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halobetasol propionate (Bryhali / Jemdel / IDP 122)

✓ Approved

Bausch + Lomb Corporation · NR3C1 · Steroids

What is halobetasol propionate?

halobetasol propionate is a steroids developed by Bausch + Lomb Corporation. It is approved for therapeutic indications via topical.

Drug Profile

Brand NamesBryhali, Jemdel, IDP 122
CompanyBausch + Lomb Corporation
Drug ClassSteroids, Small Molecule
Molecular TargetNR3C1
RouteTopical
StatusApproved
Sources: ClinicalTrials.gov, Bausch + Lomb Corporation

Mechanism of Action

Molecular Targets

halobetasol propionate acts on 1 molecular target:

NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

halobetasol propionate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersPsoriasis✓ Approved

Related Research Articles

PubMedAnimal bioscience2026-09-18

Effects of neutral detergent fiber content and its source on growth performance, rumen characteristics, digestibility, and methane concentrations in Hanwoo heifers.

Cho Hyunjin H, Jeong Sinyong S, Kang Kyewon K, Lee Mingyung M et al.

This study investigated the effects of neutral detergent fiber (NDF) content and NDF source (forage- or concentrate-derived) on growth performance, rumen characteristics, nutrient digestibility, and methane (CH4) concentrations in growing Hanwoo heifers. Thirty heifers (296 ± 25.7 kg body weight [BW]; 10 months old) were blocked by BW and assigned to three treatments: high forage-to-concentrate ratio (42.5:57.5) with high-energy concentrate (HFHC), low forage-to-concentrate ratio (30:70) with low-energy concentrate (LFLC), and low forage-to-concentrate ratio (30:70) with high-energy concentrate (LFHC). NDF-level effects were assessed by contrasting HFHC and LFLC with LFHC, whereas the NDF-source contrast compared HFHC with LFLC at similar total NDF levels. Dry matter intake (DMI) was recorded daily and BW every four weeks. Rumen fluid and fecal samples were collected, and CH4 concentrations measured, after 12 weeks. Average daily gain (ADG) and feed conversion ratio were unaffected by NDF level or source (P > 0.05), whereas DMI tended to increase with lower NDF (P = 0.099). Lower NDF reduced NDF digestibility and increased total volatile fatty acid concentration (P < 0.05), decreased acetate proportion and acetate-to-propionate ratio, and increased propionate and butyrate proportions (P < 0.001). NDF source did not affect nutrient digestibility (P > 0.05). In the NDF-source contrast, LFLC had lower acetate and propionate and higher butyrate proportions than HFHC (P < 0.05). Lower NDF also decreased CH4 concentration per DMI and ADG (P < 0.05). LFLC had lower CH4 concentration per ADG than HFHC, whereas CH4 concentration per DMI did not differ. Dietary NDF level was associated with broader changes in ruminal fermentation, NDF digestibility, and CH4 concentration per DMI and ADG, whereas NDF source had more limited effects, primarily on VFA proportions and CH4 concentration per ADG. Neither NDF level nor source significantly affected growth performance in growing Hanwoo heifers.

PMID 42755072
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PubMedAnimal bioscience2026-09-18

Comparative analysis of four compound stomachs development, fermentation dynamics, and microbiome structure in Hu sheep and its crossbred combinations.

Zhang Rui R, Niu Chun E CE, Shi Hai Na HN, An Xue Jiao XJ et al.

This study was conducted to investigate the differences in fermentation parameters, epithelial development, and microbial composition across the four stomach compartments between Hu sheep and its crossbreds. Forty-eight approximately 3-month-old male lambs, assigned to three genetic groups (HH:♂Hu×♀Hu, n=16; DH:♂Poll Dorset×♀Hu, n=16; SH:♂Southdown×♀Hu, n=16), were raised under uniform nutritional and management conditions for 95 days. Feed intake was determined daily and body weight were measured every 20 days. At the end of the trial, six sheep per group close to the average weight were slaughtered. Samples of digesta and tissue from the four stomachs were collected. Fermentation parameters, epithelial development, and microbial community structure were analyzed. Compared with the HH group (acetate: 25.8, 21.8, and 6.36 mmol/kg; propionate: 6.8, 5.60, and 3.65 mmol/kg; butyrate: 3.66, 3.19, and 1.38 mmol/kg), the DH group exhibited significantly higher acetate concentrations (45.3, 33.7, and 12.9 mmol/kg), propionate (14.3, 11.1, and 5.94 mmol/kg), and butyrate (12.9, 6.69, and 4.52 mmol/kg) in the rumen, reticulum, and omasum, respectively (p<0.05), indicating enhanced fermentation capacity, a significantly thicker rumen mucosal epithelium (p<0.05) suggesting a greater capacity for VFA absorption. Taxonomic analysis showed that Firmicutes and Bacteroidota were the predominant phyla in four stomachs. Differential analysis identified that the DH group had significantly enriched taxa associated with fiber degradation (e.g., Fibrobacterota, Spirochaetota) in the forestomachs. Conversely, the rumen of HH group was enriched with Anaerolineae, associated with complex plant fiber degradation. PICRUSt2 functional prediction indicated that differentially microbes in the DH group were primarily linked to the biosynthesis of lysine and arginine, whereas those in the HH group were enriched in degradation pathways such as amino acid degradation. The DH group markedly elevated VFA production by modulating the forestomach microbial structure. Combined with adaptive improvements in rumen epithelial, this effect potentially enhanced energy utilization and growth performance.

PMID 42755070
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PubMedFrontiers in immunology2026-09-18

SCO‑792 alleviates HFD‑aggravated chronic pancreatitis by modulating the gut-pancreas axis via the AMPK/ACC and TLR4/NF‑κB signaling pathways.

Kang Yanru Y, Sun Ningning N, Yao Weijie W, Li Jinyu J et al.

Chronic pancreatitis (CP) is an inflammatory disorder that manifests as pancreatic fibrosis and exocrine insufficiency, and premature activation of trypsinogen to trypsin. Enteropeptidase has emerged as a promising therapeutic target in CP due to its critical role in activating trypsinogen. The aim of this study was to assess the effects of SCO-792, a novel enteropeptidase inhibitor, on high-fat diet (HFD)-aggravated CP, and explore the underlying mechanisms. A mouse model of HFD-aggravated CP was established by chronic caerulein administration. The protective effects of SCO-792 were evaluated through histological analysis, biochemical assays, and molecular techniques. The composition of the gut microbiota was analyzed by 16S rRNA gene sequencing, and the fecal levels of short-chain fatty acids (SCFAs) were measured. The involvement of the gut-pancreas axis was further validated by supplementation with Akkermansia muciniphila (AKK) and propionate. SCO-792 treatment significantly alleviated HFD-aggravated pancreatic injury and fibrosis, as indicated by reduced histological scores, decreased collagen deposition, and downregulated protein levels of collagen I and α‑SMA. At the metabolic level, SCO-792 regulated pancreatic lipid metabolism homeostasis via the AMPK/ACC pathway. SCO-792 also restored the gut microbiota by increasing the abundance of Akkermansia and other beneficial bacteria, and enhancing production of SCFAs. Furthermore, SCO-792 significantly reduced the translocation of serum lipopolysaccharide(LPS) by maintaining intestinal barrier integrity. The decrease in systemic endotoxin levels eventually blocked the TLR4/NF-κB-mediated inflammatory response in the pancreas, and promoted macrophage polarization to the M2 phenotype. Supplementation with Akkermansia or propionate protected against HFD-induced CP through similar signaling pathways, and synergistically activated AMPK signaling while suppressing inflammatory pathways. SCO-792 mitigated HFD-aggravated pancreatitis in mice by modulating the gut-pancreas axis, indicating its potential as a preventive and therapeutic agent for metabolic pancreatic diseases.

PMID 42755448
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PubMedFrontiers in microbiology2026-09-18

Gut microbiota and SCFA signatures in predicting postoperative infection sites in neurocritical care patients.

Sun Weirong W, Zhang Zhen Z, Wang Congkai C, Huang Junyao J et al.

Postoperative pulmonary infection (PI) and intracranial infection (IC) are major complications in neurocritical care patients; however, reliable approaches for predicting infection site susceptibility remain unavailable. Increasing evidence suggests that the gut microbiota and its metabolites influence systemic immune responses through the gut-lung and gut-brain axes. However, whether early postoperative gut microbial signatures could discriminate between subsequent PI and IC remains unknown. In this cross-sectional study, 90 neurocritical care patients undergoing neurosurgical procedures were enrolled and subsequently categorized based on their postoperative infection status into three groups: IC (n = 30), PI (n = 30), and non-infected controls (CON, n = 30). Fecal samples were collected within 24 h after surgery for 16S rRNA gene sequencing and gas chromatography-mass spectrometry-based quantification of short-chain fatty acids (SCFAs). Microbial diversity, taxonomic composition, differential microbial biomarkers, functional profiles, and microbiota-metabolite correlations were systematically analyzed. Compared with CON patients, both infection groups exhibited significantly reduced microbial diversity and altered community structures. Distinct gut microbial and metabolic patterns were observed between IC and PI patients. The IC group showed enrichment in Enterococcus, Staphylococcus, and Clostridium, increased butyrate levels, reduced propionate levels, and elevated branched-chain SCFA proportions. In contrast, the PI group was characterized by expansion of Proteobacteria, enrichment of Klebsiella and Escherichia-Shigella, increased propionate concentrations, and decreased butyrate levels. Correlation analyses demonstrated strong associations between characteristic microbial genera and SCFA profiles. A six-genus microbial panel, comprising Enterococcus, Faecalibacterium, Dialister, Escherichia-Shigella, Agathobacter, and Blautia, effectively discriminated infection categories, achieving an area under the curve of 0.901. Functional prediction further revealed distinct metabolic and pathogenicity-related pathways among the three groups. Early postoperative gut microbiota and SCFA signatures are associated with subsequent infection sites in neurocritical care patients. These findings highlight the potential of gut microbial-metabolic profiling as a non-invasive strategy for early risk stratification and personalized prevention of postoperative pulmonary and intracranial infections.

PMID 42756303
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PubMedJournal of microbiology and biotechnology2026-09-18

Inhibitory Effects of Tenebrio molitor Larva Trypsin Hydrolysate on Androgenetic Alopecia.

Kim Seok-Hee SH, Choi Young-Jin YJ, Wedamulla Nishala Erandi NE, Zhang Qun Q et al.

Androgenetic alopecia (AGA) is the most common form of hair loss, with a high prevalence worldwide. In this study, we aimed to investigate the potential of Tenebrio molitor larva trypsin hydrolysate (TMTH), an insect-derived bioactive hydrolysate, as a functional ingredient candidate for AGA. In vitro and in vivo assessments demonstrated that TMTH promoted human hair dermal papilla (HDP) cell proliferation, restored β-catenin expression, and alleviated dihydrotestosterone (DHT)-induced inhibition. In a testosterone propionate (TP)-induced alopecia mouse model, oral TMTH administration increased hair coverage and follicle number, upregulated Wnt/β-catenin and PI3K/Akt signaling, reduced androgen receptor expression, enhanced antioxidant-related responses, and suppressed inflammatory markers. These findings suggest that TMTH may ameliorate AGA-related phenotypes by modulating hair growth-related signaling, local androgen-related responses, oxidative stress, and inflammation, thereby supporting its potential as a functional ingredient candidate for hair loss management.

PMID 42755354
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PubMedJournal of computer-aided molecular design2026-09-18

Identification of potential SARS-CoV-2 Mpro inhibitors from a Thai natural product database via interaction fingerprint-based virtual screening.

Chimprasit Aunlika A, Bret Guillaume G, Hannongbua Supa S, Saparpakorn Patchreenart P et al.

The SARS-CoV-2 main protease (Mpro) is a promising target for coronavirus disease 2019 (COVID-19) therapy due to its high conservation and essential role in viral replication. In this study, 148 crystal structures of SARS-CoV-2 Mpro complexed with non-covalent inhibitors from the Protein Data Bank (PDB) were used to map the inhibitor binding site using protein-ligand interaction fingerprints (IFPs). The analysis revealed that the S2 binding site serves as a key region to anchor most non-covalent inhibitors. This mapping was used as a guide to virtually screen an in-house Thai natural product database for potential inhibitors of SARS-CoV-2 Mpro. Seven hit compounds were selected based on docking results, including pose quality, interaction profiles, and energetic criteria. Molecular dynamics simulations confirmed the stability of the SARS-CoV-2 Mpro-hit compound complexes, revealing that panduratin A (CPD3), deacetylmammea E/BA cyclo D (CPD4), and n-pentyl beta-carboline-1-propionate (CPD5) were particularly interesting virtual hits, as they consistently formed strong interactions with key residues at the S2 site through π-π, H-π, and hydrogen bonds.

PMID 42758356
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