Drug Database
PH

PHN-021 (PCNH / PHN021)

✓ Approved

PhytoHealth · Small Molecule · Small Molecule

What is PHN-021?

PHN-021 is a small molecule developed by PhytoHealth. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesPCNH, PHN021
CompanyPhytoHealth
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, PhytoHealth

Therapeutic Indications

PHN-021 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal painPhase I

Related Research Articles

PubMedThe Eurasian journal of medicine2026-08-25

Predicting Failure of Conventional Imaging in Primary Hyperparathyroidism: The Impact of Parathyroid Hormone Levels and Thyroid Nodules.

Erdoğan Eroğlu Ceren C, Açık Şeyma Ş, Kalan Sarı Işılay I

Primary hyperparathyroidism (PHPT) is an endocrine disorder caused by excessive parathyroid hormone (PTH) secretion. Accurate localization remains essential for the clinical evaluation of patients; however, successful localization cannot be achieved in all patients. This study aimed to evaluate clinical and biochemical factors associated with unsuccessful localization using conventional imaging in patients with PHPT. This retrospective cross-sectional study analyzed data from 174 patients diagnosed with PHPT between January 1, 2015, and October 1, 2024. Localization was performed using technetium-99m MIBI scintigraphy and ultrasonography; fine-needle aspiration with PTH washout was used selectively. Patients were grouped as localized (n = 127) or non-localized (n = 47) according to conventional imaging findings. Demographic characteristics, biochemical parameters, imaging results, and clinical findings were compared. The localized group had significantly higher intact PTH (iPTH) levels (143.0 vs 115.0 pg/mL, P < .001) and serum calcium levels (11.6 vs 11.2 mg/dL, P = .004). The non-localized group had higher age (P = .012), higher 25-hydroxyvitamin D levels (21.8 vs 17.0 ng/mL, P = .024), and more frequent thyroid nodules (74.5% vs 54.3%, P = .016). In multivariable analysis, iPTH level (OR: 1.011, 95% CI:1.002-1.020, P = .021) and thyroid nodules (OR:0.391, 95% CI:0.174-0.879, P = .023) were identified as independently associated with localization success. Receiver operating characteristic (ROC) analysis showed moderate discriminative ability of iPTH cut-off: 146.5 pg/mL (area under the curve = 0.693, sensitivity = 45.7%, specificity = 87.2%). Higher serum iPTH levels were associated with successful localization, whereas the presence of thyroid nodules was associated with unsuccessful localization using conventional imaging. These findings may help identify patients who require more cautious interpretation of conventional imaging results and individualized consideration of additional imaging modalities. Cite this article as: Erdoğan Eroğlu C, Açık Ş, Kalan Sarı I. Predicting failure of conventional imaging in primary hyperparathyroidism: The impact of parathyroid hormone levels and thyroid nodules. Eurasian J Med. 2026, 58(4), 1492, doi: 10.5152/ eurasianjmed.2026.261492.

PMID 42639806
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PubMedThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2026-08-24

Pancreatic Stiffness in Patients with Type 2 Diabetes Mellitus Assessed by 2-Dimensional Shear Wave Elastography: A Pilot Case-Control Study.

İnce Yahya Erdem YE, Sezgin Orhan O, Yaraş Serkan S, Özdoğan Osman O et al.

Shear wave elastography (SWE) is a noninvasive method for assessing tissue stiffness. This study evaluated pancreatic stiffness in patients with type 2 diabetes mellitus (T2DM) and examined its association with metabolic factors and microvascular complications. This prospective case-control study included 45 patients with T2DM and 45 healthy controls. Pancreatic stiffness was measured using 2-dimensional SWE (2D-SWE). Clinical, anthropometric, and laboratory data were collected, and diabetic microvascular complications were assessed. A total of 90 participants were included, comprising 45 patients with T2DM and 45 healthy controls. Pancreatic stiffness was significantly higher in patients with T2DM than in controls across all pancreatic regions (P < .001). However, pancreatic stiffness did not differ significantly between patients with T2DM with and without microvascular complications (P > .05). Pancreatic steatosis (PS) was more prevalent in patients with T2DM than in healthy controls (P = .001). Among patients with T2DM, pancreatic stiffness was significantly higher in those with steatosis than in those without (P = .035), and stiffness increased with the severity of steatosis (P = .021). Body mass index and waist circumference (WC) were independently associated with increased pancreatic stiffness, with WC accounting for a significant proportion of the variance (P < .001). Pancreatic stiffness was significantly higher in patients with T2DM than in healthy controls and was primarily associated with metabolic factors, particularly obesity and PS, rather than microvascular complications. These findings suggest that increased pancreatic stiffness may reflect metabolic associated pancreatic alterations.

PMID 42635176
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PubMedJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2026-08-24

Right Ventricular-Pulmonary Artery Coupling by 3D Echocardiography Predicts Outcomes in Heart Failure with Preserved Ejection Fraction.

Seo Heekyung H, Kim Kyu K, Lee Seonhwa S, Seo Jiwon J et al.

In advanced heart failure with preserved ejection fraction (HFpEF), right ventricular (RV) dysfunction and impaired RV-pulmonary artery (PA) coupling are increasingly recognized as contributors to prognosis. While conventional echocardiography mainly assesses longitudinal RV function, three-dimensional (3D) imaging enables more comprehensive evaluation. We investigated the prognostic value of 3D-derived RV function and RV-PA coupling in patients with HFpEF. Of 311 prospectively enrolled patients with HFpEF between 2022 and 2023, 229 (age 74.1 ± 10.3 years; 41.5% male) were analyzed. 3D RV ejection fraction (RVEF), pulmonary artery systolic pressure (PASP), tricuspid annular plane systolic excursion (TAPSE), RV free-wall longitudinal strain (RVFWS), and coupling indices (3D RVEF/PASP, TAPSE/PASP, and RVFWS/PASP) were assessed. The primary endpoint was a composite of cardiovascular death or heart failure hospitalization. During a median follow-up of 23.5 months, 34 patients (14.8%) experienced the primary endpoint. Reduced 3D RVEF and impaired 3D RVEF/PASP were associated with higher event rates. On time-dependent ROC analysis, 3D RVEF/PASP showed higher discriminatory ability than TAPSE/PASP at 6, 12, and 18 months (P = .009, .032, and .021, respectively). In multivariable Cox analysis, 3D RVEF/PASP remained independently associated with adverse outcomes (adjusted HR 0.86, 95% CI 0.77-0.96; P = .007). The prognostic value of 3D RVEF/PASP persisted in patients with moderate-to-severe TR. 3D RVEF/PASP independently predicted cardiovascular outcomes and showed higher prognostic discrimination than TAPSE/PASP in HFpEF. 3D RV-PA coupling may provide complementary information for noninvasive risk stratification.

PMID 42637156
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PubMedJournal of pain research2026-08-23

Normative Modeling of EEG Complexity Reveals Cortical Rigidity Associated with Pain Severity in Chronic Pain.

Ye Yuntian Y, Chen Jiange J, Ma Kuizhi K, Xuan PengJia P et al.

Chronic pain is neurophysiologically heterogeneous and may be obscured by group-average EEG metrics. We hypothesized that chronic pain would be characterized by reduced cortical complexity relative to a healthy-control-derived normative reference, defined as the age- and sex-conditioned expected distribution of EEG features, and that larger negative deviations would be associated with greater pain intensity. Resting-state EEG from 147 participants, including 78 patients with chronic pain and 69 healthy controls, was analyzed. Complexity was quantified using Higuchi fractal dimension (HFD) across seven scalp regions. A Gaussian process regression normative model was trained exclusively on healthy controls, using age and sex as covariates, to estimate expected HFD values and predictive uncertainty. Individual deviations were expressed as W-scores, with more negative values indicating reduced complexity relative to the normative reference. In patients, regional W-scores were correlated with average pain intensity using Pearson correlations with false discovery rate correction. Robustness was examined after adjustment for age, sex, depression, and anxiety, and spectral power measures were evaluated as exploratory benchmarks. More negative frontal HFD W-scores were associated with higher pain intensity (r = -0.545, P_FDR < 0.001). Significant HFD-pain associations were observed across multiple regions, with correlation coefficients ranging from -0.441 to -0.545 among FDR-significant HFD features. The parietal association also survived correction (r = -0.523, P_FDR < 0.001). Compared with the examined spectral power benchmarks, HFD-based deviations showed larger descriptive associations with pain intensity. The frontal HFD-pain association persisted after adjustment for age, sex, depression, and anxiety (r = -0.520, two-tailed P < 0.001). Exploratory subgroup analyses suggested larger negative latent deviation scores in neuropathic conditions, particularly PNP and PHN. Normative deviation mapping of EEG complexity may provide a candidate research marker for quantifying inter-individual variability in chronic pain severity. These findings support further validation of HFD-based normative modeling for mechanism-informed stratification, while requiring replication in larger, harmonized, and longitudinal datasets.

PMID 42633436
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PubMedAmerican journal of translational research2026-08-22

Shaoyao Gancao decoction for neuropathic pain: a systematic review and meta-analysis of postherpetic neuralgia.

Zhao Jinfeng J, Wang Fengyun F, Wang Fang F, Ma Ling L

To systematically evaluate the efficacy and safety of Shaoyao Gancao Decoction (SGD) for neuropathic pain (NP), with a focused analysis on postherpetic neuralgia (PHN), the most evidence-rich subtype, and to provide evidence for clinical decision-making. Randomized controlled trials (RCTs) on SGD for PHN were retrieved from databases up to March 2026. Two reviewers independently screened literature, extracted data, and assessed risk of bias using the Cochrane tool. Meta-analyses were performed using RevMan 5.3, and effect sizes were expressed as odds ratio (OR) or mean difference (MD) with 95% confidence intervals (CIs). Fifteen RCTs involving 1,188 patients with PHN (594 per group) were included. Compared with conventional Western medicine alone, the addition of SGD significantly improved the overall response rate (OR=5.42, 95% CI: 3.40-8.64, P<0.0001), reduced Visual Analogue Scale (VAS) pain score (MD=-1.33, 95% CI: -1.68 to -0.99, P<0.0001), improved Pittsburgh Sleep Quality Index (PSQI) score (MD=-2.23, 95% CI: -2.85 to -1.62, P<0.0001), and lowered the incidence of adverse events (OR=0.34, 95% CI: 0.21-0.56, P<0.0001). Subgroup analyses by treatment duration (14 and 28 days) showed consistent analgesic effects and overall efficacy. Pain Rating Index (PRI) and Present Pain Intensity (PPI) scores were also significantly improved in the SGD group (both P<0.0001). Although high heterogeneity was observed in VAS (I2=97%), subgroup and sensitivity analyses suggested that the pooled results remained robust. Given that PHN represents a common NP subtype, SGD may have potential therapeutic value for broader NP conditions. Current evidence supports SGD as an adjunctive therapy for PHN, with good efficacy and safety. Its potential value for other NP types (such as diabetic peripheral neuropathy, chemotherapy-induced neuropathy) warrants further research.

PMID 42631154
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PubMedBrain & spine2026-08-22

Feeding artery remodeling and long-term regression of flow related aneurysms following obliteration of brain arteriovenous malformations.

Sokratous Giannis G, Tajsic Tamara T, Guo Yuhan Y, Brown Daniel D et al.

Flow aneurysms associated with arteriovenous malformations may increase risk of hemorrhagic presentation and unfavorable outcome but their natural history and management, following treatment of the associated malformation remain uncertain. To evaluate the relationship between changes in feeding vessel caliber and flow related aneurysm size, following complete surgical resection or stereotactic radiosurgery obliteration of the arteriovenous malformation. A retrospective observational study was performed (2008-2017), including all patients with symptomatic arteriovenous malformation, at least one flow related, conservatively managed aneurysm and angiographically complete resection or obliteration of the malformation following treatment. Aneurysm, proximal and distal feeding artery dimensions were obtained before and after treatment. Spearman rank coefficients and linear regression analysis were used to describe any correlation, its strength and direction. Eleven patients with seventeen aneurysms were eligible for inclusion, of which fourteen conservatively managed flow aneurysms were analyzed. Eight patients harboring eleven flow aneurysms underwent surgical resection, with the remaining three patients receiving radiosurgery. After excluding completely regressed aneurysms, proximal feeding artery remodeling showed moderate-to-strong correlation to aneurysm regression (ρ = 0.68, P = .021), while distal feeding artery remodeling was unrelated (ρ = 0.00, P = 1.0). Distal type IIb flow related aneurysms were more likely to regress. Changes in proximal feeding artery diameter may help predict fate of flow aneurysms. Our findings support incorporating proximal feeding artery remodeling into post-treatment radiological assessment. With further validation, it may represent a biomarker for treatment efficacy in patients with flow aneurysms, and help inform personalized treatment strategies.

PMID 42630742
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