group B (buprenorphine 10 µg/h patch), Group F (fentanyl 25 µg/h patch), and Group C (intravenous paracetamol and tramadol). Patches were applied 12 h preoperatively. The primary outcome was visual analog scale (VAS) pain score, assessed at 1, 6, 12, and 24 h. Secondary outcomes included QoR‑15 scores and rescue‑analgesic requirements. Statistical analysis was performed using the Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction. Baseline demographic characteristics and perioperative hemodynamic parameters were comparable across groups. Median postoperative VAS scores at 6, 12, and 24 h were significantly lower in both transdermal groups than in the control group. QoR-15 scores at 24 h were 124 (122-125) (C), 127 (125-129) (F), and 133 (131-134) (B), at 48 h were 129 (128-130), 136 (134-138), and 137 (135-139) for Groups C, F, and B, respectively (P = 0.001). Transdermal buprenorphine and fentanyl provided effective postoperative analgesia and were associated with improved quality of recovery compared with standard analgesia. Buprenorphine showed a significant advantage over fentanyl in QoR-15 at 24 h, however, this difference was not significant at 48 h.

PMID 42638571
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