Drug Database
PR

pregabalin (Lyrica OD)

✓ Approved

Eisai Co., Ltd. · CACNA2D1 · Small Molecule

What is pregabalin?

pregabalin is a small molecule developed by Eisai Co., Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesLyrica OD
CompanyEisai Co., Ltd.
Drug ClassSmall Molecule
Molecular TargetCACNA2D1
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Eisai Co., Ltd.

Mechanism of Action

Molecular Targets

pregabalin acts on 1 molecular target:

CACNA2D1calcium voltage-gated channel auxiliary subunit alpha2delta 1 (LINC01112, CACNA2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

pregabalin is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersFibromyalgia✓ Approved
Nervous system disordersDiabetic neuropathyPreclinical
Nervous system disordersPost herpetic neuralgiaPreclinical

Related Research Articles

PubMedFrontiers in pharmacology2026-09-19

Effects of adenosine triphosphate and reduced glutathione on biochemical, histopathological and immunofluorescence alterations associated with atezolizumab-induced cardiac tissue injury.

Yasar Yesim Kaya YK, Sezgin Esra Tuba ET, Suleyman Bahadir B, Mammadov Renad R et al.

In this study, the potential protective effects of adenosine triphosphate (ATP) and glutathione (GSH) against atezolizumab-induced cardiac injury in rat heart tissue were investigated. A total of 24 male albino Wistar rats were used in the experiment. The animals were divided into four groups: healthy group adenosine triphosphate + atezolizumab (ATAZ), GSH + atezolizumab (GHAZ), and atezolizumab alone (ATZ). ATP was administered intraperitoneally at a dose of 4 mg/kg, while GSH was administered orally at a dose of 200 mg/kg for 7 days. Atezolizumab was administered intraperitoneally to the experimental groups at a dose of 10 mg/kg twice weekly. At the end of the experiment, malondialdehyde total glutathione (tGSH), superoxide dismutase catalase, interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels in heart tissues were measured using biochemical methods. In addition, histopathological and immunofluorescence examinations were performed. The results showed that oxidative stress and inflammation markers increased, whereas antioxidant parameters decreased in the atezolizumab-treated group. ATP and GSH administration significantly attenuated these changes and exerted protective effects on cardiac tissue. Overall, ATP and GSH ameliorated the biochemical, histopathological, and immunofluorescence changes associated with atezolizumab-induced cardiac injury in this experimental model.

PMID 42761064
Read full article →
PubMedCureus2026-09-18

The ScinTwelve Study: Pharmacoscintigraphic Evaluation and Pharmacokinetic Assessment of a Vitamin B12 Sustained-Release Tablet in Healthy Human Subjects.

Vasoya Nency N, Soni Ameet A, Modi Nimesh N, Jadhav Prakash A PA et al.

Oral bioavailability of vitamin B12 is highly dependent on gastrointestinal transit and site-specific release, with optimal absorption occurring in the terminal ileum. Sustained-release formulations were designed to enhance targeted delivery and prolong systemic exposure. This study aimed to evaluate the in vivo disintegration pattern, gastric emptying, and gastrointestinal transit of a vitamin B12 sustained-release tablet using pharmacoscintigraphy and to correlate these findings with systemic bioavailability. An open-label, single-dose pharmacoscintigraphy study was conducted in six healthy adult male subjects. The investigational product (vitamin B12 1500 mcg sustained-release tablet) was radiolabeled with technetium-99m (99mTc) and administered orally. Sequential gamma imaging was performed up to eight hours post dose to determine the gastric residence, intestinal arrival, intestinal residence, and colon arrival time. Serum vitamin B12 levels were measured at predefined intervals up to 48 hours. The upper placebo layer disintegrated rapidly in the stomach within 1.0 ± 0.0 minutes, with gastric emptying completed by 0.7 ± 0.2 hours. The lower sustained-release layer remained intact in the stomach and emptied at 120.00 ± 0.00 hours, followed by gradual intestinal disintegration between four and six hours. Colonic arrival occurred at 336.00 ± 53.67 hours. Serum vitamin B12 levels peaked at eight hours (296.00 ± 94.65 pg/mL), indicating delayed absorption corresponding to intestinal release. Sustained levels were maintained up to 48 hours, and no adverse events were reported. The vitamin B12 sustained-release tablet exhibited effective biphasic release with targeted intestinal delivery and sustained bioavailability, confirming its design intent and potential for improved therapeutic efficacy.

PMID 42756790
Read full article →
PubMedACS omega2026-09-18

Structure-Function Relationships in Galactomannan Starch Films for Fast-Dissolving Applications: Effects on Physicochemical and Mechanical Properties.

Sampaio Lorena M F LMF, Oliveira Matheus X MX, Sombra Venícios G VG, Feitosa Judith P A JPA et al.

Orally disintegrating films (ODFs) have attracted increasing attention because of their rapid disintegration and ease of administration. In this study, galactomannan-starch biopolymer films were developed as fast-dissolving oral film matrices using galactomannan extracted from Caesalpinia pulcherrima combined with corn and arrowroot (Maranta arundinacea) starches at different proportions. The effect of polymer composition on structure-function relationships was systematically investigated, with emphasis on how intermolecular interactions influence the physicochemical and mechanical properties of the films. Starch incorporation significantly affected polymer-network organization, leading to changes in rheological behavior, morphology, and macroscopic performance. Mechanical properties were strongly dependent on starch type: corn starch promoted greater flexibility, whereas arrowroot starch increased rigidity, likely because of differences in amylose content. The films exhibited homogeneous morphology, high transparency, and surface pH values close to neutrality. Water affinity and disintegration behavior were directly influenced by polymer composition, highlighting the role of polymer-polymer interactions in controlling hydration and the structural stability of the developed film matrices. Spectroscopic analysis suggested the presence of intermolecular interactions, particularly hydrogen bonding, which contributed to the modulation of film properties. Among the evaluated formulations, the system containing 75% galactomannan and 25% corn starch exhibited a balanced combination of mechanical strength, flexibility, and rapid disintegration. These findings demonstrate that galactomannan-starch blends are promising materials for ODF applications and provide insights into tailoring structure-function relationships in sustainable biopolymer systems.

PMID 42757163
Read full article →
PubMedFrontiers in immunology2026-09-18

Efficacy of house dust mite allergen immunotherapy in allergic rhinitis: a network meta-analysis based on component-resolved classification.

Guo Shuo S, Wang Kun K, Shi Yawen Y, Hong Fei F et al.

House dust mite allergen immunotherapy (HDM-AIT) trials in allergic rhinitis show substantial efficacy heterogeneity, traditionally evaluated by administration route. Whether clinical efficacy differs among HDM-AIT preparations with different allergen compositional breadth remains unclear. To compare HDM-AIT efficacy using a component-resolved framework that stratifies preparations by allergen compositional breadth. We searched PubMed, Embase, and CENTRAL for double-blind, placebo-controlled randomized trials of HDM-AIT lasting at least 12 months. Interventions were classified as comprehensive-component subcutaneous immunotherapy (CC-SCIT), major-component-dominant subcutaneous immunotherapy (MCD-SCIT), or major-component-dominant sublingual immunotherapy tablet (MCD-SLIT-tablet) using a prespecified component-resolved framework in which the breadth of treatment-induced component-specific IgG4 responses served as the primary node-defining criterion, with component-specific IgG and proteomic evidence used as supportive evidence. Frequentist pairwise and Bayesian network meta-analyses were performed. The primary outcome was symptom score; secondary outcomes were medication score and combined symptom and medication score. Sixteen trials involving 7,329 participants were included. For symptom score, CC-SCIT showed the most favorable estimated treatment effect versus placebo (standardized mean difference [SMD], -0.40; 95% credible interval [CrI], -0.73 to -0.11; surface under the cumulative ranking curve [SUCRA], 82.6%), while MCD-SLIT-tablet showed a more precise estimate supported by a larger evidence base (SMD, -0.30; 95% CrI, -0.41 to -0.20; SUCRA, 60.7%). For medication score, CC-SCIT (SMD, -0.40; 95% CrI, -0.81 to 0.00; SUCRA, 79.8%) and MCD-SCIT (SMD, -0.38; 95% CrI, -0.72 to -0.05; SUCRA, 78.5%) showed similar estimated effects, whereas MCD-SLIT-tablet showed a smaller but more precise effect (SMD, -0.15; 95% CrI, -0.28 to 0.00; SUCRA, 39.9%). For combined symptom and medication score, CC-SCIT showed the largest estimated effect versus placebo (SMD, -0.84; 95% CrI, -1.53 to -0.37; SUCRA, 99.5%). The network was star-shaped, and comparisons among non-placebo treatment nodes were indirect. Posterior rank distributions also indicated uncertainty in the relative ordering of the treatment nodes, particularly those supported by fewer trials. Reported immunologic and compositional profiles of HDM-AIT preparations were associated with variability in trial-level efficacy estimates. These findings support product-level molecular characterization and direct comparative studies as priorities for future precision AIT. https://www.crd.york.ac.uk/PROSPERO/view/, CRD420261307571.

PMID 42755948
Read full article →
PubMedFrontiers in medicine2026-09-18

Case Report: A case of cutaneous collagenous vasculopathy.

Tang Chenjian C, Chen Liping L, Yu Jiangxiu J, Zhu Mei M

We report a case of a 62-year-old woman presenting with a 6-year history of purpuric patches and macules on the lower extremities, initially misdiagnosed as allergic purpura and treated with prednisone. Skin biopsy revealed dilated dermal vessels with perivascular collagen deposition, positive for collagen IV and diastase-periodic acid-Schiff (D-PAS) staining, consistent with cutaneous collagenous vasculopathy (CCV). Treatment included hydroxychloroquine, vitamin C, doxepin, and topical mucopolysaccharide polysulfate cream. Prednisone was tapered by one tablet every 3 days. After 4 weeks, the rash improved significantly with no new lesions. We would like to present a case of CCV.

PMID 42755575
Read full article →
PubMedJournal of molecular histology2026-09-18

Quercetin alleviates statin-induced myopathy in adult male rats: insights into the role of oxidative stress, apoptosis, and autophagy-related gene expression (LC3 and LAMP2).

Ahmed Shaimaa A G SAG, Abdelhaffez Azza S AS, Ali Rasha M RM, Ismaiel Amany M AM et al.

Statins, anti-hyperlipidemic drugs, are associated with skeletal muscle myopathy. New strategies to preserve muscle strength in statin-induced myopathy (SIM) are needed. This study assessed the effect of quercetin on simvastatin-induced myopathy in adult male rats, focusing on the modulation of autophagy-apoptosis crosstalk. Forty adult albino male rats were randomly divided into four groups. The control group (C) received distilled water, the quercetin group (Q) received quercetin (50 mg/kg/day, orally), the simvastatin (S) group received simvastatin (80 mg/kg/day, orally), and the quercetin + simvastatin (Q + S) group received both quercetin (50 mg/kg/day) and simvastatin (80 mg/kg/day, orally), all for 30 days. Gastrocnemius muscle contractility, muscle weight/tibial length ratio, histopathological examination, serum creatine kinase (CK) levels, oxidative stress markers, lipid profile, autophagy-related gene expression (LC3 and LAMP2), and apoptosis markers (BAX and caspase-3) were evaluated. Simvastatin induced muscle atrophy and significantly elevated serum CK levels. These changes were associated with increased oxidative stress, altered expression of autophagy-related genes (increased LC3 and decreased LAMP2), and increased expression of the apoptotic markers BAX and Caspase-3. Quercetin ameliorated these alterations by improving muscle contractility, reducing CK levels and oxidative stress, attenuating apoptosis, and modulating autophagy-related gene expression. Quercetin alleviated simvastatin-induced myopathy through its antioxidant and antiapoptotic effects and was associated with modulation of autophagy-related gene expression. These findings suggest that quercetin may represent a promising adjuvant strategy for mitigating statin-associated myopathy. Further studies evaluating autophagic flux at the protein level are warranted to clarify the underlying mechanisms.

PMID 42758399
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about pregabalin