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ior-t3 (IORt3)

✓ Approved

Center of Molecular Immunology · CD3E · Monoclonal Antibodies

What is ior-t3?

ior-t3 is a monoclonal antibodies developed by Center of Molecular Immunology. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesIORt3
CompanyCenter of Molecular Immunology
Drug ClassMonoclonal Antibodies, Antibody
Molecular TargetCD3E
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Center of Molecular Immunology

Mechanism of Action

Molecular Targets

ior-t3 acts on 1 molecular target:

CD3ECD3 epsilon subunit of T-cell receptor complex (TCRE, CD3epsilon)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

ior-t3 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersSolid organ transplant rejection✓ Approved

Related Research Articles

PubMedYing yong sheng tai xue bao = The journal of applied ecology2026-08-25

Effects of combined application of soil amendments on soil salinity, pH, yield and quality of watermelon in saline-alkali soil.

Zhi-Yi Tang T, Xin Chen C, Xi-Na Wang W, Jun-Cang Tian T et al.

We examined the effects of different combined soil amendments on the quality of saline-alkali soil and on the growth, yield, and quality of watermelon in a field experiment. There were four treatments, including 75 kg·hm-2 sulfur fertilizer+600 kg·hm-2 bio-organic fertilizer (T1), 75 kg·hm-2 sulfur fertilizer+300 kg·hm-2 soil conditioner (T2), 600 kg·hm-2 bio-organic fertilizer+300 kg·hm-2 soil conditioner (T3), and 75 kg·hm-2 sulfur fertilizer+600 kg·hm-2 bio-organic fertilizer+300 kg·hm-2 soil conditioner (T4), with no amendment application as the control (CK). We analyzed the effects of different treatments on soil pH, soil salt content in the 0-100 cm soil profile, as well as photosynthetic characteristics, growth, yield, and fruit quality of watermelon. The results showed that all amendment treatments reduced soil pH and salt content to different extents. The decrease in soil pH was mainly concentrated in the 0-60 cm soil layer. The treatments of T3 and T4 showed more obvious effects on reducing soil pH in the 20-40 cm soil layer. The T2 treatment had a more prominent effect on reducing soil salt content, with a reduction of 13.8% and 29.5% in the 0-20 cm and 20-40 cm soil layers, respectively. The T2 and T3 treatments significantly increased net photosynthetic rate, transpiration rate and stomatal conductance of watermelon. The T2 treatment mainly promoted leaf area expansion and main vine elongation. The T3 treatment mainly promoted main vine elongation and stem thickening. The T1, T2, T3, and T4 treatments increased watermelon yield by 8.9%, 12.4%, 12.3%, and 11.0%, respectively. The T3 treatment significantly increased fruit hardness, while the T2 and T4 treatments significantly increased soluble solids, vitamin C content, and sugar-acid ratio. Based on the multi-criteria decision-making model, the comprehensive ranking of different treatments on watermelon was T2>T3>T4>T1>CK. Overall, the combined application of 75 kg·hm-2 sulfur fertilizer and 300 kg·hm-2 soil conditioner was the optimal treatment for improving saline-alkali soil, promoting watermelon growth, increasing yield and improving fruit quality.

PMID 42639890
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PubMedCureus2026-08-25

Low T3 Syndrome in Acute Myocardial Infarction: Association With Cardiac Biomarkers and Implications for Myocardial Injury Severity.

Singh Piyush K PK, Supriya, Choudhary Rekha R, Rangasamy Udayakumar U et al.

Background An acute myocardial infarction (AMI) triggers widespread inflammatory, neuroendocrine, and metabolic shifts across the body. Deviations in thyroid hormone regulation, particularly the development of low triiodothyronine (T3) syndrome, are frequently observed during acute cardiovascular events and may mirror the intensity of the underlying physiological stress. Objective The objective of the study is to evaluate the prevalence of low T3 syndrome in individuals presenting with an initial episode of AMI and to investigate its independent relationship with biochemical indicators of myocardial damage. Methods This prospective observational investigation featured 100 consecutive patients aged 30 to 70 years who were admitted with their first AMI at a tertiary care teaching institution. Cases of AMI were confirmed using clinical presentations, electrocardiographic variations, and elevated troponin I and/or creatine kinase-MB (CK-MB) concentrations. Circulating blood samples collected within roughly six hours of symptom onset were evaluated for free T3 (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), troponin I, and CK-MB using a chemiluminescent microparticle immunoassay. Low T3 syndrome was identified by diminished serum fT3 concentrations alongside relatively steady fT4 and TSH profiles. Skewed biomarker distributions (fT3 and TSH) were reported as median (interquartile range) and subjected to a logarithmic transformation (log10) prior to multivariable analysis. Statistical relationships were evaluated via Pearson correlation analysis and a multivariable linear regression model using log-transformed troponin I as the primary dependent variable. Results The cohort presented a mean age of 56.3 ± 14.3 years, with male patients representing 65% of the total group. Low T3 syndrome was documented in 30% of the study population. In the multivariable linear regression model adjusting for baseline demographic confounders (age and sex), both log-transformed TSH (β = 0.33, p = 0.001) and log-transformed fT3 (β = 0.28, p = 0.003) emerged as significant independent predictors of myocardial injury severity (log-troponin I). Conclusion Low T3 syndrome occurred frequently in patients experiencing a first-episode AMI. Baseline thyroid-axis alterations, specifically log-TSH and log-fT3, are significantly and independently associated with biochemical markers of myocardial injury at admission. However, as these early neuroendocrine shifts represent a cross-sectional baseline snapshot, their direct relationship with structural infarct size, ventricular dysfunction, or long-term clinical prognosis requires further validation in larger trials.

PMID 42639098
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PubMedFrontiers in public health2026-08-25

Relationship between mobile phone use and multidimensional frailty: evidence from UK Biobank.

Kong Shuo S, Xu Shuishan S, Wu Songyu S, Kou Changgui C et al.

To investigate the longitudinal temporal relationships between weekly mobile phone call time and four dimensions of frailty. Data were derived from three instances (T1, T2, T3) of the UK Biobank. Frailty encompassed four dimensions: psychological, physical, social, and cognitive. Separate Random Intercept Cross-Lagged Panel Models (RI-CLPM) were constructed for each frailty dimension with weekly mobile phone call time, measured by self-reported weekly mobile phone call time standardized to baseline. Chi-square difference tests and the BIC were adopted for model comparisons. This study included 5,533 participants aged 40-70 years. Unconstrained models outperformed constrained models for all dimensions (P < 0.001). For psychological frailty, after false discovery rate (FDR) correction, only the path from psychological frailty T1 to weekly mobile phone call time T2 was marginally significant (β = 0.086, SE = 0.031, P = 0.008, P_FDR = 0.048), while the other cross-lagged paths (psychological frailty T2 to weekly mobile phone call time T3: β = 0.053, SE = 0.023, P = 0.025, P_FDR = 0.101; weekly mobile phone call time T2 to psychological frailty T3: β = 0.067, SE = 0.027, P = 0.010, P_FDR = 0.069) were not significant, thus robust bidirectional associations were not supported. Physical frailty was not significantly associated with subsequent weekly mobile phone call time at either interval (T1 to T2: β = 0.035, SE = 0.048, P = 0.465; T2 to T3: β = 0.052, SE = 0.029, P = 0.075; both P_FDR > 0.05). Social frailty was significantly associated with subsequent weekly mobile phone call time at T2 to T3 (β = 0.078, SE = 0.025, P = 0.002, P_FDR = 0.033). No cross-lagged associations were observed for cognitive frailty (all P > 0.05). The random intercepts of weekly mobile phone call time were all significant (P < 0.001), suggesting stable inter-individual differences rather than within-individual fluctuations. In summary, after FDR correction, only two cross-lagged associations reached statistical or marginal significance: one from psychological frailty T1 to weekly mobile phone call time T2 (β = 0.086, P_FDR = 0.048), and the other from social frailty T2 to weekly mobile phone call time T3 (β = 0.078, P_FDR = 0.033), each observed in only one time interval, with no significant associations in other directions or intervals. These results indicate weak and inconsistent temporal associations rather than consistent or robust bidirectional effects. This study examined prospective within-person associations between weekly mobile phone call time and frailty dimensions in a middle-aged and older adult sample (baseline age 40-70 years). After FDR correction for multiple testing, most cross-lagged associations were not statistically significant. Only two paths reached significance or marginal significance: social frailty T2 → weekly mobile phone call time T3 (β = 0.078, P_FDR = 0.033) and psychological frailty T1 → weekly mobile phone call time T2 (β = 0.086, P_FDR = 0.048), each occurring in only one time interval. No consistent or robust bidirectional patterns were observed across dimensions or intervals. The significant random intercepts suggest stable inter-individual differences in phone use over time. Overall, these findings do not support clear temporal relationships between weekly mobile phone call time and most frailty dimensions, and the few observed associations are weak.

PMID 42638665
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PubMedCritical care (London, England)2026-08-25

ICU-specific virtual reality for mental health after critical illness: an international three-arm randomized clinical trial.

Drop Denzel L Q DLQ, Vlake Johan H JH, van Bommel Jasper J, Wils Evert-Jan EJ et al.

Survivors of critical illness frequently experience symptoms of post-intensive care syndrome (PICS), including post-traumatic stress disorder (PTSD), anxiety, and depression, with downstream impact on health-related quality of life (HRQoL). We evaluated whether an intensive care unit-specific virtual reality (ICU-VR) video improves mental health outcomes and whether timing (early vs. late) matters. We conducted an international, three-arm, multicentre randomized clinical trial across eleven hospitals. Adults (≥ 18 years) with ICU stay ≥ 72 h and mechanical ventilation ≥ 24 h were randomized 1:1:1 to (1) standard care, (2) early ICU-VR (within 7-15 days post-ICU), or (3) late ICU-VR (≈ 3 months, during aftercare). The primary endpoint was PTSD symptom severity at six months (T3) measured by the Impact of Event Scale-Revised (range 0-88). Secondary endpoints included anxiety/depression severity and prevalence, and HRQoL. We randomized 344 participants (median age 61 years; 62% male); follow-up among survivors at six months (T3) was 80%. At six months, PTSD symptom severity did not differ between early ICU-VR and control (β = 0.32; 95% CI -3.38 to 4.02; p = 0.87) nor late ICU-VR and control (-0.82; 95% CI -4.62 to 2.97; p = 0.67). No between-group differences were observed for anxiety, depression, or HRQoL (all adjusted p > 0.05). Patients rated ICU-VR highly for improving understanding of the ICU experience and overall satisfaction (median 8/10). In this multicentre randomized clinical trial, a single ICU-VR video did not improve PTSD, anxiety, depression, or HRQoL at six months versus standard care. Findings should not be generalized to multi-session, therapist-guided, or personalized VR interventions. Future trials should target high-risk patients, make multi-session mandatory, and personalize ICU-VR. This study was prospectively registered Netherlands: Trial Register/International Clinical Trials Registry Platform, NL9812, October 21, 2021.

PMID 42638131
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PubMedFrontiers in veterinary science2026-08-25

Sustained improvements in human-cat interaction in the shelter sector: a study of a best-practice educational intervention.

Hatam Elle V EV, Barcelos Ana M AM, Waterman James J, Bhatia Avni A et al.

Human-cat interaction (HCI) in rescue settings is often inconsistent, driven by individual caregiver beliefs rather than standardised evidence-based practice. This study evaluates the efficacy of an educational intervention for shelter workers, incorporating evidence based HCI principles designed to promote cat comfort and reduce the risk of cat human-directed aggression. A pre-post study followed employees and volunteers across three timepoints: a pre-intervention baseline (T1, n = 47), 2 weeks post-intervention (T2, n = 47), and a six-month follow-up (T3, n = 19). To assess intervention efficacy, participants' real-time HCI were filmed at each time point and blind-rated by cat behaviour experts based on the degree to which participants' cat directed behaviour aligned with evidence based best practice HCI principles (either 'closely', 'somewhat' or 'not at all' aligned). Participants also completed self-reported attitude and practice questionnaires that were similarly designed to assess alignment with best practice HCI principles and approaches. Composite 'attitude' and 'practice' scores were generated with higher scores reflecting greater alignment with best practice HCI principles. Cumulative Link Mixed Models (CLMM) revealed very strong evidence that participants real-time HCI ratings improved post-intervention [LRχ 2(2) = 37.07, p < 0.001], with these gains remaining stable at the six-month follow-up. Specifically, the probability of receiving a "closely aligned" HCI rating increased from 2% (±3%) at T1 to 25% (±16%) at T2 (p = 0.008), rising further to 37% (±27%) at T3 (p = 0.023). At baseline prior to training, higher participant attitude scores were significantly predictive of higher real-time HCI ratings. This association disappeared post-intervention as both HCI ratings and attitude scores increased across the population, effectively reducing score variance and suggesting the training "levelled the playing field" across participants regardless of their starting beliefs. Staff with shorter service lengths (under 2 years) were nearly twice as likely to achieve higher HCI ratings post intervention compared to longer serving staff members, suggesting training may be more effective when delivered within shorter post-recruitment windows. The educational intervention was effective in promoting positive and sustainable improvements in participant's HCI, highlighting the benefits of evidence-based training delivered to shelter workers.

PMID 42638931
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PubMedCureus2026-08-25

Profound Hypothyroidism as a Reversible Cause of Severe Low-Density Lipoprotein Cholesterol (LDL-C) Elevation: A Case Report.

Mataraarachchi Nirosh E NE, Bhat Shalini S

Thyroid hormone plays a central role in regulating lipid metabolism. In states of profound hypothyroidism, impaired triiodothyronine (T3)-mediated regulation of hepatic LDL (low-density lipoprotein) receptor expression results in decreased clearance of apolipoprotein B-containing lipoproteins. These physiologic disturbances can lead to substantial low-density lipoprotein cholesterol (LDL-C) elevation, which can mimic primary genetic lipid disorders and complicate the clinical evaluation of severe hypercholesterolemia. Herein, we describe a patient with autoimmune thyroid disease status post total thyroidectomy who demonstrated marked, reproducible LDL-C elevations during periods of profound hypothyroidism, with substantial improvement upon restoration of euthyroidism. These fluctuations occurred in the absence of lipid-lowering therapy. This case highlights the importance of assessing thyroid function in patients with severe LDL-C elevation. Recognition and treatment of hypothyroidism can substantially improve lipid abnormalities and reveal a reversible endocrine-mediated contributor to marked hypercholesterolemia.

PMID 42639632
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