Drug Database
PH

PHN-021 (PCNH / PHN021)

✓ Approved

PhytoHealth · Small Molecule · Small Molecule

What is PHN-021?

PHN-021 is a small molecule developed by PhytoHealth. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesPCNH, PHN021
CompanyPhytoHealth
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, PhytoHealth

Therapeutic Indications

PHN-021 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal painPhase I

Related Research Articles

PubMedEuropean journal of pain (London, England)2026-10-22

Structural Reorganization of Hypothalamic Subfields in Postherpetic Neuralgia: Volumetric and Morphometric Covariance Network Analyses.

Oh Daeseok D, Lee Dong Ah DA, Lee Ho-Joon HJ, Park Kang Min KM

Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition associated with central nervous system reorganization, but hypothalamic alterations remain poorly understood. We investigated hypothalamic subfield volumes and morphometric covariance network organization in patients with PHN. This prospective cross-sectional study included 42 patients with PHN and 41 healthy controls whose hypothalamic subfield volumes were obtained from T1-weighted MRI using automated FreeSurfer segmentation. Bilateral mean raw subfield volumes were compared between groups using analysis of covariance, adjusting for age, sex and estimated total intracranial volume, with false discovery rate correction for multiple comparisons. Morphometric covariance networks were constructed from age- and sex-residualized subfield volumes and graph-theoretical measures were compared using permutation testing. After adjustment for estimated total intracranial volume, age and sex, the tubular superior subfield was nominally larger in PHN (adjusted difference, 4.95 mm3; 95% CI, 0.05-9.85; p = 0.048), but did not survive FDR correction. No other subfield or whole-hypothalamic volume differed significantly. PHN showed reduced local efficiency and clustering coefficient and increased characteristic path length, without a significant difference in global efficiency. No pain-side-dependent lateralization or significant associations between subfield volumes and pain measures or disease duration were observed. PHN was associated with altered hypothalamic morphometric covariance organization, characterized by reduced local network segregation and increased characteristic path length, while regional volume differences were limited after intracranial volume correction. These findings suggest that PHN-related central reorganization may involve hypothalamic systems related to homeostatic regulation and stress adaptation. This study demonstrates altered morphometric covariance organization of hypothalamic subfields in postherpetic neuralgia, despite limited evidence of regional volumetric differences after intracranial volume adjustment. These findings suggest that hypothalamic involvement in PHN may be better reflected by altered coordinated structural organization than by regional volume changes alone.

PMID 42902843
Read full article →
PubMedEwha medical journal2026-10-20

Psoas-lumbar vertebral index and short-term pain relief after pulsed radiofrequency treatment of the dorsal root ganglion in postherpetic neuralgia in Korea: a retrospective pilot study.

Yoo Seung Hee SH, Cho Eunbi E, Kim Won-Joong WJ

The psoas-lumbar vertebral index (PLVI), a marker of central sarcopenia measured using computed tomography (CT) or magnetic resonance imaging (MRI), has been linked to the development of postherpetic neuralgia (PHN). Whether PLVI predicts short-term pain relief after pulsed radiofrequency (pRF) treatment of the dorsal root ganglion (DRG) in established PHN remains unknown. This pilot study examined the association between PLVI and the reduction in numeric rating scale (NRS) pain scores 1 month after pRF. Patients with PHN who underwent DRG pRF and had CT or MRI scans available for PLVI measurement were retrospectively reviewed. Correlations of the NRS reduction rate with PLVI and other variables were assessed, with 95% confidence intervals (CIs). Patients were divided into low- and high-PLVI groups using sex-specific medians and compared; multivariable regression was adjusted for sex. A supplementary responder analysis used thresholds of ≥30% and ≥50% reduction. In 19 patients, NRS scores decreased from 4.8±1.7 to 3.2±1.7, with a reduction rate of 29.3%±34.0%. PLVI was not significantly correlated with the reduction rate (r=-0.17; 95% CI, -0.58 to 0.31; P=0.49); neither the reduction rate (P=0.71) nor responder rates differed between the low- and high-PLVI groups. Male sex was associated with a smaller reduction (adjusted B=-47.2 percentage points; 95% CI, -90.9 to -3.5; P=0.036), although the unadjusted group comparison was not significant (Welch P=0.051) and 15 variables were tested without correction for multiple comparisons. This pilot cohort showed no detectable association between PLVI and short-term pain relief after pRF; its small size precludes establishing the absence of an association. The exploratory sex difference warrants investigation in larger prospective studies with comprehensive sarcopenia assessment.

PMID 42897939
Read full article →
PubMedJournal of psychiatric research2026-10-18

Mental health outcomes in Prader-Willi Syndrome: An Australian cohort study.

Baker Emma K EK, Chellew Tayla T, Bui Minh M, Rogers Carolyn C et al.

Prader-Willi syndrome (PWS) is an imprinting disorder associated with complex cognitive, physical, and behavioral features, as well as high rates of mental health conditions. Understanding mental health conditions in individuals with PWS and their association with behavioral characteristics is an essential step towards better supporting individuals with PWS. Thirty individuals with PWS (14 deletion, 16 non-deletion) aged 3-45 years participated in this study to examine associations between mental health conditions (Prader-Willi Syndrome Mental Health Questionnaire), intellectual functioning (Wechsler Intelligence Scales), autistic traits (Autism Diagnostic Observation Schedule-2), and challenging daytime behaviors (Prader-Willi Syndrome Behavior Questionnaire; Aberrant Behavior Checklist). 73% of individuals with PWS had at least one parent-reported mental health condition. Anxiety (65%) was the most common, followed by obsessive compulsive disorder (43%) and depression (40%). While reports of any mental health condition and depression were more common in individuals with a deletion compared to their non-deletion counterparts, these differences were primarily driven by the fact that the deletion group was significantly older than the non-deletion group. Those with PWS and mental health conditions had lower verbal IQ (p = .003), greater autistic traits (p < .001), greater food seeking (p = .004) and oppositional behaviors (p = .021), and increased maladaptive behaviors (p = .001) compared to those without a mental health condition. This study highlighted elevated rates of mental health conditions and additional cognitive and behavioral challenges among individuals with PWS, including in young children with PWS. Age-related factors were a primary factor relating to differences between molecular classes on mental health presentations, highlighting the need for earlier supports and interventions that may improve mental health prognoses in individuals with PWS.

PMID 42892097
Read full article →
PubMedActa psychologica2026-10-18

Perceived organizational support, passion reflected on the field: A quantitative research on coaches working in football academies.

Siyahtaş Anıl A, İlk Çağrı Ç, Çelikel Baha Engin BE, Turaç Görkem G et al.

One of the most important roles in the development of children into professional football players belongs to the coaches working in football academies. Therefore, it is thought that the organizational support that coaches, who work under intense performance pressure, perceive from their clubs can have a significant impact on their passion for their work. However, it is anticipated that psychological and motivational factors may also play a significant role in explaining this relationship. The aim of this research is to examine the relationships between perceived organizational support, psychological resilience, job motivation, and job passion among coaches working in the academies of clubs in the Turkish professional football leagues, within the framework of a structural model. The study included 259 volunteer coaches (n = 259; Xage = 41.27; SDage = 11.91). The research model was tested for direct and indirect effects using SPSS PROCESS Macro with a 5000 bootstrap sample. Initially, perceived organizational support was significantly associated with job passion (β = 0.143, p = .021). However, after psychological resilience and job motivation were included as mediators, the direct relationship between perceived organizational support and job passion became non-significant (β = -0.069, 95% CI [-0.132, 0.031]). Furthermore, psychological resilience and job motivation jointly showed a significant sequential mediating role in the relationship between perceived organizational support and job passion (B = 0.016, 95% bootstrap CI [0.005, 0.032]). In conclusion, providing organizational support alone does not seem sufficient to increase the passion of academy coaches for their job. Accordingly, it is recommended that practices aimed at strengthening psychological resilience and job motivation be supported to increase coaches' passion for their jobs.

PMID 42892200
Read full article →
PubMedArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2026-10-18

Arthroscopic-Assisted Lower Trapezius Transfer Improves Outcomes in Patients With Irreparable Posterosuperior Rotator Cuff Tears Irrespective of the Presence of External Rotation Lag Sign.

Hachem Abdul-Ilah AI, Marcet Pablo P, Ezzeddine Hady H, Rius Xavier X et al.

To evaluate whether arthroscopic-assisted lower trapezius transfer for irreparable posterosuperior rotator cuff tears provides comparable outcomes in patients with and without a preoperative external rotation (ER) lag sign and to analyze the progression of postoperative functional recovery over time. Retrospective cohort study of patients with irreparable posterosuperior rotator cuff tears who underwent arthroscopic-assisted lower trapezius transfer with 2-year minimum follow-up. Patients were stratified according to the presence of a preoperative ER at the side (ER1) lag sign, and comparisons were performed. Range of motion, patient-reported outcomes, resolution of ER1 and ER at 90° of abduction (ER2) lag signs, and complications were collected preoperatively and postoperatively. The temporal pattern of functional recovery was assessed by comparing outcomes across successive follow-up time points. Fifty-three patients with a mean age of 56.5 ± 6.2 years were included. Twenty-one patients (40%) had a preoperative ER1 lag sign. Follow-up time was similar between patients with and without ER1 lag sign (39 ± 20 months [range 24-57] vs 30.5 ± 17.2 [range 24-57], respectively, P = .443). Both groups showed improvements in range of motion and patient-reported outcomes at the 24-month follow-up. At 24 months postoperatively, patients without a preoperative ER1 lag sign showed significantly greater ER1 and ER2 than those with an ER1 lag sign (ER1: 58° ± 11 vs 32° ± 16, respectively, P < .001; ER2: 84° ± 11 vs 71° ± 20, respectively, P = .021). Complete resolution of the ER1 and ER2 lag signs occurred in 81% and 80% of patients, respectively, with most recovery observed within the first 3 months postoperatively. At 24 months, the proportion of patients achieving the minimal clinically important difference was similar between groups across all range-of-motion parameters. Arthroscopic-assisted lower trapezius transfer significantly improves functional outcomes in patients with irreparable posterosuperior rotator cuff tears, irrespective of preoperative ER1 lag sign status, with most improvements occurring at 3 months postoperatively. Although overall outcomes were comparable, patients without a preoperative ER1 lag sign showed greater improvements in strength. Level III, retrospective cohort study.

PMID 42893418
Read full article →
PubMedMedicine2026-10-17

A quality appraisal of clinical practice guidelines for herpes zoster and postherpetic neuralgia using the AGREE II instrument: A systematic review.

Hong YeEun Y, Park JungGun J, Yoo Jaehyun J, Kim Kyuseok K

This study systematically assesses the methodological quality of both Western and traditional medicine clinical practice guidelines (CPGs) for herpes zoster (HZ) and postherpetic neuralgia (PHN) using the Appraisal of Guidelines Research and Evaluation (AGREE II) instrument. A systematic search was conducted up to January 10, 2025 to identify CPGs for HZ or PHN, regardless of whether they were based on Western or traditional medicine. All CPGs addressing diagnosis, evaluation, treatment, prevention, and management were included. Two evaluators independently screened the records and extracted the data. The quality of the CPGs was independently assessed by 5 evaluators using the AGREE II instrument. The intraclass correlation coefficient (ICC) was calculated to assess inter-rater reliability. Eleven CPGs were included, consisting of ten from Western medicine and 1 from traditional medicine. The AGREE II domain scores were as follows: The "Clarity of Presentation" domain received the highest score (76.2%), whereas "Editorial Independence," "Stakeholder Involvement," and "Applicability" scored below 30%, with "Applicability" receiving the lowest score (10.9%). Inter-rater reliability was excellent, with ICCs for the AGREE II domains ranging from 0.927 to 0.990. Four CPGs were rated as Moderate quality (Recommended with modifications), and 6 CPGs were of Low quality (Not recommended). Among the Western medicine CPGs, JASP 2021 was the only 1 rated as High quality (Recommended), whereas CACMS 2013, the only traditional medicine CPG, was rated as Low quality (Not recommended). The findings reveal considerable variability in quality, with overall low-to-moderate quality observed in the guidelines for HZ and PHN. These results highlight the need to address the domains with consistently low scores identified by the AGREE II instrument by adopting a multidisciplinary approach, strengthening applicability, and ensuring rigor in the development process to improve guideline quality.

PMID 42888535
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about PHN-021