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(S)-atenolol (Atpure)

✓ Approved

Emcure Pharmaceuticals · ADRB1 · Small Molecule

What is (S)-atenolol?

(S)-atenolol is a small molecule developed by Emcure Pharmaceuticals. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesAtpure
CompanyEmcure Pharmaceuticals
Drug ClassSmall Molecule
Molecular TargetADRB1
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Emcure Pharmaceuticals

Mechanism of Action

Molecular Targets

(S)-atenolol acts on 1 molecular target:

ADRB1adrenoceptor beta 1 (B1AR, RHR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

(S)-atenolol is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

Related Research Articles

PubMedSheng wu gong cheng xue bao = Chinese journal of biotechnology2026-08-25

[Expression and immunogenicity of porcine deltacoronavirus S-trimer protein].

Yu Ruiming R, Zhang Liping L, Zhang Zhongwang Z, Zhou Peng P et al.

This study aims to express the S-trimer protein of porcine deltacoronavirus (PDCoV) and study its immunogenicity. Targeting the extracellular domain (D20-N1 077) of PDCoV S protein, we introduced the signal peptide sequence (secretoglobin family 1D member 1, SCGB1D1) at the N-terminus and the T4 phage Foldon motif at the C-terminus, and cloned the recombinant sequence into pcDNA3.1(+) vector. The S-trimer fusion protein was expressed in the ExpiCHO expression system and purified, and the molecular weight of the S-trimer fusion protein was analyzed by non-denaturing polyacrylamide gel electrophoresis and molecular sieve gel filtration chromatography. The purified S-trimer fusion protein was used to immunize New Zealand white rabbits to prepare hyperimmune rabbit serum. The titer of specific IgG antibodies in rabbit hyperimmune serum against PDCoV S was measured by indirect ELISA, and the neutralizing antibody titer in the hyperimmune rabbit serum was measured by the serum microneutralization test. The application of hyperimmune rabbit serum was verified by Western blotting and immunofluorescence assay (IFA). The results showed that the PDCoV S-trimer fusion protein was successfully expressed and purified, and its molecular weight was about 660 kDa, which was consistent with the molecular weight of the trimer. Compared with previous studies, this study innovatively introduced the T4 phage Foldon motif into the S protein to stabilize the trimer structure. The S-trimer fusion protein ExpiCHO expressed in the eukaryotic expression system had complete glycosylation and a structure closer to that of the natural S protein. The prepared hyperimmune rabbit serum against rabbit PDCoV S-trimer fusion protein showed the specific antibody titer of 1:218 700 and the neutralizing antibody titer of 1:1 215.9, being able to be applied in laboratory detection of PDCoV by Western blotting and IFA. In summary, the PDCoV S-trimer protein expressed in this study has good immunogenicity, providing biomaterials for the subsequent study of PDCoV S protein structure, the screening of specific monoclonal antibodies, and the development of subunit vaccines.

PMID 42638053
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-25

Integrated Design for in Situ Ultra-Stable Gel Polymer Electrolyte Network Enables Long-Cycling and High-Voltage Lithium Metal Batteries.

Chen Jinqi J, Liu Qi Q, Niu Yanhua Y, Li Guangxian G

In situ polymerized electrolytes are considered as promising candidates for next-generation lithium metal batteries (LMBs) due to their conformal interface contact and compatibility with existing battery manufacturing processes. However, their application in LMBs is hindered by dendrite growth, a narrow electrochemical stability window, and low thermal stability. By constructing a cross-linked network via in situ copolymerization of 1,3-dioxolane (DOL) and S,S,S-triglycidyl isocyanurate (S,S,S-TGIC), the resulting TPDOL-based gel polymer electrolyte (GPE) effectively suppresses interfacial side reactions and significantly enhances oxidation stability. In addition, the electronegative nitrogen atoms on S,S,S-TGIC weaken ether-Li+ coordination, lowering the desolvation energy barrier and promoting uniform lithium deposition. Consequently, the resulting GPE delivers a high ionic conductivity of 1.66 × 10-3 S cm-1 and a wide electrochemical stability window of 5.7 V. The Li||Li symmetric cell achieves ultra-long cycling stability exceeding 2200 h at 1 mA cm-2. When coupled with high-voltage LiNi0.8Co0 .1Mn0.1O2 (NCM811) cathodes, the full cell retains 86.7% capacity after 200 cycles at 1 C. Even with a high NCM811 loading of 7.1 mg cm-2, the cell achieves a stable initial discharge capacity of 155.4 mAh g-1. This polymer design strategy demonstrates significant promise for the development of high-energy-density LMBs.

PMID 42638500
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PubMedAngewandte Chemie (International ed. in English)2026-08-25

Graphdiyne-Based Heteronuclear Dual-Atom Catalysts Enable High-Energy-Density Lithium-Sulfur Batteries.

Wang Zhongqiang Z, Zhang Wenjing W, Xiao Huang H, Liu Min M et al.

The practical application of lithium-sulfur (Li-S) batteries are hindered by lithium (Li) polysulfides (LiPSs) shuttling, sluggish sulfur (S) redox kinetics, and Li dendrite growth. Here, we report heteronuclear Co-Pt dual-atom catalysts (DACs) anchored on graphdiyne (GDY) (Co-Pt DAs/GDY) to boost S redox conversion kinetics and promote uniform Li deposition to enable high-energy-density Li-S batteries. The unique electronic coupling between sp-hybridized carbon of GDY and Co-Pt dual atoms triggers a p-d-d orbital resonance. This resonance optimizes the interfacial electronic configuration to promote strong d-p orbital hybridization with LiPSs, endowing dual-atom sites with site‑isolated redox‑complementary catalytic behavior toward sequential S redox reactions. Meanwhile, adjacent Pt atoms tailor Co sites to a high-spin state, further strengthening their adsorption and catalytic capabilities. Benefiting from these features, the redox kinetics and electrochemical performance of S cathodes are significantly enhanced, S@Co-Pt DAs/GDY cathodes deliver a remarkable areal capacity of 21.3 mA h cm-2 and an excellent cycling stability under realistic conditions. Moreover, Co-Pt DAs/GDY exhibits strong Li-ion affinity and offers dual-atom Li nucleation sites, enabling stable cycling of Li@Co-Pt DAs/GDY anodes for more than 9200 h. Assembled Ah-level Li-S pouch cells achieve a high-energy-density of 502 Wh kg-1 (based on the total cell mass).

PMID 42638177
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PubMedmSystems2026-08-25

Integrative microbiome and functional profiling identify Streptococcus anginosus as a pro-tumorigenic driver in nasopharyngeal carcinoma.

Zhu Yifan Y, Zhou Lewei L, Zhang Chenyu C, Li Zonglin Z et al.

Oral microbial dysbiosis is associated with nasopharyngeal carcinoma (NPC), yet specific microbial drivers within this niche remain poorly characterized. Through multi-cohort profiling of saliva microbiota, we identified Streptococcus as consistently enriched in NPC, whose abundance positively correlates with advanced clinical stages and poor prognosis. Subsequent functional screening across multiple Streptococcus species revealed S. anginosus as the most potent promoter of NPC progression. At the molecular level, we established the interaction between the bacterial surface protein TMPC and host receptor ANXA2 as the primary signaling axis driving S. anginosus-induced tumorigenesis. Structural analysis revealed that specific conserved residues on TMPC confer S. anginosus with superior ANXA2-binding affinity compared with other streptococci, thereby triggering a robust NF-κB/TNFα-mediated pro-inflammatory program. Further underscoring its clinical relevance, high host ANXA2 expression significantly correlates with poorer overall survival in NPC patients. Targeted blockade of this interface using a competitive peptide effectively reduced intratumoral S. anginosus persistence and attenuated tumor progression in vivo. Collectively, our findings identify S. anginosus as a critical functional driver of NPC, with TMPC-ANXA2 acting as the pivotal molecular bridge coupling intratumoral persistence to a pro-tumorigenic inflammatory program. Targeting this specific host-microbe interface offers a promising non-antibiotic, precision therapeutic approach against microbiome-promoted NPC.IMPORTANCENasopharyngeal carcinoma (NPC) has complex etiological links to microbial dysbiosis. Our study identifies S. anginosus as a key microbial driver, hijacking host ANXA2 via its surface protein TMPC to activate NF-κB/TNFα inflammatory signaling, promoting tumor progression. Structural insights into this interaction reveal targets for therapeutic intervention, with a competitive peptide showing efficacy in reducing bacterial persistence and tumor growth in vivo. This work redefines S. anginosus as a functional contributor to NPC, offering novel non-antibiotic strategies for targeting microbiota-driven cancers.

PMID 42640105
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PubMedAngewandte Chemie (International ed. in English)2026-08-25

High Saturation Polarization Ferroelectricity in a Pair of α-Phase Enantiomorphic Crystals Based on Calabash-Shaped Molecules.

Luo Mengxiang M, Sun Xiao X, Lai Yanlin Y, Yang Si S et al.

Molecular ferroelectrics have become promising alternatives to traditional inorganic ferroelectrics due to their structural tunability, flexibility, and biocompatibility. The homochiral strategy provides an effective route for constructing ferroelectric materials by increasing the probability of obtaining polar crystal structures. In this work, we designed a pair of unique calabash-shaped chiral organic cations, S/R-430 ((S/R)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazine), and successfully synthesized two novel enantiomeric ferroelectric materials, [S/R-430 M][FeBr4] (S/R-430 M = (5R,8aS/5S,8aR)-5-methyloctahydropyrrolo[2,1-c][1,4]oxazin-5-ium). Both compounds exhibit three room-temperature crystalline phases (α, β, γ) with chiral polar point groups C1, C2 and C4, respectively. Among these polymorphs, the α-phase undergoes a reversible 1 ¯ F 1 -type first-order ferroelectric phase transition at approximately 355 K, in which the second-harmonic generation (SHG) signal decreases from a nonzero value to nearly zero. Benefiting from the lowest polar symmetry of the triclinic P1 space group, the compounds display ferroelectric behavior with well-saturated polarization-electric field hysteresis loops along the a-, b-, and c-axes at room temperature. Impressively, the saturation polarization (Ps) of α-[S-430 M][FeBr4] along the b-axis reaches 31.7 µC/cm2. This work not only enriches the family of chiral organic-inorganic hybrid ferroelectrics but also facilitates the development of novel molecular ferroelectric functional materials.

PMID 42639953
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PubMedFrontiers in medicine2026-08-25

Severe ARDS caused by Strongyloides stercoralis hyperinfection in a patient with Sjögren's syndrome: a case report.

Lyu Ting T, Gao Song S, Wang Wenjun W, Liu Wei W

Strongyloides stercoralis (S. stercoralis) is a neglected tropical disease that can be fatal in immunocompromised hosts. Diagnosis is challenging due to nonspecific clinical manifestations and low sensitivity of conventional stool examination. Patients with autoimmune diseases receiving long-term glucocorticoid therapy are at high risk of hyperinfection syndrome, which can rapidly progress to acute respiratory distress syndrome (ARDS). A 65-year-old man with an 8-year history of Sjögren's syndrome and chronic interstitial lung disease, who had been on long-term oral methylprednisolone, tripterygium glycosides, and hydroxychloroquine, presented with abdominal pain and vomiting. He rapidly developed severe ARDS requiring invasive mechanical ventilation. Laboratory tests showed persistent eosinopenia (0.01 × 109/L) and lymphopenia. Bronchoalveolar lavage fluid was subjected to metagenomic capture sequencing (MetaCAP), which revealed S. stercoralis [16,030 reads per million (RPM)] and cytomegalovirus (14,397RPM). Sputum smear microscopy showed motile S. stercoralis larvae, confirming the diagnosis. The patient was treated with albendazole (0.4 g via nasogastric tube twice daily) combined with ivermectin (12 mg via nasogastric tube once daily) for strongyloidiasis, together with ganciclovir for cytomegalovirus. Because of severe ARDS and possible autoimmune flare, methylprednisolone (80 mg intravenously every 12 h followed by tapering) was cautiously administered under effective anti-infective coverage. Two days after treatment, the oxygenation index improved from 77 mmHg to 214 mmHg. One week later, repeat MetaCAP showed a marked reduction of S. stercoralis reads to 69RPM and cytomegalovirus 9 RPM. The patient was successfully extubated and discharged after consolidation therapy. At nine-month follow-up he remained well. This case demonstrates that S. stercoralis hyperinfection can occur without eosinophilia in immunocompromised patients with autoimmune diseases and can rapidly progress to ARDS. MetaCAP of bronchoalveolar lavage fluid enables rapid and sensitive diagnosis. Short-term glucocorticoid therapy to control ARDS and autoimmune disease activity is feasible and safe provided that effective anti-infective treatment is in place.

PMID 42639016
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