Drug Database
AM

AM-87 (Difur)

✓ Approved

Cantabria Labs · LTB4R

What is AM-87?

AM-87 is a therapeutic agent developed by Cantabria Labs. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDifur
CompanyCantabria Labs
Molecular TargetLTB4R, IL6R
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Cantabria Labs

Mechanism of Action

Molecular Targets

AM-87 acts on 2 molecular targets:

LTB4Rleukotriene B4 receptor (GPR16, P2Y7)
IL6Rinterleukin 6 receptor (IL6RQ, IL-6R-1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

AM-87 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersPsoriasis✓ Approved

Related Research Articles

PubMedEuropean journal of neurology2026-09-19

Association of Time of Day With Functional Outcome in Intracerebral Hemorrhage.

Lieschke Franziska F, Lo Eng H EH, Mandeville Emiri T ET, Foerch Christian C et al.

The timing of ischemic stroke and intracerebral hemorrhage (ICH) onsets follow distinct daily patterns, but it remains unclear whether these patterns influence ICH outcomes. Consecutive data were obtained from the prospective stroke inpatient quality assurance registry of Hesse, Germany from 2015 to 2023. Patients with ICH were grouped according to the time of symptom onset: morning (5:00 AM to 10:59 AM), midday (11:00 AM to 4:59 PM), evening (5:00 PM to 10:59 PM), and night (11:00 PM to 4:59 AM). The primary outcome was global disability at discharge, analyzed using ordinal logistic regression. Secondary outcomes included mortality and complications during hospitalization. To account for potential confounding, the analysis incorporated both inverse probability weighting (IPW) and propensity score matching (PSM) based on baseline characteristics. After exclusions, 5665 patients underwent final analysis. Peak ICH incidences occurred around 8:30 AM and 5:00 PM with a minimum at approximately midnight. Patients experiencing ICH during the evening and particularly at night had higher discharge disability, compared to those with symptom onset in the morning or midday. Unadjusted analyses found daily variations in mortality and in-hospital complications that were no longer significant after adjustment by PSM or IPW. Our study confirms the daily pattern previously observed in ICH onset, with peak onset during daytime. Functional outcomes were worse in evening and night onset ICH patients. These findings underscore the potential for chronobiologically informed prevention and treatment strategies and the need for further research into time-dependent pathophysiology and care delivery.

PMID 42760870
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PubMedAllergologia et immunopathologia2026-09-19

Diagnostic performance of antibodies against extractable nuclear antigens detected by immunoblot in the differentiation of connective tissue diseases.

Oliva Menacho José Enrique JE, Oliva Candela José Arturo JA, Arroyo Acevedo Jorge Luis JL

Connective tissue diseases are inflammatory, autoimmune diseases that threaten the quality of life. To evaluate the differential diagnostic performance of antibodies against extractable nuclear antigens (ENAs) detected by immunoblot in patients with connective tissue diseases. An observational, descriptive, and cross-sectional study was conducted at the Immunoserology Service of the Arzobispo Loayza National Hospital and the Pharmacology Laboratory of the Faculty of Medicine at the National University of San Marcos between June 2020 and March 2021. The medical records of 300 patients with connective tissue disease were reviewed, and the immunoblot method was used to detect antibodies against ENA in the patients' serum. Final diagnoses were established according to classification criteria predefined by the EULAR/ACR (European Alliance of Associations for Rheumatology/American College of Rheumatology). Of the 300 cases with connective tissue disease, 87 (29%) cases had systemic lupus erythematosus, and 51 cases had anti-dsDNA with sensitivity of 59%, specificity of 87%, PPV of 65%, NPV of 84%, LR+ of 4.62, and LR- of 0.47 in SLE. In 81 (27%) cases of Sjögren's syndrome, 68 had anti-Ro 52 with sensitivity of 83%, specificity of 68%, PPV of 49%, NPV of 91.4%, LR+ of 2.59, and LR- of 0.25. It was demonstrated in 35 (11.7%) cases of CREST: 31 cases had anti-Cenp B with sensitivity of 88%, specificity of 96%, PPV of 77%, NPV of 98% and LR+ of 22. Selected profiles of antibodies against ENAs detected by immunoblot can support the differential diagnosis of connective tissue diseases.

PMID 42760884
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PubMedJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2026-09-19

Prenatal Ultrasonic Detection of Fetal Cleft Lip and Palate: A 5-Year Retrospective Study.

Zeng Liqin L, Lai Hongwei H, Weng Zongjie Z, Ling Wen W et al.

To conduct a descriptive analysis of fetuses with cleft lip and/or palate (CL/P), assessing the prenatal detection proportion across trimesters and describing the subtype distribution, associated malformations, genetic findings, and pregnancy outcomes. In this retrospective study of 193 cases of CL/P, fetuses were divided into cleft lip (CL), cleft palate (CP), and cleft lip with cleft palate (CLP) according to their anatomical features. According to the clinical characteristics, they were divided into isolated, with ultrasound soft markers, and with structural malformations. The first-trimester detection rate was 40.9%, CLP was the main type of detection. The overall detection rate throughout gestation was 87.0%, which was significantly higher for CLP (99.3%) than for CL (50%) or CP (56.4%). The CLP subtype was associated with a higher incidence of structural malformations (47.1%) and chromosomal microarray analysis abnormalities (32.6%). Termination rates were significantly higher with CLP (88.6%) compared to CL (14.3%) and CP (17.9%). Prenatal ultrasound can detect the majority of CL/P cases (87%). Detection of CL/P during the early pregnancy period is feasible, but its utility is currently limited (40.9%), especially for isolated CL and CP, underscoring the need for follow-up examinations in high-risk cases. The CLP subtype carries a higher risk of structural and genetic anomalies that can significantly influence pregnancy decisions.

PMID 42760868
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PubMedBMC pulmonary medicine2026-09-19

Ultrasound assessment of diaphragm thickness and related determinants in healthy female adolescents: a retrospective study.

Celik Zeliha Z, Guzel Nevin A NA, Sendur Halit Nahit HN

The diaphragm plays a crucial role in respiration and is influenced by changes in body composition. However, data on the relationship between diaphragm thickness, respiratory muscle strength, and body composition in healthy adolescents are limited. This study aimed to investigate the clinical indicators of diaphragm thickness and their relationships with respiratory muscle performance and body composition in a healthy female adolescent population. This study included 87 healthy female adolescents (mean age 17.5 ± 2.5 years) within the 15-24 age range, aligning with the broad definition of adolescence. Pulmonary function and respiratory muscle strength (MIP, MEP) were measured using a spirometer. Diaphragm thickness was evaluated using a single ultrasound device with a linear transducer, and measurements were taken three times during breath-holding at both inspiration and expiration. Body composition was assessed using a bioelectrical impedance analyzer. Diaphragm thickness during inspiration showed positive correlation with fat-free mass (FFM) (r = 0.383, p = 0.006), height (r = 0.292, p = 0.029), and weight (r = 0.323, p = 0.015). Diaphragm thickness during expiration was positively correlated with FFM (r = 0.359, p = 0.010), weight (r = 0.297, p = 0.026), and FVC (r = 0.271, p = 0.045). No significant associations were found between diaphragm thickness and MIP, MEP, or other spirometric measures. Regression analyses demonstrated FFM was the strongest predictor of diaphragm thickness (p < 0.05). Diaphragm thickness in healthy female adolescents is significantly associated with FFM and anthropometric measures. These findings may indicate that diaphragm thickness could provide structural information about general muscle status during growth.

PMID 42760534
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PubMedAllergologia et immunopathologia2026-09-19

Inborn errors of immunity and mortality: 10 years of single-center experience.

Çevirme Leyla L, Özden Güzin G

The aim of this study was to investigate the mortality rate and causes of death among patients with rare inborn errors of immunity (IEI), conditions associated with relatively high morbidity and mortality, who were followed at our center, and to identify management strategies tailored to local conditions based on the findings. The medical records of 99 patients followed between January 1, 2015, and October 1, 2025, were retrospectively reviewed. Data on age, sex, symptom onset, and date of diagnosis were recorded, and diagnostic delay was calculated. Systemic symptoms and clinical findings observed at admission and during the disease course were documented. Laboratory parameters, including lymphocyte counts, B-cell and memory B-cell levels, as well as IgG and IgG4 levels, were analyzed. A total of 99 patients were included in the study. Of the participants, 53.5% were male (n = 53) and 46.5% were female (n = 46). The mean age was 34.8 ± 14.9 years (range, 17-72 years). The most common infection was pneumonia (n = 38, 38.4%). Evaluation of presenting symptoms at diagnosis showed that respiratory manifestations were the most frequent (n = 56, 56.6%). Twelve patients died, while 87 survived. Among the nonsurvivors, 58.3% (n = 7) died due to infection-related causes and 41.7% (n = 5) due to malignancy. The diagnostic delay was 4 years in survivors and 9 years in nonsurvivors. Although no statistically significant differences were observed between survivors and nonsurvivors in terms of lymphocyte counts, B-cell percentage, IgG, and IgG4 levels, all laboratory parameters were numerically lower in patients who died. Similarly, diagnostic delay was longer in non-survivors.

PMID 42760879
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PubMedBMC sports science, medicine & rehabilitation2026-09-19

Physical activity and oxidative stress biomarkers in humans: a systematic review and quantitative meta-analysis.

Wahib Hassan Rahim HR, Afroundeh Roghayyeh R, Farzizadeh Reza R, Malekzadeh Reza R

The effects of physical activity on oxidative stress biomarkers in humans remain heterogeneous. This systematic review and meta-analysis quantified exercise-induced changes in key redox biomarkers. Following PRISMA 2020 (PROSPERO: CRD420251144711), a systematic search of PubMed, Scopus, and Web of Science (2000-2025) identified human studies assessing malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), total antioxidant capacity (TAC), and total antioxidant status (TAS). Random-effects models estimated pooled standardized mean differences (SMD) with 95% confidence intervals (CI). Subgroup analyses, meta-regression, sensitivity analyses, publication bias, and risk-of-bias assessments were fully performed. Among 98 eligible studies (up to 31 meta-analyzed, n = 4,742), physical activity significantly reduced MDA (SMD = -1.02; 95% CI: -1.95 to -0.09; p = 0.032; I² = 94.6%) and increased TAS (SMD = 0.76; 95% CI: 0.38 to 1.15; p < 0.001; I² = 0.0%). GSH showed a non-significant trend toward reduction (SMD = -0.58; p = 0.075; I² = 88.5%), while CAT, SOD, and TAC demonstrated no significant pooled effects. Subgroup analyses identified effect modification by age, BMI, and duration, though meta-regression found no linear relationships with age or duration. Sensitivity analyses confirmed robustness for SOD, GSH, and TAS, while MDA, CAT, and TAC were influenced by influential studies. Publication bias was detected for GSH (Egger's p = 0.006). Heterogeneity was substantial (I² = 87-97%), and most studies were of moderate methodological quality. Physical activity selectively reduces lipid peroxidation and enhances non-enzymatic antioxidant capacity without uniformly upregulating enzymatic defenses. However, due to substantial heterogeneity, moderate methodological quality, and potential publication bias for GSH, these findings should be interpreted cautiously as exploratory. PROSPERO CRD420251144711.

PMID 42760575
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