Drug Database
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recombinant human growth hormone (Ansomone)

✓ Approved

Anhui Anke Biotechnology · GHR · Recombinant Proteins

What is recombinant human growth hormone?

recombinant human growth hormone is a recombinant proteins developed by Anhui Anke Biotechnology. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesAnsomone
CompanyAnhui Anke Biotechnology
Drug ClassRecombinant Proteins, Polypeptide
Molecular TargetGHR
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Anhui Anke Biotechnology

Mechanism of Action

Molecular Targets

recombinant human growth hormone acts on 1 molecular target:

GHRgrowth hormone receptor (GHBP, GHIP)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

recombinant human growth hormone is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Endocrine disordersGrowth hormone deficiency✓ Approved

Related Research Articles

PubMedFrontiers in plant science2026-09-19

Drip fertigation technique with planting models strategies trigger grain filling, endogenous hormonal changes and maize productivity under semi-arid regions.

Wang Jiaqi J, Diao Jian J, Xu Zhe Z, Ma Ning N et al.

Mulch drip fertigation strategies have been widely adopted to improve maize productivity in semi-arid regions. However, the impact of the mulch-based drip fertigation on endogenous hormone dynamics in crops and grain yield has not been fully elucidated, and the biochemical mechanisms underlying yield improvement under different drip fertigation strategies remain unclear. Grain filling has a significant impact on maize production. The aim of this study was to explore the effect of plastic film mulching materials on maize grain filling under a drip fertigation strategy, and the relationship between this effect and changes in endogenous hormones. This study compared biodegradable film mulching (BM) with soil crust ridges (SR) under high (H), medium (M), and low (L) drip irrigation conditions, and measured that the grain filling characteristics and changes in grain endogenous hormones in various parts of maize ears during the growth stage. The results showed that the grain filling rate, dry matter plant-1, hormone changes, yield components, water use efficiency (WUE), and ET of maize under the BMH treatment were significantly higher than those under the SR treatment. BMH treatment significantly increased soil water storage significantly increased plant hormone contents such as abscisic acid (ABA), indole-3-Acetic acid (IAA), and zeatin + Zeatin Riboside (Z+ZR), and decreased the evolution rate of gibberellins (Gas) and ethylene, thereby increasing maize yield. These results indicate that BMH treatment improved the filling process, soil respiration rate, WUE, yield, and yield composition of maize. High drip fertigation with BM or SR treatment significantly affected endogenous hormone changes, thereby regulating the activity grain-filling period (AGP), maximum grain-filling rate (Gmax), maximum grain weight (Wmax), mean grain-filling rates (Gmean) and occurrence time of maximal filling rate (Tmax) of maize. In addition, high drip fertigation and the BM strategy significantly increased soil water storage and soil respiration rate during the grain filling period. Based on these results, we conclude that BMH significantly improved soil water storage, thereby regulating the maize grain filling rate, which was significantly correlated with the balance of endogenous hormones in the grains.

PMID 42760979
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PubMedPlant communications2026-09-19

A three-threshold gibberellin model defines tunable uncoupling of male fertility and growth to facilitate maize hybrid seed production.

Xu Rui R, Yin Xianglan X, Qiu Keli K, Li Jianyu J et al.

Efficient hybrid seed production requires controllable male sterility systems, yet how developmental processes can be selectively manipulated to disrupt male fertility while preserving vegetative growth remains poorly understood. Whether filament elongation represents a distinct hormonal sensitivity checkpoint and how its regulation can be exploited to uncouple male fertility from vegetative growth remain largely unknown. Here, we identify a series of gibberellin-sensitive genic male sterililty (GGMS) mutants carrying allelic variations in the maize GA biosynthetic gene ZmKAO. Unlike previously characterized GA-deficient mutants with broad defects in reproductive development, ggms mutants exhibit male sterility primarily due to defective filament elongation, while anther development, pollen maturation, and female fertility remain largely unaffected even under severe GA deficiency. Notably, filament elongation in GGMS mutants can be restored by a single GA application after tasseling. Genetic, biochemical, and molecular analyses support a model in which reduced D9 accumulation relieves D9-mediated repression of the filament-preferential transcription factor ZmMYB53, thereby enhancing ZmBXL7 expression and promoting filament cell elongation. Quantification of endogenous GA levels across a series of ZmKAO alleles with different functional strengths reveals a graded relationship between GA reduction and developmental outputs. While strong alleles (ggms1/2) cause severe growth defects, weak alleles (ggms3/4) uncouple vegetative growth from male fertility by selectively disrupting filament elongation. Based on these findings, we propose a three-threshold model in which different developmental processes exhibit distinct sensitivities to GA reduction. This framework enables rational selection and engineering of GGMS materials for maize hybrid seed production. Together, our study reveals a hierarchical GA sensitivity mechanism underlying maize reproductive development and provides both conceptual insights into hormone-regulated fertility and practical strategies for engineering controllable GGMS systems in maize.

PMID 42760779
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PubMedFrontiers in allergy2026-09-19

Severe anaphylactic shock suspectedly induced by injection of recombinant humanized type III collagen lyophilized fiber for facial skin improvement: a case report.

Liu Junjie J, Yan Wenjing W, Liu Jing J, Yang Bowen B et al.

Recombinant humanized type III collagen is widely used in facial rejuvenation due to its excellent biocompatibility and overall favorable safety profile; however, severe systemic hypersensitivity reactions are exceedingly rare. We report a case of a 47-year-old woman with no prior history of allergy who received topical lidocaine to the face, followed by injection of recombinant humanized type III collagen lyophilized fibers for skin texture improvement. Immediately after the injection, she developed suspectedly severe anaphylactic shock temporally associated with the recombinant collagen injectionpresenting with confusion, respiratory distress, followed by marked bradycardia (33 beats/min), and loss of palpable arterial pulse. Emergency protocols were activated immediately, including cardiopulmonary resuscitation, intravenous adrenaline, corticosteroids, and fluid resuscitation. The patient's vital signs gradually recovered, and she was discharged after complete recovery two days later after complete recovery. This case suggests that recombinant humanized collagen, as a macromolecular protein, inherently carries the risk of triggering immediate-type anaphylactic shock despite its favorable safety profile. Clinicians should perform rigorous preoperative assessment, adhere to standardized procedures, and be proficient in the emergency management of anaphylactic shock to minimize the risk of severe adverse reactions and ensure medical safety.

PMID 42760965
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PubMedPflugers Archiv : European journal of physiology2026-09-19

High-salt diet modulates endocrine regulation between cortisol and FGF23.

Moor Matthias B MB, Sagmeister Michael S MS, Crastin Ana A, Kopper Klaudia K et al.

Excessive dietary salt intake is a global health concern, affecting cardiovascular, renal, and bone health. While the renin-angiotensin-aldosterone system (RAAS) is a known regulator of dietary salt-induced hormonal responses, the impact of adrenal cortisol remains unclear. Here, we performed a retrospective analysis in individuals (n = 321) consuming a random diet. Dietary salt intake positively correlated with urinary cortisol and inversely correlated with plasma fibroblast growth factor 23 (FGF23), a bone-derived hormone regulating phosphate and vitamin D homeostasis. Controlled salt diets in healthy individuals confirmed a dose-dependent increase in urinary cortisol and suppression of plasma FGF23. In mice, oral corticosterone, a cortisol analogue, reduced circulating FGF23 levels. RNA-seq analysis of corticosterone-treated MC3T3 osteoblasts identified suppression of FGF23 via glucocorticoid receptor activation, anti-inflammatory pathways, and reduced osteoblast activity. Our findings provide evidence for an endocrine cascade in which high salt intake elevates cortisol signaling and suppresses FGF23.

PMID 42760427
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PubMedFrontiers in endocrinology2026-09-19

Amniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome.

Wu Shimin S, Shi Jiayu J, He Chenyan C, Chen Jie J et al.

Polycystic ovary syndrome is associated with metabolic and hormonal disturbances during pregnancy, but whether these alterations are reflected in the fetal intrauterine exposure environment remains incompletely understood. This study aimed to identify polycystic ovary syndrome-related intrauterine metabolic signatures using late-gestation amniotic fluid. Untargeted metabolomic profiling was performed on late-gestation amniotic fluid samples from women with polycystic ovary syndrome and controls. Differential metabolite analysis, pathway-level analysis, and multilevel sensitivity analyses were conducted to identify robust metabolic alterations associated with maternal polycystic ovary syndrome. Exploratory placental transcriptomic analysis and targeted RT-qPCR assessment in an independent sample set were further used to examine tissue-level molecular changes related to the lipidomic findings. Amniotic fluid from pregnancies with polycystic ovary syndrome showed a distinct metabolic profile dominated by lipid remodeling. Differential metabolites were mainly enriched in membrane phospholipids, sphingolipid-related metabolites, polyunsaturated fatty acid-related pathways, and selected steroid hormone-related metabolites. Phospholipid remodeling was characterized by decreased phosphatidylcholine species, increased phosphatidylethanolamine species, a lower phosphatidylcholine/phosphatidylethanolamine ratio, and redistribution of arachidonic acid-containing phospholipids. Alpha-linolenic acid metabolism provided an additional polyunsaturated fatty acid-related signal. Sphingolipid enrichment suggested that lipid alterations extended from membrane structural remodeling to lipid-mediated signaling. Selected steroid hormone-related metabolites were also elevated, consistent with an altered hormonal milieu in pregnancies with polycystic ovary syndrome. These signatures remained largely stable across sensitivity analyses, as did the multivariable-adjusted inverse association between PE(16:0/20:4) and birth weight. Exploratory placental transcriptomic analysis and targeted RT-qPCR assessment in a small independent cohort provided preliminary tissue-level support for phospholipid-related molecular alterations, with the clearest changes involving PLA2-family genes and PCYT1A, suggesting cross-cohort convergence at the pathway level. These findings identify phospholipid remodeling as a major amniotic-fluid metabolic signature of polycystic ovary syndrome-related intrauterine exposure. PUFA-related metabolism, sphingolipid enrichment, and steroid hormone-related alterations provide additional metabolic context. Complementary placental molecular findings and the inverse association between PE(16:0/20:4) and birth weight further suggest potential links with the maternal-fetal interface and fetal growth. Further studies are needed to clarify the biological relevance of these changes and their potential role in offspring metabolic susceptibility.

PMID 42760943
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PubMedFrontiers in plant science2026-09-19

Root-TransUNet enables high-throughput phenotyping of Arabidopsis thaliana roots as a parameter in Heterodera schachtii parasitism.

Zhou Jie J, Moura de Souza Victor Hugo VH, Ju Lei L, Eves-van den Akker Sebastian S et al.

Plant parasitism by sedentary plant-parasitic nematodes is a dynamic and continuously evolving process, accompanied by profound remodelling of host root system architecture across distinct infection stages. However, the physiology and anisotropic growth of Arabidopsis thaliana roots under Heterodera schachtii infection, together with complex lateral root proliferation and increasingly dense, overlapping morphology, pose substantial challenges for accurate image segmentation. Here, we introduce Root-TransUNet, an optimised segmentation architecture that extends TransUNet by incorporating a composite loss function to improve boundary precision and structural continuity, as well as dual-stage strip-pooling (SP) modules to enhance elongated and directional root features. These adaptations address the unique morphological complexity of the infected root system. Additionally, we integrated Root-TransUNet into a high-throughput phenotyping pipeline and applied it to an existing dataset of ~120,000 images of 362 A. thaliana MAGIC recombinant inbred lines collected over several months of infection. By extracting root system architecture traits, including root surface area and estimated root volume across infection stages, we enabled stage-specific association analyses between host root growth and nematode performance across these genotypes. Root-TransUNet achieved strong segmentation performance, demonstrating improved structural continuity and boundary precision compared with widely used CNN- and Transformer-based baselines, including UNet++. Stage-specific analyses revealed that the relationship between host root traits and nematode performance changed as infection progressed. During establishment, nematode number was largely independent of initial root size and varied strongly among genotypes, whereas during the reproductive phase (10-30 dpi), greater root expansion coincided with reduced estimated nematode volume accumulation. Notably, nematode burden was largely independent of host root size before infection, indicating that root quantity was generally not a limiting factor for infection in this experiment. These results demonstrate that Root-TransUNet can robustly segment infected root systems across a wide range of nematode infection densities, providing a scalable image-analysis framework for studying plant-parasitic nematode parasitism in combination with host root phenotyping.

PMID 42761003
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