Aestura · PTGS1 · Small Molecule
ketoprofen is a small molecule developed by Aestura. It is approved for therapeutic indications via transdermal.
| Brand Names | Ketopatch, ketoprofen, Pacific, Ketotop patch |
| Company | Aestura |
| Drug Class | Small Molecule |
| Molecular Target | PTGS1, PTGS2 |
| Route | Transdermal |
| Status | Approved |
ketoprofen acts on 2 molecular targets:
| PTGS1 | prostaglandin-endoperoxide synthase 1 (COX3, PCOX1) |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2) |
ketoprofen is developed for 6 unique indications across 3 therapeutic areas.
| Therapeutic Area | Condition | Phase |
|---|---|---|
| Injury, poisoning and procedural complications | Epicondylitis | ✓ Approved |
| Hepatobiliary disorders | Hepatitis | ✓ Approved |
| Musculoskeletal and connective tissue disorders | Musculoskeletal pain | ✓ Approved |
| Musculoskeletal and connective tissue disorders | Osteoarthritis | ✓ Approved |
| Musculoskeletal and connective tissue disorders | Rheumatoid arthritis | ✓ Approved |
+1 more indication available with a free account
Sign up free to view all indications →Elangovan H H, Akbary K K, Rastogi A A, Wee A A et al.
Kim Kelly H KH, Chou Jonathan C JC
Objective: Asian Pacific Islander Desi American (APIDA) university students face unique mental health challenges, including disproportionately low rates of mental health service utilization compared to all other racial/ethnic groups. Despite increasing recognition of APIDA students' mental health needs, the underlying contributors to mental health disparities for these students are poorly understood. This narrative review summarizes the APIDA university student mental health literature from the last decade, focusing on social and structural contributors to students' mental health outcomes. Methods: We searched PubMed for research articles published between 2015-2025 on APIDA university student mental health. Results: The first subsection reviews the latest prevalence data and discusses the issues of underdiagnosis and disaggregation of data; the second focuses on social determinants of APIDA students' underutilization of mental health services; the final subsection focuses on the impact of large-scale sociocultural factors, including racial discrimination, acculturation/enculturation, and the model minority myth. Conclusion: APIDA students face significant barriers to care and concerning rates of psychological distress and mental illness. The article concludes with future directions for APIDA student mental health research and intervention.
Yu Lisan L, Toole John M JM
The "salty-gets-saltier, fresh-gets-fresher" paradigm predicts that an intensifying hydrological cycle should freshen the climatologically fresh Southern Ocean. Here we show the opposite: sea surface salinity increased at ~0.03 decade-1 across 40-50°S during 2004-2024, most coherently in the Pacific and Atlantic sectors. We attribute this salinification to the poleward expansion of the southern subtropical gyres, which advects saline subtropical water into latitudes of steepest meridional salinity gradient. The Subtropical and Subantarctic Fronts, tracked via the 35 and 34 isohalines, migrate poleward at unequal rates (-0.46° and -0.18° decade-1), narrowing the frontal corridor and sharpening the cross-frontal gradient. A mixed-layer budget shows that horizontal advection dominates the salinity trend, roughly tripling the opposing contribution from surface freshwater flux. Forced by poleward-intensifying westerlies and a positive Southern Annular Mode trend, this circulation-driven salinification demonstrates that ocean dynamics can override freshwater forcing, cautioning against interpreting salinity trends as direct fingerprints of the hydrological cycle.
Loncaric Igor I, Palmer Lauren L, Szostak Michael P MP, Rosel Adriana Cabal AC et al.
This study investigated the carriage of Staphylococcus (S.) intermedius group (SIG) isolates in marine mammals in the Pacific coastal region of Southern California, USA. We screened 452 samples from the oral cavities of California sea lions (Zalophus californianus), northern elephant seals (Mirounga angustirostris), harbor seals (Phoca vitulina), northern fur seals (Callorhinus ursinus), Guadalupe fur seals (Arctocephalus townsendi), long beaked common dolphin (Delphinus delphis bairdii), Pacific white-sided dolphins (Sagmatias obliquidens), and pygmy sperm whales (Kogia breviceps). Forty-two S. pseudintermedius and four S. delphini were obtained. Isolates were characterized by a polyphasic approach, which included antimicrobial susceptibility testing, molecular identification and characterization by rpoB/nuc sequencing, PCRs, DNA-based microarray, genotyping via spa and MLVA, and whole-genome sequencing of selected isolates. Resistance to penicillin, penicillin/tetracycline, and tetracycline alone was observed. Spa typing resulted either in novel types or in isolates that were non‑typeable. Twenty-nine MLVA types were detected. Multi-locus sequence typing revealed four STs: ST453 (previously described) and three novel STs: ST3046-8) among S. pseudintermedius and various virulence-associated genes were detected. Long-term monitoring remains essential to fully map its epidemiology, pathogenicity, and evolution of SIG in marine mammals.
Meng Nan N, Cao Xinyu X, Song Yu Y, Cong Peixu P et al.
This study confirmed that low-temperature, high-salinity depuration mitigates apoptosis and preserves quality in anhydrously stored Pacific oysters through targeted suppression of cardiolipin oxidation. We compared standard depuration (20 °C, 31‰) with low-temperature, high-salinity depuration (12 °C, 38‰). After five days, the latter maintained 30% higher survival, preserved glycogen and ATP equivalents, and sustained texture through suppressed serine protease activity. Integrated lipids and molecular index revealed that low-temperature, high-salinity depuration stabilized 23 cardiolipin (CL) molecular species, inhibited polyunsaturated fatty acid oxidation, and limited oxidized cardiolipin (oxCL) formation. These effects coincided with the down-regulation of pro-apoptotic genes (Bcl-2-associated X protein (Bax), Cytochrome c (Cyt-c), Caspase-3 (Casp3)) and the up-regulation of anti-apoptotic (B-cell Lymphoma 2 (Bcl-2), Heat shock protein 70 (Hsp70)) and cardiolipin synthase (Cls), Lysocardiolipin acyltransferase 1 (Lclat1)) genes, reducing mitochondrial reactive oxygen species, swelling, and mitochondrial permeability transition pore opening. Combined with time-lag correlation analysis and mediation effect analysis confirmed an oxCL-apoptosis-quality axis. Thus, low-temperature, high-salinity depuration safeguards mitochondrial integrity, delays apoptosis, and prolongs shelf life, offering a practical strategy for live oyster transport.
Wang Qing-Hua QH, Zhang Wei-Wei WW, Weng Zhuo-Ying ZY, Chen Yang-Fan YF et al.
Coral reef fishes, distinguished by remarkable species diversity and unique speciation mechanisms, offer an exceptional framework for understanding evolutionary diversification. As ecologically dominant predators, groupers (family Epinephelidae) exemplify high diversity in coral reef ecosystems, yet their phylogenetic relationships remain partially unresolved in previous studies based on mitochondrial and nuclear markers. Here, we performed a comprehensive phylotranscriptomic analysis of 92 specimens representing 32 species across seven genera of Epinephelidae. Leveraging concatenated nucleotide data analyzed with maximum likelihood and Bayesian inference, we first reconstructed a robust transcriptomic phylogeny with markedly enhanced resolution and nodal support compared to traditional marker-based frameworks. Our results revealed Plectropomus as the earliest diverging lineage, resolving a longstanding debate regarding the basal divergence within this family, and robustly supported the non-monophyly of Epinephelus and Cephalopholis. The origin and early diversification of Epinephelidae, currently distributed across the Indian and Pacific Oceans, may have occurred in the West Pacific during the Paleocene, followed by subsequent dispersal mediated by prevailing ocean currents. Furthermore, we found that the vicariance and speciation of major clades were likely driven by repeated episodes of sea level regression associated with glacial cycles. Enhanced upwelling and elevated primary productivity in recent periods may have further promoted the rapid radiation of groupers. To our knowledge, this represents the first application of phylotranscriptomics in the phylogenetic study of Epinephelidae, providing new insights into its phylogeny and evolutionary history.
+9996 more articles available with a free account
Sign up free to view all articles →