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chlorhexidine gluconate (PerioChip)

✓ Approved

Dexcel Pharma Ltd. · Small Molecule · Small Molecule

What is chlorhexidine gluconate?

chlorhexidine gluconate is a small molecule developed by Dexcel Pharma Ltd.. It is approved for therapeutic indications via surgical implantation.

Drug Profile

Brand NamesPerioChip
CompanyDexcel Pharma Ltd.
Drug ClassSmall Molecule
RouteSurgical Implantation
StatusApproved
Sources: ClinicalTrials.gov, Dexcel Pharma Ltd.

Therapeutic Indications

chlorhexidine gluconate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsPeriodontitis✓ Approved

Related Research Articles

PubMedPhotodiagnosis and photodynamic therapy2026-09-18

In vitro evaluation of photodynamic therapy associated with irrigation protocols in the control of multispecies endodontic biofilm.

Cardozo Bianca B, Pereira Ana Carolina Cambuí ACC, Mita Daniela D, Nunes Erica Miyazima EM et al.

To evaluate the antimicrobial efficacy of antimicrobial photodynamic therapy (aPDT), either alone or in combination with various irrigation protocols, against mature multispecies biofilms. Multispecies biofilms consisting of nine bacterial species were cultivated on 72 bovine dentin discs and randomly assigned to six groups (n = 12 each): saline (control), saline + aPDT, 2.5% sodium hypochlorite (NaOCl) + 17% EDTA, NaOCl + EDTA + aPDT, 2% chlorhexidine (CHX) + EDTA, and CHX + EDTA + aPDT. aPDT was performed using 0.005% methylene blue and a red diode laser (660 nm, 100 mW, 9 J, 90 s). The antimicrobial efficacy was assessed through colony-forming unit (CFU) counts and confocal laser scanning microscopy (CLSM). The data were analyzed using a significance level of 5%. The saline control exhibited the highest microbial load, which was significantly reduced when combined with aPDT (p < 0.05). Both NaOCl and CHX, in the absence of aPDT, significantly decreased microbial levels compared to saline (p < 0.05). When used alongside aPDT, NaOCl resulted in the lowest CFU values; however, no additional antimicrobial benefit from light activation was observed. The antimicrobial reduction achieved with saline + aPDT was comparable to 2% CHX. CLSM analysis corroborated these findings. aPDT enhanced the antimicrobial efficacy of physiological saline, resulting in an antimicrobial effect comparable to that observed with 2% liquid chlorhexidine. Among the irrigation protocols evaluated, 2.5% sodium hypochlorite showed the greatest antimicrobial efficacy, with no significant additional benefit following the application of aPDT.

PMID 42759825
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PubMedMedeniyet medical journal2026-09-18

In Vitro Antifungal Activity of Commonly Used Antiseptics and Disinfectants Against Candida auris Isolates.

Habip Zafer Z, Koçoğlu Mücahide Esra ME, Güneysu Yarar Büşra B, Özmen Merve M et al.

Candida auris (C. auris) has emerged as a multidrug-resistant nosocomial pathogen associated with outbreaks in healthcare settings and high mortality rates. Its ability to persist in the hospital environment highlights the importance of effective disinfection strategies. This study aimed to evaluate the in vitro susceptibility of clinical C. auris isolates to commonly used antiseptics and disinfectants under conditions reflecting routine clinical practice. Ten clinical C. auris isolates, along with reference strains of C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019), were tested. Sodium hypochlorite (5%, 1%, 0.5%), hydrogen peroxide (6%, 3%), povidone-iodine (10%, 5%, 2.5%), a chlorhexidine/n-propanol-containing liquid soap, and an ethanol/isopropyl alcohol-based hand disinfectant were evaluated by a qualitative suspension test at contact times of 1, 2, 5, 10, and 30 minutes. Growth inhibition was assessed after incubation. Povidone-iodine at all concentrations, chlorhexidine/n-propanol-containing liquid soap, alcohol-based hand disinfectant, and sodium hypochlorite at 5% and 1% achieved complete growth inhibition of all isolates within the first minute. In contrast, 0.5% sodium hypochlorite and hydrogen peroxide showed reduced efficacy at early contact times. Growth was observed in some C. auris isolates after 1 minute of exposure to 6% hydrogen peroxide, and in a larger proportion of isolates after 1-2 minutes of exposure to 3% hydrogen peroxide. Similar variability was observed in reference strains, particularly with hydrogen peroxide. Commonly used antiseptics and disinfectants are effective against C. auris when applied at appropriate concentrations and contact times. However, reduced efficacy at lower concentrations and with shorter exposure times underscores the importance of proper disinfectant use in preventing environmental persistence and transmission in healthcare settings.

PMID 42756048
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PubMedBMC cardiovascular disorders2026-09-18

The effect of antibacterial mouthwash on blood pressure in humans: a scoping review.

Singh Bhavik B, North Parker P, Rushetsky Zoë M ZM, Brito Richard C RC et al.

Oral hygiene is a key component of health. Practices for oral hygiene include brushing teeth with toothpaste, flossing, and mouth washing. It has been reported that 36% of United States adults use mouthwash daily. However, antibacterial mouthwashes kill oral nitrate-reducing bacteria, thus impairing nitric oxide production. Nitric oxide is a key molecule in vasodilation and blood pressure regulation, often acting as a mediator, so there is a potential for antibacterial mouthwashes to cause elevated blood pressure. Therefore, we conducted a scoping review to address the question: Does antibacterial mouthwash use significantly increase blood pressure in humans? A scoping review was conducted utilizing the databases PubMed and Scopus. Our search terms included "mouthwash," "chlorhexidine," "antibacterial," "salivary nitrite," "nitrate," and MeSH terms like "blood pressure" and "hypertension." Inclusion criteria required primary research articles since 2014 that analyzed changes in blood pressure in human adults after using antibacterial mouthwash. Studies with pediatric participants, animal studies, reviews, or studies that did not measure blood pressure changes were excluded. 51 studies were retrieved from the search, and after independent screening by two reviewers, nine studies were included in the scoping review. Reviewers extracted data on study methodology, sample size, participant characteristics, type of mouthwash, mouthwash regimen, and study results. Reviewers also appraised study quality using a modified Downs and Black assessment checklist. Nine studies were included: four randomized crossover trials, three nonrandomized crossover trials, one active-controlled trial, and one observational study. The studies were of good quality (mean modified Downs and Black score was 21.9 ± 2.9 out of 28 points). Five studies found significant blood pressure elevations after mouthwash usage, while four studies found no significant relationship. Heterogeneity in intervention lengths, mouthwash composition, participant characteristics, and blood-pressure assessment schedules, in addition to methodological weaknesses (such as inadequate washout periods and lack of randomization) in some studies make the pooled evidence inconclusive. Consequently, no firm conclusions can be drawn regarding the effect of antibacterial mouthwash on blood pressure at this time. Future research should utilize larger, randomized trials with standard washout periods and long-term monitoring to further clarify the relationship between antibacterial mouthwash usage and blood pressure.

PMID 42754848
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PubMedRevue medicale de Liege2026-09-17

[Anaphylaxis to MMR vaccine gelatin : practical recommendations].

Iordachescu Mihai M, El Abd Kamal K

This article reports two pediatric cases of anaphylaxis to the M-M-RVaxPro® vaccine, attributable to porcine gelatin used as a stabilizer (14.5 mg/dose). Both patients developed severe reactions after the booster dose, with positive skin and blood tests for gelatin. The first case had hereditary alpha-tryptasemia as an aggravating factor. Investigations ruled out the responsibility of neomycin, latex, and chlorhexidine. Key recommendations include avoidance of gelatin-containing vaccines and medications, substitution with gelatin-free alternatives (Priorix®), evaluation of food tolerance through an oral challenge test, and provision of an emergency kit with epinephrine. Hospital monitoring is recommended for future vaccinations in patients with mast cell disorders. The study highlights gelatin as the primary culprit in vaccine anaphylaxis, emphasizing the importance of systematic testing for vaccine components and proper management of sensitized patients.

PMID 42751843
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PubMedJournal of Ayurveda and integrative medicine2026-09-17

Olive oil-based interventions for gingival inflammation and plaque control- A systematic review of clinical evidence.

Narasimhan Sangeetha S, Alkandari Ghala G, Buhamad Hawraa H, Alqattan Retaj R et al.

Natural compounds have gained attention for their therapeutic potential in managing oral conditions. Olive oil, known for its anti-inflammatory and antimicrobial properties, may offer clinical benefits in managing gingivitis. This systematic review aimed to evaluate the effectiveness of olive oil in reducing gingival inflammation and plaque accumulation in patients with gingivitis. A comprehensive literature search was conducted in PubMed, PROQUEST, and EBSCOhost databases to identify studies published between January 2002 and August 2025 that assessed the impact of olive oil on gingival health. Details collected included the study design, characteristics of participants, nature of the intervention, outcome measures, and principal findings. Twelve studies that meet the inclusion criteria were analyzed. Evidence suggests that olive oil administered through various forms including, oil pulling, mouthwashes, toothpastes, and ozonated preparations, generally reduced gingival inflammation and plaque accumulation. Ozonated olive oil demonstrated superior efficacy compared to regular olive oil. Few studies found that olive oil interventions are comparable to chlorhexidine in reducing gingival inflammation. Olive oil appears to be a promising natural adjunct in the management of gingivitis, particularly in ozonated form. While current findings are encouraging, further high-quality studies with standardized methodologies and extended follow-up durations are required to confirm these outcomes and frame clinical guidelines. Dental practitioners may consider incorporating olive oil-based products as an adjunctive option alongside conventional gingivitis treatments.

PMID 42753329
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PubMedThe Saudi dental journal2026-09-17

Modulating the periodontal wound microenvironment through oxygen therapy: a narrative review on the biological basis, clinical applications and future perspectives.

Basudan Amani M AM

Topical oxygen-releasing formulations have emerged as a potential adjunctive approach to enhance wound healing outcomes in conditions such as gingivitis, periodontitis and peri-implant diseases. Periodontal wound healing is a complex biological process influenced by microbial load, tissue oxygenation, and host inflammatory responses. This narrative review aimed to evaluate the available clinical evidence on the effectiveness of topical oxygen-releasing products in oral soft and hard tissue wound management. Unlike previous broad reviews of topical oxygen therapy, this review specifically synthesizes its role in periodontal wound healing, compares clinical outcomes with conventional therapies, and evaluates emerging opportunities for integration into regenerative periodontal strategies. An organised literature search was conducted in PubMed, Scopus, Web of Science, and the Cochrane Library for studies published till 2025. Eligible studies included primarily randomized controlled trials, evaluating clinical outcomes related to periodontal wound healing. A structured search of five electronic databases was undertaken, and eligible studies were narratively synthesized in accordance with the Scale for the Assessment of Narrative Review Articles (SANRA). Included studies, were evaluated qualitatively to compare the efficacy of topical oxygen therapy as an adjunct in periodontal wound healing. The findings suggest that topical oxygen-releasing formulations provide adjunctive benefits in specific contexts, particularly in postoperative healing, periodontal therapy, enhancing soft tissue healing, and improving patient-reported outcomes such as pain and discomfort. However, many outcomes were comparable to conventional therapies such as chlorhexidine. Topical oxygen-releasing formulations appear to be a potential adjunct in periodontal wound repair, particularly in hypoxic or inflammatory conditions.

PMID 42753039
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