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meningococcal polysaccharide AC vaccine (Mengllingkang)

✓ Approved

China National Biotec Group · Vaccine · Vaccine

What is meningococcal polysaccharide AC vaccine?

meningococcal polysaccharide AC vaccine is a vaccine developed by China National Biotec Group. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesMengllingkang
CompanyChina National Biotec Group
Drug ClassVaccine
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, China National Biotec Group

Therapeutic Indications

meningococcal polysaccharide AC vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsMeningococcal bacteraemia✓ Approved

Related Research Articles

PubMedAAPS PharmSciTech2026-09-19

Comprehensive Stability Assessment of Squalene in a Nanoemulsion Adjuvant and the SpiN-Tec Vaccine: HPLC Quantification, Stress Testing, and Stability Studies.

Gomes Isabela Pereira IP, Rivelli Graziella Gomes GG, Bagno Flávia Fonseca FF, Hojo-Souza Natália Satchiko NS et al.

Squalene-based nanoemulsions are widely used as adjuvants in vaccine formulations, but their stability can be affected by environmental factors such as pH, oxidative stress, temperature, and light. We have produced a squalene nanoemulsion (CTVad1) to support the clinical development of new vaccines. This study aimed to develop and validate an HPLC method for squalene quantification in SpiN-Tec, a recombinant protein vaccine against COVID-19. We also aimed to evaluate the stability of the CTVad1 adjuvant and SpiN-Tec under controlled storage conditions. A reversed-phase HPLC method was developed and validated, and comprehensive forced degradation studies were performed on the raw material and SpiN-Tec under acidic, basic, oxidative, thermal, and photolytic conditions to demonstrate the stability-indicating capability of the method. Physicochemical, morphological, and biological characteristics were assessed, and stability studies of both the vaccine and the CTVad1 adjuvant were performed under accelerated and long-term conditions. The HPLC method was selective, precise, accurate, linear, and robust. Squalene raw material degraded under all tested conditions, whereas formulation in nano-sized globules improved its stability, with degradation observed only under hydrogen peroxide and light exposure. CTVad1 remained stable over time, exhibiting only minor, non-critical changes within the specification limits in both accelerated and long-term stability studies, regardless of the glass packaging used (clear or amber). In addition, the SpiN-Tec vaccine maintained its physicochemical and biological integrity under all tested conditions, with all evaluated parameters remaining within the established specification ranges. Our findings demonstrate that proper formulation, packaging, and storage conditions can preserve squalene stability in nanoemulsion-based vaccines, ensuring the quality, safety, and efficacy of the SpiN-Tec vaccine and its adjuvant throughout shelf life.

PMID 42760453
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PubMedOcular immunology and inflammation2026-09-19

Bilateral Maculopathy in an Infant Following Measles, Mumps, Rubella, and Varicella-Zoster (MMRV) Vaccination.

Ben-Avi Ravid R, Amer Radgonde R

To report on the long-term clinical outcome of a healthy infant who presented with posterior uveitis following the administration of the combined measles, mumps, rubella, and varicella (MMRV) vaccine. Descriptive case report. A 13-month-old infant presented with bilateral visual loss two weeks after receiving the MMRV vaccine. Ophthalmic examination revealed bilateral retinitis and retinal vasculitis with exudative retinal detachment. Extensive infectious work-up was conducted including serologic exams and PCR testing of blood, aqueous humor, cerebrospinal fluid and urine. Serological tests for measles yielded positive IgM and IgG titers. PCR testing for measles in the aqueous humor and urine was negative. Neurologic assessment and neuroimaging were unremarkable, excluding central nervous system involvement. Empiric systemic antiviral and corticosteroid therapy was initiated. Gradual resolution of posterior uveitis ensued, culminating in bilateral macular scars. Over a six-year follow-up period, the patient demonstrated stable ocular findings with no evidence of recurrent inflammation or systemic autoimmune disease. Final visual acuity was 6/9 in each eye. This case represents a rare occurrence of non-necrotizing retinitis following MMRV vaccination. To our knowledge, this is the first report describing the sequential OCT characteristics of presumed measles vaccine-associated retinitis. The prolonged follow-up period supports the absence of an alternative etiology and provides valuable insight into the long-term course and visual prognosis of vaccine-associated retinopathy.

PMID 42760840
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PubMedJournal of the American Geriatrics Society2026-09-19

Acute Care Group-Based Physical Therapy on an Inpatient Geriatrics Unit: Preliminary Data.

Crick James P JP, Hull Laura L, Maag Samuel S, Alain Gabriel N GN

Hospitalized older adults are at high risk for hospital-associated disability, but one-to-one physical therapy (PT) models often cannot meet demand for skilled mobility progression. Group-based PT is effective in outpatient and rehabilitation settings, but its feasibility in acute inpatient care is unknown. We conducted a single-site, prospective quality improvement implementation of acute care group-based PT (AC-GBPT) on a 39-bed medical-surgical geriatrics unit at an academic medical center. Sessions were offered weekly during routine clinical operations without additional staffing. Eligible patients were 60 years and older, had an active PT plan of care, were medically stable, and could transfer to a chair with human assistance. Feasibility outcomes included number of sessions delivered, participants per session, recruitment, reasons for non-participation, and adverse events. We also summarized participant characteristics and therapist productivity on days with versus without a group session. From March 19, 2025, through February 18, 2026, 37 sessions were delivered, with a mean of 4.22 participants per session (range 3-6). Across the period, 156 unique patient participations were recorded, and 69% of patients approached participated. At the time of participation, mean age was 77.9 years and mean time since admission was 8.6 days. No safety events occurred during or immediately after group sessions. Mean therapist productivity was notably higher on group days than on non-group days (1.59 vs. 1.31 patients/h; approximately 21% higher). A once-weekly AC-GBPT model for selected hospitalized older adults was feasible to deliver using existing resources and showed promising reach, safety, and operational performance, suggesting it may extend PT to more patients. Further work should assess patient acceptability, fully characterize staff time requirements, and assess patient-centered outcomes.

PMID 42760622
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PubMedMedicine2026-09-19

Unpacking the pathways using the stress and coping theory: How social support reduces substance abuse through depression.

Berhanu Kelemu Zelalem KZ, Mengistie Kefie Manaye KM

Substance abuse among university students is a significant public health concern that is typically linked to underlying mental health issues such as depression, stress, and a lack of social support networks. Thus, the study's goal was to investigate the link between social support, depression, and substance abuse. A cross-sectional design was used. Students were given 3 measures to complete for the current study: the Multidimensional Scale of Perceived Social Support, the Beck Depression Inventory, and the Alcohol, Smoking, and Substance Involvement Screening Test. The study included 257 regular undergraduate students from Addis Ababa Institute of Technology. As a result, the multivariate test of significance demonstrates that parents' marital status, monthly income, and the presence or absence of intimate friends all have a significant influence on student substance abuse and depression. The Pearson correlation demonstrated a substantial positive relationship between depression and substance abuse; however, higher levels of social support are associated with a decreased likelihood of substance abuse and depression among students. Finally, depression has a mediating role in the relationship between social support and substance abuse. These findings suggest that investing in supportive relationships and communities might be an effective way to improve mental health while simultaneously lowering risky behavior like substance abuse. Furthermore, the researchers proposed that the institution establish its own substance abuse prevention and treatment center, available to psychologists, therapists, and other health practitioners.

PMID 42760703
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PubMedMedScience2026-09-19

Neoantigen cancer vaccines for gastrointestinal tumors: opportunities and challenges.

Zhao Zixuan Z, Du Xinyu X, Gao Xiaoliang X, Zhao Sheng S et al.

Gastrointestinal tumors are characterized by high global incidence and mortality rates. Although immune checkpoint inhibitors (ICIs) have achieved breakthroughs in some of these cancers, their overall response rate remains low. Neoantigen cancer vaccines have emerged as a promising new strategy for immunotherapy in gastrointestinal tumors due to their high specificity and strong immunogenicity. These vaccines effectively activate specific T-cell immunity and can produce synergistic effects when combined with ICIs. Various vaccine platforms offer distinct advantages, and clinical trials have shown encouraging potential in inducing immune responses and extending progression-free survival. Meanwhile, current challenges and future directions cannot be ignored. Key challenges primarily involve the accuracy of neoantigen prediction, tumor heterogeneity, and optimal treatment timing. Future directions include artificial intelligence (AI)-assisted multi-omics screening, the development of universal vaccines, optimization of novel delivery systems, and multimodal combination strategies. These advances are expected to promote the application of neoantigen cancer vaccines in postoperative recurrence prevention and early-stage treatment, ultimately moving toward personalized precision immunotherapy. This article systematically reviews the clinical progress and prospects of neoantigen cancer vaccines in treating gastrointestinal tumors, aiming to provide insights for immunotherapy in this field and offer new perspectives for further optimization of such vaccines.

PMID 42760419
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PubMedCureus2026-09-19

Morphometric Analysis of Pedicles of Typical Thoracic Vertebrae for Transpedicular Screw Fixation: A Study From Eastern India.

Nayak Gyanaranjan G, Pradhan Sujita S, Nayak Lopamudra L, Sahoo Niranjan N et al.

Transpedicular screw fixation has emerged as an indispensable technique in thoracic spine surgery for conditions ranging from traumatic fractures to deformity correction and tumour resection. Precise morphometric knowledge of pedicle dimensions is mandatory to avoid neurovascular complications during screw placement. Data from the Indian subcontinent, and particularly from Eastern India, remain sparse, underscoring the need for region-specific anatomical studies. A descriptive morphometric study was conducted at the Institute of Medical Sciences and SUM Hospital Campus II, Bhubaneswar, Odisha, between January 2024 and March 2026. Pedicle height (PH), pedicle width (PW), chord length (CL), interpedicular distance (IPD), transverse pedicle angle (TPA), and sagittal pedicle angle (SPA) were measured bilaterally on 106 specimens of typical thoracic vertebrae (T2-T8) using Vernier callipers and a goniometer as per standardised protocols. Mean PH was 10.56 ± 1.24 mm (right) and 10.56 ± 1.31 mm (left). Mean PW was 4.93 ± 0.96 mm (right) and 5.02 ± 0.94 mm (left). Mean CL was 37.06 ± 4.84 mm (right) and 38.14 ± 4.44 mm (left). Mean IPD was 14.78 ± 1.50 mm. Mean TPA was 12.57 ± 1.78° (right) and 12.49 ± 1.17° (left). Mean SPA was 13.60 ± 1.50° (right) and 10.78 ± 0.76° (left). The pedicle dimensions recorded in this Eastern Indian cohort are distinct from those reported in Western and other Asian populations. The narrow pedicle width observed at mid-thoracic levels warrants cautious screw selection. These data provide a clinically relevant morphometric reference to guide safer transpedicular instrumentation in the region.

PMID 42761025
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