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nabilone (Canemes)

✓ Approved

AOP Health · CNR1

What is nabilone?

nabilone is a therapeutic agent developed by AOP Health. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesCanemes
CompanyAOP Health
Molecular TargetCNR1
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, AOP Health

Mechanism of Action

Molecular Targets

nabilone acts on 1 molecular target:

CNR1cannabinoid receptor 1 (CNR, CB1A)
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Related Research Articles

PubMedbioRxiv : the preprint server for biology2026-09-19

Cryo-EM reveals patient- versus organ-specific structural diversity and bound ligands in λ6 light chain amyloids.

Huda Noorul N, Spencer Brian B, Hicks Chad W CW, Jayaraman Shobini S et al.

Immunoglobulin light chain (LC) amyloidosis is a debilitating multiorgan disease with limited treatment options. Sequence and structural variability make LC amyloids particularly challenging for therapeutic targeting. We report four cryo-EM structures of λ6-LC amyloid fibrils from four organs of two patients. Fibrils from different patients show different N-terminal conformations expanding known repertoire of λ6-LC amyloid folds. These folds contain a planar β-arch with a flexible linker containing the complementarity-determining region 2, flanked by N- and C-terminal segments in variable patient-specific conformations. The surface location of the structurally frustrated charged segment may contribute to the overrepresentation of the λ6-LC family in amyloidosis. These and other λ6-LC amyloid structures from different patients show different side chain packing. Conversely, cardiac, renal and splenic amyloids from the same patient exhibit similar structures with small peripheral organ-specific variations. Moreover, they show similar "orphan" densities, suggesting collagen-like triple helices bound to a tyrosine ladder along the fibril spine. Mass spectrometry detects collagen type-VI in tissue-extracted amyloids. Molecular dynamics simulations suggest amyloid binds collagen-VI triple helices via mixed interactions facilitated by the geometric complementarity between the layered amyloid structure and the triple helix. Similar interactions may drive formation of other amyloid-collagen complexes, influencing biological properties of amyloids.

PMID 42760916
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PubMedPhysiological measurement2026-09-18

Measurement properties and operational feasibility of an automated arterial occlusion pressure assessment system for blood flow restriction exercise.

Silva Joanderson Felipe Soares JFS, Rolnick Nicholas N, Cerqueira Maria Luiza Araujo MLA, Silva Gabriela Mota Pinto GMP et al.

To evaluate the validity, reliability, agreement, and operational feasibility of an automated arterial occlusion pressure (AOP) assessment system compared with a manual Doppler-based assessment (MDA). Forty healthy adults (20 men and 20 women) completed upper- and lower-limb AOP assessments using automated and MDA methods in a randomized and counterbalanced design. Concurrent validity, agreement, intraday and interday reliability, operational feasibility, perceptual responses, and procedure-related symptoms were evaluated. Exploratory analyses examined whether sex modified the difference between automated and MDA-derived AOP measurements. MDA demonstrated good-to-excellent reliability (ICC = 0.84-0.98; CV = 1.38-3.25%). The automated system demonstrated moderate-to-good intraday reliability (ICC = 0.74-0.85) but poor lower-limb interday reliability (ICC = 0.36). Compared with MDA, automated AOP showed systematic bias and wide limits of agreement. No evidence of a sex-related difference in the between-method discrepancy was observed for either upper- or lower-limb AOP. Although automated assessment reduced testing time by 81.9-86.7%, frequent upper-limb measurement failures reduced the automated measurement success rate to approximately 57%, substantially increasing adjusted assessment time and limiting operational feasibility, while discomfort and affective responses were more favorable than with MDA. The automated AOP system improved assessment efficiency and participant experience but demonstrated less favorable reliability estimates, limited agreement, and frequent upper-limb measurement failures. Consequently, automated and MDA should not be considered interchangeable for individualized AOP prescription.

PMID 42759562
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PubMediScience2026-09-18

Single-cell gene regulatory networks characterize colonic stem and immune cell homeostasis in Nr4a1 knockout mice.

Romero Selim S, Gupta Shreyan S, Salinas Michael L ML, Mullens Destiny A DA et al.

Recent findings suggest that the orphan nuclear receptor 4A (NR4A) can regulate cellular energetics and epithelial defenses, contributing to a resilient, disease-resistant phenotype. To further examine the effects of NR4A on intestinal epithelial, stromal, and immune cell homeostasis, we performed single-cell transcriptomics and differential gene network analysis in wild-type and whole-body Nr4a1 knockout mice. Here we observed a widespread effect of Nr4a1 deletion on intercellular communication involving intestinal stem cells, macrophages, T and B cells, and fibroblasts, indicating a complex and pervasive remodeling of the colonic epithelial and immune microenvironments and their regulatory networks. This alteration in cell-cell crosstalk was associated with an elevated single-cell entropy and colonic crypt-derived organoid growth, indicative of higher differentiation potential and stem-like properties in epithelial cells. Our work demonstrates that Nr4a1 serves as a critical regulatory factor in stem cell and immune homeostasis in the colon.

PMID 42756602
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PubMedACS omega2026-09-18

Production and Characterization of a Brazil Nut Protein Isolate with Functional Properties for Food Applications.

Rufino João Lucas da Silva JLDS, de Assunção Pâmela Vital da Silva PVDS, Souza E Souza Laura Beatriz LB, Cezário Brandão João Pedro JP et al.

Considering the nutritional properties of the Brazil nut (Bertholletia excelsa), a protein isolate was produced using the pH-shift precipitation technique. Analyses of the proximate composition revealed a protein concentration of 73%, 0.43% total lipids, 1.96% moisture and 6.34% total phenolic compounds. Electrophoresis revealed that this product is composed of low-molecular-weight proteins, indicating a high potential for absorption and digestion. Mineral analysis demonstrated the presence of essential minerals, especially selenium (132.88 μg/g). Amino acid analysis showed the presence of essential amino acids, particularly methionine and cysteine, which act as selenium carriers and are involved in antioxidant defense. The isolate exhibited excellent functional properties and moderate rheological properties due to the difficulty in flow caused by electrostatic forces, and the results of this study may provide support for further investigations and future applications of this product, for example in the development of nutraceuticals or pharmaceuticals based on this novel product.

PMID 42757162
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PubMedAngewandte Chemie (International ed. in English)2026-09-18

Deaminative Allylation of Primary Amines.

Sun Qi Q, Li Shuhao S, Cui ZhangKai Z, Ma Panpan P et al.

Nitrogen atoms play pivotal roles in governing molecular properties and biological activity. Accordingly, nitrogen-atom manipulation has emerged as a powerful strategy for skeletal remodeling. However, its integration into classical reactions to redirect their inherent pathways and outcomes remains largely unexplored. Here, we report a deaminative allylation enabled by embedding a photoinduced N-atom deletion process within a classical N-allylation reaction. This reaction-reprogramming strategy transforms ubiquitous alkylamines into α-substituted acrylates and acrylamides-privileged motifs in covalent drugs, chemical biology probes, and functional materials. Mechanistic studies reveal multiple parallel pathways, including deaminative allylation of alkylamines, formal nitrogen-atom deletion of allyl alkylamine intermediates, and denitrogenation of allyl alkyldiazene species, which collectively converge on the same products. The method exhibits broad substrate scope and excellent functional-group tolerance, enabling late-stage modification of natural products and pharmaceuticals. Beyond providing streamlined access to valuable acrylic compounds, this work establishes a pathway-convergent reaction paradigm that harnesses, rather than suppresses, competing reaction pathways, offering new opportunities for bioactive-molecule discovery.

PMID 42757997
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PubMedAngewandte Chemie (International ed. in English)2026-09-18

Cobalt-Catalyzed C─N Bond Formation via Metal-Hydride Hydrogen Atom Transfer (MHAT).

Khosravi Arman A, Ngai Ming-Yu MY

Nitrogen-containing molecules are ubiquitous in pharmaceuticals, agrochemicals, and functional materials, making the development of efficient C─N bond-forming reactions a central goal in synthesis. Cobalt-catalyzed metal-hydride hydrogen atom transfer (Co─H/MHAT) has emerged as a powerful platform for alkene hydroamination by enabling the controlled generation of carbon-centered radicals under mild and near-neutral conditions. This review summarizes the development of Co-MHAT-enabled C─N bond formation from its origins to recent advances, tracing all transformations to a common Co─H-initiated radical/organocobalt branch point. Across both reductive Co/photoredox and oxidative Co-MHAT manifolds, a common Co─H-initiated step generates a shared radical/organocobalt intermediate that can be directed into distinct pathways, including radical-radical coupling (RRC), radical-polar crossover (RPC), and radical ligand transfer (RLT). These complementary reactivity modes enable amination at sterically hindered and electronically unbiased sites. Collectively, Co-MHAT catalysis offers a versatile and conceptually distinct strategy for selective C─N bond construction.

PMID 42758024
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