Drug Database
TK

TK-129 (TK 129 / TK129)

✓ Approved

Foshan Rexiu Biotechnology · LRP1

What is TK-129?

TK-129 is a therapeutic agent developed by Foshan Rexiu Biotechnology. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesTK 129, TK129
CompanyFoshan Rexiu Biotechnology
Molecular TargetLRP1
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Foshan Rexiu Biotechnology

Mechanism of Action

Molecular Targets

TK-129 acts on 1 molecular target:

LRP1LDL receptor related protein 1 (LRP1A, A2MR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

TK-129 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Rectosigmoid cancer✓ Approved

Related Research Articles

PubMedSpine deformity2026-09-19

Postoperative thoracic kyphosis morphology following adult spinal deformity surgery: an analysis of fused and unfused segments.

Lafage Renaud R, Elysee Jonathan C JC, Daniels Alan H AH, Diebo Bassel G BG et al.

Predicting post-operative changes in thoracic kyphosis (TK) remains challenging in adult spinal deformity (ASD) surgery. This study aimed to quantify both iatrogenic and reciprocal changes in TK following lumbar correction and assess their maintenance at 2-year follow-up. A retrospective analysis was performed on 356 ASD patients treated with posterior instrumentation from T9-11 to the pelvis, with a minimum 2-year follow-up. TK values were compared with normative data. Multivariate analysis identified thoracolumbar parameters associated with reciprocal thoracic changes and proximal failure. Pre-op TK (median 34°) was normal for 59.8% and hypokyphotic for 39.0% of patients. At 6 weeks, 79.1% of initially hypokyphotic patients normalized, while 11.3% of normokyphotic patients deteriorated. Postoperative TK increase correlated with lumbar lordosis gain (p<0.001), controlling for pre-op alignment and demographics (R2=0.40). Between 6 weeks and 2 years, 9.3% experienced TK decompensation >15°, and 9.6% required proximal extension for junctional issues-defined collectively as "thoracic failures" (17.4%). Independent predictors of failure included advanced age (OR 3.6), more proximal lumbar correction (OR 1.9), and pronounced early mid-thoracic kyphosis (OR 2.3). In ASD surgery with Upper Instrumented Vertebra (UIV) between T9 and T11, changes in TK were largely proportional to lumbar correction, leading to normalization in most cases. However, age, the location of lumbar correction, and early post-operative thoracic shape independently predicted thoracic failure, highlighting the need for tailored alignment strategies.

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PubMedThe International journal of pharmacy practice2026-09-19

A comparative analysis of disciplinary outcomes for pharmacy professions in the United States and Great Britain.

Johnson Denzil D, Umaru Nkiruka N, Gallagher Cathal T CT

Earlier comparative scholarship on physician regulation has revealed marked differences in disciplinary outcomes between the United States (US) and Great Britain (GB), the latter of which imposes more severe sanctions for comparable misconduct. This article extends the inquiry into pharmacy regulation to determine whether the identified divergence is unique to medical regulation, or whether it is representative of broader features of the procedural structures that govern professional discipline, by comparing the disciplinary outcomes from each of the US and GB for a 10-year period concluding with the latest publicly available data. A quantitative comparative analysis was undertaken on a dataset comprising of disciplinary decisions issued over a ten-year period concluding in June 2025: a total of 22 129 cases; 21 561 (97%) of which occurred in the US and 1868 (3%) in GB. Sanctions were coded into four condensed categories: warnings, conditions, suspension, and erasure, and analyzed using Pearson's chi-squared testing to assess differences in disciplinary severity between the jurisdictions. The results revealed a significant transatlantic difference in disciplinary outcomes against pharmacy practitioners: 79% of GB cases resulted in severe sanctions, whilst only 38% of US cases did so, with lenient sanctions prevailing in the US, closely replicating earlier findings relating to the discipline of doctors. While some level of self-regulation is inherent to being a profession, the current extent in the US is excessive. Although professional autonomy is deeply rooted, it shouldn't be immune to reform, especially given growing evidence that professions are failing to uphold their responsibilities to the public. It is evident that our findings are not profession-specific, instead pointing to wider features of regulatory design and execution. This study contributes new empirical evidence to scholarship on the design of professional regulatory structures and cross-jurisdictional consistency in professional discipline and highlights the need for further research into the correlation between regulatory design and disciplinary outcomes.

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PubMedMalaria journal2026-09-19

Association between number of previous malaria episodes and treatment failure among children and adults with laboratory-confirmed Plasmodium infection treated with pyronaridine-artesunate in Gabon: a retrospective cohort study.

Mombo-Ngoma Ghyslain G, Meneguim Augusto A, Zoleko Manego Rella R, Ntoumi Francine F et al.

Malaria remains a public health challenge in Gabon. Pyronaridine-artesunate is an effective oral treatment for uncomplicated malaria. In real-world context, treatment failures, though still rare, are expected to be more frequent than in clinical trials. Prior malaria episodes have been suggested as risk factor for treatment failure. However, most evidence relies on self-reported history, which is prone to bias. A secondary data analysis of the CANTAM study, a prospective multicenter single arm open-label phase IIIB/IV study assessing the safety and efficacy of pyronaridine-artesunate in real-world context, was conducted. Adults and children weighing ≥ 5 kg with uncomplicated malaria were included. Data from the Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon, were used in this sub-group analyses to assess the impact of previous malaria episodes on the risk for treatment failure, measured both as recurrence and recrudescence. Multivariate logistic regression models were used to adjust for potential confounders. From June 2017 to March 2019, 2,082 patients were enrolled in Gabon; 1,969 were included in the intention-to-treat and 1,687 in the per-protocol analysis. Adults comprised 22.6% and males 53.7% of participants. In the per-protocol population, 129 (7.7%) participants experienced recurrence from which 22 (1.3%) were recrudescence. Repeated malaria episodes accounted for 294 (17.4%) of the malaria cases. Each one-year increase in age was associated with 11% decrease in the odds of recurrence (OR 0.89, 95%CI 0.86-0.92; p-value < 0.001) and recrudescence (OR 0.89, 95%CI 0.81-0.97; p-value 0.007). Previous malaria was associated with recurrence (OR 1.96; 95%CI 1.31-2.94; p-value 0.001) and recrudescence (OR 2.44; 95%CI 1.01-5.94; p-value 0.049) in the per-protocol multivariate analysis. The association between prior malaria and treatment failure was modified by age, indicating that treatment failure was less associated with previous exposure in older children. Previous malaria episodes may constitute a surrogate marker for increased risk of recurrence and recrudescence, particularly in younger children. This association may reflect increased vulnerability or transient alterations in host immunity, although other unmeasured factors may also contribute. This understanding could improve malaria management in high-transmission settings, highlighting the need for targeted follow-up of patients at highest risk of treatment failure.

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PubMedAnimal bioscience2026-09-18

Epidemiology, risk factors, and spatio-temporal distribution of lumpy skin disease in cattle in northern Bangladesh.

Rahman Md Shajedur MS, Hossain Md Khaled MK, Alam Jahangir J, Rumi Nazmi Ara NA et al.

Lumpy skin disease (LSD) is an emerging transboundary viral disease that causes substantial economic losses in cattle production worldwide. Therefore, the present study aimed to investigate the epidemiology, risk factors, and spatial-temporal distribution through molecular detection of lumpy skin disease virus (LSDV) among cattle in northern Bangladesh. A cross-sectional study was conducted from September 2023 to August 2025 across 10 districts involving 8,650 cattle from 1,200 households. Clinical examination, questionnaire-based epidemiological investigation, spatial mapping, and PCR targeting the P32 and thymidine kinase (TK) genes were performed. The overall prevalence of LSD was 30.15% (2608/8650; 95% CI: 29.2-32.1), while mortality and case fatality rates (CFR) were 3.02% and 10.01%, respectively. Marked spatial and seasonal variations were observed, with the highest prevalence recorded in Thakurgaon (33.92%) and during the rainy season (44.56%). Calves aged below one year showed the highest prevalence (37.39%) and were approximately two times more susceptible to infection (OR = 2.04; 95% CI: 1.82-2.29). Non-vaccinated cattle showed markedly higher prevalence (36.45%) of LSD. Multivariable logistic regression identified non-vaccination (AOR = 14.3; 95% CI: 9.63-21.7), poor biosecurity (AOR = 5.18; 95% CI: 3.37-8.08), and large herd size (AOR = 2.80; 95% CI: 1.87-4.22) as major independent predictors of LSD occurrence. The findings demonstrate that LSD is widely distributed and strongly influenced by management, environmental, and host-related factors in northern Bangladesh. Strengthening vaccination coverage, farm biosecurity, vector control, and targeted surveillance programs may substantially reduce the burden of Lumpy Skin Disease in cattle populations.

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PubMedExpert review of respiratory medicine2026-09-18

Exploring climate, air pollution, and respiratory disease hospitalizations in Brazil: a scoping review.

de Lima Brum Rodrigo R, Saes-Silva Elizabet E, Neves Rosália Garcia RG, da Silva Freitas Livia L et al.

Air pollution is the leading environmental risk factor for mortality worldwide, contributing to 7.9 million deaths in 2023. In Brazil, studies evaluating the combined relationship between air pollution, climate variables, and respiratory disease hospitalizations remain fragmented and regionally concentrated. This scoping review mapped the Brazilian literature on air pollution, climate, and respiratory hospitalizations across multiple scientific databases. A total of 1,179 studies were identified, of which 129 met the eligibility criteria after screening and full-text assessment. Respiratory infections, including pneumonia and COVID-19, followed by asthma, were the most frequently investigated outcomes, with children representing the main target population. The review also revealed geographical asymmetry, as a single federative unit concentrated more than one-third of all published studies. Overall, 117 studies (90.70%) reported positive associations between environmental exposures and hospitalizations, of which 112 reported significant results. Environmental epidemiology in Brazil remains limited by methodological fragmentation, territorial inequalities, and insufficient local coverage, with only 42 municipalities (0.75% of the Brazilian municipalities) individually identified among municipal-scale studies. Although the literature establishes an important epidemiological baseline, substantial structural gaps still hinder advances in the field, reinforcing the urgent need for decentralized research strategies, methodological modernization, and integrated climate-health approaches.

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PubMedBrain, behavior, and immunity2026-09-18

The role of CD4+ T cell differentiation in cytomegalovirus-associated parahippocampal volume reduction and depressive symptoms: a dual-sample study.

Zheng Haixia H, Ford Bart B, Heritage Lily A LA, Haroon Ebrahim E et al.

Cytomegalovirus (CMV) establishes lifelong infection and promotes an immunosenescent T cell profile characterized by depletion of naïve cells and expansion of terminally differentiated effector memory cells re-expressing CD45RA (TEMRA). We examined whether CMV-related T cell differentiation was associated with brain structure and depressive symptoms in two complementary cohorts. In a neuroimaging cohort of 129 adults, higher CD4+ TEMRA percentages was associated with lower parahippocampal volume (β = -0.27, 95% CI [-0.42, -0.11], pFDR = 0.022). However, no T cell measure significantly mediated the association between CMV serostatus and parahippocampal volume after FDR correction. In a population-based sample of 5,759 older adults from the Health and Retirement Study, higher CD4+ TEMRA:naïve ratios, reflecting relative expansion of TEMRA cells and depletion of naïve CD4+ T cells, were associated with greater depressive symptom severity across three assessments from 2016 to 2020 (β = 0.097, 95% CI [0.074, 0.119], pFDR < 0.001). Structural equation models indicated significant indirect associations between CMV seropositivity and depressive symptoms through the CD4+ TEMRA:naïve ratio and CD4+ naïve cells. These findings link CMV-related T cell differentiation to reduced parahippocampal volume and increased depressive symptoms. Larger longitudinal studies integrating immunophenotyping, neuroimaging, and clinical outcomes in the same participants are needed to test this proposed pathway.

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