Drug Database
ME

megestrol (Apetrol ES / megestrol, LG Chem)

✓ Approved

LG Chem Ltd. · PGR · Small Molecule

What is megestrol?

megestrol is a small molecule developed by LG Chem Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesApetrol ES, megestrol, LG Chem
CompanyLG Chem Ltd.
Drug ClassSmall Molecule
Molecular TargetPGR
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, LG Chem Ltd.

Mechanism of Action

Molecular Targets

megestrol acts on 1 molecular target:

PGRprogesterone receptor (NR3C3, PR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

megestrol is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersCachexia✓ Approved

Related Research Articles

PubMedThe Journal of psychology2026-09-20

The Relationships of Psychological Richness, Meaning of Life, and Psychological Well-Being: The Mediating Role of Happiness.

Shirmohammadzadeh Ayoob A, Khodarahimi Siamak S, Beit-Mashal Belgheis B, Rahimian Bougar Mojtaba M et al.

This research examined the relationships among psychological richness, meaning of life, and psychological well-being (PWB), with happiness as a mediator. A sample of 494 adult participants from the general population was selected through purposive sampling. The data were gathered using the Psychologically Rich Life Questionnaire (PRLQ; Oishi et al., 2019), the Meaning in Life Questionnaire (MLQ; Steger et al., 2006), the Oxford Happiness Inventory (OHI; Argyle et al., 1989), and the Psychological Well-Being Scale (PWBS; Ryff, 1989). The analysis indicated that psychological richness, meaning in life, and happiness together explained 45.3% % of the variance in PWB. There were significant and positive relationships between psychological richness, meaning in life, happiness, and PWB. Furthermore, psychological richness and meaning in life have a significantly positive indirect relationship with PWB, mediated by happiness. This fitted model for the direct and indirect relationships between psychological richness, meaning in life, and PWB with the mediating role of happiness has implications for positive development in adults through individual and community-focused initiatives.

PMID 42763433
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PubMedJournal of the American Academy of Audiology2026-09-20

Relationship Between Age, Auditory Performance, and Quality of Life in Middle-Aged and Older Cochlear Implant Users.

Deniz Hüseyin H

Aging can result in hearing loss, and cochlear implants (CIs) provide an effective means for auditory rehabilitation. We evaluated the impact of age on CI outcomes. This study aimed to examine the effects of aging on auditory performance and quality of life in individuals who underwent unilateral cochlear implantation. This study was designed as a cross-sectional study. Participants included individuals with postlingual, profound sensorineural hearing loss who had undergone unilateral cochlear implantation. Two groups were formed: those aged 40-59 years (Group 1) and those aged ≥60 years (Group 2). There were 31 participants in Group 1 and 33 participants in Group 2, totaling 64 participants (30 women [46.88 percent] and 34 men [53.13 percent]). Quality of life was measured using the Turkish version of The World Health Organization Quality of Life Brief Version (WHOQOL-BREF), and depression levels were assessed using Beck's Depression Inventory. To assess auditory performance, free-field audiometry included pure-tone threshold at 0.5-4 kHz, speech recognition threshold, speech discrimination, and spectral-temporally modulated ripple test measurements. The Shapiro-Wilk test was used to assess the normality of the numerical variables. The Mann-Whitney U test was used to compare WHOQOL-BREF scores and auditory performance between groups, and the chi-square test was used for categorical variables. Relationships between numerical variables were assessed using Spearman's correlation coefficient. The older group exhibited significantly poorer auditory performance and quality of life scores across multiple dimensions (p < 0.05). However, no significant differences in depression levels were observed between the groups (p = 0.198). Age considerably influences auditory performance and quality of life in CI users. These findings underscore the importance of tailored rehabilitation approaches for this population. The results of this study show that aging negatively affects the auditory performance and quality of life of CI users. Moreover, CI alone is insufficient to fully improve quality of life in older individuals, highlighting the need for a comprehensive, multidisciplinary approach to address aging-related neurological and sensory changes.

PMID 42763618
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PubMedMediastinum (Hong Kong, China)2026-09-20

Mediastinal tracheostomy: techniques, outcomes and quality of life-a systematic review.

Ehrsam Jonas Peter JP, Petrone Ana-Maria AM, Aleksic Marko M, Fuchs Paul Christian PC et al.

Mediastinal tracheostomy (MT) is a rare, technically demanding salvage procedure in which the distal trachea is redirected into the upper mediastinum. It is indicated when extensive resection of the proximal trachea precludes conventional tracheal reconstruction or cervical tracheostomy. It is performed for a variety of underlying diseases. The aim of this systematic review was to summarize the available evidence on operative techniques, perioperative outcomes, disease-specific outcomes, and quality of life. A systematic review was conducted. PubMed was searched for case reports and case series. Data on surgical techniques, indications, perioperative outcomes, complications, and quality of life were descriptively analyzed. Seventy publications reporting 437 mediastinal tracheostomies over 85 years were identified. Of these, 429 were permanent anterior mediastinal tracheostomies, the predominant type. Several techniques have evolved for this procedure over time. Extended manubrial resection was performed in most cases, whereas hemi-manubrial resection (2.8%) has gained popularity in recent years. Although a tracheal stump length of ≥5 cm is generally recommended, 12.6% of tracheostomies were created with a stump measuring 0-4 cm. Tracheal transposition was performed in 52.9% of cases to increase tracheal length and avoid contact with the brachiocephalic artery. Initially, direct collar skin (20.3%) or bipedicled upper thoracic skin flaps (13.8%) were used for reconstruction; more recently, the pectoralis major myocutaneous flap (32.9%) has become the predominant technique. Postoperative mortality was 7.0% and decreased over time. Major complications included great vessel rupture (6.8%), tracheal necrosis (8.4%), and tracheal stenosis (9.6%). Patients with a tracheal stump length of 0-3cm had a failure rate of 33.3%. Available data did not permit reliable conclusions on outcomes for specific malignancy types. Quality-of-life data were scarce, although individual reports described independent daily living and return to strenuous work for more than 10 years. Permanent anterior MT remains the standard form of MT and can provide acceptable outcomes when meticulous surgical technique is applied. Tracheal transposition and well-vascularized muscle flap reconstruction appear to reduce procedure-related complications, particularly in patients with short tracheal remnants. Prospective multicenter studies are needed to define optimal surgical strategies, long-term oncological outcomes, and patient-reported quality of life.

PMID 42763627
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PubMedAIDS care2026-09-20

'I love my medicine. Thanks to this, I have the life I have'. Antiretroviral therapy as a meaning-making process shaping continuity of life with HIV: a qualitative study.

Thanasko Florian F, Nikoloudi Maria M, Antoniadou Anemi Konstantina K, Mellon Robert R et al.

Antiretroviral therapy (ART) has transformed HIV into a chronic condition; however, living with HIV extends beyond biomedical control. This interpretative phenomenological study explored how people living with HIV (PLHIV) construct the meaning of ART. Semi-structured interviews were conducted with twelve PLHIV receiving ART (5 gay men, 3 heterosexual men, and 4 heterosexual women), with investigator triangulation enhancing analytic rigor. Analysis generated one superordinate theme with four themes describing participants' evolving experiences of ART across their illness trajectory. ART initiation emerged as a negotiated process shaped by medical guidance, personal beliefs, and fears, representing an early stage of illness reconstruction. Trusting relationships with HIV physicians facilitated treatment engagement, whereas stigma, disclosure, treatment-related challenges, and persistent uncertainty regarding U = U continued to shape participants' experiences. Participants progressively integrated ART by reconstructing its meaning in relation to identity, relationships, and future aspirations. Although all participants described treatment as enabling health and a renewed sense of normality, the pathways through which this normality was reconstructed differed across subgroups. ART was experienced as the foundation of a treatment-dependent normality, through which participants adapted not by eliminating uncertainty but by integrating it into a renewed sense of everyday life.

PMID 42763418
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PubMedCurrent health sciences journal2026-09-20

From Classroom to Clinic: A Qualitative Study on Newly Graduated Nurses' Transition to Practice.

Jafarimanesh Hadi H, Zakerimoghadam Masoumeh M, Ghiyasvandian Shahrzad S

The global nursing shortage and high turnover rates among newly graduated nurses (NGNs) pose significant challenges to their transition into professional roles. Understanding NGNs' experiences is crucial for identifying the factors contributing to turnover and developing targeted strategies that facilitate their integration into clinical practice, ultimately promoting long-term retention. While extensive research has explored this transition in developed countries, there remains a notable gap in studies focusing on NGNs' experiences in developing nations. This study aims to explore the lived experiences of NGNs during their transition to clinical practice (TCP), offering valuable insights to inform policy development and improve support mechanisms in healthcare settings. This study employed a qualitative inductive content analysis approach to explore NGNs' transition experiences. Conducted in three hospitals affiliated with Tehran University of Medical Sciences, the study recruited 21 NGNs with less than one year of work experience through purposive sampling. Data were gathered via semi-structured face-to-face interviews and analyzed using the Graneheim and Lundman framework. To ensure the trustworthiness of findings, Lincoln and Guba's criteria were rigorously applied. Data management and analysis were facilitated by MAXQDA (version 20). Three main categories emerged from the data analysis: magnetic experiences, non-magnetic experiences, and transition period outcomes. The findings underscore the complex and multifaceted nature of NGNs' transition experiences, encompassing both magnetic (supportive) and non-magnetic (challenging) factors that significantly influence patient care quality, job satisfaction, and retention decisions. These findings align with transition theory and transition shock models, emphasizing the urgent need for structured, evidence-based support programs to optimize the transition process. This study provides critical insights for designing targeted interventions, fostering attractive work environments, and enhancing nursing workforce retention strategies.

PMID 42763756
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PubMedMilitary medicine2026-09-20

Feasibility of Immersive Virtual Reality for Assessing Mass-Casualty Triage Decision-Making in a NATO Civil-Military Emergency Management Exercise: A Cross-Sectional Study.

López Ferrándiz Lucia L, Pardo Rios Manuel M, Lopez Lopez Carmen Amalia CA, Tortosa Alcázar José J et al.

Mass-casualty incident (MCI) triage is difficult to teach and assess under realistic operational conditions. Immersive virtual reality (VR) may provide a standardized and operationally relevant platform for evaluating triage decision-making and prioritization of immediate life-saving interventions during disaster preparedness exercises. To evaluate performance in MCI triage and prioritization of immediate life-saving interventions using an immersive VR scenario embedded in a NATO civil-military emergency management exercise, while also describing participants' perceptions of usefulness, ease of use, immersion, and physical comfort. This cross-sectional observational study was conducted during the NATO Emergency Management Exercise "Bulgaria 2025" in Montana, Bulgaria. Civilian and military first responders who completed the immersive scenario and post-experience questionnaire were included. The VR assessment, delivered through Meta Quest 3 headsets and haptic vests, comprised 14 triage items and 2 immediate life-saving intervention items. The reference standard for triage categorization was based on the Simple Triage and Rapid Treatment (START) algorithm. The primary outcome was item-level accuracy. Secondary outcomes included perceived usefulness, ease of use, immersion, physical comfort, and perceived contribution of haptic feedback. A total of 102 valid post-simulation questionnaires were analyzed. Participants had a mean age of 34.3 years (SD 8.8), were predominantly male (98.0%), mainly military-affiliated (86.3%), and had a median of 10 years of professional experience. Triage performance was heterogeneous: accuracy exceeded 75% in several core items. Perceived usefulness and ease of use were high, with composite medians of 7.0 (IQR 6.0-7.0) and 7.0 (IQR 6.5-7.0), respectively. Presence/immersion was also high (median 6.25, IQR 5.5-7.0), and discomfort was low (median 1.0, IQR 1.0-2.0). In a NATO civil-military emergency management exercise, immersive VR was highly acceptable, usable, and well tolerated, while revealing substantial item-level variability in MCI triage decisions and immediate life-saving intervention choices. These findings suggest that immersive VR may offer a feasible and operationally relevant platform for standardized assessment of disaster triage performance and for identifying specific decision bottlenecks relevant to preparedness and interoperability.

PMID 42763421
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