Drug Database
N-

N-1037

✓ Approved

Bausch Health Companies Inc. · Small Molecule · Small Molecule

What is N-1037?

N-1037 is a small molecule developed by Bausch Health Companies Inc.. It is approved for therapeutic indications via others or inhaled or topical.

Drug Profile

CompanyBausch Health Companies Inc.
Drug ClassSmall Molecule
RouteOthers, Inhaled, Topical
StatusApproved
Sources: ClinicalTrials.gov, Bausch Health Companies Inc.

Therapeutic Indications

N-1037 is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Eye disordersConjunctivitis allergic✓ Approved
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved

Related Research Articles

PubMedThe International journal of pharmacy practice2026-09-19

Interventions to promote the early detection of cancer in community pharmacies: a systematic review.

Nabhani Gebara Shereen S, Weir Natalie McFadyen NM, Macleod Lisa L, Winter Helen H et al.

Early detection and diagnosis of cancer is associated with greater treatment success and improved survival. Community pharmacies are often the first point of contact for patients with symptoms that could be due to cancer (e.g. persistent cough, rectal bleeding, dysphagia), and could contribute to earlier cancer detection. This systematic review assessed the evidence for community pharmacy-based interventions to support the early detection of cancer. Five databases (Medline, EMBASE, HMIC, CINAHL, and PSYCINFO) and other supplementary sources were searched for the time period January 2000-February 2025. Standard systematic review methodology following PRISMA guidelines was used. Independent duplicate screening, study selection, data extraction, and quality assessment were undertaken. In total, 27 studies from 10 countries were included. Several cancer types were represented including colorectal (n = 13), lung (n = 4), skin (n = 4), breast (n = 1), prostate (n = 1), breast and cervical (n = 1), gastric (n = 1), colorectal and prostate (n = 1) and one study included multiple cancer types. The interventions included targeted screening (n = 2), population screening (n = 15), triage (n = 8) and health promotion (n = 2). From the 10 studies that reported cancer diagnosis rates, 3274 individuals had cancerous or precancerous lesions detected: colorectal (n = 2816); prostate (n = 14); and skin (n = 453), with a referral conversion rate ranging between 3.4% and 8.5%. Harnessing the expertise of community pharmacy personnel is likely to support patients in an earlier and faster diagnosis of cancer. The integration of community pharmacy into early detection pathways is key to maximizing their potential.

PMID 42760275
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PubMedJournal of nursing management2026-09-19

Rethinking Middle Management in Residential Aged Care: Evaluation of a Dyad House Leadership Model Intervention.

Radford Katrina K, Meissner Ellie E, Church Michelle M, Maddern Jenna J et al.

New leadership models in Australian aged care facilities are required to respond to increasing demands, decreasing supply of talent and more complex care clients. In this study, we cocreated and evaluated a dyad house leadership model across three residential aged care sites in South Australia using a pre-post intervention methodology. Data were collected over three time periods. We first interviewed employees (n = 28), families (n = 8) and residents (n = 8), then conducted 90 h of observations across 9 leaders. Three codesign sessions were then held to cocreate the solution. The intervention (a dyad house leadership model) was trialled for 6 months. We then evaluated by conducting interviews with employees (n = 21 mid and n = 28 post), families (n = 6 mid, and n = 8 post) and residents (n = 8 mid and n = 13 post) and observations with leaders (n = 32 h mid, n = 96 h post). Participants reported improved role clarity, career progression, wellbeing and perceptions of quality of care alongside greater satisfaction with communication and care; however, some clinicians perceived some risks to their career progression. At the 6-month point, no significant changes were found in the counts of hospitalisation, client incidents and average call-bell response time. Dyad house leadership represents promising middle-management model for residential aged care, with potential to improve role clarity, redistribute operational workload and expand leadership capacity. Successful implementation requires clearly defined clinical and nonclinical accountabilities, and careful attention to clinical governance and succession planning. Effective dyad leadership requires both deliberate career infrastructure and structures that enable clinical and nonclinical leaders to work together effectively. Clear progression pathways, reporting relationships, role transitions and shared ways of working can help broaden the leadership pipeline while preserving clinical career trajectories and reducing traditional silos.

PMID 42760590
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PubMedAllergologia et immunopathologia2026-09-19

Inborn errors of immunity and mortality: 10 years of single-center experience.

Çevirme Leyla L, Özden Güzin G

The aim of this study was to investigate the mortality rate and causes of death among patients with rare inborn errors of immunity (IEI), conditions associated with relatively high morbidity and mortality, who were followed at our center, and to identify management strategies tailored to local conditions based on the findings. The medical records of 99 patients followed between January 1, 2015, and October 1, 2025, were retrospectively reviewed. Data on age, sex, symptom onset, and date of diagnosis were recorded, and diagnostic delay was calculated. Systemic symptoms and clinical findings observed at admission and during the disease course were documented. Laboratory parameters, including lymphocyte counts, B-cell and memory B-cell levels, as well as IgG and IgG4 levels, were analyzed. A total of 99 patients were included in the study. Of the participants, 53.5% were male (n = 53) and 46.5% were female (n = 46). The mean age was 34.8 ± 14.9 years (range, 17-72 years). The most common infection was pneumonia (n = 38, 38.4%). Evaluation of presenting symptoms at diagnosis showed that respiratory manifestations were the most frequent (n = 56, 56.6%). Twelve patients died, while 87 survived. Among the nonsurvivors, 58.3% (n = 7) died due to infection-related causes and 41.7% (n = 5) due to malignancy. The diagnostic delay was 4 years in survivors and 9 years in nonsurvivors. Although no statistically significant differences were observed between survivors and nonsurvivors in terms of lymphocyte counts, B-cell percentage, IgG, and IgG4 levels, all laboratory parameters were numerically lower in patients who died. Similarly, diagnostic delay was longer in non-survivors.

PMID 42760879
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PubMedMedicine2026-09-19

Prognostic value of the HALP (hemoglobin, albumin, lymphocyte, and platelet) score in emergency versus elective inguinal hernia repair: A retrospective study.

Öğüt Mehmet Zeki MZ, Ağ Onur O, Kutluer Nizamettin N, Saricik Bekir B et al.

The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a novel prognostic biomarker that reflects a patient's immune-nutritional status. This study aimed to evaluate the diagnostic and prognostic value of the HALP score in patients undergoing emergency versus elective inguinal hernia repair. This retrospective study analyzed data from 235 patients who underwent inguinal hernia surgery at a single center. The patients were categorized into emergency (n = 97) and elective (n = 138) groups, with the emergency group further divided into intestinal resection (n = 12) and non-resection (n = 85) subgroups. Preoperative HALP scores were significantly lower in the emergency group than in the elective group (P < .001). Subgroup analysis revealed that HALP scores were significantly lower among patients who required intestinal resection compared with those who did not require resection in the emergency group and those who underwent elective surgery (P = .004 and P < .001, respectively). Univariate analysis showed that the HALP score was associated with small bowel resection. Receiver operating characteristic curve analysis demonstrated that a HALP score cutoff value of < 2.31 yielded 75% sensitivity and 90.2% specificity for predicting intestinal resection in incarcerated inguinal hernia. The accessibility and cost-effectiveness of the HALP score support its use as an adjunctive tool for risk stratification in inguinal hernia management, particularly in resource-limited settings.

PMID 42760682
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PubMedBritish journal of clinical pharmacology2026-09-19

Re-evaluating variability of circulating miR-122 in healthy volunteers: Implications for biomarker qualification in drug-induced liver injury.

Javid Irum I, Russomanno Giusy G, Evans Anthony A, Aithal Guruprasad P GP et al.

Drug-induced liver injury (DILI) remains a major challenge in clinical practice and drug development, and reliable biomarkers are still needed. MicroRNA-122 (miR-122) has shown promise, but reported inter-individual variability in healthy populations has raised concerns about its clinical utility. We analysed circulating miR-122 levels in healthy volunteers across three European sites (Antwerp, n = 96; Brussels, n = 124; and Leeds, n = 60) using small RNA sequencing within the TransBioLine programme. Only modest regional differences were observed (miR-122-5p ICC 0.864; miR-122-3p ICC 0.849). Importantly, intra-individual miR-122 levels were stable over time (CV 10.7% and 16.5%, respectively), even under physiological perturbations such as fasting and postprandial states. Our findings suggest that previously reported miR-122 variability may largely reflect analytical factors, including normalization strategies, rather than biological instability. miR-122 is a robust biomarker for liver injury when appropriate analytical approaches and individual baseline levels are considered, supporting its application in clinical pharmacology and drug development.

PMID 42760615
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PubMedPain management2026-09-19

The effect of stress ball use during the intrapartum period on labor pain and childbirth experience in primiparous women: a randomized controlled trial.

Küçük Sibel S, Avcı Sezer S, Sevil Ümran Ü

This study examined the effect of stress ball use during the intrapartum period on labor pain intensity and childbirth experience in primiparous women. This two-arm, parallel-group randomized controlled trial was conducted between October and December 2025 in the delivery unit of a public hospital in Türkiye. Sixty-six primiparous women were randomized in a 1:1 ratio to the intervention (n = 33) or control group (n = 33). Outcome analyses included 60 participants with available outcome data (intervention, n = 29; control, n = 31). Women in the intervention group used a stress ball during uterine contractions, whereas the control group received routine intrapartum care. Labor pain intensity was assessed using the Visual Analog Scale (VAS) during the latent, active, and transition phases, and childbirth experience was assessed postpartum using the Childbirth Experience Questionnaire (CEQ). Pain intensity during the transition phase was significantly lower in the intervention group than in the control group (p = 0.001; Cohen's d =  -0.89), whereas no significant between-group differences were observed during the latent or active phases (p > 0.05). The intervention group had a significantly higher total CEQ score (p < 0.001; Cohen's d = 1.08), with higher scores for birth process (p = 0.001; Cohen's d = 0.93) and agreement in decisions (p < 0.001; Cohen's d = 2.11). Stress ball use was associated with lower overall labor pain, with a significant between-group difference observed during the transition phase, and with a more positive childbirth experience. www.clinicaltrials.gov identifier NCT07011355.

PMID 42760820
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