Drug Database
OM

omeprazole

✓ Approved

Santarus, Inc. · ATP4A · Small Molecule

What is omeprazole?

omeprazole is a small molecule developed by Santarus, Inc.. It is approved for therapeutic indications via oral (po).

Drug Profile

CompanySantarus, Inc.
Drug ClassSmall Molecule
Molecular TargetATP4A
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Santarus, Inc.

Mechanism of Action

Molecular Targets

omeprazole acts on 1 molecular target:

ATP4AATPase H+/K+ transporting subunit alpha (ATP6A)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

omeprazole is developed for 3 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersDuodenal ulcer✓ Approved
Gastrointestinal disordersGastric ulcer✓ Approved
Gastrointestinal disordersGastrooesophageal reflux disease✓ Approved

Related Research Articles

PubMedChemical communications (Cambridge, England)2026-08-25

Cetyl-containing solid-state ionic liquids as hosts for organic room-temperature phosphorescence systems.

Lee Bong B, Pham Danh D, Favret Jeanne M JM, Gryczynski Zygmunt Z et al.

Solid-state analogues of ionic liquids containing a cetyl-alkyl group act as efficient hosts with designer capabilities for generating viable host-guest room-temperature phosphorescence systems, with the combination of an aliphatic cyclic cation and bromide anion exhibiting superior host capabilities when a set of all-organic phosphorescent dyes is used as guests.

PMID 42640248
Read full article →
PubMedDalton transactions (Cambridge, England : 2003)2026-08-25

Solid-state phosphorescence colour changes in a tetranuclear Cu(I)-pyrazolate cluster achieved by the conformational flexibility of peripheral alkyl chains.

Koshiba Kyoko K, Aizawa Naoya N, Sugiyasu Kazunori K, Watanabe Yuichiro Y

Polymorph-dependent luminescence is usually governed by intermolecular packing in the crystal, often causing quenching and limited colour control. Here we show that a tetranuclear Cu(I)-pyrazolate cluster achieves solid-state phosphorescence colour switching through intramolecular Cu4 core distortion induced by conformationally flexible peripheral alkyl chains.

PMID 42638612
Read full article →
PubMedChemical communications (Cambridge, England)2026-08-25

A molecularly engineered siloxane-derived hybrid interphase for dendrite-free all-solid-state lithium metal batteries.

Song Kun K, Liu Tong T, Li Siwu S, Liu Jun J et al.

A fluorinated siloxane-derived hybrid interphase featuring molecularly dispersed LiF/LiIn nanodomains in a cross-linked polysiloxane network is constructed on Li metal via co-reduction of a fluorinated alkoxysilane and InCl3. The elastic organic matrix accommodates volume fluctuations, while inorganic components suppress dendrites and enhance Li+ transport, enabling a critical current density of 3.2 mA cm-2 and 78.7% capacity retention after 200 cycles at 0.5C in sulfide all-solid-state full cells.

PMID 42640051
Read full article →
PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-25

Phase-Transformation-Driven Orientation Selection and Anisotropic Properties in Gallium Microfibers.

Liu Jinyun J, Yang Jianfang J, Kan Jingying J, Yang Huali H et al.

Ga-based liquid-metal (Ga-LM) microfibers are promising one-dimensional phase-change materials for variable-stiffness and electrically tunable devices. However, their solid-state properties remain difficult to control because of the polymorphism of Ga and the highly anisotropic bonding in the ambient-pressure stable α-Ga phase. Here, we investigate crystallographic orientation selection in Ga microfibers under different triggered phase-transformation pathways and clarify its influence on electrical and mechanical properties. During the triggered liquid-solid transition, the axial orientation of the resulting α-Ga single-crystal fibers is governed by the orientation of the α-Ga seed crystal and the local interfacial contact conditions. In contrast, after the triggered β-Ga→α-Ga solid-solid transition, no obvious inheritance from the initial α-Ga axial orientation is observed; instead, the final α-Ga fibers preferentially adopt an axial orientation close to [0 1 0]. This preferential orientation is attributed to a low-mismatch, low-strain transformation pathway associated with the β-Ga→α-Ga transition. The resulting α-Ga fibers exhibit pronounced electrical and mechanical anisotropy, especially between the [0 1 0] direction and the [1 0 0]/[0 0 1] directions. This work establishes a link among triggered transformation pathways, seed/interface-controlled orientation selection, and anisotropic properties in Ga microfibers, providing a strategy for tailoring liquid-metal fibers for programmable electronic and mechanically adaptive devices.

PMID 42639720
Read full article →
PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-25

Covalent Organic Framework Electrolytes for Solid-State Lithium Batteries: Designing Ion Highways for Next-Generation Energy Storage.

Dhanushkotti Rajesh R, G N Ningaraju N, C S Karthik K, V Karthik K et al.

Covalent organic frameworks (COFs) are emerging as a programmable platform for solid electrolytes in solid-state lithium batteries, since their crystalline, periodically ordered nanochannels can be engineered to enable directional ion transport. These low-resistance pathways promote directional lithium-ion (Li+) migration through a narrower, more spatially ordered distribution of coordination environments, achieved via site-to-site hopping and/or guest-assisted vehicular motion within the channels. This review presents a design-oriented framework linking COF structural descriptors to ion-transport metrics through a cause-effect-performance relationship. We first summarize the Li+ transport mechanism in confined COF channels, covering site-to-site hopping along pore walls and guest-assisted vehicular motion in filled channels. We then correlate (i) topology and channel architecture, (ii) pore-wall chemical functionality and framework charge, (iii) crystallinity, stacking registry, and channel alignment, and (iv) hybrid COF architectures with performance indicators including ionic conductivity (σ), activation energy (Ea), lithium-ion transference number (tLi+), transport anisotropy, and effective conductivity in working membranes (σeff). Through representative case studies, we highlight cases where high intrinsic channel transport does and does not translate into device-relevant σeff. Finally, we propose standardized reporting practices and device-level benchmarks to accelerate the shift from empirical materials discovery toward predictive ion-highway engineering for next-generation solid-state lithium batteries.

PMID 42640029
Read full article →
PubMedChemSusChem2026-08-25

Polymer Dendricolloids as Hosts for Uniform Fillers Dispersion Toward Robust All-Solid-State Electrolytes With Accelerated Li+ Kinetics.

Qin Huaisheng H, Chen Jiawei J, Song Xin X, Wang Jian J et al.

To address the safety issues associated with traditional liquid lithium-ion batteries and the performance deficiencies of single-component solid-state electrolytes, this work proposes a bioinspired strategy of designing composite solid-state electrolytes (CSE). A tree-root-like 3D skeleton containing dendritic micro- and nanopoly(vinylidene fluoride) (PVDF) fibers and uniformly distributed Li-Al layered double hydroxide or oxide (Li-Al-LDH or Li-Al-LDO) nanosheets was constructed and combined with poly(ethylene oxide) (PEO) electrolyte; hence, LDH@PVDF/PEO or LDO@PVDF/PEO CSE films were successfully prepared. LDO@PVDF/PEO electrolyte film exhibits high tensile strength (26.4 MPa) and Young's modulus (625.3 MPa) and is able to maintain structural integrity at 100 °C. LDO@PVDF/PEO exhibits ionic conductivity of 1.21 × 10-4 S cm and lithium ion transference number of 0.41 at 50 °C, both higher than those of PEO, LDO/PEO, and LDH@PVDF/PEO. In addition, its electrochemical stability window extends to 4.9 V, demonstrating its potential for use with high-voltage cathodes. Li/(LDO@PVDF/PEO)/LiFePO4 cells were assembled and tested, showing excellent rate capability and capacity retention. In addition, Li/(LDO@PVDF/PEO)/Li symmetric cells demonstrated excellent cycling stability for over 1500 h at a current density of 0.1 mA cm-2. This work provides an innovative biomimetic strategy for constructing high-performance CSE applicable to next-generation solid-state lithium metal batteries.

PMID 42639849
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about omeprazole