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somatropin (Valtropin / somatropin, LG Chem / Eutropin Pen)

✓ Approved

Takeda · GHR · Recombinant Proteins

What is somatropin?

somatropin is a recombinant proteins developed by Takeda. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesValtropin, somatropin, LG Chem, Eutropin Pen
CompanyTakeda
Drug ClassRecombinant Proteins
Molecular TargetGHR
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Takeda

Mechanism of Action

Molecular Targets

somatropin acts on 1 molecular target:

GHRgrowth hormone receptor (GHBP, GHIP)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

somatropin is developed for 4 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Endocrine disordersGrowth hormone deficiency✓ Approved
Congenital, familial and genetic disordersSex chromosome abnormality✓ Approved
Congenital, familial and genetic disordersOsteochondrodysplasia✓ Approved
Congenital, familial and genetic disordersPrader-Willi syndromePhase III

Related Research Articles

PubMedJournal of health psychology2026-09-19

Attitudes toward participation in sport and life satisfaction: The serial mediating roles of body appreciation and psychological well-being.

Aslan Tahir Volkan TV, Bozkur Binaz B

This study examined the relationship between attitudes toward sport participation and life satisfaction in young adults and tested the serial mediating roles of body appreciation and psychological well-being. The sample consisted of 472 undergraduate students from a university in the Mediterranean region of Turkey. Data were collected using standardized self-report measures and analyzed using Pearson correlations and PROCESS Macro Model 6 for serial mediation. Results indicated that attitudes toward sport were positively associated with body appreciation, psychological well-being, and life satisfaction. Mediation analyses revealed significant indirect effects of attitudes toward sport on life satisfaction through body appreciation and psychological well-being, both separately and sequentially. The serial mediation model was also supported, suggesting that more positive attitudes toward sport are associated with higher life satisfaction via increased body appreciation and psychological well-being. These findings highlight the potential sequential mechanisms linking sport-related attitudes and life satisfaction among young adults.

PMID 42760833
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PubMedFrontiers in oral health2026-09-19

Embedding planetary health and sustainability in dental education: a community-engaged training model from Kenya.

Nyachio James Johnstone JJ, Akama Gladys Mwango GM, Lukandu Ochiba O

Climate change and environmental degradation are reshaping health systems in ways that the dental profession can no longer afford to ignore. Oral health is increasingly positioned as both a victim of environmental disruption and a contributor to it. However, despite growing momentum in medicine and public health, dental education has remained largely disconnected from climate-health thinking and sustainability frameworks. This manuscript examines how planetary health principles can be meaningfully integrated into dental education through community-engaged learning. Drawing on the Community-Based Education and Service programme at Moi University College of Health Sciences in Kenya, we present a conceptual framework built on four interrelated components: curriculum reform, community-based training, sustainable clinical practice, and interdisciplinary collaboration. This approach supports prevention-focused care, develops systems thinking, and produces graduates who are equipped to engage with environmental determinants of health. This approach is designed to be scalable and adaptable, with particular relevance to low- and middle-income countries. It connects directly to global priorities, including the Sustainable Development Goals, Universal Health Coverage, and the WHO Global Oral Health Action Plan 2023-2030.

PMID 42760973
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PubMedArchives of women's mental health2026-09-19

Early life trauma and endometriosis: A case-control study on type and timing of adverse experiences.

Chiu Lauren L, Mu Eveline E, Li Qi Q, Ingleby Lucy L et al.

Endometriosis is a common chronic inflammatory gynaecological condition characterised by the abnormal presence of endometrial tissue outside the uterus. Different risk factors for endometriosis have been proposed, with some research finding a significant relationship between endometriosis and early life trauma. This study aimed to determine the prevalence, age, and type of early life trauma in a clinical sample of women with existing diagnosis of endometriosis compared with the prevalence in the general Australian female population. Participants were recruited from the Multidisciplinary Alfred Psychiatry research centre Women's Mental Health Clinic (WMHC). Women who self-reported a diagnosis of endometriosis were identified from the WMHC patient database, established in 2017. In patients who reported a presence of early life trauma, information regarding the type and age of the early traumatic experience(s) was recorded. The prevalence of each type of trauma in our participants was compared to the general female population in Australia. Of 68 included participants, the mean (SD) age was 41.6 (9.7) years. 86.8% of participants (n = 59) reported experience of any early life trauma, most commonly occurring between ages 6-10 (89.8%). The most reported type of trauma was emotional abuse (76.5%). Compared to the general female population, the prevalence of emotional abuse (76.5% vs. 37.3%), neglect (35.3% vs. 10.8%), and sexual abuse (39.7% vs. 37.3%) were higher in our sample. The findings of this study found high prevalence rates of early life trauma, in particular emotional abuse and neglect, in our clinical sample of women with endometriosis.

PMID 42760359
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PubMedBMC palliative care2026-09-19

Satisfaction with treatment decision-making and long-term experiences of life-prolonging treatments for metastatic castration-resistant prostate cancer.

Routier Cañigueral Paula P, Wennman-Larsen Agneta A, Doveson Sandra S, Rönningås Ulrika U et al.

Treatments in the phase of metastatic castration-resistant prostate cancer (mCRPC) aim to prolong survival and reduce the symptom burden. The fast development of life-prolonging therapies makes treatment decision-making (TDM) complex, weighting survival against possible side-effects and quality of life, especially in a real-world context. This study aimed to describe satisfaction with TDM at start of the first, second and third line of life-prolonging treatment and to describe and compare long-term treatment experiences when receiving one or several lines of treatment in patients with mCRPC. A longitudinal observational study. Participants completed a study-specific questionnaire every three months for up to two years from the start of any first line of life-prolonging treatment after mCRPC. Satisfaction with TDM was measured at the start of each new treatment line while treatment experiences were measured using the first and last completed questionnaire of each participant. Medical data was obtained from medical records. Descriptive statistics were used to present data while inferential statistics were used for analysis of group comparisons and over time changes. A total of 122 participants (mean age 75.3 years) with an average follow-up time of 18.3 months were included. Satisfaction with TDM was generally high at the start of the first, second and third line of treatment, but lower regarding discussions on how treatment could affect their life situation. Treatment experiences were positive, yet there was a significant decrease from the first to the last follow-up in whether they would choose (p = 0.04) and recommend (p = 0.01) the same treatment to others. For participants who received one line of treatment, a significant decrease was found between the first and the last follow-up (p = 0.02), while no differences were found for those who received two or more lines. Despite high satisfaction with aspects of TDM and the treatment given it is important to discuss how the treatment can impact the patient's life situation. The slightly decreased satisfaction over time on the treatment received could reflect a possible need to strengthen communication between patients and healthcare professionals, shifting from a disease-centered perspective towards a more person-centered and palliative care approach.

PMID 42760521
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PubMedMolecular genetics and genomics : MGG2026-09-19

Codon optimality predicts mRNA half-life but does not transfer to lncRNAs.

Tani Hidenori H

Codon optimality couples translation elongation to decay and is among the strongest reported sequence determinants of mRNA half-life. Long non-coding RNAs (lncRNAs) are largely untranslated. Is lncRNA stability sequence-encoded in the way mRNA stability is? We compared the classes on half-lives from the same assays, re-estimating the codon stabilization coefficient (CSC) inside each cross-validation fold to remove label leakage. Performance is the cross-validated coefficient of determination R² - 1 for perfect prediction, 0 for the training mean, negative for worse - and the Spearman rank correlation ρ between predicted and measured half-life. mRNA half-life was sequence-predictable (R² = 0.174, ρ = 0.44), and CSC alone (R² = 0.084) outperformed a six-member translation-independent set (R² = 0.008), an ordering that held in three further datasets, two assays and two species. lncRNA half-life was not: R² = -0.050 in same-assay HeLa lncRNAs (n = 364) and R² = +0.0007 from k-mer composition in the largest published lncRNA dataset (n = 33,285), where that study's own cross-validated ρ is 0.091. That value clears its permutation null: the classes differ in magnitude, not detectability. Pretrained genomic language models, one covering 99.6% of transcripts whole, left mRNAs at R² = 0.042 and lncRNAs at 0.0002-0.0036. Coding-potential strata change nothing; matching on length, GC and n with an identical feature set gives R² = 0.033 versus 0.0002. Signal injection puts the reliable detection limit near 0.5% of variance, above every lncRNA value obtained. mRNA-derived decay models should not be transferred to lncRNAs without re-validation.

PMID 42760417
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PubMedAllergologia et immunopathologia2026-09-19

Sensitization to Alternaria alternata, household environmental exposure and respiratory disease control in a Mediterranean agricultural area.

Martinez Antonio Carbonell AC, Garrido Cristina Navarro CN, Zamorano Javier Carbonell JC, Diaz Javier Alcover JA et al.

Environmental fungi play an important role in allergic respiratory diseases. Alternaria alternata sensitization has been associated with more severe respiratory phenotypes and poorer asthma control. Mediterranean agricultural environments may favor environmental exposure because of their climatic conditions and intensive agricultural activity. To analyze the prevalence of sensitization to Alternaria alternata, evaluate its association with asthma control and quality of life, and describe household environmental findings in a Mediterranean agricultural population. An observational, analytical, cross-sectional study with standardized collection of clinical, allergological, and environmental data was conducted in 100 consecutive adult patients (18-65 years) with allergic rhinitis/rhinoconjunctivitis, with or without associated asthma. Sensitization to Alternaria alternata was defined by a positive skin prick test and/or molecular determination against Alt a 1 (>0.35 kUA/L). Asthma control was assessed using the Asthma Control Test (ACT), quality of life using the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), and rhinitis control using the Spanish Rhinitis Questionnaire (SPRINT). Household environmental evaluation was performed in sensitized patients. Sensitization to Alternaria alternata was observed in 29% of patients (95% CI: 20.1-38.8). Skin prick testing was positive in 25 patients, whereas molecular sensitization against Alt a 1 was observed in 20 patients. Sensitized patients showed poorer asthma control and greater quality-of-life impairment than non-sensitized patients. No significant differences in the polysensitization burden were observed. Among sensitized patients, household microbiological assessment demonstrated Alternaria alternata detection in 46.4% of indoor samples and 28.6% of outdoor samples. Sensitization to Alternaria alternata was frequent in this Mediterranean agricultural population and was associated with poorer asthma control and greater quality-of-life impairment. Environmental findings support further investigation of fungal exposure in Mediterranean agricultural settings.

PMID 42760883
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